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9svw

Human fumarylacetoacetate hydrolase (FAH) in complex with S2.6

Method: X-RAY DIFFRACTION D_max: 87.3 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9svw
deposition_date	2025-10-03
title	Human fumarylacetoacetate hydrolase (FAH) in complex with S2.6
keywords	Human fumarylacetoacetate hydrolase (FAH), S2.6, chaperones, HYDROLASE; HYDROLASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	28.53 Å
rg_electron	27.62 Å
i0	264579000.00
molecular_weight	87758.0 kDa
excluded_volume	85391 Å³
envelope_volume	138020 Å³
shell_volume	39885 Å³
envelope_diameter	91.3 Å
shell_rg	36.36 Å
envelope_rg	28.00 Å
shape_rg	27.62 Å
total_rg	28.20 Å
total_atoms	6608
n_residues	838
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	87.3 Å
rg_real	28.39 Å
rg_real_error	0.54 Å
i0_real	2.6460e+08
i0_real_error	4.0370e+06
rg_reciprocal	28.43 Å
i0_reciprocal	264600000.0000
total_estimate	0.9025
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	34.3 Å
skewness	0.214
kurtosis	-0.466
angular_range	— – 0.2800 Å⁻¹
current_alpha	0.0000
highest_alpha	56520000.0000
n_real_points	57
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.946; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.995; Smooth: 0.895

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4. Crystallography & Experiment

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5. Entities & Polymer Info (8)

Entity 1 polymer

description	Fumarylacetoacetase
formula_weight	46906.7 kDa
ec_number	3.7.1.2
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	B,A
atom_count	6796

GRHMMSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	GLYCEROL
formula_weight	92.1 kDa
src_method	syn
entity_count	2

Entity 3 non-polymer

description	4-[(4-methylphenyl)sulfamoyl]benzoic acid
formula_weight	291.3 kDa
src_method	syn
entity_count	2

Entity 4 non-polymer

description	DIMETHYL SULFOXIDE
formula_weight	78.1 kDa
src_method	syn
entity_count	2

Entity 5 non-polymer

description	CALCIUM ION
formula_weight	40.1 kDa
src_method	nat
entity_count	8

Entity 6 non-polymer

description	SODIUM ION
formula_weight	23.0 kDa
src_method	nat
entity_count	8

Entity 7 non-polymer

description	CHLORIDE ION
formula_weight	35.5 kDa
src_method	syn
entity_count	2

Entity 8 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	188

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6. Citations (1)

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length_a	66.879 Å
length_b	104.989 Å
length_c	75.616 Å
angle_alpha	90.00 °
angle_beta	97.44 °
angle_gamma	90.00 °
z_pdb	4

space_group	P 1 21 1
int_tables_number	4
crystal_system	monoclinic

resolution	2.150 Å
resolution_low	43.000 Å
r_factor	0.1989
r_work	0.1976
r_free	0.2315

fit	/app/data/saxs_computation/sv/9svw/9svw.fit
pddf	/app/data/pr_computation/sv/9svw/9svw.pr.out
profile	/app/data/saxs_computation/sv/9svw/9svw.dat