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8g3x

MBP-Mcl1 in complex with ligand 32

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera

Homo sapiens

UniProt A0A4P1LXE0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 其他Polymer 1 alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose × 1 1,2-ETHANEDIOL × 10 ;N-[(1'S,3aS,5R,15S,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-{[(5S,9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]methyl}-21-methoxy-17-methyl-13,15-dioxo-2,3,3',3a,4,4',13,16,17,18,21,21a-dodecahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-(ethanediylidene)-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalen]-15-yl]-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide ; × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7fbb 7fbb 7fbc 7fbd 7fbd

5 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
8r3e

1 assemblies

Heteromeric or nucleic-acid complex
6xdj 6xdj 6xdj 6xdj 7kd4 7kd4 7kd5 7vn2 7vn2 7vn3 7vn3 7vn4

42 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name A0A4P1LXE0_SERSF
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–367； UniProt 2–368

Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera

Homo sapiens

UniProt Q07820

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 其他Polymer 1 alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose × 1 1,2-ETHANEDIOL × 10 ;N-[(1'S,3aS,5R,15S,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-{[(5S,9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]methyl}-21-methoxy-17-methyl-13,15-dioxo-2,3,3',3a,4,4',13,16,17,18,21,21a-dodecahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-(ethanediylidene)-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalen]-15-yl]-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide ; × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2mhs 3wix 3wix 3wix 3wix 3wiy 3wiy 3wiy 3wiy 3wiy 3wiy 4hw2

151 assemblies; showing the first 12

Homodimer
3mk8 4wmr 4wmr 5vkc 6oqb 6oqd 6ud2 6udi 6udt 6udu 6udv 8x62

12 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2kbw 2nl9 2nl9 2nl9 2nla 2pqk 2pqk 2pqk 2pqk 2pqk 2pqk 3d7v

123 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MCL1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 370–518； UniProt 173–321

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8g3x
Deposition date deposition_date2023-02-08
Structure title titleMBP-Mcl1 in complex with ligand 32
Keywords keywords;Myeloid cell leukemia 1, Mcl-1, B-cell lymphoma 2, Bcl-2, BH3 mimetic, Protein-protein interaction, Modulator, Apoptosis, Cancer, Leukemia, Myeloma, Lymphoma, Physicochemical properties, ADME properties, Cardiotoxicity, Therapeutic window ;; APOPTOSIS
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8g3x__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8g3x__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8g3x__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.33 Å
Rg (electron density)25.36 Å
Total Rg26.27 Å
Atom count4169
Residues518
Excluded volume74560 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8g3x__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id8g3xA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology190 — D-Maltodextrin-Binding Protein; domain 2
Homologous superfamily homologous superfamily10 — Periplasmic binding protein-like II
Domain ID domain_id8g3xA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology437 — Apoptosis Regulator Bcl-x
Homologous superfamily homologous superfamily10 — Blc2-like
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7. Citations (1)