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9syv

Symmetric hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis

Method: ELECTRON MICROSCOPY D_max: 129.7 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9syv
deposition_date	2025-10-14
title	Symmetric hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis
keywords	RND superfamily, MmpL family, siderophore export, drug resistance, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	43.24 Å
rg_electron	42.56 Å
i0	775062000.00
molecular_weight	243850.0 kDa
excluded_volume	311610 Å³
envelope_volume	421960 Å³
shell_volume	80962 Å³
envelope_diameter	129.0 Å
shell_rg	49.91 Å
envelope_rg	41.13 Å
shape_rg	42.56 Å
total_rg	42.94 Å
total_atoms	34992
n_residues	2274
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	129.7 Å
rg_real	42.91 Å
rg_real_error	0.84 Å
i0_real	7.7510e+08
i0_real_error	1.4070e+07
rg_reciprocal	43.24 Å
i0_reciprocal	775300000.0000
total_estimate	0.8937
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	63.1 Å
skewness	-0.064
kurtosis	-0.614
angular_range	— – 0.1850 Å⁻¹
current_alpha	0.0000
highest_alpha	163900000.0000
n_real_points	38
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.909; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.966; Smooth: 0.920

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

Entity 1 polymer

description	Siderophore exporter MmpL4
formula_weight	105317.1 kDa
mutation	C39S, C319S, C335S, C393S, S434C, C780S
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	A,B,C
atom_count	34992

VSTKFANDSNTNARPEKPFIARMIHAFAVPIILGWLAVSVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTPAPPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFIIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFSLSFARMPYFQTLGIPSAVGMLVAVAVALTLGPAVLHVGSRFGLFDPKRLLKVRGWRRVGTVVVRWPLPVLVATSAIALVGLLALPGYKTSYNDRDYLPDFIPANQGYAAADRHFCQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEGIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAISSLSLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLGA

Source

organism	Mycobacterium tuberculosis
ncbi_taxonomy_id	1773
host_organism	Escherichia coli MC1061

Entity 2 polymer

description	Siderophore export accessory protein MmpS4
formula_weight	15493.6 kDa
mutation	D39C
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	D,E,F

MSLMRTWIPLVILVVVIVGGFTVHRIRGFFGSENRPSYSCTNLENSKPFNPKHLTYEIFGPPGTVADISYFDVNSEPQRVDGAVLPWSLHITTNDAAVMGNIVAQGNSDSIGCRITVDGKVRAERVSNEVNAYTYCLVKSA

Source

organism	Mycobacterium tuberculosis
ncbi_taxonomy_id	1773
host_organism	Escherichia coli MC1061

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.890 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	2.89 Å
resolution_method	—
num_particles	76903

fit	/app/data/saxs_computation/sy/9syv/9syv.fit
pddf	/app/data/pr_computation/sy/9syv/9syv.pr.out
profile	/app/data/saxs_computation/sy/9syv/9syv.dat

Symmetric hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)