Histone-arginine methyltransferase CARM1
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain A； UniProt 140–480 | Fragment：methyltransferase domain | GWU 5'-{(3-aminopropyl)[2-(benzylcarbamamido)ethyl]amino}-5'-deoxyadenosine × 2 NA SODIUM ION × 2 UNX UNKNOWN LIGAND × 14 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.2 M Calcium chloride dihydrate, 0.1 M HEPES sodium pH 7.5, 28% v/v Polyethylene glycol 400 | Resolution 1.78 Å R-free 0.199 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 8SIG | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2Y1W CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Deposited 2010-12-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
135–482（348 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain B
135–482（348 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain C
135–482（348 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain D
135–482（348 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
|
Not recorded | SFG SINEFUNGIN × 4 849 2-{4-[3-FLUORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL] PIPERIDIN-1-YL}-N-METHYLETHANAMINE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.5；20-30% PEG 2000K, 0.1 M TRIS-HCL PH 8.5, 0.2 M TRIMETHYLAMINE N-OXIDE DIHYDRATE.
|
Resolution 2.10 Å R-free 0.244 |
| 2Y1X CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Deposited 2010-12-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
135–482（348 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain D
135–482（348 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
|
Not recorded | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 845 N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.5；20-30% PEG 2000K, 0.1 M TRIS-HCL PH 8.5, 0.2 M TRIMETHYLAMINE N-OXIDE DIHYDRATE
|
Resolution 2.40 Å R-free 0.264 |
| 2Y1X CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Deposited 2010-12-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
135–482（348 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain C
135–482（348 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
|
Not recorded | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 845 N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.5；20-30% PEG 2000K, 0.1 M TRIS-HCL PH 8.5, 0.2 M TRIMETHYLAMINE N-OXIDE DIHYDRATE
|
Resolution 2.40 Å R-free 0.264 |
| 4IKP Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin Deposited 2012-12-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
140–480（341 aa）
Fragment：UNP residues 140-480
Chain B
140–480（341 aa）
Fragment：UNP residues 140-480
|
Not recorded | 4IK (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid × 2 GOL GLYCEROL × 1 UNX UNKNOWN LIGAND × 25 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；20% PEG 3350, 0.2 M Di-AMMONIUM TARTRATE, vapor diffusion, hanging drop, temperature 291K
|
Resolution 2.00 Å R-free 0.231 |
| 4IKP Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin Deposited 2012-12-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
140–480（341 aa）
Fragment：UNP residues 140-480
Chain D
140–480（341 aa）
Fragment：UNP residues 140-480
|
Not recorded | 4IK (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid × 2 GOL GLYCEROL × 4 UNX UNKNOWN LIGAND × 15 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；20% PEG 3350, 0.2 M Di-AMMONIUM TARTRATE, vapor diffusion, hanging drop, temperature 291K
|
Resolution 2.00 Å R-free 0.231 |
| 5DWQ Crystal structure of CARM1, sinefungin, and methylated H3 peptide (R17) Deposited 2015-09-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain B
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Mutation：aa 134-479 Mutation：aa 134-479 | SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 2.36 Å R-free 0.257 |
| 5DWQ Crystal structure of CARM1, sinefungin, and methylated H3 peptide (R17) Deposited 2015-09-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain D
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Mutation：aa 134-479 Mutation：aa 134-479 | SFG SINEFUNGIN × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 2.36 Å R-free 0.257 |
| 5DX0 Crystal structure of CARM1, sinefungin, and H3 peptide (R17) Deposited 2015-09-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain B
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 2.05 Å R-free 0.263 |
| 5DX0 Crystal structure of CARM1, sinefungin, and H3 peptide (R17) Deposited 2015-09-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain D
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 2.05 Å R-free 0.263 |
| 5DX1 Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) Deposited 2015-09-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain B
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 1.93 Å R-free 0.238 |
| 5DX1 Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) Deposited 2015-09-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain D
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 1.93 Å R-free 0.238 |
| 5DX8 Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R455) Deposited 2015-09-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain B
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 1.94 Å R-free 0.246 |
| 5DX8 Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R455) Deposited 2015-09-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain D
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 1.94 Å R-free 0.246 |
| 5DXA Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R460) Deposited 2015-09-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain B
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 2.07 Å R-free 0.244 |
| 5DXA Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R460) Deposited 2015-09-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain D
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 2.07 Å R-free 0.244 |
| 5DXJ Crystal structure of CARM1 and sinefungin Deposited 2015-09-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain B
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 1.95 Å R-free 0.231 |
| 5DXJ Crystal structure of CARM1 and sinefungin Deposited 2015-09-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
Chain D
134–479（346 aa）
Fragment：catalytic domain (UNP residues 134-479)
|
Not recorded | SFG SINEFUNGIN × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
|
Resolution 1.95 Å R-free 0.231 |
| 5U4X Coactivator-associated arginine methyltransferase 1 with TP-064 Deposited 2016-12-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
140–480（341 aa）
Fragment：UNP residues 140-480
Chain B
140–480（341 aa）
Fragment：UNP residues 140-480
|
Not recorded | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 7VM N-methyl-N-[(2-{1-[2-(methylamino)ethyl]piperidin-4-yl}pyridin-4-yl)methyl]-3-phenoxybenzamide × 2 UNX UNKNOWN LIGAND × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；20% PEG 3350, 0.2 M AmSO4, 0.1 M Tris pH8.5
|
Resolution 1.88 Å R-free 0.215 |
| 5U4X Coactivator-associated arginine methyltransferase 1 with TP-064 Deposited 2016-12-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
140–480（341 aa）
Fragment：UNP residues 140-480
Chain D
140–480（341 aa）
Fragment：UNP residues 140-480
|
Not recorded | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 7VM N-methyl-N-[(2-{1-[2-(methylamino)ethyl]piperidin-4-yl}pyridin-4-yl)methyl]-3-phenoxybenzamide × 2 UNX UNKNOWN LIGAND × 11 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；20% PEG 3350, 0.2 M AmSO4, 0.1 M Tris pH8.5
|
Resolution 1.88 Å R-free 0.215 |
| 6ARJ Crystal structure of CARM1 with EPZ022302 and SAH Deposited 2017-08-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
134–479（346 aa）
Fragment：Catalytic domain (UNP residues 134-479)
Chain B
134–479（346 aa）
Fragment：Catalytic domain (UNP residues 134-479)
|
Not recorded | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 BW4 methyl 2-[2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG3350
|
Resolution 1.92 Å R-free 0.212 |
| 6ARJ Crystal structure of CARM1 with EPZ022302 and SAH Deposited 2017-08-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
134–479（346 aa）
Fragment：Catalytic domain (UNP residues 134-479)
Chain D
134–479（346 aa）
Fragment：Catalytic domain (UNP residues 134-479)
|
Not recorded | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 BW4 methyl 2-[2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate × 2 GOL GLYCEROL × 3 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG3350
|
Resolution 1.92 Å R-free 0.212 |
| 6ARV Crystal structure of CARM1 with Compound 2 and SAH Deposited 2017-08-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
134–479（346 aa）
Fragment：Catalytic domain (UNP residues 134-479)
Chain B
134–479（346 aa）
Fragment：Catalytic domain (UNP residues 134-479)
|
Not recorded | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 BW7 (2R)-1-amino-3-{3-[4-(morpholin-4-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]phenoxy}propan-2-ol × 2 GOL GLYCEROL × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG3350
|
Resolution 2.00 Å R-free 0.232 |
| 6ARV Crystal structure of CARM1 with Compound 2 and SAH Deposited 2017-08-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
134–479（346 aa）
Fragment：Catalytic domain (UNP residues 134-479)
Chain D
134–479（346 aa）
Fragment：Catalytic domain (UNP residues 134-479)
|
Not recorded | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 BW7 (2R)-1-amino-3-{3-[4-(morpholin-4-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]phenoxy}propan-2-ol × 2 GOL GLYCEROL × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG3350
|
Resolution 2.00 Å R-free 0.232 |
| 6D2L Crystal structure of human CARM1 with (S)-SKI-72 Deposited 2018-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
146–489（344 aa）
Chain B
146–489（344 aa）
Chain C
146–489（344 aa）
Chain D
146–489（344 aa）
Chain E
146–489（344 aa）
Chain F
146–489（344 aa）
|
Not recorded | FTG (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-hydroxyphenyl)ethyl]hexanamide × 6 SO4 SULFATE ION × 3 GOL GLYCEROL × 2 UNX UNKNOWN LIGAND × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；25% PEG 3350, 0.2 M NH4SO4, 0.1 M HEPES pH7.5
|
Resolution 2.00 Å R-free 0.236 |
| 6DVR Crystal structure of human CARM1 with (R)-SKI-72 Deposited 2018-06-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
146–489（344 aa）
Chain B
146–489（344 aa）
|
Not recorded | HDG (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name) × 2 P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL × 2 UNX UNKNOWN LIGAND × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；25% PEG 3350, 0.2 M NH4SO4, 0.1 M HEPES pH7.5
|
Resolution 1.54 Å R-free 0.215 |
| 6DVR Crystal structure of human CARM1 with (R)-SKI-72 Deposited 2018-06-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
146–489（344 aa）
Chain B
146–489（344 aa）
|
Not recorded | HDG (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name) × 8 P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL × 8 UNX UNKNOWN LIGAND × 24 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；25% PEG 3350, 0.2 M NH4SO4, 0.1 M HEPES pH7.5
|
Resolution 1.54 Å R-free 0.215 |
| 6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
145–477（333 aa）
|
Not recorded | XJ2 (2R)-1-(methylamino)-3-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)propan-2-ol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.45 Å R-free 0.248 |
| 6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
145–477（333 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.45 Å R-free 0.248 |
| 6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
145–477（333 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.45 Å R-free 0.248 |
| 6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
145–477（333 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.45 Å R-free 0.248 |
| 6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
145–477（333 aa）
Chain B
145–477（333 aa）
Chain C
145–477（333 aa）
Chain D
145–477（333 aa）
|
Not recorded | XJ2 (2R)-1-(methylamino)-3-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)propan-2-ol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.45 Å R-free 0.248 |
| 6S70 Crystal structure of CARM1 in complex with inhibitor UM251 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
135–479（345 aa）
Chain C
135–479（345 aa）
|
Not recorded | KYB 1-[5-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]pentyl]guanidine × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.2 M sodium acetate, 24 % (w/v) PEG 3350
|
Resolution 2.30 Å R-free 0.211 |
| 6S70 Crystal structure of CARM1 in complex with inhibitor UM251 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
135–479（345 aa）
Chain D
135–479（345 aa）
|
Not recorded | KYB 1-[5-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]pentyl]guanidine × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.2 M sodium acetate, 24 % (w/v) PEG 3350
|
Resolution 2.30 Å R-free 0.211 |
| 6S71 Crystal structure of CARM1 in complex with inhibitor WH5C Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
135–479（345 aa）
Chain C
135–479（345 aa）
|
Not recorded | KYE (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(5-carbamimidamidopentyl)amino]-2-azanyl-butanoic acid × 2 GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.2 M sodium acetate, 20 % (w/v) PEG 3350
|
Resolution 2.06 Å R-free 0.210 |
| 6S71 Crystal structure of CARM1 in complex with inhibitor WH5C Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
135–479（345 aa）
Chain D
135–479（345 aa）
|
Not recorded | KYE (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(5-carbamimidamidopentyl)amino]-2-azanyl-butanoic acid × 2 GOL GLYCEROL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.2 M sodium acetate, 20 % (w/v) PEG 3350
|
Resolution 2.06 Å R-free 0.210 |
| 6S74 Crystal structure of CARM1 in complex with inhibitor UM305 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
135–479（345 aa）
Chain C
135–479（345 aa）
|
Not recorded | KY8 (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyrimidin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol × 2 GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 22 % (w/v) PEG 3350
|
Resolution 2.10 Å R-free 0.216 |
| 6S74 Crystal structure of CARM1 in complex with inhibitor UM305 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
135–479（345 aa）
Chain D
135–479（345 aa）
|
Not recorded | KY8 (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyrimidin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 22 % (w/v) PEG 3350
|
Resolution 2.10 Å R-free 0.216 |
| 6S77 Crystal structure of CARM1 N265Y mutant in complex with inhibitor AA183 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
135–479（345 aa）
Chain C
135–479（345 aa）
|
Mutation：N265Y Mutation：N265Y | KXW (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 26 % (w/v) PEG 3350
|
Resolution 2.12 Å R-free 0.246 |
| 6S77 Crystal structure of CARM1 N265Y mutant in complex with inhibitor AA183 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
135–479（345 aa）
Chain D
135–479（345 aa）
|
Mutation：N265Y Mutation：N265Y | KXW (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 26 % (w/v) PEG 3350
|
Resolution 2.12 Å R-free 0.246 |
| 6S79 Crystal structure of CARM1 in complex with inhibitor AA183 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
135–479（345 aa）
Chain D
135–479（345 aa）
|
Not recorded | KXW (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bis-tris propane, 0.2 M sodium formate, 20 % (w/v) PEG 3350
|
Resolution 2.10 Å R-free 0.231 |
| 6S79 Crystal structure of CARM1 in complex with inhibitor AA183 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
135–479（345 aa）
Chain C
135–479（345 aa）
|
Not recorded | KXW (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bis-tris propane, 0.2 M sodium formate, 20 % (w/v) PEG 3350
|
Resolution 2.10 Å R-free 0.231 |
| 6S7A Crystal structure of CARM1 in complex with inhibitor AA175 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
135–479（345 aa）
Chain C
135–479（345 aa）
|
Not recorded | KY5 (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyridin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bis-tris propane, 0.2 M sodium formate, 20 % (w/v) PEG 3350
|
Resolution 1.86 Å R-free 0.220 |
| 6S7A Crystal structure of CARM1 in complex with inhibitor AA175 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
135–479（345 aa）
Chain D
135–479（345 aa）
|
Not recorded | KY5 (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyridin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol × 2 GOL GLYCEROL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bis-tris propane, 0.2 M sodium formate, 20 % (w/v) PEG 3350
|
Resolution 1.86 Å R-free 0.220 |
| 6S7B Crystal structure of CARM1 in complex with inhibitor UM249 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
135–479（345 aa）
Chain C
135–479（345 aa）
|
Not recorded | KYH 1-[4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]butyl]guanidine × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M potassium phosphate, 22 % (w/v) PEG 3350
|
Resolution 2.66 Å R-free 0.227 |
| 6S7B Crystal structure of CARM1 in complex with inhibitor UM249 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
135–479（345 aa）
Chain D
135–479（345 aa）
|
Not recorded | KYH 1-[4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]butyl]guanidine × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M potassium phosphate, 22 % (w/v) PEG 3350
|
Resolution 2.66 Å R-free 0.227 |
| 6S7C Crystal structure of CARM1 in complex with inhibitor UM079 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
135–479（345 aa）
Chain C
135–479（345 aa）
|
Not recorded | KY2 1-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]propyl]guanidine × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 21 % (w/v) PEG 3350
|
Resolution 2.30 Å R-free 0.233 |
| 6S7C Crystal structure of CARM1 in complex with inhibitor UM079 Deposited 2019-07-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
135–479（345 aa）
Chain D
135–479（345 aa）
|
Not recorded | KY2 1-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]propyl]guanidine × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 21 % (w/v) PEG 3350
|
Resolution 2.30 Å R-free 0.233 |
| 7FAI CARM1 bound with compound 9 Deposited 2021-07-06 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
142–477（336 aa）
|
Not recorded | XJ3 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.10 Å R-free 0.232 |
| 7FAI CARM1 bound with compound 9 Deposited 2021-07-06 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
142–477（336 aa）
|
Not recorded | XJ3 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.10 Å R-free 0.232 |
| 7FAI CARM1 bound with compound 9 Deposited 2021-07-06 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
142–477（336 aa）
|
Not recorded | XJ3 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.10 Å R-free 0.232 |
| 7FAI CARM1 bound with compound 9 Deposited 2021-07-06 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
142–477（336 aa）
|
Not recorded | XJ3 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.10 Å R-free 0.232 |
| 7FAJ CARM1 bound with compound 43 Deposited 2021-07-06 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
142–477（336 aa）
|
Not recorded | XJ4 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.25 Å R-free 0.240 |
| 7FAJ CARM1 bound with compound 43 Deposited 2021-07-06 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
142–477（336 aa）
|
Not recorded | XJ4 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.25 Å R-free 0.240 |
| 7FAJ CARM1 bound with compound 43 Deposited 2021-07-06 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
142–477（336 aa）
|
Not recorded | XJ4 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.25 Å R-free 0.240 |
| 7FAJ CARM1 bound with compound 43 Deposited 2021-07-06 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
142–477（336 aa）
|
Not recorded | XJ4 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
|
Resolution 2.25 Å R-free 0.240 |
| 7U9I Co-crystal structure of human CARM1 in complex with MT556 inhibitor Deposited 2022-03-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
146–489（344 aa）
Chain B
146–489（344 aa）
|
Not recorded | 44T 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine × 2 UNX UNKNOWN LIGAND × 14 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；20% PEG3350, 0.2M di-Sodium Tartrate
|
Resolution 2.00 Å R-free 0.267 |
| 8G2H Crystal Structure of PRMT4 with Compound YD1113 Deposited 2023-02-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
140–480（341 aa）
Fragment：methyltransferase domain
|
Not recorded | YVU 5'-S-[2-(benzylcarbamamido)ethyl]-5'-thioadenosine × 2 GOL GLYCEROL × 4 NA SODIUM ION × 2 UNX UNKNOWN LIGAND × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M Calcium chloride dihydrate, 0.05 M HEPES sodium pH 7.5, 28% v/v Polyethylene glycol 400, 0.002 M Spermine
|
Resolution 1.49 Å R-free 0.177 |
| 8G2I Crystal Structure of PRMT4 with Compound YD1290 Deposited 2023-02-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
140–480（341 aa）
Fragment：methyltransferase domain
|
Not recorded | I0B 5'-([2-(benzylcarbamamido)ethyl]{3-[N'-(3-bromophenyl)carbamimidamido]propyl}amino)-5'-deoxyadenosine × 2 UNX UNKNOWN LIGAND × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；291 K；0.1 M BICINE pH 9.0, 2.0 M Magnesium chloride hexahydrate
|
Resolution 2.17 Å R-free 0.225 |
| 8SIH Crystal Structure of PRMT4 with Compound YD1-289 Deposited 2023-04-16 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
140–480（341 aa）
Fragment：methyltransferase domain
|
Not recorded | I1K 5'-{[2-(benzylcarbamamido)ethyl][3-(N'-cyclopentylcarbamimidamido)propyl]amino}-5'-deoxyadenosine × 2 CA CALCIUM ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；3.5 M Ammonium chloride, 0.1 M BIS-TRIS propane pH 7.0
|
Resolution 2.35 Å R-free 0.246 |
| 8UQH X-ray crystal structure of PRMT4 bound to compound YD-1130 Deposited 2023-10-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
139–479（341 aa）
Chain B
139–479（341 aa）
Chain C
139–479（341 aa）
Chain D
139–479（341 aa）
|
Not recorded | X9L 5'-S-(2-{[(3-bromophenyl)methyl]amino}ethyl)-5'-thioadenosine × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；7.5% (w/v) PEG 20,000, 0.1M Tris, 0.08M sodium formate, pH 7.5
|
Resolution 1.87 Å R-free 0.253 |
| 9O37 The structure of PRMT4 in complex with YD1305 Deposited 2025-04-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
145–477（333 aa）
Fragment：UNP Residues 145-477
|
Not recorded | A1B7X 5'-{[2-(benzylcarbamamido)ethyl](3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)amino}-5'-deoxyadenosine × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 2 CA CALCIUM ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2M calcium acetate hydrate, 0.1M HEPES: NaOH, pH 7.5, 10% (w/v) PEG 8,000
|
Resolution 2.11 Å R-free 0.233 |
| 9O6H The Structure of PRMT4 in complex with SGC8172 Deposited 2025-04-13 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
146–476（331 aa）
|
Not recorded | A1B9W 5'-S-(3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)-5'-thioadenosine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium tartrate dibasic, 20% (w/v) PEG 3,350
|
Resolution 1.97 Å R-free 0.269 |
| 9O6H The Structure of PRMT4 in complex with SGC8172 Deposited 2025-04-13 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
146–476（331 aa）
|
Not recorded | A1B9W 5'-S-(3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)-5'-thioadenosine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium tartrate dibasic, 20% (w/v) PEG 3,350
|
Resolution 1.97 Å R-free 0.269 |
| 9O6H The Structure of PRMT4 in complex with SGC8172 Deposited 2025-04-13 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
146–476（331 aa）
|
Not recorded | A1B9W 5'-S-(3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)-5'-thioadenosine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium tartrate dibasic, 20% (w/v) PEG 3,350
|
Resolution 1.97 Å R-free 0.269 |
| 9O6H The Structure of PRMT4 in complex with SGC8172 Deposited 2025-04-13 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
146–476（331 aa）
|
Not recorded | A1B9W 5'-S-(3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)-5'-thioadenosine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium tartrate dibasic, 20% (w/v) PEG 3,350
|
Resolution 1.97 Å R-free 0.269 |
32 other PDB entries and 65 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | CARM1_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 19–359； UniProt 140–480 |