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5dxa

Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R460)

Method: X-RAY DIFFRACTION Dmax: 128.2 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Histone-arginine methyltransferase CARM1

Homo sapiens

UniProt Q86X55

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count Chain A； UniProt 134–479 Chain B； UniProt 134–479 Fragment：catalytic domain (UNP residues 134-479) methylated PABP1 peptide × 2 （P11940） SFG SINEFUNGIN × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350 Resolution 2.07 Å R-free 0.244
2 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain C； UniProt 134–479 Chain D； UniProt 134–479 Fragment：catalytic domain (UNP residues 134-479) methylated PABP1 peptide × 1 （P11940） SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350 Resolution 2.07 Å R-free 0.244

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 5DXA Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2Y1W CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Deposited 2010-12-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 135–482（348 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain B 135–482（348 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain C 135–482（348 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain D 135–482（348 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Not recorded SFG SINEFUNGIN × 4 849 2-{4-[3-FLUORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL] PIPERIDIN-1-YL}-N-METHYLETHANAMINE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.5；20-30% PEG 2000K, 0.1 M TRIS-HCL PH 8.5, 0.2 M TRIMETHYLAMINE N-OXIDE DIHYDRATE.
Resolution 2.10 Å R-free 0.244
2Y1X CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Deposited 2010-12-10 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 135–482（348 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain D 135–482（348 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 845 N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE × 2 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.5；20-30% PEG 2000K, 0.1 M TRIS-HCL PH 8.5, 0.2 M TRIMETHYLAMINE N-OXIDE DIHYDRATE
Resolution 2.40 Å R-free 0.264
2Y1X CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Deposited 2010-12-10 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 135–482（348 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Chain C 135–482（348 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 135-482
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 845 N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE × 2 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.5；20-30% PEG 2000K, 0.1 M TRIS-HCL PH 8.5, 0.2 M TRIMETHYLAMINE N-OXIDE DIHYDRATE
Resolution 2.40 Å R-free 0.264
4IKP Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin Deposited 2012-12-27 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 140–480（341 aa） Fragment：UNP residues 140-480
Chain B 140–480（341 aa） Fragment：UNP residues 140-480
Not recorded 4IK (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid × 2 GOL GLYCEROL × 1 UNX UNKNOWN LIGAND × 25 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；20% PEG 3350, 0.2 M Di-AMMONIUM TARTRATE, vapor diffusion, hanging drop, temperature 291K
Resolution 2.00 Å R-free 0.231
4IKP Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin Deposited 2012-12-27 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 140–480（341 aa） Fragment：UNP residues 140-480
Chain D 140–480（341 aa） Fragment：UNP residues 140-480
Not recorded 4IK (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid × 2 GOL GLYCEROL × 4 UNX UNKNOWN LIGAND × 15 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；20% PEG 3350, 0.2 M Di-AMMONIUM TARTRATE, vapor diffusion, hanging drop, temperature 291K
Resolution 2.00 Å R-free 0.231
5DWQ Crystal structure of CARM1, sinefungin, and methylated H3 peptide (R17) Deposited 2015-09-22 Different mutation/modification Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain B 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Mutation：aa 134-479 Mutation：aa 134-479 SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 2.36 Å R-free 0.257
5DWQ Crystal structure of CARM1, sinefungin, and methylated H3 peptide (R17) Deposited 2015-09-22 Different mutation/modification Different ligand/ion Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain D 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Mutation：aa 134-479 Mutation：aa 134-479 SFG SINEFUNGIN × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 2.36 Å R-free 0.257
5DX0 Crystal structure of CARM1, sinefungin, and H3 peptide (R17) Deposited 2015-09-23 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain B 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Not recorded SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 2.05 Å R-free 0.263
5DX0 Crystal structure of CARM1, sinefungin, and H3 peptide (R17) Deposited 2015-09-23 Different ligand/ion Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain D 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Not recorded SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 2.05 Å R-free 0.263
5DX1 Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) Deposited 2015-09-23 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain B 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Not recorded SFG SINEFUNGIN × 2 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.93 Å R-free 0.238
5DX1 Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) Deposited 2015-09-23 Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain D 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Not recorded SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.93 Å R-free 0.238
5DX8 Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R455) Deposited 2015-09-23 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain B 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Not recorded SFG SINEFUNGIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.94 Å R-free 0.246
5DX8 Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R455) Deposited 2015-09-23 Different ligand/ion Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain D 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Not recorded SFG SINEFUNGIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.94 Å R-free 0.246
5DXJ Crystal structure of CARM1 and sinefungin Deposited 2015-09-23 Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain B 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Not recorded SFG SINEFUNGIN × 2 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.95 Å R-free 0.231
5DXJ Crystal structure of CARM1 and sinefungin Deposited 2015-09-23 Different oligomeric state Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Chain D 134–479（346 aa） Fragment：catalytic domain (UNP residues 134-479)
Not recorded SFG SINEFUNGIN × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.95 Å R-free 0.231
5U4X Coactivator-associated arginine methyltransferase 1 with TP-064 Deposited 2016-12-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 140–480（341 aa） Fragment：UNP residues 140-480
Chain B 140–480（341 aa） Fragment：UNP residues 140-480
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 7VM N-methyl-N-[(2-{1-[2-(methylamino)ethyl]piperidin-4-yl}pyridin-4-yl)methyl]-3-phenoxybenzamide × 2 UNX UNKNOWN LIGAND × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；20% PEG 3350, 0.2 M AmSO4, 0.1 M Tris pH8.5
Resolution 1.88 Å R-free 0.215
5U4X Coactivator-associated arginine methyltransferase 1 with TP-064 Deposited 2016-12-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 140–480（341 aa） Fragment：UNP residues 140-480
Chain D 140–480（341 aa） Fragment：UNP residues 140-480
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 7VM N-methyl-N-[(2-{1-[2-(methylamino)ethyl]piperidin-4-yl}pyridin-4-yl)methyl]-3-phenoxybenzamide × 2 UNX UNKNOWN LIGAND × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；20% PEG 3350, 0.2 M AmSO4, 0.1 M Tris pH8.5
Resolution 1.88 Å R-free 0.215
6ARJ Crystal structure of CARM1 with EPZ022302 and SAH Deposited 2017-08-22 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 134–479（346 aa） Fragment：Catalytic domain (UNP residues 134-479)
Chain B 134–479（346 aa） Fragment：Catalytic domain (UNP residues 134-479)
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 BW4 methyl 2-[2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG3350
Resolution 1.92 Å R-free 0.212
6ARJ Crystal structure of CARM1 with EPZ022302 and SAH Deposited 2017-08-22 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 134–479（346 aa） Fragment：Catalytic domain (UNP residues 134-479)
Chain D 134–479（346 aa） Fragment：Catalytic domain (UNP residues 134-479)
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 BW4 methyl 2-[2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate × 2 GOL GLYCEROL × 3 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG3350
Resolution 1.92 Å R-free 0.212
6ARV Crystal structure of CARM1 with Compound 2 and SAH Deposited 2017-08-23 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 134–479（346 aa） Fragment：Catalytic domain (UNP residues 134-479)
Chain B 134–479（346 aa） Fragment：Catalytic domain (UNP residues 134-479)
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 BW7 (2R)-1-amino-3-{3-[4-(morpholin-4-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]phenoxy}propan-2-ol × 2 GOL GLYCEROL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG3350
Resolution 2.00 Å R-free 0.232
6ARV Crystal structure of CARM1 with Compound 2 and SAH Deposited 2017-08-23 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 134–479（346 aa） Fragment：Catalytic domain (UNP residues 134-479)
Chain D 134–479（346 aa） Fragment：Catalytic domain (UNP residues 134-479)
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 BW7 (2R)-1-amino-3-{3-[4-(morpholin-4-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]phenoxy}propan-2-ol × 2 GOL GLYCEROL × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG3350
Resolution 2.00 Å R-free 0.232
6D2L Crystal structure of human CARM1 with (S)-SKI-72 Deposited 2018-04-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 146–489（344 aa）
Chain B 146–489（344 aa）
Chain C 146–489（344 aa）
Chain D 146–489（344 aa）
Chain E 146–489（344 aa）
Chain F 146–489（344 aa）
Not recorded FTG (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-hydroxyphenyl)ethyl]hexanamide × 6 SO4 SULFATE ION × 3 GOL GLYCEROL × 2 UNX UNKNOWN LIGAND × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；25% PEG 3350, 0.2 M NH4SO4, 0.1 M HEPES pH7.5
Resolution 2.00 Å R-free 0.236
6DVR Crystal structure of human CARM1 with (R)-SKI-72 Deposited 2018-06-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 146–489（344 aa）
Chain B 146–489（344 aa）
Not recorded HDG (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name) × 2 P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL × 2 UNX UNKNOWN LIGAND × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；25% PEG 3350, 0.2 M NH4SO4, 0.1 M HEPES pH7.5
Resolution 1.54 Å R-free 0.215
6DVR Crystal structure of human CARM1 with (R)-SKI-72 Deposited 2018-06-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric
Chain A 146–489（344 aa）
Chain B 146–489（344 aa）
Not recorded HDG (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name) × 8 P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL × 8 UNX UNKNOWN LIGAND × 24 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；25% PEG 3350, 0.2 M NH4SO4, 0.1 M HEPES pH7.5
Resolution 1.54 Å R-free 0.215
6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 145–477（333 aa）
Not recorded XJ2 (2R)-1-(methylamino)-3-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)propan-2-ol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.45 Å R-free 0.248
6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 145–477（333 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.45 Å R-free 0.248
6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 145–477（333 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.45 Å R-free 0.248
6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 145–477（333 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.45 Å R-free 0.248
6IZQ PRMT4 bound with a bicyclic compound Deposited 2018-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric
Chain A 145–477（333 aa）
Chain B 145–477（333 aa）
Chain C 145–477（333 aa）
Chain D 145–477（333 aa）
Not recorded XJ2 (2R)-1-(methylamino)-3-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)propan-2-ol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.45 Å R-free 0.248
6S70 Crystal structure of CARM1 in complex with inhibitor UM251 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 135–479（345 aa）
Chain C 135–479（345 aa）
Not recorded KYB 1-[5-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]pentyl]guanidine × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.2 M sodium acetate, 24 % (w/v) PEG 3350
Resolution 2.30 Å R-free 0.211
6S70 Crystal structure of CARM1 in complex with inhibitor UM251 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 135–479（345 aa）
Chain D 135–479（345 aa）
Not recorded KYB 1-[5-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]pentyl]guanidine × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.2 M sodium acetate, 24 % (w/v) PEG 3350
Resolution 2.30 Å R-free 0.211
6S71 Crystal structure of CARM1 in complex with inhibitor WH5C Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 135–479（345 aa）
Chain C 135–479（345 aa）
Not recorded KYE (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(5-carbamimidamidopentyl)amino]-2-azanyl-butanoic acid × 2 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.2 M sodium acetate, 20 % (w/v) PEG 3350
Resolution 2.06 Å R-free 0.210
6S71 Crystal structure of CARM1 in complex with inhibitor WH5C Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 135–479（345 aa）
Chain D 135–479（345 aa）
Not recorded KYE (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(5-carbamimidamidopentyl)amino]-2-azanyl-butanoic acid × 2 GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.2 M sodium acetate, 20 % (w/v) PEG 3350
Resolution 2.06 Å R-free 0.210
6S74 Crystal structure of CARM1 in complex with inhibitor UM305 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 135–479（345 aa）
Chain C 135–479（345 aa）
Not recorded KY8 (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyrimidin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol × 2 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 22 % (w/v) PEG 3350
Resolution 2.10 Å R-free 0.216
6S74 Crystal structure of CARM1 in complex with inhibitor UM305 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 135–479（345 aa）
Chain D 135–479（345 aa）
Not recorded KY8 (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyrimidin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 22 % (w/v) PEG 3350
Resolution 2.10 Å R-free 0.216
6S77 Crystal structure of CARM1 N265Y mutant in complex with inhibitor AA183 Deposited 2019-07-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 135–479（345 aa）
Chain C 135–479（345 aa）
Mutation：N265Y Mutation：N265Y KXW (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 26 % (w/v) PEG 3350
Resolution 2.12 Å R-free 0.246
6S77 Crystal structure of CARM1 N265Y mutant in complex with inhibitor AA183 Deposited 2019-07-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 135–479（345 aa）
Chain D 135–479（345 aa）
Mutation：N265Y Mutation：N265Y KXW (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 26 % (w/v) PEG 3350
Resolution 2.12 Å R-free 0.246
6S79 Crystal structure of CARM1 in complex with inhibitor AA183 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 135–479（345 aa）
Chain D 135–479（345 aa）
Not recorded KXW (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bis-tris propane, 0.2 M sodium formate, 20 % (w/v) PEG 3350
Resolution 2.10 Å R-free 0.231
6S79 Crystal structure of CARM1 in complex with inhibitor AA183 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 135–479（345 aa）
Chain C 135–479（345 aa）
Not recorded KXW (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bis-tris propane, 0.2 M sodium formate, 20 % (w/v) PEG 3350
Resolution 2.10 Å R-free 0.231
6S7A Crystal structure of CARM1 in complex with inhibitor AA175 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 135–479（345 aa）
Chain C 135–479（345 aa）
Not recorded KY5 (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyridin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bis-tris propane, 0.2 M sodium formate, 20 % (w/v) PEG 3350
Resolution 1.86 Å R-free 0.220
6S7A Crystal structure of CARM1 in complex with inhibitor AA175 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 135–479（345 aa）
Chain D 135–479（345 aa）
Not recorded KY5 (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyridin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol × 2 GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bis-tris propane, 0.2 M sodium formate, 20 % (w/v) PEG 3350
Resolution 1.86 Å R-free 0.220
6S7B Crystal structure of CARM1 in complex with inhibitor UM249 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 135–479（345 aa）
Chain C 135–479（345 aa）
Not recorded KYH 1-[4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]butyl]guanidine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M potassium phosphate, 22 % (w/v) PEG 3350
Resolution 2.66 Å R-free 0.227
6S7B Crystal structure of CARM1 in complex with inhibitor UM249 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 135–479（345 aa）
Chain D 135–479（345 aa）
Not recorded KYH 1-[4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]butyl]guanidine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M potassium phosphate, 22 % (w/v) PEG 3350
Resolution 2.66 Å R-free 0.227
6S7C Crystal structure of CARM1 in complex with inhibitor UM079 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 135–479（345 aa）
Chain C 135–479（345 aa）
Not recorded KY2 1-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]propyl]guanidine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 21 % (w/v) PEG 3350
Resolution 2.30 Å R-free 0.233
6S7C Crystal structure of CARM1 in complex with inhibitor UM079 Deposited 2019-07-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 135–479（345 aa）
Chain D 135–479（345 aa）
Not recorded KY2 1-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]propyl]guanidine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Bis-tris propane, 0.02 M sodium phosphate, 21 % (w/v) PEG 3350
Resolution 2.30 Å R-free 0.233
7FAI CARM1 bound with compound 9 Deposited 2021-07-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 142–477（336 aa）
Not recorded XJ3 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.10 Å R-free 0.232
7FAI CARM1 bound with compound 9 Deposited 2021-07-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 142–477（336 aa）
Not recorded XJ3 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.10 Å R-free 0.232
7FAI CARM1 bound with compound 9 Deposited 2021-07-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 142–477（336 aa）
Not recorded XJ3 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.10 Å R-free 0.232
7FAI CARM1 bound with compound 9 Deposited 2021-07-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 142–477（336 aa）
Not recorded XJ3 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.10 Å R-free 0.232
7FAJ CARM1 bound with compound 43 Deposited 2021-07-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 142–477（336 aa）
Not recorded XJ4 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.25 Å R-free 0.240
7FAJ CARM1 bound with compound 43 Deposited 2021-07-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 142–477（336 aa）
Not recorded XJ4 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.25 Å R-free 0.240
7FAJ CARM1 bound with compound 43 Deposited 2021-07-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 142–477（336 aa）
Not recorded XJ4 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.25 Å R-free 0.240
7FAJ CARM1 bound with compound 43 Deposited 2021-07-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 142–477（336 aa）
Not recorded XJ4 N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22-27% PEG 3350, 0.15M sodium malate, pH 7.0
Resolution 2.25 Å R-free 0.240
7U9I Co-crystal structure of human CARM1 in complex with MT556 inhibitor Deposited 2022-03-10 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 146–489（344 aa）
Chain B 146–489（344 aa）
Not recorded 44T 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine × 2 UNX UNKNOWN LIGAND × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；20% PEG3350, 0.2M di-Sodium Tartrate
Resolution 2.00 Å R-free 0.267
8G2H Crystal Structure of PRMT4 with Compound YD1113 Deposited 2023-02-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 140–480（341 aa） Fragment：methyltransferase domain
Not recorded YVU 5'-S-[2-(benzylcarbamamido)ethyl]-5'-thioadenosine × 2 GOL GLYCEROL × 4 NA SODIUM ION × 2 UNX UNKNOWN LIGAND × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M Calcium chloride dihydrate, 0.05 M HEPES sodium pH 7.5, 28% v/v Polyethylene glycol 400, 0.002 M Spermine
Resolution 1.49 Å R-free 0.177
8G2I Crystal Structure of PRMT4 with Compound YD1290 Deposited 2023-02-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 140–480（341 aa） Fragment：methyltransferase domain
Not recorded I0B 5'-([2-(benzylcarbamamido)ethyl]{3-[N'-(3-bromophenyl)carbamimidamido]propyl}amino)-5'-deoxyadenosine × 2 UNX UNKNOWN LIGAND × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9；291 K；0.1 M BICINE pH 9.0, 2.0 M Magnesium chloride hexahydrate
Resolution 2.17 Å R-free 0.225
8SIG Crystal Structure of PRMT4 with Compound YD1-288 Deposited 2023-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 140–480（341 aa） Fragment：methyltransferase domain
Not recorded GWU 5'-{(3-aminopropyl)[2-(benzylcarbamamido)ethyl]amino}-5'-deoxyadenosine × 2 NA SODIUM ION × 2 UNX UNKNOWN LIGAND × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.2 M Calcium chloride dihydrate, 0.1 M HEPES sodium pH 7.5, 28% v/v Polyethylene glycol 400
Resolution 1.78 Å R-free 0.199
8SIH Crystal Structure of PRMT4 with Compound YD1-289 Deposited 2023-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 140–480（341 aa） Fragment：methyltransferase domain
Not recorded I1K 5'-{[2-(benzylcarbamamido)ethyl][3-(N'-cyclopentylcarbamimidamido)propyl]amino}-5'-deoxyadenosine × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；3.5 M Ammonium chloride, 0.1 M BIS-TRIS propane pH 7.0
Resolution 2.35 Å R-free 0.246
8UQH X-ray crystal structure of PRMT4 bound to compound YD-1130 Deposited 2023-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric
Chain A 139–479（341 aa）
Chain B 139–479（341 aa）
Chain C 139–479（341 aa）
Chain D 139–479（341 aa）
Not recorded X9L 5'-S-(2-{[(3-bromophenyl)methyl]amino}ethyl)-5'-thioadenosine × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；7.5% (w/v) PEG 20,000, 0.1M Tris, 0.08M sodium formate, pH 7.5
Resolution 1.87 Å R-free 0.253
9O37 The structure of PRMT4 in complex with YD1305 Deposited 2025-04-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 145–477（333 aa） Fragment：UNP Residues 145-477
Not recorded A1B7X 5'-{[2-(benzylcarbamamido)ethyl](3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)amino}-5'-deoxyadenosine × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 2 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；0.2M calcium acetate hydrate, 0.1M HEPES: NaOH, pH 7.5, 10% (w/v) PEG 8,000
Resolution 2.11 Å R-free 0.233
9O6H The Structure of PRMT4 in complex with SGC8172 Deposited 2025-04-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 146–476（331 aa）
Not recorded A1B9W 5'-S-(3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)-5'-thioadenosine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium tartrate dibasic, 20% (w/v) PEG 3,350
Resolution 1.97 Å R-free 0.269
9O6H The Structure of PRMT4 in complex with SGC8172 Deposited 2025-04-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 146–476（331 aa）
Not recorded A1B9W 5'-S-(3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)-5'-thioadenosine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium tartrate dibasic, 20% (w/v) PEG 3,350
Resolution 1.97 Å R-free 0.269
9O6H The Structure of PRMT4 in complex with SGC8172 Deposited 2025-04-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 146–476（331 aa）
Not recorded A1B9W 5'-S-(3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)-5'-thioadenosine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium tartrate dibasic, 20% (w/v) PEG 3,350
Resolution 1.97 Å R-free 0.269
9O6H The Structure of PRMT4 in complex with SGC8172 Deposited 2025-04-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 146–476（331 aa）
Not recorded A1B9W 5'-S-(3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)-5'-thioadenosine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium tartrate dibasic, 20% (w/v) PEG 3,350
Resolution 1.97 Å R-free 0.269

32 other PDB entries and 64 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CARM1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–349； UniProt 134–479 Author chain B； PDBConstruct 4–349； UniProt 134–479 Author chain C； PDBConstruct 4–349； UniProt 134–479 Author chain D； PDBConstruct 4–349； UniProt 134–479

methylated PABP1 peptide

OrganismNot specified

UniProt P11940

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count Chain F； UniProt 449–466 Chain G； UniProt 449–466 Fragment：UNP residues 449-466 Mutation：Nterminal biotin and aminohexanoic acid, methylated R460, asymmetrically dimethylated R455 Non-standard monomer：Yes (specific site not provided by mmCIF) Histone-arginine methyltransferase CARM1 × 2 （Q86X55） SFG SINEFUNGIN × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350 Resolution 2.07 Å R-free 0.244
2 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain I； UniProt 449–466 Fragment：UNP residues 449-466 Mutation：Nterminal biotin and aminohexanoic acid, methylated R460, asymmetrically dimethylated R455 Non-standard monomer：Yes (specific site not provided by mmCIF) Histone-arginine methyltransferase CARM1 × 2 （Q86X55） SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350 Resolution 2.07 Å R-free 0.244

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 5DXA Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1CVJ X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA Deposited 1999-08-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–RNA Monomer；Protein × 1 PDB declaration: dimeric
Chain A 1–190（190 aa） Fragment：RESIDUES 1-190
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；296.7 K；AMMONIUM SULFATE, TCEP, TRIS-HCL, POTASSIUM CHLORIDE, GLYCEROL, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296.7K
Resolution 2.60 Å R-free 0.304
1CVJ X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA Deposited 1999-08-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein–RNA Monomer；Protein × 1 PDB declaration: dimeric
Chain B 1–190（190 aa） Fragment：RESIDUES 1-190
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；296.7 K；AMMONIUM SULFATE, TCEP, TRIS-HCL, POTASSIUM CHLORIDE, GLYCEROL, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296.7K
Resolution 2.60 Å R-free 0.304
1CVJ X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA Deposited 1999-08-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein–RNA Monomer；Protein × 1 PDB declaration: dimeric
Chain C 1–190（190 aa） Fragment：RESIDUES 1-190
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；296.7 K；AMMONIUM SULFATE, TCEP, TRIS-HCL, POTASSIUM CHLORIDE, GLYCEROL, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296.7K
Resolution 2.60 Å R-free 0.304
1CVJ X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA Deposited 1999-08-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein–RNA Monomer；Protein × 1 PDB declaration: dimeric
Chain D 1–190（190 aa） Fragment：RESIDUES 1-190
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；296.7 K；AMMONIUM SULFATE, TCEP, TRIS-HCL, POTASSIUM CHLORIDE, GLYCEROL, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296.7K
Resolution 2.60 Å R-free 0.304
1CVJ X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA Deposited 1999-08-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein–RNA Monomer；Protein × 1 PDB declaration: dimeric
Chain E 1–190（190 aa） Fragment：RESIDUES 1-190
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；296.7 K；AMMONIUM SULFATE, TCEP, TRIS-HCL, POTASSIUM CHLORIDE, GLYCEROL, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296.7K
Resolution 2.60 Å R-free 0.304
1CVJ X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA Deposited 1999-08-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein–RNA Monomer；Protein × 1 PDB declaration: dimeric
Chain F 1–190（190 aa） Fragment：RESIDUES 1-190
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；296.7 K；AMMONIUM SULFATE, TCEP, TRIS-HCL, POTASSIUM CHLORIDE, GLYCEROL, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296.7K
Resolution 2.60 Å R-free 0.304
1CVJ X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA Deposited 1999-08-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 7 Protein–RNA Monomer；Protein × 1 PDB declaration: dimeric
Chain G 1–190（190 aa） Fragment：RESIDUES 1-190
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；296.7 K；AMMONIUM SULFATE, TCEP, TRIS-HCL, POTASSIUM CHLORIDE, GLYCEROL, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296.7K
Resolution 2.60 Å R-free 0.304
1CVJ X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA Deposited 1999-08-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 8 Protein–RNA Monomer；Protein × 1 PDB declaration: dimeric
Chain H 1–190（190 aa） Fragment：RESIDUES 1-190
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；296.7 K；AMMONIUM SULFATE, TCEP, TRIS-HCL, POTASSIUM CHLORIDE, GLYCEROL, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296.7K
Resolution 2.60 Å R-free 0.304
1G9L SOLUTION STRUCTURE OF THE PABC DOMAIN OF HUMAN POLY(A) BINDING PROTEIN Deposited 2000-11-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 498–636（139 aa） Fragment：C-TERMINAL DOMAIN (RESIDUES 498-636)
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.3；303 K；Ionic strength (raw mmCIF value) 0.2；Pressure ambient
NMR sample composition 3mM 15N-labeled PABC; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 90% H2O/10% D2O
NMR sample composition 3mM 15N,13C-labeled PABC; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 100% D2O
NMR sample composition 3mM unlabeled PABC; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 90% H2O/10% D2O
Resolution not provided
1JGN Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip2 Deposited 2001-06-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 544–636（93 aa） Fragment：C-terminal domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.3；303 K；Ionic strength (raw mmCIF value) 0.1M NaCl；Pressure ambient
NMR sample composition 3mM 15N-labeled PABC; 4mM unlabeled peptide; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 90% H2O/10% D2O
NMR sample composition 3mM 15N,13C-labeled PABC; 4mM unlabeled peptide; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 100% D2O
NMR sample composition 2.5mM 15N-labeled peptide; 3mM unlabeled PABC; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 90% H2O/10% D2O
NMR sample composition 2mM 15N,13C-labeled peptide; 3mM unlabeled PABC; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 100% D2O
NMR sample composition 3mM unlabeled PABC; 3mM unlabeled peptide; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 90% H2O/10% D2O
NMR sample composition 3mM unlabeled PABC; 3mM unlabeled peptide; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 100% D2O
Resolution not provided
1JH4 Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip1 Deposited 2001-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 544–636（93 aa） Fragment：C-terminal domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.3；303 K；Ionic strength (raw mmCIF value) 0.1M NaCl；Pressure ambient
NMR sample composition 3mM 15N-labeled PABC; 3mM 15N-labeled peptide; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 90% H2O/10% D2O
NMR sample composition 3mM unlabeled PABC; 3mM unlabeled peptide; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 90% H2O/10% D2O
NMR sample composition 3mM unlabeled PABC; 3mM unlabeled peptide; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 100% D2O
NMR sample composition 3mM unlabeled PABC; 3mM N15-labeled peptide; 50mM phosphate buffer; 0.1M NaCl; 1mM NaN3; pH 6.3 | 90% H2O/10% D2O
Resolution not provided
2K8G Solution structure of RRM2 domain of PABP1 Deposited 2008-09-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 90–182（93 aa） Fragment：RRM2 domain (UNP residues 90-182)
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.1；303 K；Ionic strength (raw mmCIF value) 0.04；Pressure ambient
NMR sample composition 1 mM [U-98% 13C; U-98% 15N] PABP1, 20 mM sodium chloride, 20 mM sodium phosphate, 1 mM DTT, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1 mM [U-98% 15N] PABP1, 20 mM sodium chloride, 20 mM sodium phosphate, 1 mM DTT, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1 mM PABP1, 20 mM sodium chloride, 20 mM sodium phosphate, 1 mM DTT, 100% D2O | 100% D2O
Resolution not provided
2RQG Structure of GSPT1/ERF3A-PABC Deposited 2009-05-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 541–623（83 aa） Fragment：PABC DOMAIN
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；303 K；Ionic strength (raw mmCIF value) 0.15M；Pressure AMBIENT
NMR sample composition 1 mM [U-98% 13C; U-98% 15N] G1 TO S PHASE TRANSITION 1-1, 1 mM [U-98% 13C; U-98% 15N] POLYADENYLATE-BINDING PROTEIN 1-2, 93% H2O/7% D2O | 93% H2O/7% D2O
Resolution not provided
2RQH Structure of GSPT1/ERF3A-PABC Deposited 2009-05-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 541–623（83 aa） Fragment：PABC DOMAIN
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；303 K；Ionic strength (raw mmCIF value) 0.15M；Pressure AMBIENT
NMR sample composition 1 mM G1 TO S PHASE TRANSITION 1-1, 1 mM [U-98% 13C; U-98% 15N] POLYADENYLATE-BINDING PROTEIN 1-2, 93% H2O/7% D2O | 93% H2O/7% D2O
Resolution not provided
2X04 Crystal structure of the PABC-TNRC6C complex Deposited 2009-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 456–530（75 aa） Fragment：C-TERMINAL DOMAIN (PABC), RESIDUES 456-530
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.6；0.1 M NA-ACETATE PH 4.6, 200 MM AMMONIUM SULFATE, 30% (W/V) PEG 4000
Resolution 1.49 Å R-free 0.186
2X04 Crystal structure of the PABC-TNRC6C complex Deposited 2009-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 456–530（75 aa） Fragment：C-TERMINAL DOMAIN (PABC), RESIDUES 456-530
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.6；0.1 M NA-ACETATE PH 4.6, 200 MM AMMONIUM SULFATE, 30% (W/V) PEG 4000
Resolution 1.49 Å R-free 0.186
3KTP Structural basis of GW182 recognition by poly(A)-binding protein Deposited 2009-11-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 544–626（83 aa） Fragment：C-terminal domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；295 K；2.0 M ammonium sulfate, 0.1 M Tris, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.50 Å R-free 0.231
3KTR Structural basis of ataxin-2 recognition by poly(A)-binding protein Deposited 2009-11-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 544–626（83 aa） Fragment：C-terminal domain
Not recorded CD CADMIUM ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；2.2 M ammonium sulfate, 0.2 M CdCl2, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.70 Å R-free 0.245
3KUI Crystal structure of C-terminal domain of PABPC1 in complex with binding region of eRF3a Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 544–626（83 aa） Fragment：C-terminal domain
Not recorded ZN ZINC ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.4；295 K；2.1M ammonium sulfate, 0.2M sodium sulfate, 10mM zinc chloride, 0.1M sodium acetate, pH 5.4, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.30 Å R-free 0.255
3KUJ Crystal structure of C-terminal domain of PABPC1 in complex with binding region of eRF3a Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 544–626（83 aa） Fragment：C-terminal domain
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；1.4M ammonium sulfate, 0.1M citric acid, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.40 Å R-free 0.223
3KUR Crystal structure of the MLLE domain of poly(A)-binding protein Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 544–617（74 aa） Fragment：C-terminal domain
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；1.3M ammonium sulfate, 0.5M lithium sulfate, 5% glycerol, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.50 Å R-free 0.272
3KUR Crystal structure of the MLLE domain of poly(A)-binding protein Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 544–617（74 aa） Fragment：C-terminal domain
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；1.3M ammonium sulfate, 0.5M lithium sulfate, 5% glycerol, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.50 Å R-free 0.272
3KUR Crystal structure of the MLLE domain of poly(A)-binding protein Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 544–617（74 aa） Fragment：C-terminal domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；1.3M ammonium sulfate, 0.5M lithium sulfate, 5% glycerol, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.50 Å R-free 0.272
3KUR Crystal structure of the MLLE domain of poly(A)-binding protein Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 544–617（74 aa） Fragment：C-terminal domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；1.3M ammonium sulfate, 0.5M lithium sulfate, 5% glycerol, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.50 Å R-free 0.272
3KUR Crystal structure of the MLLE domain of poly(A)-binding protein Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain E 544–617（74 aa） Fragment：C-terminal domain
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；1.3M ammonium sulfate, 0.5M lithium sulfate, 5% glycerol, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.50 Å R-free 0.272
3KUR Crystal structure of the MLLE domain of poly(A)-binding protein Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain F 544–617（74 aa） Fragment：C-terminal domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；1.3M ammonium sulfate, 0.5M lithium sulfate, 5% glycerol, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.50 Å R-free 0.272
3KUR Crystal structure of the MLLE domain of poly(A)-binding protein Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain G 544–617（74 aa） Fragment：C-terminal domain
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；1.3M ammonium sulfate, 0.5M lithium sulfate, 5% glycerol, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.50 Å R-free 0.272
3KUR Crystal structure of the MLLE domain of poly(A)-binding protein Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain H 544–617（74 aa） Fragment：C-terminal domain
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；1.3M ammonium sulfate, 0.5M lithium sulfate, 5% glycerol, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.50 Å R-free 0.272
3KUS Crystal structure of the MLLE domain of poly(A)-binding protein in complex with the binding region of Paip2 Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 544–626（83 aa） Fragment：C-terminal domain
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；295 K；2.3M ammonium sulfate, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.40 Å R-free 0.205
3KUS Crystal structure of the MLLE domain of poly(A)-binding protein in complex with the binding region of Paip2 Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 544–626（83 aa） Fragment：C-terminal domain
Not recorded EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；295 K；2.3M ammonium sulfate, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.40 Å R-free 0.205
3KUT Crystal structure of the MLLE domain of poly(A)-binding protein in complex with the binding region of Paip2 Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 544–626（83 aa） Fragment：C-terminal domain
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；2.25M ammonium sulfate, 0.2M KBr, 0.1 M Bis-Tris, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.50 Å R-free 0.201
3KUT Crystal structure of the MLLE domain of poly(A)-binding protein in complex with the binding region of Paip2 Deposited 2009-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 544–626（83 aa） Fragment：C-terminal domain
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；2.25M ammonium sulfate, 0.2M KBr, 0.1 M Bis-Tris, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.50 Å R-free 0.201
3PKN Crystal structure of MLLE domain of poly(A) binding protein in complex with PAM2 motif of La-related protein 4 (LARP4) Deposited 2010-11-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 544–626（83 aa） Fragment：MLLE domain (UNP residues 544-626)
Not recorded SO4 SULFATE ION × 1 IOD IODIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；295 K；0.25 M potassium iodide, 1.9 M ammonium sulfate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.80 Å R-free 0.269
3PKN Crystal structure of MLLE domain of poly(A) binding protein in complex with PAM2 motif of La-related protein 4 (LARP4) Deposited 2010-11-11 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 544–626（83 aa） Fragment：MLLE domain (UNP residues 544-626)
Not recorded SO4 SULFATE ION × 2 IOD IODIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；295 K；0.25 M potassium iodide, 1.9 M ammonium sulfate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.80 Å R-free 0.269
3PTH The PABC1 MLLE domain bound to the variant PAM2 motif of LARP4B Deposited 2010-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 543–621（79 aa） Fragment：UNP residues 543-621
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6.5；289 K；2 ul protein solution at 43 mg/ml containing the 1.5 fold molar amount of peptide ligand was mixed with 2ul reservoir solution containing 1.5M magnesium sulfate, pH 6.5, VAPOR DIFFUSION, temperature 289K
Resolution 1.70 Å R-free 0.218
4F02 Crystal structure of the PABP-binding site of eIF4G in complex with RRM1-2 of PABP and poly(A) Deposited 2012-05-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–RNA Heteromer；Protein × 2 PDB declaration: trimeric
Chain A 1–190（190 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；294 K；0.03 M Tris, 1.3 M (NH4)2SO4, 5% glycerol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 2.00 Å R-free 0.230
4F02 Crystal structure of the PABP-binding site of eIF4G in complex with RRM1-2 of PABP and poly(A) Deposited 2012-05-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein–RNA Heteromer；Protein × 2 PDB declaration: trimeric
Chain D 1–190（190 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；294 K；0.03 M Tris, 1.3 M (NH4)2SO4, 5% glycerol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 2.00 Å R-free 0.230
4F25 Crystal structure of the second RRM domain of human PABPC1 at pH 6.0 Deposited 2012-05-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 99–199（101 aa） Fragment：RRM2 domain (un residues 99-119)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；294 K；25% PEG 1500 and 0.1 M MIB buffer, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.90 Å R-free 0.269
4F26 Crystal structure of the second RRM domain of human PABPC1 a pH 9.0 Deposited 2012-05-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 99–199（101 aa） Fragment：RRM2 domain (un residues 99-119)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9；294 K；25% PEG 1500 and 0.1 M MMT buffer , pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 2.00 Å R-free 0.286
5DX1 Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) Deposited 2015-09-23 Different mutation/modification Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 449–466（18 aa） Fragment：UNP residues 449-466
Chain G 449–466（18 aa） Fragment：UNP residues 449-466
Mutation：Nterminal biotin and aminohexanoic acid, methylated R460 Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：Nterminal biotin and aminohexanoic acid, methylated R460 Non-standard monomer：Yes (specific site not provided by mmCIF) SFG SINEFUNGIN × 2 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.93 Å R-free 0.238
5DX1 Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) Deposited 2015-09-23 Different mutation/modification Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain H 449–466（18 aa） Fragment：UNP residues 449-466
Chain I 449–466（18 aa） Fragment：UNP residues 449-466
Mutation：Nterminal biotin and aminohexanoic acid, methylated R460 Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：Nterminal biotin and aminohexanoic acid, methylated R460 Non-standard monomer：Yes (specific site not provided by mmCIF) SFG SINEFUNGIN × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.93 Å R-free 0.238
5DX8 Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R455) Deposited 2015-09-23 Different mutation/modification Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 449–466（18 aa） Fragment：UNP residues 449-466
Chain F 449–466（18 aa） Fragment：UNP residues 449-466
Mutation：Nterminal biotin and aminohexanoic acid, methylated R455 and R460 Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：Nterminal biotin and aminohexanoic acid, methylated R455 and R460 Non-standard monomer：Yes (specific site not provided by mmCIF) SFG SINEFUNGIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.94 Å R-free 0.246
5DX8 Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R455) Deposited 2015-09-23 Different mutation/modification Different ligand/ion Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain G 449–466（18 aa） Fragment：UNP residues 449-466
Chain H 449–466（18 aa） Fragment：UNP residues 449-466
Mutation：Nterminal biotin and aminohexanoic acid, methylated R455 and R460 Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：Nterminal biotin and aminohexanoic acid, methylated R455 and R460 Non-standard monomer：Yes (specific site not provided by mmCIF) SFG SINEFUNGIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.2 M Ammonium Sulfate, 0.1 M Tris pH 8.5, 18% w/v PEG 3350
Resolution 1.94 Å R-free 0.246
5LGQ Crystal structure of mouse CARM1 in complex with ligand P2C3s Deposited 2016-07-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 456–466（11 aa）
Chain F 456–466（11 aa）
Chain G 456–466（11 aa）
Chain H 456–466（11 aa）
Not recorded EDO 1,2-ETHANEDIOL × 7 PEG DI(HYDROXYETHYL)ETHER × 4 DXE 1,2-DIMETHOXYETHANE × 1 PG6 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE × 1 SO4 SULFATE ION × 1 8ZB (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-propyl-oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；100 mM Tris-HCl pH 8.5 14% PEG 3350 200 mM A.S.
Resolution 2.11 Å R-free 0.236
5LGR Crystal structure of mouse CARM1 in complex with ligand P1C3u Deposited 2016-07-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 447–458（12 aa）
Chain F 447–458（12 aa）
Chain G 447–458（12 aa）
Chain H 447–458（12 aa）
Not recorded SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 6 DXE 1,2-DIMETHOXYETHANE × 1 PG6 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE × 1 PEG DI(HYDROXYETHYL)ETHER × 1 QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 4 LPD L-PROLINAMIDE × 4 ACE ACETYL GROUP × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；Tris-HCl pH 8.5 100 mM PEG 3350 14 % Ammonium Sulfate 200 mM
Resolution 2.00 Å R-free 0.234
5LGS Crystal structure of mouse CARM1 in complex with ligand P2C3u Deposited 2016-07-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 456–464（9 aa）
Chain F 456–464（9 aa）
Chain G 456–464（9 aa）
Chain H 456–464（9 aa）
Not recorded SO4 SULFATE ION × 1 DXE 1,2-DIMETHOXYETHANE × 3 PEG DI(HYDROXYETHYL)ETHER × 1 PG4 TETRAETHYLENE GLYCOL × 1 EDO 1,2-ETHANEDIOL × 3 QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.5 100 mM PEG 3350 20 % A.S. 200 mM
Resolution 2.10 Å R-free 0.215
7BN3 Crystal structure of C-terminal domain of PABPC1 in complex with Nucleoprotein from Human Coronavirus 229E Deposited 2021-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 455–537（83 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；0.1 M MES sodium salt pH-6.5, 1.8 M Ammonium Sulfate
Resolution 1.93 Å R-free 0.228
7BN3 Crystal structure of C-terminal domain of PABPC1 in complex with Nucleoprotein from Human Coronavirus 229E Deposited 2021-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 455–537（83 aa）
Not recorded SO4 SULFATE ION × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；0.1 M MES sodium salt pH-6.5, 1.8 M Ammonium Sulfate
Resolution 1.93 Å R-free 0.228
7BN3 Crystal structure of C-terminal domain of PABPC1 in complex with Nucleoprotein from Human Coronavirus 229E Deposited 2021-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 455–537（83 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；0.1 M MES sodium salt pH-6.5, 1.8 M Ammonium Sulfate
Resolution 1.93 Å R-free 0.228
8SMO Crystal structure of the complex between truncated MLLE domain of PABPC1 and engineered superPAM2 peptide Deposited 2023-04-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 556–626（71 aa） Fragment：MLLE domain
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1 M citric acid pH 4.0, 1.6 M ammonium sulfate
Resolution 3.00 Å R-free 0.292
8SMO Crystal structure of the complex between truncated MLLE domain of PABPC1 and engineered superPAM2 peptide Deposited 2023-04-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 556–626（71 aa） Fragment：MLLE domain
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1 M citric acid pH 4.0, 1.6 M ammonium sulfate
Resolution 3.00 Å R-free 0.292
8SMO Crystal structure of the complex between truncated MLLE domain of PABPC1 and engineered superPAM2 peptide Deposited 2023-04-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 556–626（71 aa） Fragment：MLLE domain
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1 M citric acid pH 4.0, 1.6 M ammonium sulfate
Resolution 3.00 Å R-free 0.292
8SMO Crystal structure of the complex between truncated MLLE domain of PABPC1 and engineered superPAM2 peptide Deposited 2023-04-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 556–626（71 aa） Fragment：MLLE domain
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1 M citric acid pH 4.0, 1.6 M ammonium sulfate
Resolution 3.00 Å R-free 0.292
8SMO Crystal structure of the complex between truncated MLLE domain of PABPC1 and engineered superPAM2 peptide Deposited 2023-04-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain I 556–626（71 aa） Fragment：MLLE domain
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1 M citric acid pH 4.0, 1.6 M ammonium sulfate
Resolution 3.00 Å R-free 0.292
8SMO Crystal structure of the complex between truncated MLLE domain of PABPC1 and engineered superPAM2 peptide Deposited 2023-04-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain K 556–626（71 aa） Fragment：MLLE domain
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1 M citric acid pH 4.0, 1.6 M ammonium sulfate
Resolution 3.00 Å R-free 0.292
8SMO Crystal structure of the complex between truncated MLLE domain of PABPC1 and engineered superPAM2 peptide Deposited 2023-04-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain M 556–626（71 aa） Fragment：MLLE domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1 M citric acid pH 4.0, 1.6 M ammonium sulfate
Resolution 3.00 Å R-free 0.292
8SMO Crystal structure of the complex between truncated MLLE domain of PABPC1 and engineered superPAM2 peptide Deposited 2023-04-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain O 556–626（71 aa） Fragment：MLLE domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1 M citric acid pH 4.0, 1.6 M ammonium sulfate
Resolution 3.00 Å R-free 0.292

27 other PDB entries and 57 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name PABP1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain F； PDBConstruct 1–18； UniProt 449–466 Author chain G； PDBConstruct 1–18； UniProt 449–466 Author chain I； PDBConstruct 1–18； UniProt 449–466

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 5dxa

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 5dxa
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2. Structure Basics 2. Structure Basics

Entry ID entry_id5dxa
Deposition date deposition_date2015-09-23
Structure title titleCrystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R460)
Keywords keywordsprotein-substrate ternary complex, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier39.73 Å
Radius of gyration Rg (electron density) rg_electron39.42 Å
Forward intensity I(0) i0360795000.00
Molecular weight molecular_weight160130.0 kDa
Excluded volume excluded_volume201960 ų
Envelope volume envelope_volume249470 ų
Hydration-shell volume shell_volume52887 ų
Envelope diameter envelope_diameter130.6 Å
Shell Rg shell_rg45.24 Å
Envelope Rg envelope_rg38.76 Å
Shape Rg shape_rg39.38 Å
Total Rg total_rg39.87 Å
Total atoms total_atoms11304
Residues n_residues1390
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax128.2 Å
Rg (real space) rg_real39.73 Å
Rg uncertainty (real space) rg_real_error1.06 Å
I(0) (real space) i0_real3.6080e+08
I(0) uncertainty (real space) i0_real_error6.3290e+06
Rg (reciprocal space) rg_reciprocal39.74 Å
I(0) (reciprocal space) i0_reciprocal360800000.0000
Solution quality estimate total_estimate0.8990
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary44.9 Å
Skewness Skewness skewness0.249
Kurtosis Kurtosis kurtosis-0.643
Angular range angular_range— – 0.2000 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha51220000.0000
Real-space data points n_real_points41
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.938; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.983; Smooth: 0.886
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (5)

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7. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id5dxaA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily150 — Vaccinia Virus protein VP39
Domain ID domain_id5dxaA02
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology160 — Hnrnp arginine n-methyltransferase1
Homologous superfamily homologous superfamily11 — Hnrnp arginine n-methyltransferase1
Domain ID domain_id5dxaB01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily150 — Vaccinia Virus protein VP39
Domain ID domain_id5dxaB02
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology160 — Hnrnp arginine n-methyltransferase1
Homologous superfamily homologous superfamily11 — Hnrnp arginine n-methyltransferase1
Domain ID domain_id5dxaC01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily150 — Vaccinia Virus protein VP39
Domain ID domain_id5dxaC02
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology160 — Hnrnp arginine n-methyltransferase1
Homologous superfamily homologous superfamily11 — Hnrnp arginine n-methyltransferase1
Domain ID domain_id5dxaD01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily150 — Vaccinia Virus protein VP39
Domain ID domain_id5dxaD02
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology160 — Hnrnp arginine n-methyltransferase1
Homologous superfamily homologous superfamily11 — Hnrnp arginine n-methyltransferase1
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8. Citations (1)

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9. Files and Curves (10)