;Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905) ;

Method: ELECTRON MICROSCOPY D_max: 71.0 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9pln
deposition_date	2025-07-15
title	;Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905) ;
keywords	Receptor, Drug, Complex, GPCR, G-protein, scFv16, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	20.90 Å
rg_electron	19.94 Å
i0	25929300.00
molecular_weight	27810.0 kDa
excluded_volume	27918 Å³
envelope_volume	44879 Å³
shell_volume	19272 Å³
envelope_diameter	72.1 Å
shell_rg	26.09 Å
envelope_rg	20.37 Å
shape_rg	19.88 Å
total_rg	20.74 Å
total_atoms	2136
n_residues	266
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	71.0 Å
rg_real	20.89 Å
rg_real_error	0.51 Å
i0_real	2.5930e+07
i0_real_error	3.7440e+05
rg_reciprocal	20.89 Å
i0_reciprocal	25930000.0000
total_estimate	0.8728
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	24.7 Å
skewness	0.358
kurtosis	-0.280
angular_range	— – 0.3800 Å⁻¹
current_alpha	0.0000
highest_alpha	2348000.0000
n_real_points	70
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.801; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.983; Smooth: 0.957

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.800 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	2.80 Å
resolution_method	—
num_particles	323827

description	Alpha-2A adrenergic receptor
formula_weight	53643.9 kDa
src_method	man
entity_count	1

;Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905) ;

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Source

Entity 2 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

description	N-(5-methylnaphthalen-1-yl)pyridin-4-amine
formula_weight	234.3 kDa
src_method	syn
entity_count	1

fit	/app/data/saxs_computation/pl/9pln/9pln.fit
pddf	/app/data/pr_computation/pl/9pln/9pln.pr.out
profile	/app/data/saxs_computation/pl/9pln/9pln.dat

type	polypeptide(L)
strand_id	R
atom_count	2136