SAXSdb — 8t7r

▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

MHC class I antigen (Fragment)

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 50	Light chain from antibody JTK191b E07 × 12 Fab heavy chain from antibody JTK191b E07 × 12 peptide × 9 Beta-2-microglobulin × 8 （P61769）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	F6IQR9_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–274； UniProt 25–298 Author chain G； PDBConstruct 1–274； UniProt 25–298 Author chain K； PDBConstruct 1–274； UniProt 25–298 Author chain O； PDBConstruct 1–274； UniProt 25–298 Author chain S； PDBConstruct 1–274； UniProt 25–298 Author chain W； PDBConstruct 1–274； UniProt 25–298 Author chain a； PDBConstruct 1–274； UniProt 25–298 Author chain e； PDBConstruct 1–274； UniProt 25–298 Author chain i； PDBConstruct 1–274； UniProt 25–298

Beta-2-microglobulin

Homo sapiens

UniProt P61769

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 50	Light chain from antibody JTK191b E07 × 12 Fab heavy chain from antibody JTK191b E07 × 12 MHC class I antigen (Fragment) × 9 （F6IQR9） peptide × 9	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B2MG_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain D； PDBConstruct 1–99； UniProt 21–119 Author chain H； PDBConstruct 1–99； UniProt 21–119 Author chain L； PDBConstruct 1–99； UniProt 21–119 Author chain P； PDBConstruct 1–99； UniProt 21–119 Author chain T； PDBConstruct 1–99； UniProt 21–119 Author chain X； PDBConstruct 1–99； UniProt 21–119 Author chain b； PDBConstruct 1–99； UniProt 21–119 Author chain f； PDBConstruct 1–99； UniProt 21–119

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id	8t7r
Deposition date deposition_date	2023-06-21
Structure title title	Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07
Keywords keywords	human leukocyte antigen, HLA, HLA class I, antibodies, autoimmunity, Fab, alloreactive, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method method	X-RAY DIFFRACTION

▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8t7r__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8t7r__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8t7r__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	85.45 Å
Rg (electron density)	85.53 Å
Total Rg	85.67 Å
Atom count	63611
Residues	8165
Excluded volume	1116400 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8t7r__assembly_1__model_1`	50-meric （50）	Success	4.1.3-1-20251215 (887e7ef)	View Download

▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (5)

Entity 1 Entity 1 polymer

Description description	Light chain from antibody JTK191b E07
Molecular weight formula_weight	22731.1 kDa
Source method src_method	man
Copy count entity_count	12

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,E,I,M,Q,U,Y,c,g,k,o,s
Atom count atom_count	63611

QSVSTQPPSVSVAPGQTARITCGGNNIGSKSVHWYRQKPGQAPVLVVYDNNARPSGIPERISGSNFANTATLTISRVEAGDEADYYCHVWDSSSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 2 Entity 2 polymer

Description description	Fab heavy chain from antibody JTK191b E07
Molecular weight formula_weight	25938.8 kDa
Source method src_method	man
Copy count entity_count	12

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,F,J,N,R,V,Z,d,h,l,p,t

QVQLQESGGGVVQPGGSLRLSCAASGFNFSNYGMHWVRQTPGKGLEWVASIPYDGSHQWHADSVKGRFTISRDNSKNTLYLQINSLRPEDTAMYYCSKARISYLSAPAWWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTDYKDDDDK

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 3 Entity 3 polymer

Description description	MHC class I antigen (Fragment)
Molecular weight formula_weight	31637.0 kDa
Source method src_method	man
Copy count entity_count	9

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,G,K,O,S,W,a,e,i

GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 4 Entity 4 polymer

Description description	peptide
Molecular weight formula_weight	1091.2 kDa
Source method src_method	syn
Copy count entity_count	9

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	0,1,2,3,4,5,6,7,8

VTEHDTLLY

Entity 5 Entity 5 polymer

Description description	Beta-2-microglobulin
Molecular weight formula_weight	11748.2 kDa
Source method src_method	man
Copy count entity_count	8

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,H,L,P,T,X,b,f

IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

▶

Unit-cell length a length_a	357.076 Å
Unit-cell length b length_b	259.582 Å
Unit-cell length c length_c	255.361 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	133.13 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	48

Space group space_group	C 1 2 1
Space-group number int_tables_number	5
Crystal system crystal_system	—

Resolution resolution	3.840 Å
Low-resolution limit resolution_low	30.130 Å
R factor r_factor	0.2171
R_work r_work	0.2165
R_free r_free	0.2625

Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07

1. Protein Identity and Related Structures Protein Identity & Related Structures

MHC class I antigen (Fragment)

State in the Current Structure

Other States of the Same Protein in the Database

Beta-2-microglobulin

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

8t7r__assembly_1__model_1

8t7r__assembly_1__model_1 | I(q)

8t7r__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (5)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 polymer

Polymer Polymer

Source Source

Entity 4 Entity 4 polymer

Polymer Polymer

Entity 5 Entity 5 polymer

Polymer Polymer

Source Source

7. Citations (1)

Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07

1. Protein Identity and Related Structures Protein Identity & Related Structures

MHC class I antigen (Fragment)

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Beta-2-microglobulin

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

8t7r__assembly_1__model_1

8t7r__assembly_1__model_1 | I(q)

8t7r__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (5)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 polymer

Polymer Polymer

Source Source

Entity 4 Entity 4 polymer

Polymer Polymer

Entity 5 Entity 5 polymer

Polymer Polymer

Source Source

7. Citations (1)