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4f02

Crystal structure of the PABP-binding site of eIF4G in complex with RRM1-2 of PABP and poly(A)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Polyadenylate-binding protein 1

Homo sapiens

UniProt P11940

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 2 RNA 1 ;RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') ; × 1 Eukaryotic translation initiation factor 4 gamma 1 × 1 （Q04637） water × 3 Consistent with all polymers
2 Protein–RNA Heteromer Protein 2 RNA 1 ;RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') ; × 1 Eukaryotic translation initiation factor 4 gamma 1 × 1 （Q04637） water × 2 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1g9l 2k8g 3kur 3kur 3kur 3kur 3kur 3kur 3kur 3kur 4f25 4f26

12 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1cvj 1cvj 1cvj 1cvj 1cvj 1cvj 1cvj 1cvj 1jgn 1jh4 2rqg 2rqh

47 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PABP1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 6–195； UniProt 1–190 Author chain D； PDBConstruct 6–195； UniProt 1–190

Eukaryotic translation initiation factor 4 gamma 1

OrganismNot specified

UniProt Q04637

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 2 RNA 1 Polyadenylate-binding protein 1 × 1 （P11940） ;RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') ; × 1 water × 3 Consistent with all polymers
2 Protein–RNA Heteromer Protein 2 RNA 1 Polyadenylate-binding protein 1 × 1 （P11940） ;RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') ; × 1 water × 2 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1ug3 1ug3

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1lj2 2w97 4f02 4f02 5ehc 5t46 5t46 5zk5 6zmw 8huj 8j7r 8oz0

12 assemblies

View Construct and Data Evidence
UniProt name IF4G1_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–26； UniProt 178–203 Author chain F； PDBConstruct 1–26； UniProt 178–203

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4f02
Deposition date deposition_date2012-05-03
Structure title titleCrystal structure of the PABP-binding site of eIF4G in complex with RRM1-2 of PABP and poly(A)
Keywords keywordsTranslation initiation, mRNA, eukaryotic initiation factors (eIFs), Paip1 and Paip2, Translation-RNA complex; Translation/RNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4f02__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4f02__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4f02__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.94 Å
Rg (electron density)18.07 Å
Total Rg18.95 Å
Atom count1720
Residues204
Excluded volume29806 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4f02__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4f02__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 4 domains

CATH v4.4 (4 domains)

Domain ID domain_id4f02A01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily330 — RRM (RNA recognition motif) domain
Domain ID domain_id4f02A02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily330 — RRM (RNA recognition motif) domain
Domain ID domain_id4f02D01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily330 — RRM (RNA recognition motif) domain
Domain ID domain_id4f02D02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily330 — RRM (RNA recognition motif) domain
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7. Citations (1)