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9odr

Structure of CRBN TBD bound to compound C1

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Protein cereblon

Homo sapiens

UniProt Q96SW2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 (3S)-3-(6-oxo-6,8-dihydro-2H,7H-spiro[furo[2,3-e]isoindole-3,4'-piperidin]-7-yl)piperidine-2,6-dione × 1 ZINC ION × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 (3S)-3-(6-oxo-6,8-dihydro-2H,7H-spiro[furo[2,3-e]isoindole-3,4'-piperidin]-7-yl)piperidine-2,6-dione × 1 ZINC ION × 1 water × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 (3S)-3-(6-oxo-6,8-dihydro-2H,7H-spiro[furo[2,3-e]isoindole-3,4'-piperidin]-7-yl)piperidine-2,6-dione × 1 ZINC ION × 1 water × 1 Consistent with protein count
4 Protein monomer Monomer Protein 1 (3S)-3-(6-oxo-6,8-dihydro-2H,7H-spiro[furo[2,3-e]isoindole-3,4'-piperidin]-7-yl)piperidine-2,6-dione × 1 ZINC ION × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
8rq1 8rq8 8rqa 9gy3 9gy3 9odr 9odr 9odr 9odr 9ods 9ods 9ods

14 assemblies; showing the first 12

Homodimer
9gao

1 assemblies

Homotetramer

None

Other homooligomers
9cuo 9cuo

2 assemblies

Heteromeric or nucleic-acid complex
10ay 11mr 4m91 4tz4 5fqd 5fqd 5hxb 5hxb 5v3o 6bn7 6bn8 6bn9

125 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CRBN_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–111； UniProt 319–426 Author chain B； PDBConstruct 4–111； UniProt 319–426 Author chain C； PDBConstruct 4–111； UniProt 319–426 Author chain D； PDBConstruct 4–111； UniProt 319–426

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9odr
Deposition date deposition_date2025-04-27
Structure title titleStructure of CRBN TBD bound to compound C1
Keywords keywordsProtein degrader, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9odr__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9odr__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9odr__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）14.65 Å
Rg (electron density)13.31 Å
Total Rg14.73 Å
Atom count879
Residues109
Excluded volume15624 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9odr__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9odr__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 9odr__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 9odr__assembly_4__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)