SAXSdb — 9rss

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1. Structure Basics

entry_id	9rss
deposition_date	2025-07-01
title	Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) with the Avo1 PH domain
keywords	cell growth, metabolism, SIGNALING PROTEIN; SIGNALING PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	78.17 Å
rg_electron	78.02 Å
i0	12300700000.00
molecular_weight	970800.0 kDa
excluded_volume	1227100 Å³
envelope_volume	1994500 Å³
shell_volume	212830 Å³
envelope_diameter	275.7 Å
shell_rg	79.22 Å
envelope_rg	75.38 Å
shape_rg	78.01 Å
total_rg	78.08 Å
total_atoms	68304
n_residues	8458
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	274.7 Å
rg_real	81.40 Å
rg_real_error	1.56 Å
i0_real	1.2300e+10
i0_real_error	2.4970e+08
rg_reciprocal	78.48 Å
i0_reciprocal	12310000000.0000
total_estimate	0.8991
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	96.2 Å
skewness	0.480
kurtosis	0.080
angular_range	— – 0.1000 Å⁻¹
current_alpha	1.1080
highest_alpha	918400000.0000
n_real_points	21
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.836; Stabil: 0.883; Sysdev: 1.000; Positv: 1.000; Valcen: 0.970; Smooth: 0.584

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4. Crystallography & Experiment

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5. Entities & Polymer Info (7)

Entity 1 polymer

description	Target of rapamycin complex subunit LST8
formula_weight	34077.9 kDa
src_method	nat
entity_count	2

Polymer

type	polypeptide(L)
strand_id	B,I
atom_count	68304

MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV

Entity 2 polymer

description	Serine/threonine-protein kinase TOR2
formula_weight	281915.4 kDa
ec_number	2.7.1.67,2.7.11.1
src_method	nat
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,F

MNKYINKYTTPPNLLSLRQRAEGKHRTRKKLTHKSHSHDDEMSTTSNTDSNHNGPNDSGRVITGSAGHIGKISFVDSELDTTFSTLNLIFDKLKSDVPQERASGANELSTTLTSLAREVSAEQFQRFSNSLNNKIFELIHGFTSSEKIGGILAVDTLISFYLSTEELPNQTSRLANYLRVLIPSSDIEVMRLAANTLGRLTVPGGTLTSDFVEFEVRTCIDWLTLTADNNSSSSKLEYRRHAALLIIKALADNSPYLLYPYVNSILDNIWVPLRDAKLIIRLDAAVALGKCLTIIQDRDPALGKQWFQRLFQGCTHGLSLNTNDSVHATLLVFRELLSLKAPYLRDKYDDIYKSTMKYKEYKFDVIRREVYAILPLLAAFDPAIFTKKYLDRIMVHYLRYLKNIDMNAANNSDKPFILVSIGDIAFEVGSSISPYMTLILDNIREGLRTKFKVRKQFEKDLFYCIGKLACALGPAFAKHLNKDLLNLMLNCPMSDHMQETLMILNEKIPSLESTVNSRILNLLSISLSGEKFIQSNQYDFNNQFSIEKARKSRNQSFMKKTGESNDDITDAQILIQCFKMLQLIHHQYSLTEFVRLITISYIEHEDSSVRKLAALTSCDLFIKDDICKQTSVHALHSVSEVLSKLLMIAITDPVAEIRLEILQHLGSNFDPQLAQPDNLRLLFMALNDEIFGIQLEAIKIIGRLSSVNPAYVVPSLRKTLLELLTQLKFSNMPKKKEESATLLCTLINSSDEVAKPYIDPILDVILPKCQDASSAVASTALKVLGELSVVGGKEMTRYLKELMPLIINTFQDQSNSFKRDAALTTLGQLAASSGYVVGPLLDYPELLGILINILKTENNPHIRRGTVRLIGILGALDPYKHREIEVTSNSKSSVEQNAPSIDIALLMQGVSPSNDEYYPTVVIHNLMKILNDPSLSIHHTAAIQAIMHIFQNLGLRCVSFLDQIIPGIILVMRSCPPSQLDFYFQQLGSLISIVKQHIRPHVEKIYGVIREFFPIIKLQITIISVIESISKALEGEFKRFVPETLTFFLDILENDQSNKRIVPIRILKSLVTFGPNLEDYSHLIMPIVVRMTEYSAGSLKKISIITLGRLAKNINLSEMSSRIVQALVRILNNGDRELTKATMNTLSLLLLQLGTDFVVFVPVINKALLRNRIQHSVYDQLVNKLLNNECLPTNIIFDKENEVPERKNYEDEMQVTKLPVNQNILKNAWYCSQQKTKEDWQEWIRRLSIQLLKESPSACLRSCSSLVSVYYPLARELFNASFSSCWVELQTSYQEDLIQALCKALSSSENPPEIYQMLLNLVEFMEHDDKPLPIPIHTLGKYAQKCHAFAKALHYKEVEFLEEPKNSTIEALISINNQLHQTDSAIGILKHAQQHNELQLKETWYEKLQRWEDALAAYNEKEAAGEDSVEVMMGKLRSLYALGEWEELSKLASEKWGTAKPEVKKAMAPLAAGAAWGLEQWDEIAQYTSVMKSQSPDKEFYDAILCLHRNNFKKAEVHIFNARDLLVTELSALVNESYNRAYNVVVRAQIIAELEEIIKYKKLPQNSDKRLTMRETWNTRLLGCQKNIDVWQRILRVRSLVIKPKEDAQVRIKFANLCRKSGRMALAKKVLNTLLEETDDPDHPNTAKASPPVVYAQLKYLWATGLQDEALKQLINFTSRMAHDLGLDPNNMIAQSVPQQSKRVPRHVEDYTKLLARCFLKQGEWRVCLQPKWRLSNPDSILGSYLLATHFDNTWYKAWHNWALANFEVISMLTSVSKKKQEGSDASSVTDINEFDNGMIGVNTFDAKEVHYSSNLIHRHVIPAIKGFFHSISLSESSSLQDALRLLTLWFTFGGIPEATQAMHEGFNLIQIGTWLEVLPQLISRIHQPNQIVSRSLLSLLSDLGKAHPQALVYPLMVAIKSESLSRQKAALSIIEKMRIHSPVLVDQAELVSHELIRMAVLWHEQWYEGLDDASRQFFGEHNTEKMFAALEPLYEMLKRGPETLREISFQNSFGRDLNDAYEWLMNYKKSKDVSNLNQAWDIYYNVFRKIGKQLPQLQTLELQHVSPKLLSAHDLELAVPGTRASGGKPIVKISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQMAPDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAFAFDPLINWGFDLPTKKIEEETGIQLPVMNANELLSNGAITEEEVQRVENEHKNAIRNARAMLVLKRITDKLTGNDIRRFNDLDVPEQVDKLIQQATSVENLCQHYIGWCPFW

Entity 3 polymer

description	Target of rapamycin complex 2 subunit TSC11
formula_weight	164580.6 kDa
src_method	nat
entity_count	2

Polymer

type	polypeptide(L)
strand_id	C,J

MSIPHSAKQSSPLSSRRRSVTNTTPLLTPRHSRDNSSTQISSAKNITSSSPSTITNESSKRNKQNLVLSTSFISTKRLENSAPSPTSPLMARRTRSTMTKALLNLKAEINNQYQELARLRKKKDDIEHLRDSTISDIYSGSYSTNHLQKHSMRIRANTQLREIDNSIKRVEKHIFDLKQQFDKKRQRSLTTSSSIKADVGSIRNDDGQNNDSEELGDHDSLTDQVTLDDEYLTTPTSGTERNSQQNLNRNSTVNSRNNENHSTLSIPDLDGSNKVNLTGDTEKDLGDLENENQIFTSTTTEAATWLVSDYMQSFQEKNVNPDFIAQKANGLVTLLKEHSEIRKDLVLTSFMSSIQNLLLNGNKLIAASAYRVCRYLINSSIFIDELLELRLDAFIIISLAKDNSFQIEREQALKMVRRFIEYNNGVTQGIMQAIISCVEKPEDSLRHMALETLLELCFVAPEMVKECRGMRVIEGFLQDYTSFSLASVILDTILQLMATHKTRQHFLEDFNVSVLTTVFSDTNTKSNVNVEKMQNASTLISITLNSYNGFMLFSNNNFKPLKQLVSFFQIPICAQYLIDIFLDVLKIKPLPYKPRGRHSHSFKPIPSQYYKECMSVNQRLALIVLILENSEFVPHLLELLNEEDRDDHLVAKGRYLLTEYFNLRMNLVDKKYTSVSKPIYKENFTYVNETFQFKKIAYKMNRNRNTIGMSGIDYAQNIKSFSKNIKENTLLREVDDFRFRRMVYDSKVLQTKDFTRWNWNIINELLEGPLLNKKQLEELVKSTKFIRRLLVFYRPLRLRFSNVNKGAKLSQKYVQVGCQFFKTLTATPEGMKILMDDTKIIPQLASLMFRAMEGNISGNIFNKNKLREKIIFGYFKFIGILTQSKNGVHILTRWNFFTVIYKMFQFESKLGLEFLLLTIPELDLKYSSHCRVIIGKALVVANEKVRIEATKHIGDKLKELLSTKESDLKLKANKVKLQQFKMEMLTRQLYDLSPSVVAVADQALYECIVAGNGSEELGTSFRMFLNQMVFIRSPILFELLSRPYGFQLLNEINFVKEERDSWLSKKNIEYVHIVEEFLKKNESINAKSLTFQQKSRLPLHFYESLTKTEDGILLLSQTGDLVTFMNVIKKYVNGNNMATVENAKEILDLKAALWCVGFIGSTELGIGLLDNYSLVEDIIEVAYNASVTSVRFTAFYVLGLISMTREGCEILDEMGWNCCVSVQDEPIGIALPNRLDRFLSYNEHKWSAFGEYSDEMIVFNKSDGDLIEKCLPIEFDLDKLLKEKDTAENPLNEKIITNKYDNDITSQTITVSGENSSLFANEGLSSPYVTQYRNDDDSIESKVLHIVSQLGNHILSNHAVKEITEINNKYGPRLFENEKMFFKVFNMMSKYRFKPHVRKFLCGLFINNRALENVIRHDNKRDKRPANFTR

Entity 4 polymer

description	Target of rapamycin complex 2 subunit AVO2
formula_weight	47206.5 kDa
src_method	nat
entity_count	2

Polymer

type	polypeptide(L)
strand_id	D,K

MLKEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKATFEDGPSPVLSMNSPYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITNPVFNPRKPTLSTDSFSSSSNSSSRLRVNSINVKTPVGVSPKKELVSESVRHSATPTSPHNNIALINRYLLPNKSNDNVRGDSQTATINDDGGGGNGGDATIGMGLRKDPDDENENKYKIKVNNGEPRRRVSLLNIPISKLRNSNNTRAED

Entity 5 polymer

description	Target of rapamycin complex 2 subunit BIT61
formula_weight	60908.7 kDa
src_method	nat
entity_count	2

Polymer

type	polypeptide(L)
strand_id	E,L

MTAEDILLRERTSTTTQRPVNSEQYLNVQLATAPVKNFQTTSEISRQTLVDTSNDDVYSIKNLKGSRNPISPSVSNVGFQSIFHTVDHPRSKVSVASNHSLRSNDNASAATSKSGSSQIGESHSVDTVECSNNLSKKLSSDAISITQKSLHSTPSGRYMKGKASGFFNRRNRAHTTISSDPASFLTDSSTLHNSSHSFRNVIKNFFQNKSHRHIGQDAIEPAIPNSLSKFLHSSYGRHKSPSQFIHTNAGQLVDSGTSVYSLNVNPSGVNPNTIVEDPLSGTDPASPNPVSMLHDLLRNLPSLEANYKHFNSQELTTLTNNIWNIFCSNVAELFRTQRIWKLRAKIENFNEVLEFYCILKTDPRVTHSGMNRIISDLKEFLVSSLYNLENQIVFNYSNEDTINNALKRLGVIWRIFYQEVYYDLAAVLLPLDQSIREDGNSTVLKSGNESRTHINGNYSIGFLLLMCFRDSIVLPCYENFVNSNDGISKSFQLYIFNQEEESNVTETDKLTLLQCFGILSTIQSNDRNQRIIEELLAGIRMSI

Entity 6 polymer

description	Target of rapamycin complex 2 subunit AVO1
formula_weight	131565.5 kDa
src_method	nat
entity_count	2

Polymer

type	polypeptide(L)
strand_id	G,M

MDTVTVLNELRAQFLRVCPEKDQMKRIIKPYIPVDEFNTEQCLDSSIRELYMNSDGVSLLPELESPPVSKDFMENYASLGKMRIMRENEGQKGKANQNLIGAEKTERDEEETRNLQDKSAKNTLIVEENGTLRYNPLNSSASNSLLNDDDHTSGKHHKTSSKEDSYLNSSMEMQKKSSKRSSLPFVRIFKSRRDHSNTSGNKNVMNTTNTRAKSSTLHPPGARHNKKGSKFDMNFDFDENLEEEDDDDDDDEEGDDIHSQFFQLDDDFDAKGSGASPAHKGINGMSNNKNNTYTNNRNSISILDDRESSNGNIGSASRLKSHFPTSQKGKIFLTDNKNDGQKSDSLNANKGIHGDGSSASGNGSVSRDGLTETESNNISDMESYINEKDLDDLNFDTVTSNINKTVSDLGGHESTNDGTAVMNRDSKDSRSNSNEFNAQNRDRITPGSSYGKSLLGSEYSEERYSNNDSSTMESGEMSLDSDMQTNTIPSHSIPMSMQKYGIYHGDDDSTLNNVFDKAVLTMNSSRHPKERRDTVISGKEPTSLTSSNRKFSVSSNLTSTRSPLLRGHGRTSSTASSEHMKAPKVSDSVLHRARKSTLTLKQDHSQPSVPSSVHKSSKEGNILIEKTTDYLVSKPKASQLSNMFNKKKKRTNTNSVDVLEYFSFVCGDKVPNYESMGLEIYIQASKKYKRNSFTTKVRKSSTIFEVIGFALFLYSTEKKPDNFEEDGLTVEDISNPNNFSLKIVDEDGEPFEDNFGKLDRKSTIQSISDSEVVLCKVDDAEKSQNEIETPLPFETGGGLMDASTLDANSSHDTTDGTINQLSFYKPIIGNEDDIDKTNGSKIIDVTVYLYPNVNPKFNYTTISVLVTSHINDILVKYCKMKNMDPNEYALKVLGKNYILDLNDTVLRLDGINKVELISKKDARELHLEKMKPDLKKPVLPTIQSNDLTPLTLEPLNSYLKADAGGAVAAIPENTKVTSKAKKISTKYKLGLAKQHSSSSVASGSVSTAGGLANGNGFFKNKNSSKSSLHGTLQFHNINRSQSTMEHTPDTPNGVGDNFQDLFTGAYHKYKVWRRQQMSFINKHERTLAIDGDYIYIVPPEGRIHWHDNVKTKSLHISQVVLVKKSKRVPEHFKIFVRREGQDDIKRYYFEAVSGQECTEIVTRLQNLLSAYRMNHK

Entity 7 non-polymer

description	INOSITOL HEXAKISPHOSPHATE
formula_weight	660.0 kDa
src_method	syn
entity_count	2

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.010 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.01 Å
resolution_method	—
num_particles	51729

fit	/app/data/saxs_computation/rs/9rss/9rss.fit
pddf	/app/data/pr_computation/rs/9rss/9rss.pr.out
profile	/app/data/saxs_computation/rs/9rss/9rss.dat

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) with the Avo1 PH domain

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (7)

Entity 1 polymer

Polymer

Entity 2 polymer

Polymer

Entity 3 polymer

Polymer

Entity 4 polymer

Polymer

Entity 5 polymer

Polymer

Entity 6 polymer

Polymer

Entity 7 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)