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9iki

Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Cytochrome c oxidase subunit 1

物种未注明

UniProt P00396

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 A； UniProt 1–514 链 N； UniProt 1–514 非标准单体：是（mmCIF未提供具体位点） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 L 1–514（514 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 y 1–514（514 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 x 1–514（514 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 a 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 a 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 x 1–514（514 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 Bx 1–514（514 aa）
链 x 1–514（514 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C3 1–514（514 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A9 1–514（514 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A9 1–514（514 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A3 1–514（514 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–513（513 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 A 1–514（514 aa）
链 N 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 A 1–514（514 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX1_BOVIN
Isoform —
PDB实体 1
链与序列区间 作者链 A； PDB构建体 1–514； UniProt 1–514 作者链 N； PDB构建体 1–514； UniProt 1–514

Cytochrome c oxidase subunit 2

物种未注明

UniProt P68530

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 B； UniProt 1–227 链 O； UniProt 1–227 非标准单体：是（mmCIF未提供具体位点） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 M 1–227（227 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 z 1–227（227 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 y 1–227（227 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 b 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 b 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 y 1–227（227 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 By 1–227（227 aa）
链 y 1–227（227 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C1 1–227（227 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C4 1–227（227 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B9 1–227（227 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B3 1–227（227 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 B 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 B 1–227（227 aa）
链 O 1–227（227 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155

共 88 个其他 PDB 条目、127 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX2_BOVIN
Isoform —
PDB实体 2
链与序列区间 作者链 B； PDB构建体 1–227； UniProt 1–227 作者链 O； PDB构建体 1–227； UniProt 1–227

Cytochrome c oxidase subunit 3

物种未注明

UniProt P00415

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 C； UniProt 1–261 链 P； UniProt 1–261 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 N 1–261（261 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 3–261（259 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 3–261（259 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 3–261（259 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 3–261（259 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 C 3–261（259 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 P 3–261（259 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 z 1–261（261 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 c 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 c 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 2–261（260 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 2–261（260 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 z 1–261（261 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 Bz 1–261（261 aa）
链 z 1–261（261 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 3–261（259 aa）
链 P 3–261（259 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 3–261（259 aa）
链 P 3–261（259 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 3–261（259 aa）
链 P 3–261（259 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 3–261（259 aa）
链 P 3–261（259 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A9 1–261（261 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C2 1–261（261 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B7 1–261（261 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C3 1–261（261 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 3–261（259 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 3–261（259 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 3–261（259 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 3–261（259 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 C 3–261（259 aa）
链 P 3–261（259 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 3–261（259 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 4–261（258 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 C 1–261（261 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 P 1–261（261 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 C 1–261（261 aa）
链 P 1–261（261 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 C 4–259（256 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 90 个其他 PDB 条目、132 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX3_BOVIN
Isoform —
PDB实体 3
链与序列区间 作者链 C； PDB构建体 1–261； UniProt 1–261 作者链 P； PDB构建体 1–261； UniProt 1–261

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

物种未注明

UniProt P00423

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 D； UniProt 23–169 链 Q； UniProt 23–169 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 1–169（169 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 1–169（169 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 O 23–169（147 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 26–169（144 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 26–169（144 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 26–169（144 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 26–169（144 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 1 23–169（147 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 D 26–169（144 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 Q 26–169（144 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 1 23–169（147 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa） 片段：residues 23-169
链 d 23–169（147 aa） 片段：residues 23-169
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 d 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 0 26–169（144 aa） 片段：UNP RESIDUES 28-169
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 构建体不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 0 26–169（144 aa） 片段：UNP RESIDUES 26-169
链 B0 26–169（144 aa） 片段：UNP RESIDUES 26-169
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 26–169（144 aa）
链 Q 26–169（144 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 26–169（144 aa）
链 Q 26–169（144 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 26–169（144 aa）
链 Q 26–169（144 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 26–169（144 aa）
链 Q 26–169（144 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A7 1–169（169 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A7 1–169（169 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A7 1–169（169 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 D3 1–169（169 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 26–169（144 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 26–169（144 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 26–169（144 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 26–169（144 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 D 26–169（144 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 26–169（144 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 32–168（137 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 D 23–169（147 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 D 23–169（147 aa）
链 Q 23–169（147 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 D 33–168（136 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX41_BOVIN
Isoform —
PDB实体 4
链与序列区间 作者链 D； PDB构建体 1–147； UniProt 23–169 作者链 Q； PDB构建体 1–147； UniProt 23–169

Cytochrome c oxidase subunit 5A

物种未注明

UniProt P00426

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 E； UniProt 44–152 链 R； UniProt 44–152 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 1–109（109 aa）
链 R 1–109（109 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 1–109（109 aa）
链 R 1–109（109 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 1–109（109 aa）
链 R 1–109（109 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 1–109（109 aa）
链 R 1–109（109 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 1–109（109 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 1–109（109 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 1–109（109 aa）
链 R 1–109（109 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 1–152（152 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 1–152（152 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 P 44–152（109 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 48–152（105 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 48–152（105 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 48–152（105 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 48–152（105 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 2 44–152（109 aa） 片段：UNP RESIDUES 44-152
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 E 48–152（105 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 R 48–152（105 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 2 44–152（109 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa） 片段：residues 44-152
链 e 44–152（109 aa） 片段：residues 44-152
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 e 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 1 44–152（109 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 1 44–152（109 aa）
链 B1 44–152（109 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 48–152（105 aa）
链 R 48–152（105 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 48–152（105 aa）
链 R 48–152（105 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 48–152（105 aa）
链 R 48–152（105 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 48–152（105 aa）
链 R 48–152（105 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B4 1–152（152 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C0 1–152（152 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A6 1–152（152 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 E3 1–152（152 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 48–152（105 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 48–152（105 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 48–152（105 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 48–152（105 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 E 49–152（104 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 49–152（104 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 49–150（102 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 E 44–152（109 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 R 44–152（109 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 E 44–152（109 aa）
链 R 44–152（109 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 E 50–151（102 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX5A_BOVIN
Isoform —
PDB实体 5
链与序列区间 作者链 E； PDB构建体 1–109； UniProt 44–152 作者链 R； PDB构建体 1–109； UniProt 44–152

Cytochrome c oxidase subunit 5B, mitochondrial

物种未注明

UniProt P00428

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 F； UniProt 32–129 链 S； UniProt 32–129 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 1–98（98 aa）
链 S 1–98（98 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 1–98（98 aa）
链 S 1–98（98 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 1–98（98 aa）
链 S 1–98（98 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 1–98（98 aa）
链 S 1–98（98 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 1–98（98 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 1–98（98 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 1–98（98 aa）
链 S 1–98（98 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 1–129（129 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 1–129（129 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 Q 32–129（98 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 3 32–129（98 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 F 32–129（98 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 3 32–129（98 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa） 片段：residues 32-129
链 f 32–129（98 aa） 片段：residues 32-129
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 f 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 2 32–129（98 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 2 32–129（98 aa）
链 B2 32–129（98 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–125（94 aa）
链 S 32–125（94 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–125（94 aa）
链 S 32–125（94 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–125（94 aa）
链 S 32–125（94 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A5 1–129（129 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A6 1–129（129 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B2 1–129（129 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 F3 1–129（129 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–125（94 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 F 33–125（93 aa）
链 S 33–125（93 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 33–125（93 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 35–125（91 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 F 32–129（98 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 S 32–129（98 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 F 32–129（98 aa）
链 S 32–129（98 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 F 34–124（91 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX5B_BOVIN
Isoform —
PDB实体 6
链与序列区间 作者链 F； PDB构建体 1–98； UniProt 32–129 作者链 S； PDB构建体 1–98； UniProt 32–129

Cytochrome c oxidase subunit 6A2, mitochondrial

物种未注明

UniProt P07471

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 G； UniProt 13–97 链 T； UniProt 13–97 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–96（84 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–96（84 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 1–97（97 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 1–97（97 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 R 13–96（84 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–96（84 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–96（84 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 4 13–96（84 aa） 片段：UNP RESIDUES 13-96
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 G 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 T 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 4 13–96（84 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa） 片段：residues 13-97
链 g 13–97（85 aa） 片段：residues 13-97
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 g 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 3 13–96（84 aa） 片段：UNP RESIDUES 13-96
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 构建体不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 3 13–96（84 aa） 片段：UNP RESIDUES 13-96
链 B3 13–96（84 aa） 片段：UNP RESIDUES 13-96
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A6 1–97（97 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A4 1–97（97 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A4 1–97（97 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 G3 1–97（97 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 G 13–96（84 aa）
链 T 13–96（84 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–96（84 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–96（84 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 24–95（72 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 G 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 T 13–97（85 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 G 13–97（85 aa）
链 T 13–97（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 G 24–95（72 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 CX6A2_BOVIN
Isoform —
PDB实体 7
链与序列区间 作者链 G； PDB构建体 1–85； UniProt 13–97 作者链 T； PDB构建体 1–85； UniProt 13–97

Cytochrome c oxidase subunit 6B1

物种未注明

UniProt P00429

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 H； UniProt 2–86 链 U； UniProt 2–86 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 1–85（85 aa）
链 U 1–85（85 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 1–85（85 aa）
链 U 1–85（85 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 1–85（85 aa）
链 U 1–85（85 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 1–85（85 aa）
链 U 1–85（85 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 1–85（85 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 1–85（85 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 1–85（85 aa）
链 U 1–85（85 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 1–86（86 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 1–86（86 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 S 2–86（85 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 8–86（79 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 8–86（79 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 8–86（79 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 8–86（79 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 5 2–86（85 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 H 8–86（79 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 U 8–86（79 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 5 2–86（85 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 h 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 h 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 4 12–86（75 aa） 片段：UNP RESIDUES 12-86
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 构建体不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 4 12–86（75 aa） 片段：UNP RESIDUES 12-86
链 B4 12–86（75 aa） 片段：UNP RESIDUES 12-86
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 8–86（79 aa）
链 U 8–86（79 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 8–86（79 aa）
链 U 8–86（79 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 8–86（79 aa）
链 U 8–86（79 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 8–86（79 aa）
链 U 8–86（79 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C0 1–86（86 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A5 1–86（86 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A5 1–86（86 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 H3 1–86（86 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 8–86（79 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 8–86（79 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 8–86（79 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 8–86（79 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 H 8–86（79 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 8–86（79 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 9–86（78 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 H 2–86（85 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 U 2–86（85 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 H 2–86（85 aa）
链 U 2–86（85 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 H 6–86（81 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 CX6B1_BOVIN
Isoform —
PDB实体 8
链与序列区间 作者链 H； PDB构建体 1–85； UniProt 2–86 作者链 U； PDB构建体 1–85； UniProt 2–86

Cytochrome c oxidase subunit 6C

物种未注明

UniProt P04038

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 I； UniProt 2–74 链 V； UniProt 2–74 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 1–73（73 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 1–73（73 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 1–73（73 aa）
链 V 1–73（73 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 1–74（74 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 1–74（74 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 T 2–74（73 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 1–73（73 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 6 2–74（73 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 6 2–74（73 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 i 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 i 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 5 2–74（73 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 5 2–74（73 aa）
链 B5 2–74（73 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C2 1–74（74 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B4 1–74（74 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B6 1–74（74 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 I3 1–74（74 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 5–74（70 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 I 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 V 2–74（73 aa）
非标准单体：是（mmCIF未提供具体位点） HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 I 2–74（73 aa）
链 V 2–74（73 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 I 4–73（70 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX6C_BOVIN
Isoform —
PDB实体 9
链与序列区间 作者链 I； PDB构建体 1–73； UniProt 2–74 作者链 V； PDB构建体 1–73； UniProt 2–74

Cytochrome c oxidase subunit 7A1

物种未注明

UniProt P07470

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 J； UniProt 22–80 链 W； UniProt 22–80 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 1–80（80 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 1–80（80 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 U 22–80（59 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–79（58 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–79（58 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–79（58 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–79（58 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 7 22–80（59 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 J 22–79（58 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 W 22–79（58 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 7 22–80（59 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa） 片段：residues 22-80
链 j 22–80（59 aa） 片段：residues 22-80
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 j 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 6 22–77（56 aa） 片段：UNP RESIDUES 22-77
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 构建体不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 6 22–77（56 aa） 片段：UNP RESIDUES 22-77
链 B6 22–77（56 aa） 片段：UNP RESIDUES 22-77
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–79（58 aa）
链 W 22–79（58 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–79（58 aa）
链 W 22–79（58 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–79（58 aa）
链 W 22–79（58 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–79（58 aa）
链 W 22–79（58 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B2 1–80（80 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C3 1–80（80 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B8 1–80（80 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 J3 1–80（80 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–79（58 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–79（58 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–79（58 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–79（58 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 J 22–78（57 aa）
链 W 22–78（57 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–78（57 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–76（55 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 J 22–80（59 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 W 22–80（59 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 J 22–80（59 aa）
链 W 22–80（59 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 J 22–76（55 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

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UniProt名称 CX7A1_BOVIN
Isoform —
PDB实体 10
链与序列区间 作者链 J； PDB构建体 1–59； UniProt 22–80 作者链 W； PDB构建体 1–59； UniProt 22–80

Cytochrome c oxidase subunit 7B, mitochondrial

物种未注明

UniProt P13183

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 K； UniProt 25–80 链 X； UniProt 25–80 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 33–88（56 aa）
链 X 33–88（56 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 33–88（56 aa）
链 X 33–88（56 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 33–88（56 aa）
链 X 33–88（56 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 33–88（56 aa）
链 X 33–88（56 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 33–88（56 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 33–88（56 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 33–88（56 aa）
链 X 33–88（56 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 1–80（80 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 1–80（80 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 V 25–80（56 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 8 25–80（56 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 K 30–78（49 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 X 30–78（49 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 8 25–80（56 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa） 片段：residues 25-80
链 k 25–80（56 aa） 片段：residues 25-80
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 k 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 7 30–78（49 aa） 片段：UNP RESIDUES 30-78
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 构建体不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 7 30–78（49 aa） 片段：UNP RESIDUES 30-78
链 B7 30–78（49 aa） 片段：UNP RESIDUES 30-78
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 30–78（49 aa）
链 X 30–78（49 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 30–78（49 aa）
链 X 30–78（49 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 30–78（49 aa）
链 X 30–78（49 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 30–78（49 aa）
链 X 30–78（49 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B3 1–80（80 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B0 1–80（80 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B0 1–80（80 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 K3 1–80（80 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 K 30–78（49 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 32–78（47 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 K 25–80（56 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 X 25–80（56 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 K 25–80（56 aa）
链 X 25–80（56 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 K 30–78（49 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX7B_BOVIN
Isoform —
PDB实体 11
链与序列区间 作者链 K； PDB构建体 1–56； UniProt 25–80 作者链 X； PDB构建体 1–56； UniProt 25–80

Cytochrome c oxidase subunit 7C, mitochondrial

物种未注明

UniProt P00430

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 L； UniProt 17–63 链 Y； UniProt 17–63 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 1–63（63 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 1–63（63 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 W 17–63（47 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 18–63（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 18–63（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 18–63（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 18–63（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 9 17–63（47 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 L 18–63（46 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 Y 18–63（46 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 9 17–63（47 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa） 片段：residues 17-63
链 l 17–63（47 aa） 片段：residues 17-63
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 l 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 8 17–63（47 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 8 17–63（47 aa）
链 B8 17–63（47 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 18–63（46 aa）
链 Y 18–63（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 18–63（46 aa）
链 Y 18–63（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 18–63（46 aa）
链 Y 18–63（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 18–63（46 aa）
链 Y 18–63（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A0 1–63（63 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 C1 1–63（63 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 B1 1–63（63 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 L3 1–63（63 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 18–63（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 18–63（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 18–63（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 18–63（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 L 18–63（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 18–63（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound 提交 2022-06-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 18–63（46 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 L 17–63（47 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 L 17–63（47 aa）
链 Y 17–63（47 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 L 19–62（44 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 91 个其他 PDB 条目、133 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX7C_BOVIN
Isoform —
PDB实体 12
链与序列区间 作者链 L； PDB构建体 1–47； UniProt 17–63 作者链 Y； PDB构建体 1–47； UniProt 17–63

Cytochrome c oxidase subunit 8B, mitochondrial

物种未注明

UniProt P10175

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 26 PDB 声明：26-meric（26） 与蛋白拷贝数一致 链 M； UniProt 25–70 链 Z； UniProt 25–70 未记录 Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1 × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION X-ray结晶条件：BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000 分辨率 1.75 Å R-free 0.189

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB 相对当前条目 9IKI Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法与环境 结构质量
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1996-04-18 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE 提交 1998-07-09 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE 提交 1998-07-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE 提交 1998-07-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state 提交 2003-11-21 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD 提交 2006-09-16 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state 提交 2007-03-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE 提交 1998-05-26 配体/离子不同 实验环境不同 结构质量不同 Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8；pH 6.8
分辨率 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 1–70（70 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen 提交 2011-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 1–70（70 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) 提交 2011-03-02 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 48 PDB 声明：48-meric
链 X 25–70（46 aa）
未记录 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE
cryo-EM玻璃化条件 冷冻剂 ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING
分辨率 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) 提交 2009-01-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) 提交 2009-12-16 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
分辨率 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K 提交 2010-03-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength 提交 2010-12-17 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
分辨率 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography 提交 2013-07-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
分辨率 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution 提交 2014-12-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
分辨率 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–67（43 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution 提交 2015-12-01 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–67（43 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
分辨率 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–67（43 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) 提交 2016-03-11 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–67（43 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
分辨率 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome 提交 2016-08-03 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 84 PDB 声明：84-meric
链 s 25–70（46 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2
cryo-EM玻璃化条件 冷冻剂 NITROGEN
分辨率 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 M 25–67（43 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution 提交 2016-03-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：tetradecameric
链 Z 25–67（43 aa）
未记录 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
分辨率 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome 提交 2016-09-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 62 PDB 声明：62-meric
链 0 25–70（46 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.7
cryo-EM玻璃化条件 冷冻剂 ETHANE；10 s blotting
分辨率 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature 提交 2017-06-22 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa） 片段：residues 25-70
链 m 25–70（46 aa） 片段：residues 25-70
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
分辨率 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K 提交 2017-06-27 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 m 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
分辨率 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K 提交 2017-01-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
分辨率 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution 提交 2017-03-29 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
分辨率 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution 提交 2017-03-30 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
分辨率 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 提交 2017-06-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 9 25–67（43 aa） 片段：UNP RESIDUES 25-67
未记录 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 提交 2017-06-19 构建体不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 138 PDB 声明：138-meric
链 9 25–67（43 aa） 片段：UNP RESIDUES 25-67
链 B9 25–67（43 aa） 片段：UNP RESIDUES 25-67
未记录 SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
分辨率 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days 提交 2018-01-31 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days 提交 2018-02-19 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
分辨率 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray 提交 2019-01-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.8；277 K；PEG 4000
分辨率 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION 提交 2019-04-15 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–67（43 aa）
链 Z 25–67（43 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2019-04-26 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
分辨率 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature 提交 2019-01-07 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature 提交 2019-01-10 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature 提交 2019-01-11 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
分辨率 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State 提交 2020-08-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
分辨率 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution 提交 2020-08-06 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–67（43 aa）
链 Z 25–67（43 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–67（43 aa）
链 Z 25–67（43 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution 提交 2020-09-28 构建体不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–67（43 aa）
链 Z 25–67（43 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
分辨率 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A8 1–70（70 aa）
未记录 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A8 1–70（70 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 A8 1–70（70 aa）
未记录 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 7.80 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric
链 M3 1–70（70 aa）
未记录 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K 提交 2021-05-20 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-12 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
分辨率 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
分辨率 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure 提交 2022-01-13 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
分辨率 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–67（43 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K 提交 2021-11-04 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–67（43 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
分辨率 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–67（43 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K 提交 2021-11-08 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–67（43 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 19 PDB 声明：tridecameric
链 M 25–65（41 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K 提交 2021-11-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–65（41 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
分辨率 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 信息不足 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
分辨率 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 提交 2022-04-25 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
分辨率 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution 提交 2022-06-14 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
分辨率 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution 提交 2022-08-05 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
分辨率 1.50 Å R-free 0.177
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase 提交 2023-02-28 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution 提交 2023-03-02 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
分辨率 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days 提交 2022-09-15 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
分辨率 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State 提交 2022-10-24 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 M 25–70（46 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 提交 2023-02-27 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同 Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 13 PDB 声明：tridecameric
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
分辨率 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State 提交 2024-06-27 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.75 Å R-free 0.174
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition 提交 2024-12-04 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State 提交 2024-12-04 配体/离子不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State 提交 2025-03-05 配体/离子不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 26 PDB 声明：26-meric
链 M 25–70（46 aa）
链 Z 25–70（46 aa）
未记录 HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
分辨率 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A 提交 2025-07-28 构建体不同 突变/修饰不同 聚集状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量不同 Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 14 PDB 声明：14-meric
链 M 25–64（40 aa）
未记录 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.61 Å

共 90 个其他 PDB 条目、132 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 COX8B_BOVIN
Isoform —
PDB实体 13
链与序列区间 作者链 M； PDB构建体 1–46； UniProt 25–70 作者链 Z； PDB构建体 1–46； UniProt 25–70

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

SAXS 散射曲线 SAXS Profile

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P(r) 距离分布 P(r) Distribution

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id9iki
沉积日期 deposition_date2024-06-27
结构标题 titleBovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State
关键词 keywordsnitrous oxide, fully reduced, OXIDOREDUCTASE; OXIDOREDUCTASE
实验方法 methodX-RAY DIFFRACTION
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3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

该条目暂无 SAXS 数据。

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4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

该条目暂无 P(r) 分析数据。

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5. 晶体学与实验 5. Crystallography & Experiment

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6. 实体与聚合物信息 Entities & Polymers (29)

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8. 引用文献 (1)

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9. 文件与曲线 (0)