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8r7e

MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA mismatch repair protein Msh2

Homo sapiens

UniProt P43246

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 2 DNA 2 DNA mismatch repair protein Msh3 × 1 （P20585） ;DNA (5'-D(*TP*CP*TP*AP*TP*CP*TP*GP*AP*AP*GP*CP*CP*GP*AP*TP*CP*GP*AP*TP*GP*G)-3') ; × 1 ;DNA (5'-D(*CP*AP*TP*CP*GP*AP*TP*CP*GP*CP*AP*GP*CP*TP*TP*CP*AP*GP*AP*TP*AP*GP*G)-3') ; × 1 ADENOSINE-5'-DIPHOSPHATE × 1 1,2-ETHANEDIOL × 3 CHLORIDE ION × 2 Abivertinib × 1 SULFATE ION × 3 water × 2 Consistent with all polymers
2 Protein–DNA Heteromer Protein 2 DNA 2 DNA mismatch repair protein Msh3 × 1 （P20585） ;DNA (5'-D(*TP*CP*TP*AP*TP*CP*TP*GP*AP*AP*GP*CP*CP*GP*AP*TP*CP*GP*AP*TP*GP*G)-3') ; × 1 ;DNA (5'-D(*CP*AP*TP*CP*GP*AP*TP*CP*GP*CP*AP*GP*CP*TP*TP*CP*AP*GP*AP*TP*AP*GP*G)-3') ; × 1 ADENOSINE-5'-DIPHOSPHATE × 1 1,2-ETHANEDIOL × 2 CHLORIDE ION × 3 Abivertinib × 1 SULFATE ION × 2 water × 4 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2o8b 2o8c 2o8d 2o8e 2o8f 3thw 3thx 3thy 3thz 8ag6 8olx 8om5

33 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MSH2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–930； UniProt 1–930 Author chain E； PDBConstruct 1–930； UniProt 1–930

DNA mismatch repair protein Msh3

Homo sapiens

UniProt P20585

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 2 DNA 2 DNA mismatch repair protein Msh2 × 1 （P43246） ;DNA (5'-D(*TP*CP*TP*AP*TP*CP*TP*GP*AP*AP*GP*CP*CP*GP*AP*TP*CP*GP*AP*TP*GP*G)-3') ; × 1 ;DNA (5'-D(*CP*AP*TP*CP*GP*AP*TP*CP*GP*CP*AP*GP*CP*TP*TP*CP*AP*GP*AP*TP*AP*GP*G)-3') ; × 1 ADENOSINE-5'-DIPHOSPHATE × 1 1,2-ETHANEDIOL × 3 CHLORIDE ION × 2 Abivertinib × 1 SULFATE ION × 3 water × 2 Consistent with all polymers
2 Protein–DNA Heteromer Protein 2 DNA 2 DNA mismatch repair protein Msh2 × 1 （P43246） ;DNA (5'-D(*TP*CP*TP*AP*TP*CP*TP*GP*AP*AP*GP*CP*CP*GP*AP*TP*CP*GP*AP*TP*GP*G)-3') ; × 1 ;DNA (5'-D(*CP*AP*TP*CP*GP*AP*TP*CP*GP*CP*AP*GP*CP*TP*TP*CP*AP*GP*AP*TP*AP*GP*G)-3') ; × 1 ADENOSINE-5'-DIPHOSPHATE × 1 1,2-ETHANEDIOL × 2 CHLORIDE ION × 3 Abivertinib × 1 SULFATE ION × 2 water × 4 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8olx 8om5 8om9 8oma 8omo 8omq 8r7c 8r7c 8r7e 8r7e 8r7v 8rau

23 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MSH3_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 3–918； UniProt 219–1134 Author chain F； PDBConstruct 3–918； UniProt 219–1134

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8r7e
Deposition date deposition_date2023-11-24
Last revision last_revision2024-11-27
Structure title titleMutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form
Keywords keywordsPROTEROS BIOSTRUCTURES GMBH, DNA BINDING PROTEIN, DNA mismatch Repair; DNA BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8r7e__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8r7e__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8r7e__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）42.98 Å
Rg (electron density)42.47 Å
Total Rg42.81 Å
Atom count14528
Residues1746
Excluded volume257330 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8r7e__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8r7e__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (10)

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7. Citations (1)