9pj8

C. acnes 70S ribosome bound to Sarecycline

Method: ELECTRON MICROSCOPY D_max: 295.7 Å Quality: EXCELLENT

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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1. 结构基本信息 1. Structure Basics

条目编号 entry_id	9pj8
沉积日期 deposition_date	2025-07-12
结构标题 title	C. acnes 70S ribosome bound to Sarecycline
关键词 keywords	Tetracycline, bacterial ribosome, protein translation, Sarecycline, Antibiotic, RIBOSOME; RIBOSOME
实验方法 method	ELECTRON MICROSCOPY

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2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	84.18 Å
回转半径 Rg (电子) rg_electron	84.99 Å
零角强度 I(0) i0	151646000000.00
分子量 molecular_weight	2148500.0 kDa
排除体积 excluded_volume	2202500 Å³
包络体积 envelope_volume	3849300 Å³
水化壳体积 shell_volume	346630 Å³
包络直径 envelope_diameter	282.3 Å
壳层 Rg shell_rg	99.01 Å
包络 Rg envelope_rg	83.29 Å
形状 Rg shape_rg	85.07 Å
总 Rg total_rg	84.91 Å
总原子数 total_atoms	144271
残基数 n_residues	10326
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	295.7 Å
Rg (实空间) rg_real	86.51 Å
Rg 误差 (实空间) rg_real_error	1.56 Å
I(0) (实空间) i0_real	1.5050e+11
I(0) 误差 (实空间) i0_real_error	3.2320e+09
Rg (倒空间) rg_reciprocal	85.54 Å
I(0) (倒空间) i0_reciprocal	152300000000.0000
解质量估计 total_estimate	0.9073
解质量评级 solution_quality	EXCELLENT a EXCELLENT solution
P(r) 峰数 n_peaks	2
主峰位置 r_peak_primary	109.0 Å
偏度 Skewness skewness	0.377
峰度 Kurtosis kurtosis	0.045
角度范围 angular_range	— – 0.0950 Å⁻¹
当前正则化参数 α current_alpha	1.1740
最高正则化参数 α highest_alpha	9156000000.0000
实空间数据点数 n_real_points	20
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.778; Stabil: 0.907; Sysdev: 1.000; Positv: 1.000; Valcen: 0.962; Smooth: 0.790

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合体信息 (58)

Entity 1 polymer

描述 description	50S ribosomal protein L33
分子量 formula_weight	6725.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	0
原子数 atom_count	144415

MAKKSGDVRPKITLACTECKERNYITKKNRRNNPDRMEMAKFCPRCRKHTAHRETR

Entity 2 polymer

描述 description	50S ribosomal protein L34
分子量 formula_weight	5185.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1

MKRTFQPSNRRRARNHGFRSRMSTRAGRSILAARRRKGRVNLSA

Entity 3 polymer

描述 description	Large ribosomal subunit protein bL35
分子量 formula_weight	7457.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	2

MPKMKSHSGTKKRFKVTGSGKVTARKAGKRHLNEHKSSRVTRRLTGETVLSKGEAAKVKKLLAGHPGR

Entity 4 polymer

描述 description	50S ribosomal protein L36
分子量 formula_weight	4386.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	3

MKVQPSVKKICDKCKVIRRHGRVMVICDNPRHKQRQG

Entity 5 polymer

描述 description	50S ribosomal protein L31
分子量 formula_weight	7731.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	4

MKQGIHPDYRETTVVCTCGNTFTTRSTSQSGTLNADVCSKCHPFYTGKQKILDAGGRVARFERRYGKKN

Entity 6 polymer

描述 description	16S rRNA
分子量 formula_weight	498742.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	A

UUUUUCAUUGGAGAGUUUGAUCCUGGCUCAGGACGAACGCUGGCGGCGUGCUUAACACAUGCAAGUCGAACGGAAAGGCCCUGCUUUUGUGGGGUGCUCGAGUGGCGAACGGGUGAGUAACACGUGAGUAACCUGCCCUUGACUUUGGGAUAACUUCAGGAAACUGGGGCUAAUACCGGAUAGGAGCUCCUGCUGCAUGGUGGGGGUUGGAAAGUUUCGGCGGUUGGGGAUGGACUCGCGGCUUAUCAGCUUGUUGGUGGGGUAGUGGCUUACCAAGGCUUUGACGGGUAGCCGGCCUGAGAGGGUGACCGGCCACAUUGGGACUGAGAUACGGCCCAGACUCCUACGGGAGGCAGCAGUGGGGAAUAUUGCACAAUGGGCGGAAGCCUGAUGCAGCAACGCCGCGUGCGGGAUGACGGCCUUCGGGUUGUAAACCGCUUUCGCCUGUGACGAAGCGUGAGUGACGGUAAUGGGUAAAGAAGCACCGGCUAACUACGUGCCAGCAGCCGCGGUGAUACGUAGGGUGCGAGCGUUGUCCGGAUUUAUUGGGCGUAAAGGGCUCGUAGGUGGUUGAUCGCGUCGGAAGUGUAAUCUUGGGGCUUAACCCUGAGCGUGCUUUCGAUACGGGUUGACUUGAGGAAGGUAGGGGAGAAUGGAAUUCCUGGUGGAGCGGUGGAAUGCGCAGAUAUCAGGAGGAACACCAGUGGCGAAGGCGGUUCUCUGGGCCUUUCCUGACGCUGAGGAGCGAAAGCGUGGGGAGCGAACAGGCUUAGAUACCCUGGUAGUCCACGCUGUAAACGGUGGGUACUAGGUGUGGGGUCCAUUCCACGGGUUCCGUGCCGUAGCUAACGCUUUAAGUACCCCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAAAGGAAUUGACGGGGCCCCGCACAAGCGGCGGAGCAUGCGGAUUAAUUCGAUGCAACGCGUAGAACCUUACCUGGGUUUGACAUGGAUCGGGAGUGCUCAGAGAUGGGUGUGCCUCUUUUGGGGUCGGUUCACAGGUGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCUUGUUCACUGUUGCCAGCACGUUAUGGUGGGGACUCAGUGGAGACCGCCGGGGUCAACUCGGAGGAAGGUGGGGAUGACGUCAAGUCAUCAUGCCCCUUAUGUCCAGGGCUUCACGCAUGCUACAAUGGCUGGUACAGAGAGUGGCGAGCCUGUGAGGGUGAGCGAAUCUCGGAAAGCCGGUCUCAGUUCGGAUUGGGGUCUGCAACUCGACCUCAUGAAGUCGGAGUCGCUAGUAAUCGCAGAUCAGCAACGCUGCGGUGAAUACGUUCCCGGGGCUUGUACACACCGCCCGUCAAGUCAUGAAAGUUGGUAACACCCGAAGCCGGUGGCCUAACCGUUGUGGGGGAGCCGUCGAAGGUGGGACUGGUGAUUAGGACUAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGGAUCACCUCCUUUCUAAGGAG

Entity 7 polymer

描述 description	30S ribosomal protein S2
分子量 formula_weight	31583.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	B

MAVVTTRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLHQSLTYIDKAYAFVKETVAKGGQILFVGTKKQAQESIVEQATRVGMPYVNQRWLGGMLTNFQTISKRIARLKELEAMDFDKVSGSGLTKKELLMLSREKDKLEKDLGGIRDMPKVPQAVWVVDTKKEHLAIDEARKLKIPVVAILDTNCDPDEVDYAIPGNDDAIRSVSLLTRIIADAAAEGLMARSAGKSGEQPAEAEPMPDWERELLEGDGAKTEAKAEEPKAEAKKADEAPEAEKSN

Entity 8 polymer

描述 description	initiator tRNA Met (76-MER)
分子量 formula_weight	24846.9 kDa
来源方法 src_method	man
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	C

CGCGGGGUGGAGCAGCCUGGUAGCUCGUCGGGCUCAUAACCCGAAGGUCGUCGGUUCAAAUCCGGCCCCCGCAACCA

来源 Source

来源生物 organism	Escherichia coli
NCBI 分类编号 ncbi_taxonomy_id	562
宿主生物 host_organism	Escherichia coli

Entity 9 polymer

描述 description	30S ribosomal protein S4
分子量 formula_weight	23271.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	D

MARYTGPLTKKSRRLGTDLVGNDKSFERRPYPPGVHGRGRTKDSEYSLQLREKQKARYAYGVLEKQFRRYYEEADRAQGKTGDVLLQILESRLDNVVYRAGLAATRRQARQMVSHGHFLVNGKKVNIPSYRVSTHDIIDVREKSKDLPPIVIARETFETRDVPAWLEVRPNKGRILVHQLPTRDQIVIDVNEQAIVELYSK

Entity 10 polymer

描述 description	Small ribosomal subunit protein uS5
分子量 formula_weight	22603.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	E

MSGTQRRGGGAGGERRGRDNRRGQNDRNRNQNEYLERVVAINRVAKVVQGGRRFSFTALVVVGDGEGSVGVGYGKAKEVPAAIAKAVEEAKKHFFKVPLVGRTITHPVIGEKAAGVVMLRPASPGTGVIAGGSARAVLECAGVHDVLAKSLGSSNAINVVHATVDALQQLEEPEEVARRRGKSVEDIAPAAMLRARKEADEAAAAARMEEKAGVN

Entity 11 polymer

描述 description	30S ribosomal protein S6
分子量 formula_weight	11270.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	F

MRKYEVMIIIDPTVEERQVDSLMEKYLKVITDEKGTVDNVDVWGKRRLAYDIQKKSEGIYVVVNATCEPATIQELDRLLAIDEKIMRTKVMRPEIH

Entity 12 polymer

描述 description	30S ribosomal protein S3
分子量 formula_weight	29728.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	G

MGQKINPHGFRLGVTTDHKTRWYAEKQYAELVGEDVKIREWLHKNLERAGLSSIEIERRSERVTIFLYAARPGIVIGRNGAEAERVRGELEKLTGKQIQLNILEVKSPETDAQLVAQGIAEQLAARVAFRRAMRKAQQSAMNAGALGIRIKCSGRLGGAEMSRSEGYREGRVPLHTLRADIDYGFFEARTTFGRIGVKVWIYKGDVTGTRAERAAQKAARQAAQGGRGGRGGNRRGRGDRPDRRGGRRRAEAAKQSAETPAPQTENAGA

Entity 13 polymer

描述 description	30S ribosomal protein S8
分子量 formula_weight	14677.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	H

MTMTDPIADMLTRLRNANQAYHDQTSMPHSKIKAGIAGILKSEGYIADYKVNEPKEGEVGKTLTLTLKYGENRERSIAGVRRISKPGLRVYAKSTALPKVLGGLGIAIISTSQGLLTDKQAHEKSVGGEVLAYVW

Entity 14 polymer

描述 description	30S ribosomal protein S7
分子量 formula_weight	17615.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	I

MPRKGPAPKRPVMVDPVYGSPLVSQLVSKILLDGKKTVAQNIVYTALEGCRAKNNTDPVQTLKRALDNIKPSLEVKSRRVGGATYQVPVEVKPARQTTLAMRWLVNFSRERREKTMAERLMNEILDASNGLGASVKRREDTHKMAEANRAFAHYRW

Entity 15 polymer

描述 description	30S ribosomal protein S9
分子量 formula_weight	18630.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	J

MTDTPTENLENTEVTPFTEGDREIAYRTDSNPTVAAGDSKRPAMIAPGAATGRRKEAIARVRITPGSGQWKINGRTLEDYFPNKVHQQIVTEPFATAGVEGAYDVIARIGGGGVTGQAGALRLGIARALNNVDPEASRPALKKAGMLTRDARVKERKKAGLKKARKAPQYSKR

Entity 16 polymer

描述 description	30S ribosomal protein S11
分子量 formula_weight	14194.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	K

MATAGHKGAPKTKVRRKEKKNVVAGQAHIKSTFNNTIIAITDPSGAVISWASAGTVGFKGSRKSTPFAAQMAAEAAGRRAMEHGMKRVDVFVKGPGSGRETAIRSLGAVGLEIGPISDVTPVPHNGCRPPKRRRV

Entity 17 polymer

描述 description	30S ribosomal protein S12
分子量 formula_weight	13666.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	L

MPTIQQLVRKGRTDKISKNKTPALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLSSGIEVTAYIPGVGHNLQEHSMVLVRGGRVKDLPGVRYKIVRGSLDTQGVKGRKQARSRYGAKKEK

Entity 18 polymer

描述 description	Small ribosomal subunit protein uS10
分子量 formula_weight	11750.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	M

MAGQKIRIRLRAYDHEVIDSSARKIVDTVTRTGAKVAGPVPLPTEKNVFCVIRSPHKYKDSREHFEMRTHKRLIDILEPTPKTVDSLMRLDLPAGVDIEIKLP

Entity 19 polymer

描述 description	30S ribosomal protein S13
分子量 formula_weight	14030.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	N

MARLIGVDLPRDKRLEVALTYIYGIGRTRATETLKATGISGDLRVHELTDDQLVALRDHIEANYHVEGDLRREVAADIRRKIEIGTYQGRRHRSGLPVRGQRTRTNARTRKGKRKAVAKKKAK

Entity 20 polymer

描述 description	30S ribosomal protein S15
分子量 formula_weight	10102.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	O

MDAAEKKKIIEEYATHPGDTGSPDVQVAILTKRIAELTEHLKVHKGDHHSRRGLMLMVGQRRRLLNYIAKNDIEHYRELIARLGLRR

Entity 21 polymer

描述 description	30S ribosomal protein S16
分子量 formula_weight	15980.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	P

MATKIRLKRLGKIRTPHYRVVVMDSRAKRDGRAIEEIGQYHPKADPSVIVIDSERVQYWLGVGAQPTEAVVALLKRTGDWQKFTGDTSPSGVKPQPERPNKDDLFNAALAEADEAPREAITKKSEGAAADEASESAAGDNSGEKAEA

Entity 22 polymer

描述 description	30S ribosomal protein S17
分子量 formula_weight	10475.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	Q

MSENTAERTTRRKVREGLVVSDKMNKTITVMVEDRVKHPLYGKVMTKSVRLKAHDENNEAGMGDRVRIMETRPLSATKRWRLVEIIEKAK

Entity 23 polymer

描述 description	30S ribosomal protein S18
分子量 formula_weight	8817.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	R

MAGPQRKSVNKKKVVPIKTVHIGAVDYKDTALLRKFISERGKIRARRVTGLSVQDQRKVAIAIKNARELALLPYASTAR

Entity 24 polymer

描述 description	30S ribosomal protein S14 type Z
分子量 formula_weight	6924.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	S

MAKTALKVKAARKPKFGVRAYTRCQRCGRPHSVYRKFGLCRICLREMAHAGQLPGVTKSSW

Entity 25 polymer

描述 description	30S ribosomal protein S20
分子量 formula_weight	9724.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	T

MPNIKSQIKRVKTNEKSRQRNKAVKSALRTYVRNFRRAAEAGDVEAATKAARVANRQLDKAASKGVIHKNQAANRKSAISKKLNSLAA

Entity 26 polymer

描述 description	30S ribosomal protein S19
分子量 formula_weight	10536.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	U

MPRSLKKGPFVDEHLAKKVTAQNEAGTHNVIKTWSRRSMVTPDMIGHTIGVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHVKDDKKARRR

Entity 27 polymer

描述 description	50S ribosomal protein bL37
分子量 formula_weight	2744.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	V

MGKTGRKRRARRKKGANHGKRPNA

Entity 28 polymer

描述 description	AURKAIP1/COX24 domain-containing protein
分子量 formula_weight	4120.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	X

MGSVIKKRRKRMAKKKHRKLLKRTRIQRRRAGK

Entity 29 polymer

描述 description	mRNA 32MF
分子量 formula_weight	7115.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	Y

CAAGGAGGUAAAAAUGUUUUAA

Entity 30 polymer

描述 description	23S rRNA
分子量 formula_weight	1002554.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	a

GCAAAGUUGUGUAGUGCGAUCGGUGGAUGCCUUGGCACCAAGAGCCGAUGAAGGACGUUGUGACCUGCGAUAAGCCCUGGGGAGUUGGUGAGCGAGCUGUGAUCCGGGGGUGUCCGAAUGGGGAAACCUGGAAUGUCCGGAGUAGUGUCCGGUGGCCCUGCCCUGAAUGUAUAGGGGUGUGGGUGGUAACGCGGGGAAGUGAAACAUCUUAGUACCCGUAGGAAGAGAAAACAAGUGUGAUUCCGUGAGUAGUGGCGAGCGAAAGCGGAGGAGGCUAAACCGUGUGUGUGUUCAAGCCGGCAGGUGUUGCAUGUGCGGGGUUGUGGGGGCCUUGUGGUUCUGCUGCCGCAGGAUUGGCCAGUGAGAAAUGUUGCGUGAAGGUGAAGCGUCUGGGAAGGCGUACCGGAGUGGGUGAGAGUCCUGUAACUGUAAGCGUGGCACUGGUGUGGGGUUGCCCCGAGUAGCGUGGGACUCGUGGAAUUUCGCGUGAAUCUGGCGGGACCACCCGUCAAGCCUAAAUACUCCUUGGUGACCGAUAGUGGAUGAGUACCGUGAGGGAAGGGUGAAAAGUACCCCGGGAGGGGAGUGAAAGAGUUCCUGAAACCGGUCGCAUGCAAGCCGUCAGAGCCUGUGUGGUGAUGGCGUGCCUUUUGAAGAAUGAGCCUGCGAGUUAGUGAUGCGUGGCGAGGUUAACCCGUGGUGGGGGAGUCGUAGCGAAAGCGAGUCCGAUAAGGGCGUGAGUCGCGUGUUCUAGACCCGAAGCGGUGUGAUCUAUCCAUGGCCAGGAUGAAGCGUCGGUAAGACGUCGUGGAGGUCCGAACCCACUUCAGUUGAAAAUGGAGGGGAUGAGUUGUGGAUAGGGGUGAAAGGCCAAUCAAACACCGUGAUAGCUGGUUCUCCCCGAAAUGCAUUUAGGUGCAGCGUUGCGUGGUUCUUGUUGGAGGUAGAGCACUGGAUGGUCUAGGGGGCUUAUCGGCUUACCGAAAUCAGCCAAACUCCGAAUGCUGGCAAGUGUAGCGUGGCAGUGAGACGGCGGGUGAUAAGCUUCGUCGUCGAGAGGGAAACAGCCCAGAUCAUCAGCUAAGGCCCCUAAGUGGUGACUCAGUGGGAAAGGAUGUGGAGUUGCGUAGACAACCAGGAGGUUGGCUUGGAAGCAGCCAUCCUUGAAAGAGUGCGUAAUAGCUCACUGGUCAAGUGAUUCCGCGCCGAUAAUGUAGCGGGGCUUAAGUUAUCCGCCGAAGCUGUGGCAACCUGUGUGGUUGGGUAGGGGAGCGUCGUGUCAGUGGUGAAGCUGCCGGGUGACUGUGUGGUGGAGUUGAUGCGAGUGAGAAUGCAGGCAUGAGUAGCGUGUGACGGGUGGGAAUCCCGUCCGCCGAUUAUCCAAGGGUUCCAGGGUCAAGUUUGUCUGCCCUGGGUGAGUCGGGUCCUAAGGCGAGGCCGACAGGCGUAGUCGAUGGGUAACCAGUUGAUAUUCUGGUACCGGCUUGUCACCGUCCGUGUCGAGGUGUGUGAUGCUAAGCAUGUGAGCUUGUCUUGGGAGUGUUUUUGAUGCUUCUGGGGUGGGUGAGUGUGUGAACCGAUCAUGUAGUAGGCAAGCUGCGGAGGGACGCAGUGAGGUAGCUCAUCCCCGGUGAUGGUUGUCCGGGGCUAAGUGUGUGGACUGUCUGGUAGGUAAAUCCGCUGGGCGUGAAGGUUGAGGCAUGAUGGGGAGCCCAUGGUUGUGGGUGAGUGAGUGAUCCUGUACUGUCGAGAAAAGCUUCGUGAGCGAGGUGGCGGGUCCGCCCGUACCCUAAACCGACACUGGUGGAUAGGUAGAGUAUACCGAGGCGAUCGAGUGAAUCGUGGUGAAGGAACUCGGCAAAAUGCCCCCGUAACUUUGGGAUAAGGGGGACCUGAGCUGUCGUGCACCCGUGCGGUGUGGUGGCGGUGAGGGGCGCAGAGUCCAGGGGGAAACGACUGUUUACCAAAAACACAGGUCCGUGCGAAGUCGUAAGACGAUGUAUACGGACUGACUCCUGCCCGGUGCUGGAAGGUUAAGGGGAACUGUGAGUGUAUGCGUAGCGGUGAACUUAAGCCCCAGUAAACGGCGGUGGUAACXAUAACCAUCCUAAGGUAGCGAAAUUCCUUGUCGGGUAAGUUCCGACCUGCACGAAUGGAGUAACGAUUUCCCUACUGUCUCCACCAUGAACUCGGUGAAAUUGCAUUACGAGUAAAGAUGCUCGUUACGCGCAGCAGGACGGAAAGACCCCGGGACCUUUACUAUAGUUUGGUAUUGGUGAUUGGGACGGUUUGUGUAGGAUAGGUGGGAGACGUUGAUGCGGCCACGCUAGUGGUGGUGGAGUCGUUGGUGAAAUACCACUCUGAUUGUUCUGGUUAUCUCACUGUGGACCGUGAUCCGGUUCAAGGACAGUGCCUGAUGGGUAGUUUGACUGGGGCGGUCGCCUCCUAAAGGGUAACGGAGGCGCCCAAAGGUUCCCUCAGCCUGGUUGGUAAUCAGGUGGUGAGUGUAAGUGCACAAGGGGGCUUGACUGUGAGACUGACAGGUCGAGCAGGGACGAAAGUCGGGACUAGUGAUCUGACGGUGGCUUGUGGAUGCGCCGUCACUCAACGGAUAAAAGGUACCCCGGGGAUAACAGGCUGAUCUUGCCCGAGCGCUCAUAGCGACGGCAUGGUUUGGCACCUCGAUGUCGGCUCGUCGCAUCCUGGGGCUGGAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCAUUAAAGCGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGCUGCGCGCGGAGGAAUCUUGAGAAGGGCUGUCUUUAGUACGAGAGGACCGAGACGGACUGACCUCUGGUGUGCCAGUUGUUCUGCCAAGAGCAUGGCUGGUUGGCUACGUCGGGUUGUGAUAACCGCUGAAAGCAUCUAAGCGGGAAGCACGCUUCAAGAUAAGGGUUCCCACAGGAGUGUUCCUGGUAAGGUCCCCGAGAGAUGAUCGGGUUGAUAGGCCAGACGUGGACGCAUCGUAAGGUGUGGAGCUGACUGGUACUAAUAGACCGAGGACUUUCAUUAACA

Entity 31 polymer

描述 description	5S rRNA
分子量 formula_weight	38770.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	b

UUUCCGGUGGCCAUAGUGGAAGGGAAACACCCGGUCCCAUUCCGAACCCGGUCGUUAAGCCUUCCAACGCUGAUGGUACUGCACGAGGGAUCGUGUGGGAGAGUAAGACGCUGCCGGAAU

Entity 32 polymer

描述 description	50S ribosomal protein L2
分子量 formula_weight	30309.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	c

MGIRKYKPTTPGRRGSSVSDFVELTRSTPEKSLLVAKPKTGGRNNTGRITTRHIGGGHKQAYRIIDFKRYDKDGVPAKVAHIEYDPNRTARIALLHYADGEKRYIIAPDGVGQGTVVVSGPEADIKPGNNLPLRNIPVGTTVHAVELRPGGGAKMGRSAGASVQLVAREGKYATVRLPSGEMRMVDIRCRATIGEVGNAEQININWGKAGRNRWKGIRPTVRGVVMNPIDHPHGGGEGRTSGGRHPVSPWGKPEGRTRNKKKASSRLIVRRRKSGKKR

Entity 33 polymer

描述 description	50S ribosomal protein L3
分子量 formula_weight	23553.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	d

MTNERTVKGVLGTKLGMTQLWDEHNRLVPVTVIQAGPCVVTQVRTPETDGYSAVQLGYGAVKAKNVTKPEAGHFEKAGVTPRRHLVELRTADASEYTLGQEIAADVFSESDFVDVTGTSKGKGTAGVMKRHGFGGLRATHGVHRKHRSPGSIGGCSTPGKVIKGLRMAGRMGVERVTVQNLQVHSVDAERGIMLVRGAVPGPKGSLLVVRSAAKKAAKNGDAA

Entity 34 polymer

描述 description	50S ribosomal protein L4
分子量 formula_weight	32342.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	e

MNETKTIDVLDVKGKKAGSAELPGDLFDVNTNIPLIHQVVVAQLAAARQGTHATKTRGQVSGGGKKPWRQKGTGRARQGSTRAPQWVGGGTVHGPQPRSYAQRTPKKMVGAALRGALSDMARDNRIFVVTSLVDGDKPSTKQAKAVLSGLAELRKVLVVLDRSDEIDWLSVRNLSEVHVLAADQLNTYDVVNARTIVFSQAGLDAFVGARSANTQALSAEPEVPETNVADQHPYGEDSFRGDNPPAGFDIKGNEDSMKFHEPSSPWYGRTIAEVWFRSAAAAEAAGFVNAVKSDSEKEDAK

Entity 35 polymer

描述 description	50S ribosomal protein L5
分子量 formula_weight	23901.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	f

MSTDAIAHEMPRLKKQYREQIRAAMQEEFGYRNPMLIPGLEKIVVNMGVGDAAHDSKVMDGAIRDITAITGQKPQVTKARKSIAQFKLREGQPIGCHVTLRGDRMWEFADRLLTLALPRIRDFRGLNSNQFDGKGNYTFGLSEQVMFLEIDQDKIDRIRGMDITFVTTAQTNEEGKALLKHLGFPFKAKDDPKKAKTKRGPAYYAKKKKK

Entity 36 polymer

描述 description	50S ribosomal protein L6
分子量 formula_weight	19868.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	g

MSRIGRLPIAVPSGVEVKLDGQYVEVKGPKGTLNFTVREPITVSKNDEGAILVERPDDERENRSLHGLTRTLINNMVIGVTEGYEKKLEIQGVGYRVLSKGPKQLEFNLGFSHPVIVDAPEGITFAVENPTKFSVQGIDKQVVGETAANIRKIRKPEPYKGKGVRYEGENVRRKVGKAGK

Entity 37 polymer

描述 description	50S ribosomal protein L13
分子量 formula_weight	16325.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	i

MTTYSPKAGEVQRKWYVIDAEDIVLGRLATTAANLLRGKHKPQYAPHIDTGDFVVVVNASKIALTGKKATDSLRYDHSGRPGGLRVTSIGEMLAKNPRRAVERAVWGMMPKNKLSRQQLKKLKVYGGPEHPHAAQNPQPYEITQIAQ

Entity 38 polymer

描述 description	50S ribosomal protein L14
分子量 formula_weight	13503.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	j

MIQQETRLKVADNTGAKELLCIRVLGGSKRRYAYLGDTIVCTVKDAIPGGNVKKGEVVKAVVVRTVKSHRRPDGSYIKFDENAAVLLKGDGEPRGTRIFGPIARELREKKFMRIVSLAPEVI

Entity 39 polymer

描述 description	50S ribosomal protein L15
分子量 formula_weight	15542.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	k

MAIELHDLKPAPGAHKAKTRVGRGEGSKGKTAGRGTKGTGARKNVPEFFAGGQMPIHMQAPKLGGFHNPFRTEYQVVNLDKVEALFPKGGKITVDDLVSVGAVRDNELVKVLGTGELTVKVDLVVDAWSKSAQEKIEKAGGSVTKR

Entity 40 polymer

描述 description	50S ribosomal protein L16
分子量 formula_weight	15700.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	l

MLIPRRVKYRKQHHPKRTGAAKGGTQLAFGDYGIQATEGGYLTNRQIEAARIAMTRYIKRGGKVWINVYPDRPMTKHPAESRMGSGKGTPEWWIANIKPGRVLFELSGVPEDVAREAMRLAIHKLPMKARFISREGGDN

Entity 41 polymer

描述 description	Large ribosomal subunit protein bL17
分子量 formula_weight	20058.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	m

MPKPTKGPRLGGSPAHERIILRNLASQLFEHGRVVTTVTKAKRVRPLAEKLINRAKTDTVANRRFVNRTITDRGIVHILFTEIGPRMEGRDGGYTRVTRIGIRKGDNAPMAVIEVISDKVAPKAPASAADAKAQINTATEAKDAEPEAGDAAVEHNAPAEDAAAQAPVADEQEAAEADEKAEEKPEA

Entity 42 polymer

描述 description	50S ribosomal protein L18
分子量 formula_weight	13727.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	n

MASTLTVRKSLSDRAKARARRQARGRKKIFGTVERPRMVVTRSSKHVFVQVIDDVAGNTLVSASTMEAELREMSGDKTAKAARVGTIIGERAKAAGITKVVFDKAGNQYHGRIAALADAAREAGLDF

Entity 43 polymer

描述 description	50S ribosomal protein L19
分子量 formula_weight	13106.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	o

MSNIIDEIDKASMRDDIPEFRPGDSVKVHVKVVEGSRTRVQVFSGIVISRTGGGVQESFTVRKLSFGTGVERTFPLHSPIIDKIEVDRHGAVRRAKLYYLRGRRGKAAKIKERGSAR

Entity 44 polymer

描述 description	50S ribosomal protein L20
分子量 formula_weight	13988.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	p

MARVKRSVNAKKKRREVLDQASGYRGQRSRLYRKAKEQTLHSATYSFRDRRAKKGDFRSLWIQRINAASRAQGMTYNRFINGLKNAGVEVDRKMLAELAVSDINAFNSLVEVAKASQPQNAAA

Entity 45 polymer

描述 description	Large ribosomal subunit protein bL21
分子量 formula_weight	11087.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	q

MYAIVRSGGRQHKVAVGDVVEIDKVADEAGSSIELTPLLVVDGESVTSDKDALGKVKVTAEVLGETKGPKIRILKYKNKTGYKKRQGHRQKYTQVKVTGIEG

Entity 46 polymer

描述 description	50S ribosomal protein L22
分子量 formula_weight	16729.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	r

MSKTERPSRRAALLGDRPGSYAIARHVRMSASKCRRVINLVRGMDAVDAVTMLKFQPQAAAEPIRKVIASAMANAEQTEGLRADDLYISQAFVDEGITMRRIRPRAKGSASRILKRSAHITVVVEPKEARQARKKAKSGRPAAAAKSETEKGA

Entity 47 polymer

描述 description	50S ribosomal protein L23
分子量 formula_weight	11349.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	s

MSELKIRDPRDIILAPVVSEKSYGLLDQNTYTFVVKPTANKTEIKIAIEQIFGVKVTSVNTMNRKGKVRRTRTGVGKRPDTKRAIVTVAEGDRIDIFTGPVA

Entity 48 polymer

描述 description	Large ribosomal subunit protein uL24
分子量 formula_weight	13514.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	t

MKSLKIKKGDRVKVIAGNDKGAIGEVLSVDPARERVVVEGVNIRKHHRRDMPTPQGGTTKGGIISSEAPIHVSNVQLVTKIDGKDVVTRVGYRRVDVTKRRPDGSEYAAQRSVRYLKKEEAK

Entity 49 polymer

描述 description	50S ribosomal protein L25
分子量 formula_weight	22349.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	u

MADIIHLKAEQRTEFGKGAARRIRRDDKVPAVMYGHDHDPIHVTLDGHATLLALRTENPLLSIEIEGQKPMLALPKDVQRDVLKGFVRHVDLLTVRRGEKVDVNVALRITGESAPGTIAMTEFNEIEVQADLLNIPEVIEIDVTGLEAGTTIYLGDLKLPEGTSLLGDAEDVAATVAFPETEPVEDEESAGEDAQGESEEKAAKE

Entity 50 polymer

描述 description	50S ribosomal protein L27
分子量 formula_weight	9540.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	v

MAHKKGASSSRNGRDSNAQRLGVKRFGGQLVNAGEIIVRQRGTHFHPGDGVGRGGDDTLFALRDGNVEFGTRRGRRVVNVTPVEAPVEA

Entity 51 polymer

描述 description	50S ribosomal protein L28
分子量 formula_weight	6953.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	w

MAAVCDICAKRPGFGHNVPWSKKKTNRRWSPNIQRVRVVENGTHKRMNVCTSCLKAGRVSR

Entity 52 polymer

描述 description	50S ribosomal protein L29
分子量 formula_weight	8899.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	x

MPKLSAAELRQLSGEELRNKVRELKEELFGLRFQSATGQLENTARLREVRKDIARVYTVLQERNLNIVDDPDSTKEA

Entity 53 polymer

描述 description	50S ribosomal protein L30
分子量 formula_weight	6932.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	y

MSKLKITQIKSGIATKPNHRETLRSLGLKRIGDTVIKEDRPEFRGMVRTVRHLVTMEEVD

Entity 54 polymer

描述 description	50S ribosomal protein L32
分子量 formula_weight	6991.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	z

MAVPKRKMSRSNTRHRRSQWKTVATKLVTCANPACGEKHLPHTACPSCGGYGPRGDRRQVVEA

Entity 55 non-polymer

描述 description	ZINC ION
分子量 formula_weight	65.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	6

Entity 56 non-polymer

描述 description	MAGNESIUM ION
分子量 formula_weight	24.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	301

Entity 57 non-polymer

描述 description	Sarecycline
分子量 formula_weight	487.5 kDa
来源方法 src_method	syn
拷贝数 entity_count	2

Entity 58 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	121

▶

7. 引用文献 (1)

▶

分辨率 resolution	2.50 Å
分辨率测定方法 resolution_method	—
颗粒数 num_particles	80548

fit	/app/data/saxs_computation/pj/9pj8/9pj8.fit
pddf	/app/data/pr_computation/pj/9pj8/9pj8.pr.out
profile	/app/data/saxs_computation/pj/9pj8/9pj8.dat

C. acnes 70S ribosome bound to Sarecycline

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

1. 结构基本信息 1. Structure Basics

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

4. 晶体学与实验 4. Crystallography & Experiment

冷冻电镜 EM 3D

5. 实体与聚合体信息 (58)

Entity 1 polymer

聚合体 Polymer

Entity 2 polymer

聚合体 Polymer

Entity 3 polymer

聚合体 Polymer

Entity 4 polymer

聚合体 Polymer

Entity 5 polymer

聚合体 Polymer

Entity 6 polymer

聚合体 Polymer

Entity 7 polymer

聚合体 Polymer

Entity 8 polymer

聚合体 Polymer

来源 Source

Entity 9 polymer

聚合体 Polymer

Entity 10 polymer

聚合体 Polymer

Entity 11 polymer

聚合体 Polymer

Entity 12 polymer

聚合体 Polymer

Entity 13 polymer

聚合体 Polymer

Entity 14 polymer

聚合体 Polymer

Entity 15 polymer

聚合体 Polymer

Entity 16 polymer

聚合体 Polymer

Entity 17 polymer

聚合体 Polymer

Entity 18 polymer

聚合体 Polymer

Entity 19 polymer

聚合体 Polymer

Entity 20 polymer

聚合体 Polymer

Entity 21 polymer

聚合体 Polymer

Entity 22 polymer

聚合体 Polymer

Entity 23 polymer

聚合体 Polymer

Entity 24 polymer

聚合体 Polymer

Entity 25 polymer

聚合体 Polymer

Entity 26 polymer

聚合体 Polymer

Entity 27 polymer

聚合体 Polymer

Entity 28 polymer

聚合体 Polymer

Entity 29 polymer

聚合体 Polymer

Entity 30 polymer

聚合体 Polymer

Entity 31 polymer

聚合体 Polymer

Entity 32 polymer

聚合体 Polymer

Entity 33 polymer

聚合体 Polymer

Entity 34 polymer

聚合体 Polymer

Entity 35 polymer

聚合体 Polymer