SAXSdb — 8pqk

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Platelet-derived growth factor receptor alpha

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein monomer	Monomer	Protein 1	water × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PGFRA_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–147； UniProt 550–696 Author chain A； PDBConstruct 148–352； UniProt 769–973

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8pqk
Deposition date deposition_date	2023-07-11
Structure title title	APO crystal structure of PDGFRA-T674I kinase domain
Keywords keywords	;PDGFRA, protein kinase, tyrosine kinase, transmembrane receptor, platelet-derived growth factor, platelet-derived growth factor receptor, GIST, gastrointestinal stromal tumors, cancer, gatekeeper mutant, gatekeeper mutation, P16234, TRANSFERASE ;; TRANSFERASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8pqk__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8pqk__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8pqk__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	20.44 Å
Rg (electron density)	19.32 Å
Total Rg	20.32 Å
Atom count	2558
Residues	322
Excluded volume	46050 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8pqk__assembly_1__model_1`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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Unit-cell length a length_a	95.900 Å
Unit-cell length b length_b	49.020 Å
Unit-cell length c length_c	76.980 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	100.69 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	4

Space group space_group	C 1 2 1
Space-group number int_tables_number	5
Crystal system crystal_system	monoclinic

Resolution resolution	2.000 Å
Low-resolution limit resolution_low	43.810 Å
R factor r_factor	0.1974
R_work r_work	0.1960
R_free r_free	0.2219

Description description	Platelet-derived growth factor receptor alpha
Molecular weight formula_weight	40226.4 kDa
EC 编号 ec_number	2.7.10.1
Mutation mutation	T674I
Source method src_method	man
Copy count entity_count	1

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	2717

APO crystal structure of PDGFRA-T674I kinase domain

1. Protein Identity and Related Structures Protein Identity & Related Structures

Platelet-derived growth factor receptor alpha

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

8pqk__assembly_1__model_1

8pqk__assembly_1__model_1 | I(q)

8pqk__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

7. Citations (1)

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Spodoptera frugiperda

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	138

APO crystal structure of PDGFRA-T674I kinase domain

1. Protein Identity and Related Structures Protein Identity & Related Structures

Platelet-derived growth factor receptor alpha

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

8pqk__assembly_1__model_1

8pqk__assembly_1__model_1 | I(q)

8pqk__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

7. Citations (1)