SAXSdb — 9boz

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Glycine receptor subunit alpha-3

Homo sapiens

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Insufficient information Heteromer Protein × 5 PDB declaration: pentameric（5） Consistent with protein copy count	Chain A； UniProt 34–464 Chain B； UniProt 34–464 Chain C； UniProt 34–464 Chain D； UniProt 34–464	Not recorded	Glycine receptor subunit beta,Green fluorescent protein × 1 （P48167,A0A9X4KGN5） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5	ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.84 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 9BOZ	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5CFB Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine Deposited 2015-07-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain A 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain B 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain B 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain C 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain C 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain D 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain D 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain E 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain E 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted	Not recorded	SY9 STRYCHNINE × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；30-33% PEG-400, 200 mM magnesium chloride, 100 mM potassium chloride, 25 mM sodium citrate	Resolution 3.04 Å R-free 0.283
5TIN Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607 Deposited 2016-10-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain A 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain B 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain B 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain C 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain C 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain D 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain D 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain E 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain E 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted	Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q	7C6 (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one × 5 GLY GLYCINE × 5 ZN ZINC ION × 5 CL CHLORIDE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；200 mM Calcium Chloride, 22.5-27.5% PEG-350MME, 100 mM MES	Resolution 2.61 Å R-free 0.214
5TIO Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607 Deposited 2016-10-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain A 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain B 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain B 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain C 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain C 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain D 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain D 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain E 34–342（309 aa） Fragment：UNP residues 34-460, with 343-418 deleted Chain E 419–460（42 aa） Fragment：UNP residues 34-460, with 343-418 deleted	Not recorded	7C6 (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one × 5 GLY GLYCINE × 5 ZN ZINC ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；200 mM Calcium Chloride, 22.5-27.5% PEG-350MME, 100 mM MES	Resolution 3.25 Å R-free 0.254
5VDH Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin Deposited 2017-04-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain A 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain B 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain B 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain C 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain C 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain D 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain D 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain E 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain E 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460	Not recorded	7C6 (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one × 5 GLY GLYCINE × 5 IVM (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside × 5 ZN ZINC ION × 5 CL CHLORIDE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；200 mM calcium chloride, 22.5-27.5% PEG350 MME, 100 mM MES, pH 6.5	Resolution 2.85 Å R-free 0.236
5VDI Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607, Glycine, and Ivermectin Deposited 2017-04-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain A 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain B 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain B 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain C 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain C 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain D 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain D 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain E 34–342（309 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460 Chain E 419–460（42 aa） Fragment：UNP residues 34-342, ATG linker, UNP residues 419-460	Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q Mutation：N38Q	7C6 (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one × 5 GLY GLYCINE × 5 IVM (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside × 5 ZN ZINC ION × 5	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；200 mM calcium chloride, 22.5-27.5% PEG350 MME, 100 mM MES, pH 6.5	Resolution 3.10 Å R-free 0.256
9BOY Cryo-EM structure of human Glycine Receptor apha3-beta heteromer with glycine in nanodisc Deposited 2024-05-06	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain A 34–464（431 aa） Chain B 34–464（431 aa） Chain C 34–464（431 aa） Chain D 34–464（431 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.81 Å
9BP0 Cryo-EM structure of human heteromeric Glycine Receptor alpha3S346E-beta with glycine Deposited 2024-05-06	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain A 34–464（431 aa） Chain B 34–464（431 aa） Chain C 34–464（431 aa） Chain D 34–464（431 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.67 Å
9BP7 Cryo-EM structure of human heteromeric Glycine Receptor alpha3S346E-beta in presence of glycine and 2,6-DTBP Deposited 2024-05-07	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain A 34–464（431 aa） Chain B 34–464（431 aa） Chain C 34–464（431 aa） Chain D 34–464（431 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.60 Å
9BU2 Homomeric alpha3 glycine receptor in the presence of 1 mM glycine at pH 6.4 in a desensitized state Deposited 2024-05-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	GLY GLYCINE × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20	ELECTRON MICROSCOPY cryo-EM buffer pH 6.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.87 Å
9BU3 Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine in a desensitized state Deposited 2024-05-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	GLY GLYCINE × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.80 Å
9BVH Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine in an apo state. Deposited 2024-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 20 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 CLR CHOLESTEROL × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
9BVJ Homomeric alpha3 glycine receptor in the presence of 1 mM glycine in an desensitized state. Deposited 2024-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	GLY GLYCINE × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.80 Å
9BWB Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in a desensitized state Deposited 2024-05-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	GLY GLYCINE × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20	ELECTRON MICROSCOPY cryo-EM buffer pH 6.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.21 Å
9BWC Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in an apo state Deposited 2024-05-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 25 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 5 GLY GLYCINE × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 6.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.19 Å
9BWE Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in an intermediate state Deposited 2024-05-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 30 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 GLY GLYCINE × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 6.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.07 Å
9BWG Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine and 0.1 mM zinc in a desensitized state Deposited 2024-05-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	GLY GLYCINE × 5 ZN ZINC ION × 10 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.59 Å
9BWJ Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine and 0.1 mM zinc in an apo state Deposited 2024-05-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	ZN ZINC ION × 10 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 35	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.21 Å
9BZP Homomeric alpha3 glycine receptor in the presence of 0.1 millimolar glycine and 1 micromolar zinc in a desensitized state Deposited 2024-05-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 1–464（464 aa） Chain B 1–464（464 aa） Chain C 1–464（464 aa） Chain D 1–464（464 aa） Chain E 1–464（464 aa）	Not recorded	GLY GLYCINE × 5 ZN ZINC ION × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.88 Å

18 other PDB entries and 18 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	GLRA3_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–422； UniProt 34–464 Author chain B； PDBConstruct 1–422； UniProt 34–464 Author chain C； PDBConstruct 1–422； UniProt 34–464 Author chain D； PDBConstruct 1–422； UniProt 34–464

Glycine receptor subunit beta,Green fluorescent protein

Homo sapiens

UniProt A0A9X4KGN5

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Insufficient information Heteromer Protein × 5 PDB declaration: pentameric（5） Consistent with protein copy count	Chain E； UniProt 9–248	Not recorded	Glycine receptor subunit alpha-3 × 4 （O75311） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5	ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.84 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 9BOZ	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
8TU9 Cryo-EM structure of HGSNAT-acetyl-CoA complex at pH 7.5 Deposited 2023-08-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric	Chain A 9–251（243 aa） Chain B 9–251（243 aa）	Not recorded	ACO ACETYL COENZYME A × 2 NAG* 2-acetamido-2-deoxy-beta-D-glucopyranose × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.26 Å
8VDO Cryogenic electron microscopy model of full-length talin lacking F2, R12 and FABD. Deposited 2023-12-16	Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric	Chain A 8–246（239 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å
9BOY Cryo-EM structure of human Glycine Receptor apha3-beta heteromer with glycine in nanodisc Deposited 2024-05-06	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 9–248（240 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.81 Å
9BP0 Cryo-EM structure of human heteromeric Glycine Receptor alpha3S346E-beta with glycine Deposited 2024-05-06	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 9–248（240 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.67 Å
9BP7 Cryo-EM structure of human heteromeric Glycine Receptor alpha3S346E-beta in presence of glycine and 2,6-DTBP Deposited 2024-05-07	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 9–248（240 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.60 Å

5 other PDB entries and 5 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	A0A9X4KGN5_9BACI
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain E； PDBConstruct 339–578； UniProt 9–248

Glycine receptor subunit beta,Green fluorescent protein

Homo sapiens

UniProt P48167

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Insufficient information Heteromer Protein × 5 PDB declaration: pentameric（5） Consistent with protein copy count	Chain E； UniProt 25–355 Chain E； UniProt 400–497	Not recorded	Glycine receptor subunit alpha-3 × 4 （O75311） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5	ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.84 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 9BOZ	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5BKF Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, Glycine bound, desensitized state Deposited 2021-03-19	Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–355（331 aa） Chain E 400–497（98 aa）	Mutation：four substitutions in the GFP portion Mutation：four substitutions in the GFP portion	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 GLY GLYCINE × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.60 Å
5BKG Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, glycine bound, (semi)open state Deposited 2021-03-19	Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–355（331 aa） Chain E 400–497（98 aa）	Mutation：four substitutions in the GFP Mutation：four substitutions in the GFP	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 GLY GLYCINE × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.80 Å
7KUY Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, strychnine bound state Deposited 2020-11-25	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–355（331 aa） Chain E 400–497（98 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 SY9 STRYCHNINE × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.60 Å
7L31 Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, strychnine bound state, 3.8 Angstrom Deposited 2020-12-17	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–353（329 aa） Chain E 400–497（98 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 SY9 STRYCHNINE × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.80 Å
8DN2 Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state 2(expanded open) Deposited 2022-07-10	Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–355（331 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 HEX HEXANE × 10 HP6 HEPTANE × 9 UND UNDECANE × 3 OCT N-OCTANE × 7 GLY GLYCINE × 3 DD9 nonane × 2 NBU N-BUTANE × 3 D10 DECANE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
8DN3 Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, apo state Deposited 2022-07-10	Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–355（331 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 HEX HEXANE × 15 UND UNDECANE × 12 DD9 nonane × 13 NBU N-BUTANE × 5 HP6 HEPTANE × 8 D10 DECANE × 1 CL CHLORIDE ION × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.55 Å
8DN4 Cryo-EM structure of human Glycine Receptor alpha-1 beta heteromer, glycine-bound state3(desensitized state) Deposited 2022-07-10	Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–356（332 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 LNK PENTANE × 1 HEX HEXANE × 9 NBU N-BUTANE × 3 OCT N-OCTANE × 1 DD9 nonane × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.10 Å
8DN5 Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state1(open state) Deposited 2022-07-10	Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–355（331 aa）	Not recorded	GLY GLYCINE × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 DD9 nonane × 4 HP6 HEPTANE × 6 HEX HEXANE × 13 UND UNDECANE × 6 NBU N-BUTANE × 8 D10 DECANE × 3 OCT N-OCTANE × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.63 Å
9BOY Cryo-EM structure of human Glycine Receptor apha3-beta heteromer with glycine in nanodisc Deposited 2024-05-06	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–355（331 aa） Chain E 400–497（98 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.81 Å
9BP0 Cryo-EM structure of human heteromeric Glycine Receptor alpha3S346E-beta with glycine Deposited 2024-05-06	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–355（331 aa） Chain E 400–497（98 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.67 Å
9BP7 Cryo-EM structure of human heteromeric Glycine Receptor alpha3S346E-beta in presence of glycine and 2,6-DTBP Deposited 2024-05-07	Different ligand/ion Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain E 25–355（331 aa） Chain E 400–497（98 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.60 Å

11 other PDB entries and 11 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	GLRB_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain E； PDBConstruct 1–331； UniProt 25–355 Author chain E； PDBConstruct 583–680； UniProt 400–497

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	9boz
Deposition date deposition_date	2024-05-06
Structure title title	Cryo-EM structure of human Glycine Receptor alpha3-beta heteromer in presence of glycine
Keywords keywords	glycine receptor subunit alpha-3, glycine receptor subunit beta, Green fluorescent protein, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method method	ELECTRON MICROSCOPY

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	38.93 Å
Radius of gyration Rg (electron density) rg_electron	38.49 Å
Forward intensity I(0) i0	505773000.00
Molecular weight molecular_weight	194650.0 kDa
Excluded volume excluded_volume	247800 Å³
Envelope volume envelope_volume	322530 Å³
Hydration-shell volume shell_volume	68413 Å³
Envelope diameter envelope_diameter	133.1 Å
Shell Rg shell_rg	45.72 Å
Envelope Rg envelope_rg	38.03 Å
Shape Rg shape_rg	38.52 Å
Total Rg total_rg	38.78 Å
Total atoms total_atoms	13723
Residues n_residues	1705
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	124.2 Å
Rg (real space) rg_real	38.84 Å
Rg uncertainty (real space) rg_real_error	0.81 Å
I(0) (real space) i0_real	5.0580e+08
I(0) uncertainty (real space) i0_real_error	9.2470e+06
Rg (reciprocal space) rg_reciprocal	38.90 Å
I(0) (reciprocal space) i0_reciprocal	505800000.0000
Solution quality estimate total_estimate	0.8702
Solution quality rating solution_quality	GOOD a GOOD solution
P(r) peaks n_peaks	1
Primary peak position r_peak_primary	48.5 Å
Skewness Skewness skewness	0.332
Kurtosis Kurtosis kurtosis	-0.283
Angular range angular_range	— – 0.2050 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	90520000.0000
Real-space data points n_real_points	42
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.872; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.991; Smooth: 0.703

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

Entity 1 Entity 1 polymer

Description description	Glycine receptor subunit alpha-3
Molecular weight formula_weight	48936.5 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D
Atom count atom_count	13732

ARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Homo sapiens

Entity 2 Entity 2 polymer

Description description	Glycine receptor subunit beta,Green fluorescent protein
Molecular weight formula_weight	76584.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

KSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNGGSSAAAVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITHGMDELYKSGSGSGVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Homo sapiens

Entity 3 Entity 3 non-polymer

Description description	2-acetamido-2-deoxy-beta-D-glucopyranose
Molecular weight formula_weight	221.2 kDa
Source method src_method	syn
Copy count entity_count	5

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8. Citations (1)

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.84 Å
Resolution测定方法 resolution_method	—
颗粒数 num_particles	19993

fit	/app/data/saxs_computation/bo/9boz/9boz.fit
pddf	/app/data/pr_computation/bo/9boz/9boz.pr.out
profile	/app/data/saxs_computation/bo/9boz/9boz.dat

Cryo-EM structure of human Glycine Receptor alpha3-beta heteromer in presence of glycine

1. Protein Identity and Related Structures Protein Identity & Related Structures

Glycine receptor subunit alpha-3

State in the Current Structure

Other States of the Same Protein in the Database

Glycine receptor subunit beta,Green fluorescent protein

State in the Current Structure

Other States of the Same Protein in the Database

Glycine receptor subunit beta,Green fluorescent protein

State in the Current Structure

Other States of the Same Protein in the Database

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

冷冻电镜 EM 3D

6. Entities and Polymers Entities & Polymers (3)

Entity 1 Entity 1 polymer

Polymer Polymer

来源 Source

Entity 2 Entity 2 polymer

Polymer Polymer

来源 Source

Entity 3 Entity 3 non-polymer

8. Citations (1)

9. Files and Curves (10)

Files (7)

Curves (3)