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8g25

Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 7.5

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Cathepsin-G

OrganismNot specified

UniProt P08311

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Neutrophil elastase × 1 （P08246） MAP domain-containing protein × 1 （A0A0H3JUK5） water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Neutrophil elastase × 1 （P08246） MAP domain-containing protein × 1 （A0A0H3JUK5） water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 3 Neutrophil elastase × 1 （P08246） MAP domain-containing protein × 1 （A0A0H3JUK5） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1au8 1cgh 1kyn 1kyn 1t32 7h6g 7h6g 7h6h

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6vtm 6vtm 6vtm 6vtm 8d4s 8d4s 8d4s 8d4s 8d4v 8d4v 8d7i 8d7i

30 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CATG_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–223； UniProt 21–243 Author chain F； PDBConstruct 1–223； UniProt 21–243 Author chain I； PDBConstruct 1–223； UniProt 21–243

Neutrophil elastase

OrganismNot specified

UniProt P08246

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Cathepsin-G × 1 （P08311） MAP domain-containing protein × 1 （A0A0H3JUK5） water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Cathepsin-G × 1 （P08311） MAP domain-containing protein × 1 （A0A0H3JUK5） water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 3 Cathepsin-G × 1 （P08311） MAP domain-containing protein × 1 （A0A0H3JUK5） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1b0f 1h1b 1hne 1ppf 1ppg 1ppg 2rg3 2z7f 3q76 3q76 3q77 4nzl

71 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ELNE_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–218； UniProt 30–247 Author chain E； PDBConstruct 1–218； UniProt 30–247 Author chain H； PDBConstruct 1–218； UniProt 30–247

MAP domain-containing protein

Staphylococcus aureus subsp. aureus Mu50

UniProt A0A0H3JUK5

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Cathepsin-G × 1 （P08311） Neutrophil elastase × 1 （P08246） water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Cathepsin-G × 1 （P08311） Neutrophil elastase × 1 （P08246） water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 3 Cathepsin-G × 1 （P08311） Neutrophil elastase × 1 （P08246） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8g24 8g25 8g25 8g25 8g26

5 assemblies

View Construct and Data Evidence
UniProt name A0A0H3JUK5_STAAM
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 4–117； UniProt 31–144 Author chain D； PDBConstruct 4–117； UniProt 31–144 Author chain G； PDBConstruct 4–117； UniProt 31–144

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8g25
Deposition date deposition_date2023-02-03
Structure title titleCrystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 7.5
Keywords keywordsProtease Inhibitor, Immune Evasion, Neutrophil, S. aureus, HYDROLASE-INHIBITOR complex; HYDROLASE/INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8g25__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8g25__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8g25__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）29.17 Å
Rg (electron density)28.56 Å
Total Rg29.21 Å
Atom count4234
Residues544
Excluded volume74944 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8g25__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8g25__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 8g25__assembly_3__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)