← Back to search

9rhg

FZD7 in complex with negative allosteric modulator C407

Method: ELECTRON MICROSCOPY D_max: 96.7 Å Quality: GOOD

SAXS Profile

P(r) Distribution

▼

1. Structure Basics

entry_id	9rhg
deposition_date	2025-06-09
title	FZD7 in complex with negative allosteric modulator C407
keywords	G protein-coupled receptor, Frizzled, negative allosteric modulator, small molecule, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	28.85 Å
rg_electron	27.94 Å
i0	181471000.00
molecular_weight	75836.0 kDa
excluded_volume	75730 Å³
envelope_volume	127450 Å³
shell_volume	37434 Å³
envelope_diameter	104.3 Å
shell_rg	35.85 Å
envelope_rg	28.09 Å
shape_rg	27.92 Å
total_rg	28.56 Å
total_atoms	5767
n_residues	694
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	96.7 Å
rg_real	28.80 Å
rg_real_error	0.66 Å
i0_real	1.8150e+08
i0_real_error	2.9040e+06
rg_reciprocal	28.83 Å
i0_reciprocal	181500000.0000
total_estimate	0.8833
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	35.2 Å
skewness	0.314
kurtosis	-0.290
angular_range	— – 0.2750 Å⁻¹
current_alpha	0.0000
highest_alpha	41840000.0000
n_real_points	56
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.843; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.984; Smooth: 0.965

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (3)

Entity 1 polymer

description	Frizzled-7
formula_weight	67460.9 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	B,A
atom_count	5767

MKTIIALSYIFCLVFADYKDDDDQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAVSRLEVLFQGPWSHPQFEKGGGSGGGSGGGSWSHPQFEK

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

Entity 2 non-polymer

description	CHOLESTEROL HEMISUCCINATE
formula_weight	486.7 kDa
src_method	syn
entity_count	4

Entity 3 non-polymer

description	ethyl 3-[2-[(2-fluorophenyl)amino]-2-oxidanylidene-ethyl]-5-methyl-4-oxidanylidene-thieno[2,3-d]pyrimidine-6-carboxylate
formula_weight	389.4 kDa
src_method	syn
entity_count	1

▶

6. Citations (1)

▶

length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.500 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	2.50 Å
resolution_method	—
num_particles	191045

fit	/app/data/saxs_computation/rh/9rhg/9rhg.fit
pddf	/app/data/pr_computation/rh/9rhg/9rhg.pr.out
profile	/app/data/saxs_computation/rh/9rhg/9rhg.dat

FZD7 in complex with negative allosteric modulator C407

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D