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8wgc

heterodimer of mGlu2 and mGlu4 bound with mGlu2 agonist LY379268

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Metabotropic glutamate receptor 2

Homo sapiens

UniProt Q14416

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Metabotropic glutamate receptor 4 × 1 （Q14833） (1R,4R,5S,6R)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5kzn 5kzq

2 assemblies

Homodimer
4xaq 4xas 5cni 5cnj 7epa 7mtq 7mtr

7 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7e9g 7epb 7epd 7mts 8jcu 8jcv 8jcw 8jcx 8jcy 8jcz 8jd0 8jd1

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GRM2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain D； PDBConstruct 1–854； UniProt 19–872

Metabotropic glutamate receptor 4

Homo sapiens

UniProt Q14833

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Metabotropic glutamate receptor 2 × 1 （Q14416） (1R,4R,5S,6R)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7e9h 8jd4 8jd5 8jd6 8wg9 8wgb 8wgc 8wgd

8 assemblies

View Construct and Data Evidence
UniProt name GRM4_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain A； PDBConstruct 1–880； UniProt 33–912

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8wgc
Deposition date deposition_date2023-09-20
Structure title titleheterodimer of mGlu2 and mGlu4 bound with mGlu2 agonist LY379268
Keywords keywordsGPCR, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8wgc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8wgc__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8wgc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）57.79 Å
Rg (electron density)58.26 Å
Total Rg58.23 Å
Atom count6193
Residues1545
Excluded volume85333 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8wgc__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)