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8qe8

Structure of the non-canonical CTLH E3 substrate receptor WDR26 bound to NMNAT1 substrate

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

Homo sapiens

UniProt Q9HAN9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 WD repeat-containing protein 26 × 2 （Q9H7D7） BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE × 2 ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
1gzu 1kku 1kqn 1kqo 1kr2

5 assemblies

Heteromeric or nucleic-acid complex
8qe8

1 assemblies

View Construct and Data Evidence
UniProt name NMNA1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain 1； PDBConstruct 1–279； UniProt 1–279 Author chain 2； PDBConstruct 1–279； UniProt 1–279 Author chain 3； PDBConstruct 1–279； UniProt 1–279 Author chain 4； PDBConstruct 1–279； UniProt 1–279 Author chain 5； PDBConstruct 1–279； UniProt 1–279 Author chain 6； PDBConstruct 1–279； UniProt 1–279

WD repeat-containing protein 26

Homo sapiens

UniProt Q9H7D7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 × 6 （Q9HAN9） BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE × 2 ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8qbn 8qe8 9rsc 9rsd

4 assemblies

View Construct and Data Evidence
UniProt name WDR26_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain A； PDBConstruct 1–191； UniProt 1–191 Author chain A； PDBConstruct 192–645； UniProt 208–661 Author chain B； PDBConstruct 1–191； UniProt 1–191 Author chain B； PDBConstruct 192–645； UniProt 208–661

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8qe8
Deposition date deposition_date2023-08-30
Structure title titleStructure of the non-canonical CTLH E3 substrate receptor WDR26 bound to NMNAT1 substrate
Keywords keywordsE3 ubiquitin ligase, CTLH, GID, NMNAT1, YPEL5, NAD, NADH, LIGASE; LIGASE
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8qe8__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8qe8__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8qe8__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）46.86 Å
Rg (electron density)46.84 Å
Total Rg46.98 Å
Atom count15796
Residues2044
Excluded volume281230 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8qe8__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)