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9tpw

cryo-ET structure of mTOR complex 2 on a PIP2-containing membrane

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Serine/threonine-protein kinase mTOR

Homo sapiens

UniProt P42345

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Target of rapamycin complex subunit LST8 × 2 （Q9BVC4） Rapamycin-insensitive companion of mTOR × 2 （Q6R327） Target of rapamycin complex 2 subunit MAPKAP1 × 2 （Q9BPZ7） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1aue 1aue 2gaq 2npu 3jbz 5wbh 5wbh 5wbh 5wbh

9 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1fap 1nsg 2fap 2rse 3fap 4drh 4drh 4dri 4drj 4fap 4jsn 4jsn

76 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MTOR_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 42–2590； UniProt 1–2549 Author chain B； PDBConstruct 42–2590； UniProt 1–2549

Target of rapamycin complex subunit LST8

Homo sapiens

UniProt Q9BVC4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Serine/threonine-protein kinase mTOR × 2 （P42345） Rapamycin-insensitive companion of mTOR × 2 （Q6R327） Target of rapamycin complex 2 subunit MAPKAP1 × 2 （Q9BPZ7） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4jsn 4jsn 4jsp 4jsp 4jsv 4jsv 4jsx 4jsx 4jt5 4jt5 4jt6 4jt6

53 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name LST8_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–326； UniProt 1–326 Author chain D； PDBConstruct 1–326； UniProt 1–326

Rapamycin-insensitive companion of mTOR

Homo sapiens

UniProt Q6R327

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Serine/threonine-protein kinase mTOR × 2 （P42345） Target of rapamycin complex subunit LST8 × 2 （Q9BVC4） Target of rapamycin complex 2 subunit MAPKAP1 × 2 （Q9BPZ7） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5zcs 6zwm 6zwo 7pe7 7pe8 7pe9 7tzo 9t7j 9t92 9t93 9t94 9tds

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RICTR_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain E； PDBConstruct 27–1734； UniProt 1–1708 Author chain F； PDBConstruct 27–1734； UniProt 1–1708

Target of rapamycin complex 2 subunit MAPKAP1

Homo sapiens

UniProt Q9BPZ7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Serine/threonine-protein kinase mTOR × 2 （P42345） Target of rapamycin complex subunit LST8 × 2 （Q9BVC4） Rapamycin-insensitive companion of mTOR × 2 （Q6R327） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
3voq

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5zcs 6zwm 6zwo 7lc1 7lc1 7lc2 7lc2 7pe7 7pe8 7pe9 7tzo 7vv8

24 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name SIN1_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain G； PDBConstruct 2–522； UniProt 2–522 Author chain H； PDBConstruct 2–522； UniProt 2–522

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9tpw
Deposition date deposition_date2025-12-18
Structure title titlecryo-ET structure of mTOR complex 2 on a PIP2-containing membrane
Keywords keywordsKinase, Complex, Signaling protein, TRANSFERASE; TRANSFERASE
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9tpw__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9tpw__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9tpw__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）74.87 Å
Rg (electron density)74.28 Å
Total Rg74.38 Å
Atom count61288
Residues7634
Excluded volume1096900 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9tpw__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)