Nucleoprotein
Severe acute respiratory syndrome coronavirus 2
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain A； UniProt 41–174 | Fragment：N-terminal domain | No other associated polymer | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；0.005 M Spermine tetrahydrochloride, 0.05 M Potassium Chloride, 0.05 M Bis-Tris HCl pH 7.0, 31 % PEG 3350 | Resolution 2.30 Å R-free 0.289 |
| 2 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain B； UniProt 41–174 | Fragment：N-terminal domain | No other associated polymer | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；0.005 M Spermine tetrahydrochloride, 0.05 M Potassium Chloride, 0.05 M Bis-Tris HCl pH 7.0, 31 % PEG 3350 | Resolution 2.30 Å R-free 0.289 |
| 3 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain C； UniProt 41–174 | Fragment：N-terminal domain | No other associated polymer | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；0.005 M Spermine tetrahydrochloride, 0.05 M Potassium Chloride, 0.05 M Bis-Tris HCl pH 7.0, 31 % PEG 3350 | Resolution 2.30 Å R-free 0.289 |
| 4 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain D； UniProt 41–174 | Fragment：N-terminal domain | No other associated polymer | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；0.005 M Spermine tetrahydrochloride, 0.05 M Potassium Chloride, 0.05 M Bis-Tris HCl pH 7.0, 31 % PEG 3350 | Resolution 2.30 Å R-free 0.289 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 8IQJ | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 26UI Dimeric C-terminal domain of Nucleocapsid protein of SARS-CoV-2. Deposited 2026-05-15 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
254–364（111 aa）
Chain B
254–364（111 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；294 K；0.2M ammonium chloride, 0.1M sodium acetate pH 5, 20% PEG 6000
|
Resolution 1.85 Å R-free 0.218 |
| 6M3M Crystal structure of SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain Deposited 2020-03-04 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
Fragment：N-terminal RNA binding domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；20 mM sodium acetate, 100 mM sodium cacodylate (pH 6.5), 26 % PEG 8000
|
Resolution 2.70 Å R-free 0.293 |
| 6M3M Crystal structure of SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain Deposited 2020-03-04 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
41–174（134 aa）
Fragment：N-terminal RNA binding domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；20 mM sodium acetate, 100 mM sodium cacodylate (pH 6.5), 26 % PEG 8000
|
Resolution 2.70 Å R-free 0.293 |
| 6M3M Crystal structure of SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain Deposited 2020-03-04 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
41–174（134 aa）
Fragment：N-terminal RNA binding domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；20 mM sodium acetate, 100 mM sodium cacodylate (pH 6.5), 26 % PEG 8000
|
Resolution 2.70 Å R-free 0.293 |
| 6M3M Crystal structure of SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain Deposited 2020-03-04 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
41–174（134 aa）
Fragment：N-terminal RNA binding domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；20 mM sodium acetate, 100 mM sodium cacodylate (pH 6.5), 26 % PEG 8000
|
Resolution 2.70 Å R-free 0.293 |
| 6VYO Crystal structure of RNA binding domain of nucleocapsid phosphoprotein from SARS coronavirus 2 Deposited 2020-02-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
47–173（127 aa）
Fragment：RNA binding domain
Chain B
47–173（127 aa）
Fragment：RNA binding domain
Chain C
47–173（127 aa）
Fragment：RNA binding domain
Chain D
47–173（127 aa）
Fragment：RNA binding domain
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 4 CL CHLORIDE ION × 4 ZN ZINC ION × 4 GOL GLYCEROL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；289 K；20.0% PEG6000, 0.1M MES, 10.0 mM Zinc chloride
|
Resolution 1.70 Å R-free 0.205 |
| 6WJI 2.05 Angstrom Resolution Crystal Structure of C-terminal Dimerization Domain of Nucleocapsid Phosphoprotein from SARS-CoV-2 Deposited 2020-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
257–364（108 aa）
Fragment：C-terminal dimerization domain (UNP residues 257-364)
Chain B
257–364（108 aa）
Fragment：C-terminal dimerization domain (UNP residues 257-364)
|
Not recorded | CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；292 K；20.0 mg/mL protein in 0.1 M sodium chloride, 0.01 M Tris, pH 8.3 against Classics II screen D8 (0.1 M HEPES, pH 7.5, 25% w/v PEG3350)
|
Resolution 2.05 Å R-free 0.228 |
| 6WJI 2.05 Angstrom Resolution Crystal Structure of C-terminal Dimerization Domain of Nucleocapsid Phosphoprotein from SARS-CoV-2 Deposited 2020-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
257–364（108 aa）
Fragment：C-terminal dimerization domain (UNP residues 257-364)
Chain D
257–364（108 aa）
Fragment：C-terminal dimerization domain (UNP residues 257-364)
|
Not recorded | CL CHLORIDE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；292 K；20.0 mg/mL protein in 0.1 M sodium chloride, 0.01 M Tris, pH 8.3 against Classics II screen D8 (0.1 M HEPES, pH 7.5, 25% w/v PEG3350)
|
Resolution 2.05 Å R-free 0.228 |
| 6WJI 2.05 Angstrom Resolution Crystal Structure of C-terminal Dimerization Domain of Nucleocapsid Phosphoprotein from SARS-CoV-2 Deposited 2020-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
257–364（108 aa）
Fragment：C-terminal dimerization domain (UNP residues 257-364)
Chain F
257–364（108 aa）
Fragment：C-terminal dimerization domain (UNP residues 257-364)
|
Not recorded | CL CHLORIDE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；292 K；20.0 mg/mL protein in 0.1 M sodium chloride, 0.01 M Tris, pH 8.3 against Classics II screen D8 (0.1 M HEPES, pH 7.5, 25% w/v PEG3350)
|
Resolution 2.05 Å R-free 0.228 |
| 6WKP Crystal structure of RNA-binding domain of nucleocapsid phosphoprotein from SARS CoV-2, monoclinic crystal form Deposited 2020-04-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
47–173（127 aa）
Fragment：RNA-binding domain (UNP residues 47-173)
Chain B
47–173（127 aa）
Fragment：RNA-binding domain (UNP residues 47-173)
Chain C
47–173（127 aa）
Fragment：RNA-binding domain (UNP residues 47-173)
Chain D
47–173（127 aa）
Fragment：RNA-binding domain (UNP residues 47-173)
|
Not recorded | ZN ZINC ION × 4 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289 K；0.1 M MES, 30% PEG4000
|
Resolution 2.67 Å R-free 0.248 |
| 6WZO Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P1 form Deposited 2020-05-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
247–364（118 aa）
Chain B
247–364（118 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Sodium acetate pH 4.5, 50 mM Sodium/potassium tartrate, and 34% polyethylene glycol PEG 3350
|
Resolution 1.42 Å R-free 0.173 |
| 6WZO Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P1 form Deposited 2020-05-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
247–364（118 aa）
Chain D
247–364（118 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Sodium acetate pH 4.5, 50 mM Sodium/potassium tartrate, and 34% polyethylene glycol PEG 3350
|
Resolution 1.42 Å R-free 0.173 |
| 6WZQ Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P21 form Deposited 2020-05-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
247–364（118 aa）
Chain B
247–364（118 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；100 mM Tris-HCl pH 8.5, 50 mM Ammonium Sulfate, and 38% polyethylene glycol (PEG) 3350
|
Resolution 1.45 Å R-free 0.180 |
| 6WZQ Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P21 form Deposited 2020-05-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
247–364（118 aa）
Chain D
247–364（118 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；100 mM Tris-HCl pH 8.5, 50 mM Ammonium Sulfate, and 38% polyethylene glycol (PEG) 3350
|
Resolution 1.45 Å R-free 0.180 |
| 6YI3 The N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein Deposited 2020-03-31 | Different construct Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
44–180（137 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 125；Pressure 1
NMR sample composition
1 mM [U-13C; U-15N] N-NTD, 25 mM sodium phosphate, 50 mM sodium chloride, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 6YUN 1.45 Angstrom Resolution Crystal Structure of C-terminal Dimerization Domain of Nucleocapsid Phosphoprotein from SARS-CoV-2 Deposited 2020-04-27 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
249–364（116 aa）
Chain B
249–364（116 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.8；277 K；31% PEG 4K
0.2 M Lithium sulfate
50 mM Tris pH 7.8
|
Resolution 1.44 Å R-free 0.189 |
| 6ZCO Crystal Structure of C-terminal Dimerization Domain of Nucleocapsid Phosphoprotein from SARS-CoV-2, crystal form II Deposited 2020-06-11 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
247–364（118 aa）
Fragment：Dimerization domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；277 K；tba
|
Resolution 1.36 Å R-free 0.196 |
| 7ACS The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 7mer dsRNA Deposited 2020-09-11 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein–RNA Monomer；Protein × 1 PDB declaration: trimeric |
Chain A
44–180（137 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 5.5；298 K；Ionic strength (raw mmCIF value) 70；Pressure 1
NMR sample composition
100 uM [U-13C; U-15N] N-NTD, 100 uM RNA (5'-R(P*CP*AP*CP*UP*GP*AP*C)-3'), 100 uM RNA (5'-R(P*GP*UP*CP*AP*GP*UP*G)-3'), 20 mM sodium phosphate, 50 mM sodium chloride, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 7ACT The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 10mer ssRNA Deposited 2020-09-11 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein–RNA Monomer；Protein × 1 PDB declaration: dimeric |
Chain A
44–180（137 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 125；Pressure 1
NMR sample composition
100 uM [U-13C; U-15N] N-NTD, 100 uM ssRNA, 100 mM sodium chloride, 25 mM sodium phosphate, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 7C22 Crystal structure of the C-terminal domain of SARS-CoV-2 nucleocapsid protein Deposited 2020-05-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
248–364（117 aa）
Chain B
248–364（117 aa）
|
Not recorded | ACT ACETATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.2M Ammonium acetate,
0.1M Sodium acetate pH 4.6,
30% PEG 4000
|
Resolution 2.00 Å R-free 0.238 |
| 7C22 Crystal structure of the C-terminal domain of SARS-CoV-2 nucleocapsid protein Deposited 2020-05-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
248–364（117 aa）
Chain D
248–364（117 aa）
|
Not recorded | ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.2M Ammonium acetate,
0.1M Sodium acetate pH 4.6,
30% PEG 4000
|
Resolution 2.00 Å R-free 0.238 |
| 7CDZ Crystal structure of 2019-nCoV nucleocapsid N-terminal domain (NTD) protein Deposited 2020-06-21 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
44–174（131 aa）
Fragment：NTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M SPG, pH6.0, 25 % w/v PEG 1500
|
Resolution 1.80 Å R-free 0.227 |
| 7CDZ Crystal structure of 2019-nCoV nucleocapsid N-terminal domain (NTD) protein Deposited 2020-06-21 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
44–174（131 aa）
Fragment：NTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M SPG, pH6.0, 25 % w/v PEG 1500
|
Resolution 1.80 Å R-free 0.227 |
| 7CDZ Crystal structure of 2019-nCoV nucleocapsid N-terminal domain (NTD) protein Deposited 2020-06-21 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
44–174（131 aa）
Fragment：NTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M SPG, pH6.0, 25 % w/v PEG 1500
|
Resolution 1.80 Å R-free 0.227 |
| 7CDZ Crystal structure of 2019-nCoV nucleocapsid N-terminal domain (NTD) protein Deposited 2020-06-21 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
44–174（131 aa）
Fragment：NTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M SPG, pH6.0, 25 % w/v PEG 1500
|
Resolution 1.80 Å R-free 0.227 |
| 7CE0 Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) protein Deposited 2020-06-21 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
255–364（110 aa）
Fragment：CTD
Chain D
255–364（110 aa）
Fragment：CTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；291 K；4M Potassium formate, 0.1M BIS-TRIS propane, pH 9.0, 2% w/v Polyethylene glycol monomethyl ether 2000
|
Resolution 1.50 Å R-free 0.190 |
| 7CE0 Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) protein Deposited 2020-06-21 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
255–364（110 aa）
Fragment：CTD
Chain C
255–364（110 aa）
Fragment：CTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；291 K；4M Potassium formate, 0.1M BIS-TRIS propane, pH 9.0, 2% w/v Polyethylene glycol monomethyl ether 2000
|
Resolution 1.50 Å R-free 0.190 |
| 7CR5 Complex structure of a human monoclonal antibody with SARS-CoV-2 nucleocapsid protein NTD Deposited 2020-08-12 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
41–174（134 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.2；289.15 K；0.01M Calcium chloride dihydrate, 0.05 M Sodium cacodylate trihydrate (pH 7.2) ,1.675M Ammonium sulfate, 0.5mM spermine
|
Resolution 2.08 Å R-free 0.222 |
| 7DE1 Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal RNA binding domain Deposited 2020-11-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
250–364（115 aa）
Fragment：C-terminal RNA binding domain
Chain B
250–364（115 aa）
Fragment：C-terminal RNA binding domain
|
Not recorded | PEG DI(HYDROXYETHYL)ETHER × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9.3；289.15 K；100 mM CHES (pH 9.3) , 40% PEG 6000
|
Resolution 2.00 Å R-free 0.223 |
| 7F2B Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal RNA binding domain at 2.0A resolution Deposited 2021-06-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
257–362（106 aa）
Chain B
257–362（106 aa）
|
Not recorded | PO4 PHOSPHATE ION × 6 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.2；291 K；0.2 M Sodium chloride, 0.1M potassium phosphate pH 6.2, 52% v/vPEG 200
|
Resolution 2.00 Å R-free 0.213 |
| 7F2E SARS-CoV-2 nucleocapsid protein C-terminal domain (dodecamer) Deposited 2021-06-10 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
255–362（108 aa）
Chain B
255–362（108 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；0.1M phosphate citrate pH 4.5, 40% PEG 300
|
Resolution 3.10 Å R-free 0.297 |
| 7F2E SARS-CoV-2 nucleocapsid protein C-terminal domain (dodecamer) Deposited 2021-06-10 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
255–362（108 aa）
Chain D
255–362（108 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；0.1M phosphate citrate pH 4.5, 40% PEG 300
|
Resolution 3.10 Å R-free 0.297 |
| 7F2E SARS-CoV-2 nucleocapsid protein C-terminal domain (dodecamer) Deposited 2021-06-10 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
255–362（108 aa）
Chain F
255–362（108 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；0.1M phosphate citrate pH 4.5, 40% PEG 300
|
Resolution 3.10 Å R-free 0.297 |
| 7F2E SARS-CoV-2 nucleocapsid protein C-terminal domain (dodecamer) Deposited 2021-06-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
255–362（108 aa）
Chain H
255–362（108 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；0.1M phosphate citrate pH 4.5, 40% PEG 300
|
Resolution 3.10 Å R-free 0.297 |
| 7F2E SARS-CoV-2 nucleocapsid protein C-terminal domain (dodecamer) Deposited 2021-06-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
255–362（108 aa）
Chain J
255–362（108 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；0.1M phosphate citrate pH 4.5, 40% PEG 300
|
Resolution 3.10 Å R-free 0.297 |
| 7F2E SARS-CoV-2 nucleocapsid protein C-terminal domain (dodecamer) Deposited 2021-06-10 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
255–362（108 aa）
Chain L
255–362（108 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；0.1M phosphate citrate pH 4.5, 40% PEG 300
|
Resolution 3.10 Å R-free 0.297 |
| 7KGO Crystal Structure of HLA-A*0201in complex with SARS-CoV-2 N351-359 Deposited 2020-10-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
351–359（9 aa）
Fragment：residues 351-359
|
Not recorded | 3NI NICKEL (III) ION × 3 CL CHLORIDE ION × 3 CD CADMIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；20% PEG3350 w/v, 0.2 M NaFormate, 1 mM CdCl2
|
Resolution 2.15 Å R-free 0.229 |
| 7KGP Crystal Structure of HLA-A*0201 in complex with SARS-CoV-2 N316-324 Deposited 2020-10-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
316–324（9 aa）
Fragment：residues 316-324
|
Not recorded | ACT ACETATE ION × 1 CD CADMIUM ION × 2 NA SODIUM ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% 3350, 0.2M NaFluoride, 1 mM CdCl2
|
Resolution 1.40 Å R-free 0.203 |
| 7KGQ Crystal Structure of HLA-A*0201in complex with SARS-CoV-2 N222-230 Deposited 2020-10-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
222–230（9 aa）
Fragment：residues 222-230
|
Not recorded | CD CADMIUM ION × 2 CA CALCIUM ION × 2 EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；20% PEG3350, 0.2M KFormate, 1mM CaCl2
|
Resolution 1.34 Å R-free 0.198 |
| 7KGR Crystal Structure of HLA-A*0201in complex with SARS-CoV-2 N159-167 Deposited 2020-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
159–167（9 aa）
Fragment：residues 159-167
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；20% PEG3350 w/v, 0.2 M NaFormate
|
Resolution 1.55 Å R-free 0.221 |
| 7KGS Crystal Structure of HLA-A*0201 in complex with SARS-CoV-2 N138-146 Deposited 2020-10-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
138–146（9 aa）
Fragment：residues 138-146
|
Not recorded | CD CADMIUM ION × 2 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG3350 w/v, 0.2 M NaFormate, 1 mM CdCl2
|
Resolution 1.58 Å R-free 0.197 |
| 7KGT Crystal Structure of HLA-A*0201 in complex with SARS-CoV-2 N226-234 Deposited 2020-10-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
226–234（9 aa）
Fragment：residues 226-234
|
Not recorded | CD CADMIUM ION × 2 NA SODIUM ION × 1 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；20% PEG3350 w/v, 0.2M KFormate, 1mM CdCl2
|
Resolution 1.90 Å R-free 0.205 |
| 7LGD HLA-B*07:02 in complex with SARS-CoV-2 nucleocapsid peptide N105-113 Deposited 2021-01-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain F
105–113（9 aa）
|
Not recorded | CL CHLORIDE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；2M Ammonium Sulfate, 0.1M HEPES pH 7.5
|
Resolution 2.88 Å R-free 0.269 |
| 7LGD HLA-B*07:02 in complex with SARS-CoV-2 nucleocapsid peptide N105-113 Deposited 2021-01-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
105–113（9 aa）
|
Not recorded | CL CHLORIDE ION × 2 SO4 SULFATE ION × 4 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；2M Ammonium Sulfate, 0.1M HEPES pH 7.5
|
Resolution 2.88 Å R-free 0.269 |
| 7LUX AALALL segment from the Nucleoprotein of SARS-CoV-2, residues 217-222, crystal form 2 Deposited 2021-02-23 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 18 PDB declaration: octadecameric |
Chain A
217–222（6 aa）
|
Not recorded | PG4 TETRAETHYLENE GLYCOL × 36 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9.5；298 K；polyethylene glycol 3000, CHES, pH 9.5
|
Resolution 1.30 Å R-free 0.236 |
| 7LUZ GQTVTK segment from the Nucleoprotein of SARS-CoV-2, residues 243-248 Deposited 2021-02-23 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 18 PDB declaration: octadecameric |
Chain A
243–248（6 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2M Ammonium Sulfate, HEPES, pH 7.5, PEG 400
|
Resolution 1.10 Å R-free 0.150 |
| 7LV2 GSQASS segment from the Nucleoprotein of SARS-CoV-2, residues 179-184 Deposited 2021-02-23 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 16 PDB declaration: hexadecameric |
Chain A
179–184（6 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；sodium potassium tartrate, lithium sulfate, TRIS, pH 7.0
|
Resolution 1.30 Å R-free 0.242 |
| 7N0I Structure of the SARS-CoV-2 N protein C-terminal domain bound to single-domain antibody E2 Deposited 2021-05-25 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
269–364（96 aa）
Fragment：C-terminal domain
Chain B
269–364（96 aa）
Fragment：C-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20 mM HEPES pH 7.0, 200 mM NaCl, 5 mM MgCl2, 1 mM TCEP
|
Resolution 2.20 Å R-free 0.271 |
| 7N0I Structure of the SARS-CoV-2 N protein C-terminal domain bound to single-domain antibody E2 Deposited 2021-05-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
269–364（96 aa）
Fragment：C-terminal domain
Chain D
269–364（96 aa）
Fragment：C-terminal domain
|
Not recorded | ACT ACETATE ION × 1 MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20 mM HEPES pH 7.0, 200 mM NaCl, 5 mM MgCl2, 1 mM TCEP
|
Resolution 2.20 Å R-free 0.271 |
| 7N0I Structure of the SARS-CoV-2 N protein C-terminal domain bound to single-domain antibody E2 Deposited 2021-05-25 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
269–364（96 aa）
Fragment：C-terminal domain
Chain F
269–364（96 aa）
Fragment：C-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20 mM HEPES pH 7.0, 200 mM NaCl, 5 mM MgCl2, 1 mM TCEP
|
Resolution 2.20 Å R-free 0.271 |
| 7N0I Structure of the SARS-CoV-2 N protein C-terminal domain bound to single-domain antibody E2 Deposited 2021-05-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain G
269–364（96 aa）
Fragment：C-terminal domain
Chain H
269–364（96 aa）
Fragment：C-terminal domain
|
Not recorded | ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20 mM HEPES pH 7.0, 200 mM NaCl, 5 mM MgCl2, 1 mM TCEP
|
Resolution 2.20 Å R-free 0.271 |
| 7N0R Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody C2 Deposited 2021-05-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
49–174（126 aa）
Fragment：RNA-binding domain
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl pH 8.5, 0.2 M LiSO4, and 20% PEG 4000
|
Resolution 1.42 Å R-free 0.166 |
| 7N0R Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody C2 Deposited 2021-05-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
49–174（126 aa）
Fragment：RNA-binding domain
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl pH 8.5, 0.2 M LiSO4, and 20% PEG 4000
|
Resolution 1.42 Å R-free 0.166 |
| 7N3C Crystal Structure of Human Fab S24-202 in the complex with the N-terminal Domain of Nucleocapsid protein from SARS CoV-2 Deposited 2021-05-31 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
47–173（127 aa）
Fragment：CoV N NTD domain, residues 47-173
|
Not recorded | EDO 1,2-ETHANEDIOL × 9 IOD IODIDE ION × 12 PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.2 M Potassium iodide, 20% w/v Polyethylene glycol 3,350
|
Resolution 1.82 Å R-free 0.210 |
| 7N3D Crystal Structure of Human Fab S24-1564 in the complex with the N-terminal Domain of Nucleocapsid protein from SARS CoV-2 Deposited 2021-05-31 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
47–173（127 aa）
Fragment：CoV N NTD domain, residues 47-173
|
Not recorded | EDO 1,2-ETHANEDIOL × 7 CL CHLORIDE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；0.2 M Magnesium chloride hexahydrate, 0.1 M HEPES pH 7.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 1.53 Å R-free 0.190 |
| 7O05 Crystal structure of SARS-CoV-2 N-CTD Deposited 2021-03-25 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
247–364（118 aa）
Chain C
247–364（118 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；0.1 M tri-Sodium citrate pH 4.5; 0.1 M bisTris pH 5.5; 25% PEG 3350
|
Resolution 1.94 Å R-free 0.233 |
| 7O05 Crystal structure of SARS-CoV-2 N-CTD Deposited 2021-03-25 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
247–364（118 aa）
Chain D
247–364（118 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；0.1 M tri-Sodium citrate pH 4.5; 0.1 M bisTris pH 5.5; 25% PEG 3350
|
Resolution 1.94 Å R-free 0.233 |
| 7O35 Crystal Structure of SARS-CoV-2 N-CTD in complex with GTP (I) Deposited 2021-04-01 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
247–364（118 aa）
Chain B
247–364（118 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.6；294 K；30% PEG 3350
0.1 M sodium acetate pH 4.6
|
Resolution 1.80 Å R-free 0.203 |
| 7O35 Crystal Structure of SARS-CoV-2 N-CTD in complex with GTP (I) Deposited 2021-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
247–364（118 aa）
Chain D
247–364（118 aa）
|
Not recorded | GTP GUANOSINE-5'-TRIPHOSPHATE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.6；294 K；30% PEG 3350
0.1 M sodium acetate pH 4.6
|
Resolution 1.80 Å R-free 0.203 |
| 7O36 Crystal Structure of SARS-CoV-2 N-CTD in complex with GTP (II) Deposited 2021-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
247–364（118 aa）
Chain B
247–364（118 aa）
|
Not recorded | GTP GUANOSINE-5'-TRIPHOSPHATE × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.6；294 K；30% PEG 3350 and 0.1 M sodium acetate pH 4.6
|
Resolution 2.00 Å R-free 0.241 |
| 7O36 Crystal Structure of SARS-CoV-2 N-CTD in complex with GTP (II) Deposited 2021-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
247–364（118 aa）
Chain D
247–364（118 aa）
|
Not recorded | GTP GUANOSINE-5'-TRIPHOSPHATE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.6；294 K；30% PEG 3350 and 0.1 M sodium acetate pH 4.6
|
Resolution 2.00 Å R-free 0.241 |
| 7R98 Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody B6 Deposited 2021-06-28 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
49–174（126 aa）
Fragment：RNA-binding domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium citrate pH 5.6, 0.1 M sodium-potassium tartrate, and 19% PEG 3350
|
Resolution 2.51 Å R-free 0.273 |
| 7R98 Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody B6 Deposited 2021-06-28 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
49–174（126 aa）
Fragment：RNA-binding domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium citrate pH 5.6, 0.1 M sodium-potassium tartrate, and 19% PEG 3350
|
Resolution 2.51 Å R-free 0.273 |
| 7R98 Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody B6 Deposited 2021-06-28 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
49–174（126 aa）
Fragment：RNA-binding domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium citrate pH 5.6, 0.1 M sodium-potassium tartrate, and 19% PEG 3350
|
Resolution 2.51 Å R-free 0.273 |
| 7SD4 SARS-CoV-2 Nucleocapsid N-terminal domain (N-NTD) protein Deposited 2021-09-29 | Different construct Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
40–174（135 aa）
|
Not recorded | No recorded non-water small molecule |
SOLID-STATE NMR
NMR measurement conditions
pH 6.2；298.15 K；Ionic strength (raw mmCIF value) 50；Pressure 1
NMR sample composition
30 mg/mL [U-100% 13C; U-100% 15N] N-NTD, water | water
|
Resolution not provided |
| 7STR Crystal Structure of Human Fab S24-1063 in the Complex with the N-teminal Domain of Nucleocapsid Protein from SARS CoV-2 Deposited 2021-11-15 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
47–173（127 aa）
Fragment：N-terminal RNA binding domain, residues 47-173
|
Not recorded | EDO 1,2-ETHANEDIOL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；289 K；0.1 M Bis Tris HCl pH 5.5, 25 % (w/v) PEG 3350
|
Resolution 1.50 Å R-free 0.202 |
| 7STS Crystal Structure of Human Fab S24-1379 in the Complex with the N-teminal Domain of Nucleocapsid Protein from SARS CoV-2 Deposited 2021-11-15 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain D
47–173（127 aa）
Fragment：N-terminal RNA binding domain, residues 47-173
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；289 K；0.2 M Calcium chloride, 0.1 M Tris pH 8.0, 20 % (w/v) PEG 6000
|
Resolution 2.16 Å R-free 0.209 |
| 7STS Crystal Structure of Human Fab S24-1379 in the Complex with the N-teminal Domain of Nucleocapsid Protein from SARS CoV-2 Deposited 2021-11-15 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
47–173（127 aa）
Fragment：N-terminal RNA binding domain, residues 47-173
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；289 K；0.2 M Calcium chloride, 0.1 M Tris pH 8.0, 20 % (w/v) PEG 6000
|
Resolution 2.16 Å R-free 0.209 |
| 7SUE Crystal Structure of Human Fab S24-188 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 Deposited 2021-11-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain J
47–173（127 aa）
Fragment：N-terminal RNA binding domain, residues 47-173
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；289 K；0.1 M Sodium Citrate pH 5.6, 20 % (w/v) PEG 4000, 20 % (v/v) 2-propanol
|
Resolution 2.90 Å R-free 0.292 |
| 7SUE Crystal Structure of Human Fab S24-188 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 Deposited 2021-11-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain K
47–173（127 aa）
Fragment：N-terminal RNA binding domain, residues 47-173
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；289 K；0.1 M Sodium Citrate pH 5.6, 20 % (w/v) PEG 4000, 20 % (v/v) 2-propanol
|
Resolution 2.90 Å R-free 0.292 |
| 7SUE Crystal Structure of Human Fab S24-188 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 Deposited 2021-11-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
47–173（127 aa）
Fragment：N-terminal RNA binding domain, residues 47-173
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；289 K；0.1 M Sodium Citrate pH 5.6, 20 % (w/v) PEG 4000, 20 % (v/v) 2-propanol
|
Resolution 2.90 Å R-free 0.292 |
| 7SUE Crystal Structure of Human Fab S24-188 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 Deposited 2021-11-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain D
47–173（127 aa）
Fragment：N-terminal RNA binding domain, residues 47-173
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；289 K；0.1 M Sodium Citrate pH 5.6, 20 % (w/v) PEG 4000, 20 % (v/v) 2-propanol
|
Resolution 2.90 Å R-free 0.292 |
| 7UW3 Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal Domain Deposited 2022-05-02 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
40–174（135 aa）
Fragment：N-terminal domain (UNP residues 40-174)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；290 K；30% PEG4000, 100 mM MES, pH 6.5
|
Resolution 1.70 Å R-free 0.299 |
| 7UW3 Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal Domain Deposited 2022-05-02 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
40–174（135 aa）
Fragment：N-terminal domain (UNP residues 40-174)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；290 K；30% PEG4000, 100 mM MES, pH 6.5
|
Resolution 1.70 Å R-free 0.299 |
| 7UW3 Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal Domain Deposited 2022-05-02 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
40–174（135 aa）
Fragment：N-terminal domain (UNP residues 40-174)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；290 K；30% PEG4000, 100 mM MES, pH 6.5
|
Resolution 1.70 Å R-free 0.299 |
| 7UW3 Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal Domain Deposited 2022-05-02 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
40–174（135 aa）
Fragment：N-terminal domain (UNP residues 40-174)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；290 K；30% PEG4000, 100 mM MES, pH 6.5
|
Resolution 1.70 Å R-free 0.299 |
| 7UXX Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain Deposited 2022-05-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
251–364（114 aa）
Chain CCC
251–364（114 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；291 K；100 mM Tris-HCl (pH 8.3), 30% PEG 4000, 0.2 M sodium acetate
|
Resolution 1.85 Å R-free 0.207 |
| 7UXX Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain Deposited 2022-05-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain BBB
251–364（114 aa）
Chain DDD
251–364（114 aa）
|
Not recorded | GOL GLYCEROL × 1 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；291 K；100 mM Tris-HCl (pH 8.3), 30% PEG 4000, 0.2 M sodium acetate
|
Resolution 1.85 Å R-free 0.207 |
| 7UXX Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain Deposited 2022-05-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain EEE
251–364（114 aa）
Chain FFF
251–364（114 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；291 K；100 mM Tris-HCl (pH 8.3), 30% PEG 4000, 0.2 M sodium acetate
|
Resolution 1.85 Å R-free 0.207 |
| 7UXZ Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain complexed with Chicoric acid Deposited 2022-05-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
251–364（114 aa）
Chain BBB
251–364（114 aa）
|
Not recorded | GKP (2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid × 1 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；291 K；100 mM Tris -HCl (pH 8.3), 30% PEG 4000, 0.2 M sodium acetate
|
Resolution 1.73 Å R-free 0.215 |
| 7UXZ Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain complexed with Chicoric acid Deposited 2022-05-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain CCC
251–364（114 aa）
Chain DDD
251–364（114 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；291 K；100 mM Tris -HCl (pH 8.3), 30% PEG 4000, 0.2 M sodium acetate
|
Resolution 1.73 Å R-free 0.215 |
| 7UXZ Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain complexed with Chicoric acid Deposited 2022-05-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain EEE
251–364（114 aa）
Chain FFF
251–364（114 aa）
|
Not recorded | PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；291 K；100 mM Tris -HCl (pH 8.3), 30% PEG 4000, 0.2 M sodium acetate
|
Resolution 1.73 Å R-free 0.215 |
| 7VBD Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0 Deposited 2021-08-31 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
48–174（127 aa）
Fragment：N-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；pH 8.0, 0.05M Tris,38% PEG 4000
|
Resolution 1.94 Å R-free 0.262 |
| 7VBD Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0 Deposited 2021-08-31 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
48–174（127 aa）
Fragment：N-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；pH 8.0, 0.05M Tris,38% PEG 4000
|
Resolution 1.94 Å R-free 0.262 |
| 7VBD Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0 Deposited 2021-08-31 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
48–174（127 aa）
Fragment：N-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；pH 8.0, 0.05M Tris,38% PEG 4000
|
Resolution 1.94 Å R-free 0.262 |
| 7VBD Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0 Deposited 2021-08-31 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
48–174（127 aa）
Fragment：N-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；pH 8.0, 0.05M Tris,38% PEG 4000
|
Resolution 1.94 Å R-free 0.262 |
| 7VBE 1.6 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 5.0 Deposited 2021-08-31 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
257–364（108 aa）
Fragment：dimerization domain
Chain B
257–364（108 aa）
Fragment：dimerization domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；0.1 M Sodium citrate tribasic dihydrate pH 5.0, 30% v/v Polyethylene glycol monomethyl ether 550
|
Resolution 1.59 Å R-free 0.226 |
| 7VBF 1.3 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 8.5 Deposited 2021-08-31 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
255–364（110 aa）
Fragment：dimerization domain
Chain B
255–364（110 aa）
Fragment：dimerization domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Lithium sulfate monohydrate, 0.1 M TRIS hydrochloride pH 8.5, 30% w/v Polyethylene glycol 4000
|
Resolution 1.30 Å R-free 0.204 |
| 7VNU Crystal structure of the N-terminal domain of SARS-CoV-2 nucleocapsid protein Deposited 2021-10-12 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–174（128 aa）
Fragment：N-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.2M Sodium acetate trihydrate,, 0.1M sodium cacodylate pH 7.5,
4% PEG 8000
|
Resolution 1.95 Å R-free 0.226 |
| 7VNU Crystal structure of the N-terminal domain of SARS-CoV-2 nucleocapsid protein Deposited 2021-10-12 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–174（128 aa）
Fragment：N-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.2M Sodium acetate trihydrate,, 0.1M sodium cacodylate pH 7.5,
4% PEG 8000
|
Resolution 1.95 Å R-free 0.226 |
| 7VNU Crystal structure of the N-terminal domain of SARS-CoV-2 nucleocapsid protein Deposited 2021-10-12 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
47–174（128 aa）
Fragment：N-terminal domain
|
Not recorded | ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.2M Sodium acetate trihydrate,, 0.1M sodium cacodylate pH 7.5,
4% PEG 8000
|
Resolution 1.95 Å R-free 0.226 |
| 7VNU Crystal structure of the N-terminal domain of SARS-CoV-2 nucleocapsid protein Deposited 2021-10-12 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
47–174（128 aa）
Fragment：N-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.2M Sodium acetate trihydrate,, 0.1M sodium cacodylate pH 7.5,
4% PEG 8000
|
Resolution 1.95 Å R-free 0.226 |
| 7WZO Crystal structure of the SARS-CoV-2 nucleocapsid protein N-terminal domain in complex with Ubl1 Deposited 2022-02-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
47–174（128 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；291 K；0.1 M sodium citrate, pH 5.0, 20% w/v PEG 8000
|
Resolution 2.64 Å R-free 0.247 |
| 7XWX Crystal structure of SARS-CoV-2 N-CTD Deposited 2022-05-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
269–367（99 aa）
Fragment：C-terminal domain
Chain E
269–367（99 aa）
Fragment：C-terminal domain
|
Not recorded | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；NaNO3, Na2HPO4, (NH4)2SO4, Tris(base), Bicine, PEG MME500, PEG 20000, 1,8-ANS
|
Resolution 3.00 Å R-free 0.268 |
| 7XWX Crystal structure of SARS-CoV-2 N-CTD Deposited 2022-05-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
269–367（99 aa）
Fragment：C-terminal domain
Chain F
269–367（99 aa）
Fragment：C-terminal domain
|
Not recorded | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；NaNO3, Na2HPO4, (NH4)2SO4, Tris(base), Bicine, PEG MME500, PEG 20000, 1,8-ANS
|
Resolution 3.00 Å R-free 0.268 |
| 7XWX Crystal structure of SARS-CoV-2 N-CTD Deposited 2022-05-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
269–367（99 aa）
Fragment：C-terminal domain
Chain D
269–367（99 aa）
Fragment：C-terminal domain
|
Not recorded | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；NaNO3, Na2HPO4, (NH4)2SO4, Tris(base), Bicine, PEG MME500, PEG 20000, 1,8-ANS
|
Resolution 3.00 Å R-free 0.268 |
| 7XWX Crystal structure of SARS-CoV-2 N-CTD Deposited 2022-05-27 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
269–367（99 aa）
Fragment：C-terminal domain
Chain H
269–367（99 aa）
Fragment：C-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；NaNO3, Na2HPO4, (NH4)2SO4, Tris(base), Bicine, PEG MME500, PEG 20000, 1,8-ANS
|
Resolution 3.00 Å R-free 0.268 |
| 7XWZ Crystal structure of SARS-CoV-2 N-NTD and dsRNA complex Deposited 2022-05-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein–RNA Monomer；Protein × 1 PDB declaration: trimeric |
Chain A
48–172（125 aa）
Fragment：N-terminal domain
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；Malonic Acid, Imidazole, Boric Acid, PEG 1500
|
Resolution 2.25 Å R-free 0.269 |
| 7XWZ Crystal structure of SARS-CoV-2 N-NTD and dsRNA complex Deposited 2022-05-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein–RNA Monomer；Protein × 1 PDB declaration: trimeric |
Chain B
48–172（125 aa）
Fragment：N-terminal domain
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；Malonic Acid, Imidazole, Boric Acid, PEG 1500
|
Resolution 2.25 Å R-free 0.269 |
| 7XX1 Crystal structure of SARS-CoV-2 N-NTD Deposited 2022-05-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
49–173（125 aa）
Fragment：N-terminal domain
Chain B
49–173（125 aa）
Fragment：N-terminal domain
Chain C
49–173（125 aa）
Fragment：N-terminal domain
Chain D
49–173（125 aa）
Fragment：N-terminal domain
|
Not recorded | ZN ZINC ION × 4 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；Zinc chloride, MES, PEG 6000
|
Resolution 1.90 Å R-free 0.258 |
| 7XXK Crystal structure of SARS-CoV-2 N-CTD in complex with GMP Deposited 2022-05-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
248–364（117 aa）
Fragment：C-terminal domain
Chain B
248–364（117 aa）
Fragment：C-terminal domain
|
Not recorded | SCN THIOCYANATE ION × 1 5GP GUANOSINE-5'-MONOPHOSPHATE × 2 K POTASSIUM ION × 5 CL CHLORIDE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.15 M potassium thiocyanate, 30% w/v PEG MME 2000
|
Resolution 2.00 Å R-free 0.232 |
| 7XXK Crystal structure of SARS-CoV-2 N-CTD in complex with GMP Deposited 2022-05-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
248–364（117 aa）
Fragment：C-terminal domain
Chain D
248–364（117 aa）
Fragment：C-terminal domain
|
Not recorded | 5GP GUANOSINE-5'-MONOPHOSPHATE × 1 K POTASSIUM ION × 3 CL CHLORIDE ION × 6 GUN GUANINE × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.15 M potassium thiocyanate, 30% w/v PEG MME 2000
|
Resolution 2.00 Å R-free 0.232 |
| 7XXK Crystal structure of SARS-CoV-2 N-CTD in complex with GMP Deposited 2022-05-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
248–364（117 aa）
Fragment：C-terminal domain
Chain F
248–364（117 aa）
Fragment：C-terminal domain
|
Not recorded | K POTASSIUM ION × 1 CL CHLORIDE ION × 4 NA SODIUM ION × 1 GMP GUANOSINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.15 M potassium thiocyanate, 30% w/v PEG MME 2000
|
Resolution 2.00 Å R-free 0.232 |
| 7YLB Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis Deposited 2022-07-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
247–364（118 aa）
Fragment：CTD
Chain D
247–364（118 aa）
Fragment：CTD
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293.15 K；0.2M K2SO4, 18% PEG 3350
|
Resolution 2.41 Å R-free 0.326 |
| 7YLB Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis Deposited 2022-07-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
247–364（118 aa）
Fragment：CTD
Chain B
247–364（118 aa）
Fragment：CTD
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293.15 K；0.2M K2SO4, 18% PEG 3350
|
Resolution 2.41 Å R-free 0.326 |
| 7YLB Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis Deposited 2022-07-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain G
247–364（118 aa）
Fragment：CTD
Chain H
247–364（118 aa）
Fragment：CTD
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293.15 K；0.2M K2SO4, 18% PEG 3350
|
Resolution 2.41 Å R-free 0.326 |
| 7YLB Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis Deposited 2022-07-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain J
247–364（118 aa）
Fragment：CTD
Chain K
247–364（118 aa）
Fragment：CTD
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293.15 K；0.2M K2SO4, 18% PEG 3350
|
Resolution 2.41 Å R-free 0.326 |
| 7YLD Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis Deposited 2022-07-26 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
47–174（128 aa）
Fragment：NTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293.15 K；0.2M ZnSO4, 25% (v/v) MPD
|
Resolution 2.80 Å R-free 0.343 |
| 7YLD Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis Deposited 2022-07-26 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
47–174（128 aa）
Fragment：NTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293.15 K；0.2M ZnSO4, 25% (v/v) MPD
|
Resolution 2.80 Å R-free 0.343 |
| 7YLD Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis Deposited 2022-07-26 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
47–174（128 aa）
Fragment：NTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293.15 K；0.2M ZnSO4, 25% (v/v) MPD
|
Resolution 2.80 Å R-free 0.343 |
| 7YLD Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis Deposited 2022-07-26 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
47–174（128 aa）
Fragment：NTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293.15 K；0.2M ZnSO4, 25% (v/v) MPD
|
Resolution 2.80 Å R-free 0.343 |
| 7ZIT 14-3-3 in complex with SARS-COV2 N phospho-peptide Deposited 2022-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
194–200（7 aa）
Chain D
194–200（7 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ACT ACETATE ION × 2 GOL GLYCEROL × 1 BEZ BENZOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；9 0.2 M Sodium acetate
0.1 M Sodium cacodylate pH 6.5
30% (w/v) PEG 8000
|
Resolution 1.79 Å R-free 0.205 |
| 8DNT SARS-CoV-2 specific T cell receptor Deposited 2022-07-11 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain D
222–230（9 aa）
Fragment：LLL peptide from nucleocapsid protein 222-230
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；295 K；13.5% (w/v) PEG 20,000, 0.1 M Tris-HCl
|
Resolution 3.18 Å R-free 0.313 |
| 8DNT SARS-CoV-2 specific T cell receptor Deposited 2022-07-11 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain J
222–230（9 aa）
Fragment：LLL peptide from nucleocapsid protein 222-230
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；295 K；13.5% (w/v) PEG 20,000, 0.1 M Tris-HCl
|
Resolution 3.18 Å R-free 0.313 |
| 8DNT SARS-CoV-2 specific T cell receptor Deposited 2022-07-11 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain Q
222–230（9 aa）
Fragment：LLL peptide from nucleocapsid protein 222-230
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；295 K；13.5% (w/v) PEG 20,000, 0.1 M Tris-HCl
|
Resolution 3.18 Å R-free 0.313 |
| 8DNT SARS-CoV-2 specific T cell receptor Deposited 2022-07-11 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain X
222–230（9 aa）
Fragment：LLL peptide from nucleocapsid protein 222-230
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；295 K；13.5% (w/v) PEG 20,000, 0.1 M Tris-HCl
|
Resolution 3.18 Å R-free 0.313 |
| 8IV3 Crystal structure of SARS-CoV2 N-NTD complexed with 5-Benzyloxygramine Deposited 2023-03-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
41–174（134 aa）
Fragment：N-terminal domain
Chain B
41–174（134 aa）
Fragment：N-terminal domain
Chain C
41–174（134 aa）
Fragment：N-terminal domain
Chain D
41–174（134 aa）
Fragment：N-terminal domain
|
Not recorded | DJU N,N-dimethyl-1-(5-phenylmethoxy-1H-indol-3-yl)methanamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；spermine tetrahydrochlorid, potassium chloride, Bis-Tris HCl pH 7.0, PEG 3350
|
Resolution 1.90 Å R-free 0.286 |
| 8J6X Crystal structure of SARS-CoV2 N-NTD complexed with 5-Benzyloxygramine derivative (P3-8) Deposited 2023-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
41–174（134 aa）
Fragment：N-terminal domain
Chain B
41–174（134 aa）
Fragment：N-terminal domain
Chain C
41–174（134 aa）
Fragment：N-terminal domain
Chain D
41–174（134 aa）
Fragment：N-terminal domain
|
Not recorded | U2H ~{N}-methyl-~{N}-[(5-phenylmethoxy-1~{H}-indol-3-yl)methyl]propan-1-amine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；spermine tetrahydrochloride, potassium chloride, Bis-Tris HCl (pH 7.0), PEG 3350
|
Resolution 2.70 Å R-free 0.279 |
| 8TFD Crystal structure of a stem-loop DNA aptamer complexed with SARS-CoV-2 nucleocapsid protein RNA-binding domain Deposited 2023-07-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric |
Chain A
46–174（129 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；0.2M Ammonium formate,10% w/v Polyvinylpyrrolidone, 20% w/v PEG 4000
|
Resolution 1.55 Å R-free 0.189 |
| 8TH1 Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein D3L mutant Deposited 2023-07-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain E
1–25（25 aa）
Chain F
1–25（25 aa）
Chain G
1–25（25 aa）
Chain H
1–25（25 aa）
|
Mutation：D3L Mutation：D3L Mutation：D3L Mutation：D3L | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2 M sodium thiocyanate, 20% PEG 3350
|
Resolution 1.80 Å R-free 0.238 |
| 8TH5 Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein P13L mutant Deposited 2023-07-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain K
1–25（25 aa）
Chain P
1–25（25 aa）
|
Mutation：P13L Mutation：P13L | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277.15 K；0.2 M lithium sulfate, 0.1 M Tris pH 8.5, 25% PEG3350
|
Resolution 2.62 Å R-free 0.336 |
| 8TH5 Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein P13L mutant Deposited 2023-07-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain L
1–25（25 aa）
Chain O
1–25（25 aa）
|
Mutation：P13L Mutation：P13L | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277.15 K；0.2 M lithium sulfate, 0.1 M Tris pH 8.5, 25% PEG3350
|
Resolution 2.62 Å R-free 0.336 |
| 8TH5 Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein P13L mutant Deposited 2023-07-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain M
1–25（25 aa）
|
Mutation：P13L | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277.15 K；0.2 M lithium sulfate, 0.1 M Tris pH 8.5, 25% PEG3350
|
Resolution 2.62 Å R-free 0.336 |
| 8TH5 Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein P13L mutant Deposited 2023-07-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain N
1–25（25 aa）
|
Mutation：P13L | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277.15 K；0.2 M lithium sulfate, 0.1 M Tris pH 8.5, 25% PEG3350
|
Resolution 2.62 Å R-free 0.336 |
| 8TH5 Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein P13L mutant Deposited 2023-07-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain Q
1–25（25 aa）
|
Mutation：P13L | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277.15 K；0.2 M lithium sulfate, 0.1 M Tris pH 8.5, 25% PEG3350
|
Resolution 2.62 Å R-free 0.336 |
| 8UTC HUMAN LEUKOCYTE ANTIGEN B*07:02 IN COMPLEX WITH SARS-COV2 EPITOPE N105-113 (Y111F mutant) Deposited 2023-10-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
105–113（9 aa）
Fragment：residues 105-113 (Uniprot numbering)
|
Mutation：Y7F | PGE TRIETHYLENE GLYCOL × 1 PG4 TETRAETHYLENE GLYCOL × 1 CL CHLORIDE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；289 K；0.1 M HEPES-NaOH, pH 7.5, 25% PEG 3350
|
Resolution 2.40 Å R-free 0.240 |
| 8UTC HUMAN LEUKOCYTE ANTIGEN B*07:02 IN COMPLEX WITH SARS-COV2 EPITOPE N105-113 (Y111F mutant) Deposited 2023-10-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain F
105–113（9 aa）
Fragment：residues 105-113 (Uniprot numbering)
|
Mutation：Y7F | PG4 TETRAETHYLENE GLYCOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；289 K；0.1 M HEPES-NaOH, pH 7.5, 25% PEG 3350
|
Resolution 2.40 Å R-free 0.240 |
| 8W6W Crystal Structure of C-terminal domain of nucleocapsid protein from SARS-CoV-2 in complex with ampicillin Deposited 2023-08-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
247–419（173 aa）
Fragment：C-terminal domain
Chain B
247–419（173 aa）
Fragment：C-terminal domain
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 AIC (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30% PEG4000, 0.2 M Lithium sulfate, 50 mM Tris pH 8.0, Ampicillin
|
Resolution 2.20 Å R-free 0.238 |
| 8X1H Crystal structure of N-terminal domain of Nucleocapsid protein of SARS-CoV-2 Deposited 2023-11-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
44–175（132 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；293 K；27 % PEG3350, Bicine buffer pH 9.0
|
Resolution 2.00 Å R-free 0.278 |
| 8X1H Crystal structure of N-terminal domain of Nucleocapsid protein of SARS-CoV-2 Deposited 2023-11-07 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
44–175（132 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；293 K；27 % PEG3350, Bicine buffer pH 9.0
|
Resolution 2.00 Å R-free 0.278 |
| 8X1H Crystal structure of N-terminal domain of Nucleocapsid protein of SARS-CoV-2 Deposited 2023-11-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
44–175（132 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；293 K；27 % PEG3350, Bicine buffer pH 9.0
|
Resolution 2.00 Å R-free 0.278 |
| 8X1H Crystal structure of N-terminal domain of Nucleocapsid protein of SARS-CoV-2 Deposited 2023-11-07 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
44–175（132 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；293 K；27 % PEG3350, Bicine buffer pH 9.0
|
Resolution 2.00 Å R-free 0.278 |
| 8ZBF Crystal structure of the A58-T10 DNA aptamer in complex with SARS-CoV-2 N-NTD Deposited 2024-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric |
Chain A
41–174（134 aa）
Chain B
41–174（134 aa）
|
Not recorded | NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291.15 K；0.05 M Magnesium chloride hexahydrate, 0.1 M HEPES pH 7.5, 30% v/v Polyethylene glycol monomethyl ether 550
|
Resolution 2.80 Å R-free 0.261 |
| 8ZBF Crystal structure of the A58-T10 DNA aptamer in complex with SARS-CoV-2 N-NTD Deposited 2024-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric |
Chain C
41–174（134 aa）
Chain D
41–174（134 aa）
|
Not recorded | NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291.15 K；0.05 M Magnesium chloride hexahydrate, 0.1 M HEPES pH 7.5, 30% v/v Polyethylene glycol monomethyl ether 550
|
Resolution 2.80 Å R-free 0.261 |
| 8ZFV Crystal Structure of C-terminal domain of nucleocapsid protein from SARS-CoV-2 in complex with ceftriaxone Deposited 2024-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
247–419（173 aa）
Fragment：C-terminal domain
Chain B
247–419（173 aa）
Fragment：C-terminal domain
|
Not recorded | SO4 SULFATE ION × 1 9F2 Ceftriaxone × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30% PEG4000, 0.2 M Lithium sulfate, 50 mM Tris pH 8.0
|
Resolution 2.00 Å R-free 0.205 |
| 8ZFV Crystal Structure of C-terminal domain of nucleocapsid protein from SARS-CoV-2 in complex with ceftriaxone Deposited 2024-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
247–419（173 aa）
Fragment：C-terminal domain
Chain D
247–419（173 aa）
Fragment：C-terminal domain
|
Not recorded | 9F2 Ceftriaxone × 1 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30% PEG4000, 0.2 M Lithium sulfate, 50 mM Tris pH 8.0
|
Resolution 2.00 Å R-free 0.205 |
| 9C2H SARS-CoV-2 Nucleocapsid Dimerization Domain bound to Fab-NP1E9 and Fab-NP3B4 Deposited 2024-05-31 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric |
Chain A
244–364（121 aa）
Fragment：UNP Residues 244-364
Chain D
244–364（121 aa）
Fragment：UNP Residues 244-364
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 9CJ6 Crystal Structure of SARS-CoV-2 N-NTD with part of N-arm complex with ssDNA. Deposited 2024-07-05 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric |
Chain A
1–419（419 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；277 K；0.2M HEPES, pH 7.4 + 20% PEG4000
|
Resolution 1.55 Å R-free 0.204 |
| 9EVY SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant E136D Deposited 2024-04-02 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
|
Mutation：E136D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；100mM BICINE pH 9.3
20% PEG 3350
|
Resolution 1.55 Å R-free 0.236 |
| 9EVY SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant E136D Deposited 2024-04-02 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
41–174（134 aa）
|
Mutation：E136D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；100mM BICINE pH 9.3
20% PEG 3350
|
Resolution 1.55 Å R-free 0.236 |
| 9EVY SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant E136D Deposited 2024-04-02 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
41–174（134 aa）
|
Mutation：E136D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；100mM BICINE pH 9.3
20% PEG 3350
|
Resolution 1.55 Å R-free 0.236 |
| 9EVY SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant E136D Deposited 2024-04-02 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
41–174（134 aa）
|
Mutation：E136D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；100mM BICINE pH 9.3
20% PEG 3350
|
Resolution 1.55 Å R-free 0.236 |
| 9EWH SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant Y109A Deposited 2024-04-03 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
|
Mutation：Y109A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；PEG 3350
|
Resolution 1.93 Å R-free 0.255 |
| 9EWH SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant Y109A Deposited 2024-04-03 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
41–174（134 aa）
|
Mutation：Y109A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；PEG 3350
|
Resolution 1.93 Å R-free 0.255 |
| 9EWH SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant Y109A Deposited 2024-04-03 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
41–174（134 aa）
|
Mutation：Y109A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；PEG 3350
|
Resolution 1.93 Å R-free 0.255 |
| 9EWH SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant Y109A Deposited 2024-04-03 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
41–174（134 aa）
|
Mutation：Y109A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；PEG 3350
|
Resolution 1.93 Å R-free 0.255 |
| 9EXB SARS-CoV-2 Nucleocapsid N-terminal domain NTD Deposited 2024-04-06 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；20% PEG 6000
100mM MES pH 6.0
10mM Zinc Chloride
|
Resolution 2.30 Å R-free 0.320 |
| 9EXB SARS-CoV-2 Nucleocapsid N-terminal domain NTD Deposited 2024-04-06 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
41–174（134 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；20% PEG 6000
100mM MES pH 6.0
10mM Zinc Chloride
|
Resolution 2.30 Å R-free 0.320 |
| 9EXB SARS-CoV-2 Nucleocapsid N-terminal domain NTD Deposited 2024-04-06 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
41–174（134 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；20% PEG 6000
100mM MES pH 6.0
10mM Zinc Chloride
|
Resolution 2.30 Å R-free 0.320 |
| 9EXB SARS-CoV-2 Nucleocapsid N-terminal domain NTD Deposited 2024-04-06 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
41–174（134 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；20% PEG 6000
100mM MES pH 6.0
10mM Zinc Chloride
|
Resolution 2.30 Å R-free 0.320 |
| 9EZB SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P67S Deposited 2024-04-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
|
Mutation：P67S | CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；150mM Sodium Chloride
28% PEG Smear Medium
|
Resolution 1.60 Å R-free 0.237 |
| 9EZB SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P67S Deposited 2024-04-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
41–174（134 aa）
|
Mutation：P67S | PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；150mM Sodium Chloride
28% PEG Smear Medium
|
Resolution 1.60 Å R-free 0.237 |
| 9EZB SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P67S Deposited 2024-04-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
41–174（134 aa）
|
Mutation：P67S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；150mM Sodium Chloride
28% PEG Smear Medium
|
Resolution 1.60 Å R-free 0.237 |
| 9EZB SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P67S Deposited 2024-04-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
41–174（134 aa）
|
Mutation：P67S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；150mM Sodium Chloride
28% PEG Smear Medium
|
Resolution 1.60 Å R-free 0.237 |
| 9F13 Crystal structure of HLA-C*12:02 in complex with KAYNVTQAF (KF9), a 9-mer epitope from SARS-CoV-2 Nucleocapsid (N266-274) Deposited 2024-04-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain C
266–274（9 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；2% PEG400, 20% PEG3350
|
Resolution 1.61 Å R-free 0.231 |
| 9F2G Crystal structure of SARS-CoV-2 N-protein C-terminal domain (apo form) Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
256–364（109 aa）
Chain B
256–364（109 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 37%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
|
Resolution 1.57 Å R-free 0.229 |
| 9F2G Crystal structure of SARS-CoV-2 N-protein C-terminal domain (apo form) Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
256–364（109 aa）
Chain D
256–364（109 aa）
|
Not recorded | GOL GLYCEROL × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 37%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
|
Resolution 1.57 Å R-free 0.229 |
| 9F2G Crystal structure of SARS-CoV-2 N-protein C-terminal domain (apo form) Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
256–364（109 aa）
Chain F
256–364（109 aa）
|
Not recorded | GOL GLYCEROL × 1 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 37%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
|
Resolution 1.57 Å R-free 0.229 |
| 9F2G Crystal structure of SARS-CoV-2 N-protein C-terminal domain (apo form) Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
256–364（109 aa）
Chain H
256–364（109 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 37%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
|
Resolution 1.57 Å R-free 0.229 |
| 9F2H Crystal structure of SARS-CoV-2 N-protein C-terminal domain in complex with riluzole Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
256–364（109 aa）
Chain B
256–364（109 aa）
|
Not recorded | 657 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 38%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
Soaking o/n with saturated concentration of riluzole in PEG 3350 40%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate, 1 mM InsP6 condition.
|
Resolution 1.30 Å R-free 0.189 |
| 9F2H Crystal structure of SARS-CoV-2 N-protein C-terminal domain in complex with riluzole Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
256–364（109 aa）
Chain D
256–364（109 aa）
|
Not recorded | SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 38%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
Soaking o/n with saturated concentration of riluzole in PEG 3350 40%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate, 1 mM InsP6 condition.
|
Resolution 1.30 Å R-free 0.189 |
| 9F2I Crystal structure of SARS-CoV-2 N-protein C-terminal domain in complex with 2-amino-1,3-benzothiazol-6-ol Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
256–364（109 aa）
Chain B
256–364（109 aa）
|
Not recorded | A1H88 2-amino-1,3-benzothiazol-6-ol × 1 SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 38%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
Soaking 2 weeks with saturated concentration of riluzole-like compound in PEG 3350 40%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate, 1 mM InsP6 condition.
|
Resolution 1.45 Å R-free 0.214 |
| 9F2I Crystal structure of SARS-CoV-2 N-protein C-terminal domain in complex with 2-amino-1,3-benzothiazol-6-ol Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
256–364（109 aa）
Chain D
256–364（109 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 38%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
Soaking 2 weeks with saturated concentration of riluzole-like compound in PEG 3350 40%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate, 1 mM InsP6 condition.
|
Resolution 1.45 Å R-free 0.214 |
| 9F2I Crystal structure of SARS-CoV-2 N-protein C-terminal domain in complex with 2-amino-1,3-benzothiazol-6-ol Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
256–364（109 aa）
Chain F
256–364（109 aa）
|
Not recorded | SO4 SULFATE ION × 2 EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 38%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
Soaking 2 weeks with saturated concentration of riluzole-like compound in PEG 3350 40%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate, 1 mM InsP6 condition.
|
Resolution 1.45 Å R-free 0.214 |
| 9F2I Crystal structure of SARS-CoV-2 N-protein C-terminal domain in complex with 2-amino-1,3-benzothiazol-6-ol Deposited 2024-04-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
256–364（109 aa）
Chain H
256–364（109 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；PEG 3350 38%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6.
Protein:precipitant ratio 1:1.
Protein concentration: 16.5 mg/ml.
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.
Soaking 2 weeks with saturated concentration of riluzole-like compound in PEG 3350 40%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate, 1 mM InsP6 condition.
|
Resolution 1.45 Å R-free 0.214 |
| 9F5J SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant Q58I Deposited 2024-04-29 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
44–180（137 aa）
|
Not recorded | CD CADMIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；200mM Ammonium sulfate
10mM Cadmium chloride
25% PEG Smear Medium
100mM HEPES pH 7.5
30mM Manganese chloride
|
Resolution 2.20 Å R-free 0.242 |
| 9F5J SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant Q58I Deposited 2024-04-29 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
44–180（137 aa）
|
Not recorded | CD CADMIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；200mM Ammonium sulfate
10mM Cadmium chloride
25% PEG Smear Medium
100mM HEPES pH 7.5
30mM Manganese chloride
|
Resolution 2.20 Å R-free 0.242 |
| 9F5L SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant A119S Deposited 2024-04-29 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
|
Mutation：A119S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；200mM Sodium acetate trihydrate
100mM Tris-HCl pH 8.5
30% PEG 4000
|
Resolution 2.36 Å R-free 0.323 |
| 9F5L SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant A119S Deposited 2024-04-29 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
41–174（134 aa）
|
Mutation：A119S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；200mM Sodium acetate trihydrate
100mM Tris-HCl pH 8.5
30% PEG 4000
|
Resolution 2.36 Å R-free 0.323 |
| 9F5L SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant A119S Deposited 2024-04-29 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
41–174（134 aa）
|
Mutation：A119S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；200mM Sodium acetate trihydrate
100mM Tris-HCl pH 8.5
30% PEG 4000
|
Resolution 2.36 Å R-free 0.323 |
| 9F5L SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant A119S Deposited 2024-04-29 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
41–174（134 aa）
|
Mutation：A119S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；200mM Sodium acetate trihydrate
100mM Tris-HCl pH 8.5
30% PEG 4000
|
Resolution 2.36 Å R-free 0.323 |
| 9F7A SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P80R Deposited 2024-05-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
|
Mutation：P80R | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；285 K；22% PEG 3350
200mM Zinc Acetate dihydrate
|
Resolution 1.90 Å R-free 0.348 |
| 9F7C SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant S105I Deposited 2024-05-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
|
Mutation：S105I | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；22% PEG 3350
200mM Zinc Acetate dihydrate
|
Resolution 2.00 Å R-free 0.273 |
| 9F83 SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant D63G Deposited 2024-05-06 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；50mM HEPES pH 6.8
150mM Sodium Chloride
24% PEG 3350
2% PEG 400
|
Resolution 1.70 Å R-free 0.280 |
| 9F83 SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant D63G Deposited 2024-05-06 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
41–174（134 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；50mM HEPES pH 6.8
150mM Sodium Chloride
24% PEG 3350
2% PEG 400
|
Resolution 1.70 Å R-free 0.280 |
| 9F83 SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant D63G Deposited 2024-05-06 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
41–174（134 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；50mM HEPES pH 6.8
150mM Sodium Chloride
24% PEG 3350
2% PEG 400
|
Resolution 1.70 Å R-free 0.280 |
| 9F83 SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant D63G Deposited 2024-05-06 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
41–174（134 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；50mM HEPES pH 6.8
150mM Sodium Chloride
24% PEG 3350
2% PEG 400
|
Resolution 1.70 Å R-free 0.280 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 10 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain J
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 11 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain K
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 12 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain L
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 13 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain M
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 14 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain N
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 15 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain O
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 16 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain P
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 17 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain Q
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 18 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain R
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain F
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain H
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9FBG SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S Deposited 2024-05-13 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 9 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain I
41–174（134 aa）
|
Mutation：P151S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100mM Sodium HEPES pH 7.5
4.3M Sodium chloride
|
Resolution 2.54 Å R-free 0.261 |
| 9HLJ Crystal structure of GV37-TCR in complex with HLA-C*12:02 with KAYNVTQAF (KF9), a 9-mer epitope from SARS-CoV-2 Nucleocapsid (N266-274) Deposited 2024-12-05 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain C
266–274（9 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Magnesium formate dihydrate, 20% PEG3350
|
Resolution 2.54 Å R-free 0.257 |
| 9IN1 Crystal Structure of C-terminal domain of nucleocapsid protein from SARS-CoV-2 Deposited 2024-07-05 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
247–364（118 aa）
Fragment：C-terminal domain
Chain B
247–364（118 aa）
Fragment：C-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30% PEG4000, 0.2 M Lithium sulfate, 50 mM Tris pH 8.0
|
Resolution 1.40 Å R-free 0.170 |
| 9IN1 Crystal Structure of C-terminal domain of nucleocapsid protein from SARS-CoV-2 Deposited 2024-07-05 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
247–364（118 aa）
Fragment：C-terminal domain
Chain D
247–364（118 aa）
Fragment：C-terminal domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30% PEG4000, 0.2 M Lithium sulfate, 50 mM Tris pH 8.0
|
Resolution 1.40 Å R-free 0.170 |
| 9J4S Structural basis for recognition of SARS-CoV-2 conserved nucleocapside epitopes by dominant T cell receptors Deposited 2024-08-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain J
105–113（9 aa）
|
Not recorded | SO4 SULFATE ION × 5 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291 K；0.1M Tris-base/hydrochloric acid (pH 7.0), 0.2 M lithium sulfate, and 1.9 M ammonium sulfate
|
Resolution 2.95 Å R-free 0.238 |
| 9J4S Structural basis for recognition of SARS-CoV-2 conserved nucleocapside epitopes by dominant T cell receptors Deposited 2024-08-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain E
105–113（9 aa）
|
Not recorded | SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291 K；0.1M Tris-base/hydrochloric acid (pH 7.0), 0.2 M lithium sulfate, and 1.9 M ammonium sulfate
|
Resolution 2.95 Å R-free 0.238 |
| 9J4S Structural basis for recognition of SARS-CoV-2 conserved nucleocapside epitopes by dominant T cell receptors Deposited 2024-08-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric |
Chain E
105–113（9 aa）
Chain J
105–113（9 aa）
|
Not recorded | SO4 SULFATE ION × 9 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291 K；0.1M Tris-base/hydrochloric acid (pH 7.0), 0.2 M lithium sulfate, and 1.9 M ammonium sulfate
|
Resolution 2.95 Å R-free 0.238 |
| 9J4T Structural basis for recognition of SARS-CoV-2 conserved nucleocapside epitopes by dominant T cell receptors Deposited 2024-08-10 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain C
105–113（9 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.1 M ammonium citrate dibasic, and 20% (w/v) PEG 3350
|
Resolution 2.04 Å R-free 0.232 |
| 9J4U Structural basis for recognition of SARS-CoV-2 conserved nucleocapside epitopes by dominant T cell receptors Deposited 2024-08-10 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain C
222–230（9 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M potassium sodium tartrate tetrahydrate, and 20% (w/v) PEG 3350
|
Resolution 2.17 Å R-free 0.239 |
| 9J4V Structural basis for recognition of SARS-CoV-2 conserved nucleocapside epitopes by dominant T cell receptors Deposited 2024-08-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
105–113（9 aa）
|
Not recorded | P6G HEXAETHYLENE GLYCOL × 1 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.1 HEPES (pH 7.5), 0.2 M ammonium acetate, and 24% (w/v) PEG 3350
|
Resolution 1.98 Å R-free 0.243 |
| 9J4V Structural basis for recognition of SARS-CoV-2 conserved nucleocapside epitopes by dominant T cell receptors Deposited 2024-08-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain F
105–113（9 aa）
|
Not recorded | PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.1 HEPES (pH 7.5), 0.2 M ammonium acetate, and 24% (w/v) PEG 3350
|
Resolution 1.98 Å R-free 0.243 |
| 9KN1 Crystal structure of SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain(N-NTD) in complex with UMP Deposited 2024-11-18 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
49–173（125 aa）
Fragment：N-terminal domain
|
Not recorded | U URIDINE-5'-MONOPHOSPHATE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；30% PEG3350, 100 mM Tris-HCl pH8.0, 5 mM UMP
|
Resolution 2.12 Å R-free 0.293 |
| 9KN1 Crystal structure of SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain(N-NTD) in complex with UMP Deposited 2024-11-18 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–174（128 aa）
|
Not recorded | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；30% PEG3350, 100 mM Tris-HCl pH8.0, 5 mM UMP
|
Resolution 2.12 Å R-free 0.293 |
| 9KN1 Crystal structure of SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain(N-NTD) in complex with UMP Deposited 2024-11-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
47–173（127 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；30% PEG3350, 100 mM Tris-HCl pH8.0, 5 mM UMP
|
Resolution 2.12 Å R-free 0.293 |
| 9KN1 Crystal structure of SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain(N-NTD) in complex with UMP Deposited 2024-11-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
48–173（126 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；30% PEG3350, 100 mM Tris-HCl pH8.0, 5 mM UMP
|
Resolution 2.12 Å R-free 0.293 |
| 9KUR Crystal structure of mAb nCoV400Fab with SARS-CoV-2 N-CTD Complex Deposited 2024-12-04 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
250–365（116 aa）
Fragment：CoV N CTD
Chain B
250–365（116 aa）
Fragment：CoV N CTD
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；289.15 K；0.2 M sodium formate, 16% PEG3350
|
Resolution 2.06 Å R-free 0.249 |
| 9QWI The N-terminal domain (44-180) of the SARS-CoV-2 nucleocapsid phosphoprotein using an automatic assignment/modeling software Deposited 2025-04-14 | Different construct Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
44–180（137 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 170；Pressure 1
NMR sample composition
450 uM [U-100% 13C; U-100% 15N] NTD (44-180) of N protein from SARS-CoV-2, 0.03 % NaN3, 150 mM KCl, 95 % H2O, 5 % [U-2H] D2O, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 9RXL SARS-CoV-2 nucleocapsid C-terminal domain in complex with BCY00018176 Deposited 2025-07-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
247–364（118 aa）
Chain D
247–364（118 aa）
|
Not recorded | LFI 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M Na Acet 4.6 pH,25 % w/v PEG 4K., 0.2 M (NH4)2SO4
|
Resolution 1.46 Å R-free 0.214 |
| 9S3N SARS-CoV-2 nucleocapsid N/C-terminal domain in complex with BCY17628 Deposited 2025-07-24 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
44–173（130 aa）
|
Not recorded | KZ0 2,4,6-tris(chloromethyl)-1,3,5-triazine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.2；293 K；18 % w/v PEG 1000 0.1 M Sodium/potassium phosphate 6.2 0.2 M Sodium chloride
|
Resolution 1.93 Å R-free 0.262 |
| 9UJ2 14-3-3 zeta chimera with the S202R peptide of SARS-CoV-2 N (residues 200-213) Deposited 2025-04-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
200–213（14 aa）
Chain B
200–213（14 aa）
|
Mutation：S202R,S58A,E73A,K74A,K75A,K157A,K158A,E159A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：S202R,S58A,E73A,K74A,K75A,K157A,K158A,E159A Non-standard monomer：Yes (specific site not provided by mmCIF) | EDO 1,2-ETHANEDIOL × 16 PEG DI(HYDROXYETHYL)ETHER × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；288 K；1.8M Ammonium sulfate, 0.1M BIS-TRIS pH 6.5, 2% v/v Polyethylene glycol monomethyl ether 550
|
Resolution 1.80 Å R-free 0.233 |
| 9WBD Crystal structure of HLA-B*07:02 in complex with SPR epitope and Q04 TCR Deposited 2025-08-13 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric |
Chain E
105–113（9 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；Tris-HCl, calcium chloride, PEG 3350
|
Resolution 2.75 Å R-free 0.270 |
| 9WBD Crystal structure of HLA-B*07:02 in complex with SPR epitope and Q04 TCR Deposited 2025-08-13 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric |
Chain J
105–113（9 aa）
|
Not recorded | PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；Tris-HCl, calcium chloride, PEG 3350
|
Resolution 2.75 Å R-free 0.270 |
| 9WBD Crystal structure of HLA-B*07:02 in complex with SPR epitope and Q04 TCR Deposited 2025-08-13 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric |
Chain O
105–113（9 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；Tris-HCl, calcium chloride, PEG 3350
|
Resolution 2.75 Å R-free 0.270 |
| 9WBD Crystal structure of HLA-B*07:02 in complex with SPR epitope and Q04 TCR Deposited 2025-08-13 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric |
Chain T
105–113（9 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；Tris-HCl, calcium chloride, PEG 3350
|
Resolution 2.75 Å R-free 0.270 |
96 other PDB entries and 218 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | NCAP_SARS2 |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 22–155； UniProt 41–174 Author chain B； PDBConstruct 22–155； UniProt 41–174 Author chain C； PDBConstruct 22–155； UniProt 41–174 Author chain D； PDBConstruct 22–155； UniProt 41–174 |
