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8xpg

The Crystal Structure of polo box domain of Plk4 from Biortus.

Method: X-RAY DIFFRACTION Dmax: 100.6 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Serine/threonine-protein kinase PLK4

Homo sapiens

UniProt O00444

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count Chain A； UniProt 581–808 Chain B； UniProt 581–808 Not recorded SO4 SULFATE ION × 8 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；2.00M Ammonium sulfate, 100mM TRIS, pH7.0, 200mM Lithium sulfate Resolution 2.70 Å R-free 0.260

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 8XPG Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2N19 STIL binding to the Polo-box domain 3 of PLK4 regulates centriole duplication Deposited 2015-03-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；293.15 K；Ionic strength (raw mmCIF value) 0.03；Pressure ambient
NMR sample composition 0.6-1.2 M [U-13C; U-15N; U-2H] PLK4-PB3, 20 mM MOPS, 30 mM sodium chloride, 2 mM TCEP, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.6-1.2 M [U-2H,15N,methyl13C/rest-12C-ILV]-PB3 PLK4-PB3, 20 mM MOPS, 30 mM sodium chloride, 2 mM TCEP, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1200 mM [U-2H,15N,13C,methyl13C/1H-ILV]-PB3 PLK4-PB3, 20 mM MOPS, 30 mM sodium chloride, 2 mM TCEP, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 600 mM [U-2H, U-15N] PLK4-PB3, 20 mM MOPS, 30 mM sodium chloride, 2 mM TCEP, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
3COK Crystal structure of PLK4 kinase Deposited 2008-03-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–275（274 aa） Fragment：Protein kinase domain: Residues 2-275
Not recorded SO4 SULFATE ION × 2 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；294 K；100mM Sodium citrate pH 6.0, 16% PEG 4000, 200mM Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 2.25 Å R-free 0.261
3COK Crystal structure of PLK4 kinase Deposited 2008-03-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 2–275（274 aa） Fragment：Protein kinase domain: Residues 2-275
Not recorded SO4 SULFATE ION × 2 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；294 K；100mM Sodium citrate pH 6.0, 16% PEG 4000, 200mM Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 2.25 Å R-free 0.261
4JXF Crystal Structure of PLK4 Kinase with an inhibitor: 400631 ((1R,2S)-2-{3-[(E)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}ETHENYL]-2H-INDAZOL-6-YL}-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOL]-2'(1'H)-ONE) Deposited 2013-03-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 4–269（266 aa） Fragment：PLK4 kinase
Not recorded 631 (1R,2S)-2-{3-[(E)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one × 1 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；23% PEG 3350, 0.1 M HEPES pH 7.5 0.16 M MgCl2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.40 Å R-free 0.268
4N7V Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep152 N-terminal fragment Deposited 2013-10-16 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 580–808（229 aa） Fragment：UNP residues 580-808
Chain B 580–808（229 aa） Fragment：UNP residues 580-808
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；295.15 K；22% PEG 4000, 3% Iso-propanol, 0.1M Tris-HCl, 0.2M Lithium Sulfate , pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 295.15K
Resolution 2.76 Å R-free 0.288
4N7Z Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep192 N-terminal fragment Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 580–808（229 aa） Fragment：UNP residues 580-808
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295.15 K；20% PEG 1500, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295.15K
Resolution 2.85 Å R-free 0.260
4N9J Crystal structure of the cryptic polo box domain of human Plk4 Deposited 2013-10-21 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 581–808（228 aa） Fragment：cryptic polo box, UNP residues 580-808
Chain B 581–808（228 aa） Fragment：cryptic polo box, UNP residues 580-808
Not recorded CL CHLORIDE ION × 6 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；295 K；100 mM Bis-Tris (pH 5.5), 2.0 M ammonium sulfate, 1% (v/v) methanol , VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 2.60 Å R-free 0.249
4YUR Crystal Structure of Plk4 Kinase Domain Bound to Centrinone Deposited 2015-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–275（274 aa） Fragment：UNP residues 2-275
Not recorded 4J7 2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；0.1 M HEPES, 0.2 M MgCl2, 30% PEG 400
Resolution 2.65 Å R-free 0.270
4YYP Crystal structure of human PLK4-PB3 in complex with STIL-CC Deposited 2015-03-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 884–970（87 aa） Fragment：residues 884-970
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；Thin needles grew in precipitant solution containing 100 mM Hepes, pH 7.0, 20 mM MgCl2 and 22% Poly(acrylic acid sodium salt) 5100. After extensive optimization and seeding plate-like crystals were grown in a drop consisting of 50% PLK4-PB3/STIL-CC complex solution, 33.3% precipitant solution (100 mM phosphate/citrate pH 4.2, 40% (v/v) Ethanol, 5% (w/v) PEG 1000) and 16.7% of seed stock solution.
Resolution 2.60 Å R-free 0.254
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 884–970（87 aa） Fragment：UNP residues 884-970
Chain B 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 10 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain S 884–970（87 aa） Fragment：UNP residues 884-970
Chain T 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 11 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain U 884–970（87 aa） Fragment：UNP residues 884-970
Chain V 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 12 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain W 884–970（87 aa） Fragment：UNP residues 884-970
Chain X 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 13 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain Y 884–970（87 aa） Fragment：UNP residues 884-970
Chain Z 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 14 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain 1 884–970（87 aa） Fragment：UNP residues 884-970
Chain 2 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 15 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain 3 884–970（87 aa） Fragment：UNP residues 884-970
Chain 4 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 16 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain 5 884–970（87 aa） Fragment：UNP residues 884-970
Chain 6 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 17 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain 7 884–970（87 aa） Fragment：UNP residues 884-970
Chain 8 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 18 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain 9 884–970（87 aa） Fragment：UNP residues 884-970
Chain a 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 19 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain b 884–970（87 aa） Fragment：UNP residues 884-970
Chain c 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 884–970（87 aa） Fragment：UNP residues 884-970
Chain D 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 20 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain d 884–970（87 aa） Fragment：UNP residues 884-970
Chain e 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 21 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain f 884–970（87 aa） Fragment：UNP residues 884-970
Chain g 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 22 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain h 884–970（87 aa） Fragment：UNP residues 884-970
Chain i 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 23 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain j 884–970（87 aa） Fragment：UNP residues 884-970
Chain k 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 24 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain l 884–970（87 aa） Fragment：UNP residues 884-970
Chain m 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 25 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain n 884–970（87 aa） Fragment：UNP residues 884-970
Chain o 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 26 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain p 884–970（87 aa） Fragment：UNP residues 884-970
Chain q 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 27 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain r 884–970（87 aa） Fragment：UNP residues 884-970
Chain s 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 28 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain t 884–970（87 aa） Fragment：UNP residues 884-970
Chain u 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 29 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain v 884–970（87 aa） Fragment：UNP residues 884-970
Chain w 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 884–970（87 aa） Fragment：UNP residues 884-970
Chain F 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 30 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain x 884–970（87 aa） Fragment：UNP residues 884-970
Chain y 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain G 884–970（87 aa） Fragment：UNP residues 884-970
Chain H 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain I 884–970（87 aa） Fragment：UNP residues 884-970
Chain J 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain K 884–970（87 aa） Fragment：UNP residues 884-970
Chain L 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 7 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain M 884–970（87 aa） Fragment：UNP residues 884-970
Chain N 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 8 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain O 884–970（87 aa） Fragment：UNP residues 884-970
Chain P 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHY PB3 Domain of Human PLK4 (apo) Deposited 2016-07-13 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 9 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain Q 884–970（87 aa） Fragment：UNP residues 884-970
Chain R 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；100 nl protein solution (52.3 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 100 nl mother liquor (32.27% v/v PPG400, 100 mM NaCl, 50 mM MgCl2, unbuffered)
Resolution 3.31 Å R-free 0.295
5LHZ PB3 Domain of Human PLK4 in Complex with Coiled-Coil Domain of STIL Deposited 2016-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；292 K；150nl Protein solution (41.87 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 50 nl mother liquor (100mM MES pH 6.0, 191.7 mM Zn acetate, 10% Isopropanol)
Resolution 2.51 Å R-free 0.282
5LHZ PB3 Domain of Human PLK4 in Complex with Coiled-Coil Domain of STIL Deposited 2016-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；292 K；150nl Protein solution (41.87 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 50 nl mother liquor (100mM MES pH 6.0, 191.7 mM Zn acetate, 10% Isopropanol)
Resolution 2.51 Å R-free 0.282
5LHZ PB3 Domain of Human PLK4 in Complex with Coiled-Coil Domain of STIL Deposited 2016-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 884–970（87 aa） Fragment：UNP residues 884-970
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；292 K；150nl Protein solution (41.87 mg/ml protein in 20 mM Tris pH 7.5, 150 mM NaCl, 2 mM DTT) and 50 nl mother liquor (100mM MES pH 6.0, 191.7 mM Zn acetate, 10% Isopropanol)
Resolution 2.51 Å R-free 0.282
6N45 Crystal structure of the cryptic polo box domain of human activated Plk4 variant 1 Deposited 2018-11-17 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 581–808（228 aa）
Chain B 581–808（228 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；4.3M Ammonium Acetate 0.1M BisTris propane pH 8.0
Resolution 2.64 Å R-free 0.314
6N46 Crystal structure of the cryptic polo box domain of a human activated Plk4 Deposited 2018-11-17 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 581–808（228 aa）
Chain B 581–808（228 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；281 K；22.5% (w/v) PEG2000 3% (w/v) dextran sulfate sodium salt 0.1M bicine (pH 8.5) 24 uM nonaethylene glycol monododecyl ether (C12E9) 8% (w/v) glycerol
Resolution 3.71 Å R-free 0.309
6N46 Crystal structure of the cryptic polo box domain of a human activated Plk4 Deposited 2018-11-17 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 581–808（228 aa）
Chain D 581–808（228 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；281 K；22.5% (w/v) PEG2000 3% (w/v) dextran sulfate sodium salt 0.1M bicine (pH 8.5) 24 uM nonaethylene glycol monododecyl ether (C12E9) 8% (w/v) glycerol
Resolution 3.71 Å R-free 0.309
6N46 Crystal structure of the cryptic polo box domain of a human activated Plk4 Deposited 2018-11-17 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 581–808（228 aa）
Chain F 581–808（228 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；281 K；22.5% (w/v) PEG2000 3% (w/v) dextran sulfate sodium salt 0.1M bicine (pH 8.5) 24 uM nonaethylene glycol monododecyl ether (C12E9) 8% (w/v) glycerol
Resolution 3.71 Å R-free 0.309
6N46 Crystal structure of the cryptic polo box domain of a human activated Plk4 Deposited 2018-11-17 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain G 581–808（228 aa）
Chain H 581–808（228 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；281 K；22.5% (w/v) PEG2000 3% (w/v) dextran sulfate sodium salt 0.1M bicine (pH 8.5) 24 uM nonaethylene glycol monododecyl ether (C12E9) 8% (w/v) glycerol
Resolution 3.71 Å R-free 0.309
6W38 Crystal structure of the FAM46C/Plk4 complex Deposited 2020-03-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 585–807（223 aa） Fragment：UNP residues 585-807
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 10；293 K；0.2 M Tris, pH 10
Resolution 4.48 Å R-free 0.295
6W3I Crystal structure of a FAM46C mutant in complex with Plk4 Deposited 2020-03-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 585–807（223 aa） Fragment：UNP residues 585-807
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；25% v/v pentaerythritol ethoxylate (15/4 EO/OH), 0.05 M ammonium sulfate, 0.05 M Bis-Tris, pH 6.0
Resolution 3.80 Å R-free 0.261
6W3J Crystal structure of the FAM46C/Plk4/Cep192 complex Deposited 2020-03-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 585–807（223 aa） Fragment：UNP residues 585-807
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 10；293 K；0.2 M Tris, pH 10
Resolution 4.38 Å R-free 0.314
9O63 Crystal structure of PLK4 and RP1664 complex Deposited 2025-04-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–275（274 aa）
Not recorded SO4 SULFATE ION × 2 A1CAD 5-cyclopropyl-N~2~-[2,6-difluoro-4-(methanesulfonyl)phenyl]-N~2~-methyl-6-(1-methyl-1H-imidazol-4-yl)-N~4~-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291.15 K；9 - 14% PEG4K, 0.1 M Na Cit; pH 5.4 - 5.5, 0.2 M (NH4)2SO4
Resolution 2.26 Å R-free 0.264
9Y9B PLK4 in complex with Compound 6 (3-hydroxy-N-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide) Deposited 2025-09-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–275（274 aa）
Not recorded SO4 SULFATE ION × 1 A1CTX (1R,3r,5S)-3-hydroxy-N-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-8-azabicyclo[3.2.1]octane-8-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 8.5；293 K；0.1 M Tris pH 8.5, 16% ethanol , 5 mM DTT
Resolution 2.70 Å R-free 0.335
9Y9N PLK4 in complex with Compound 25 ((R)-7-hydroxy-N-(3-(1-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-1H-pyrazol-4-yl)-7-(trifluoromethyl)-4-azaspiro[2.5]octane-4-carboxamide) Deposited 2025-09-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 4–269（266 aa）
Not recorded A1CTV (7R)-7-hydroxy-N-{(5P)-5-[1-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-1H-pyrazol-4-yl}-7-(trifluoromethyl)-4-azaspiro[2.5]octane-4-carboxamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；293 K；1.4 M sodium phosphate monobasic monohydrate/potassium phosphate dibasic pH 5.6
Resolution 1.81 Å R-free 0.237

18 other PDB entries and 53 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name PLK4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–228； UniProt 581–808 Author chain B； PDBConstruct 1–228； UniProt 581–808

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 8xpg

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 8xpg
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2. Structure Basics 2. Structure Basics

Entry ID entry_id8xpg
Deposition date deposition_date2024-01-03
最后修订 last_revision2024-03-06
Structure title titleThe Crystal Structure of polo box domain of Plk4 from Biortus.
Keywords keywordsSerine/threonine-protein kinase, Transferase, CELL CYCLE; CELL CYCLE
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier29.69 Å
Radius of gyration Rg (electron density) rg_electron29.33 Å
Forward intensity I(0) i045122500.00
Molecular weight molecular_weight52365.0 kDa
Excluded volume excluded_volume65590 ų
Envelope volume envelope_volume87641 ų
Hydration-shell volume shell_volume26437 ų
Envelope diameter envelope_diameter104.5 Å
Shell Rg shell_rg34.47 Å
Envelope Rg envelope_rg29.53 Å
Shape Rg shape_rg29.35 Å
Total Rg total_rg29.78 Å
Total atoms total_atoms3679
Residues n_residues446
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax100.6 Å
Rg (real space) rg_real29.82 Å
Rg uncertainty (real space) rg_real_error0.73 Å
I(0) (real space) i0_real4.5120e+07
I(0) uncertainty (real space) i0_real_error6.9160e+05
Rg (reciprocal space) rg_reciprocal29.77 Å
I(0) (reciprocal space) i0_reciprocal45120000.0000
Solution quality estimate total_estimate0.8667
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary39.9 Å
Skewness Skewness skewness0.418
Kurtosis Kurtosis kurtosis-0.278
Angular range angular_range— – 0.2650 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha10970000.0000
Real-space data points n_real_points54
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.839; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.877; Smooth: 0.869
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

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8. Citations (1)

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9. Files and Curves (10)