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8qn6

Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Amyloid-beta A4 protein

OrganismNot specified

UniProt B4DM00

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 20 No other associated polymer Review required

Other States of the Same Protein in the Database

Monomer
8b9q 8b9r 8qn7

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
8ot1 8ot3 8ot4 8ovk 8ovm 8owd 8owe 8owj 8owk 8qn6 9raw 9rax

12 assemblies

Heteromeric or nucleic-acid complex
7f29

1 assemblies

View Construct and Data Evidence
UniProt name B4DM00_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–40； UniProt 430–469 Author chain F； PDBConstruct 1–40； UniProt 430–469

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8qn6
Deposition date deposition_date2023-09-25
Structure title titleAmyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy
Keywords keywords;amyloid-beta, amyloid, filaments, quadruplet, Abeta40, human brain, cryo-EM, Alzheimer's disease, cerebral amyloid angiopathy, PROTEIN FIBRIL ;; PROTEIN FIBRIL
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8qn6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8qn6__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8qn6__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）36.56 Å
Rg (electron density)37.13 Å
Total Rg36.96 Å
Atom count3492
Residues456
Excluded volume61026 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8qn6__assembly_1__model_1 12-meric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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7. Citations (1)