← Back to search

9t27

Human fumarylacetoacetate hydrolase (FAH) in complex with S1.1

Method: X-RAY DIFFRACTION D_max: 88.5 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

▼

1. Structure Basics

entry_id	9t27
deposition_date	2025-10-22
title	Human fumarylacetoacetate hydrolase (FAH) in complex with S1.1
keywords	Chemical chaperone, Human fumarylacetoacetate hydrolase, tyrosinemia, HYDROLASE; HYDROLASE
method	X-RAY DIFFRACTION

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	28.55 Å
rg_electron	27.58 Å
i0	267050000.00
molecular_weight	88383.0 kDa
excluded_volume	86102 Å³
envelope_volume	138140 Å³
shell_volume	39952 Å³
envelope_diameter	88.7 Å
shell_rg	36.33 Å
envelope_rg	27.95 Å
shape_rg	27.60 Å
total_rg	28.14 Å
total_atoms	6640
n_residues	840
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	88.5 Å
rg_real	28.40 Å
rg_real_error	0.46 Å
i0_real	2.6700e+08
i0_real_error	3.7220e+06
rg_reciprocal	28.45 Å
i0_reciprocal	267100000.0000
total_estimate	0.9020
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	34.8 Å
skewness	0.216
kurtosis	-0.468
angular_range	— – 0.2800 Å⁻¹
current_alpha	0.0000
highest_alpha	55030000.0000
n_real_points	57
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.933; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.996; Smooth: 0.925

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (7)

Entity 1 polymer

description	Fumarylacetoacetase
formula_weight	46906.7 kDa
ec_number	3.7.1.2
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	E,F
atom_count	6973

GRHMMSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	2-[4-(3-methanoyl-2,5-dimethyl-pyrrol-1-yl)phenoxy]ethanoic acid
formula_weight	273.3 kDa
src_method	syn
entity_count	2

Entity 3 non-polymer

description	GLYCEROL
formula_weight	92.1 kDa
src_method	syn
entity_count	5

Entity 4 non-polymer

description	CHLORIDE ION
formula_weight	35.5 kDa
src_method	syn
entity_count	2

Entity 5 non-polymer

description	CALCIUM ION
formula_weight	40.1 kDa
src_method	syn
entity_count	15

Entity 6 non-polymer

description	SODIUM ION
formula_weight	23.0 kDa
src_method	syn
entity_count	9

Entity 7 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	333

▶

6. Citations (1)

▶

length_a	66.930 Å
length_b	104.991 Å
length_c	75.931 Å
angle_alpha	90.00 °
angle_beta	98.04 °
angle_gamma	90.00 °
z_pdb	4

space_group	P 1 21 1
int_tables_number	4
crystal_system	—

resolution	1.789 Å
resolution_low	61.000 Å
r_factor	—
r_work	0.1819
r_free	0.2078

fit	/app/data/saxs_computation/t2/9t27/9t27.fit
pddf	/app/data/pr_computation/t2/9t27/9t27.pr.out
profile	/app/data/saxs_computation/t2/9t27/9t27.dat