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9tu0

Crystal structure of human ERK1 in complex with the KIM1 motif of the T. gondii protein GRA24

Method: X-RAY DIFFRACTION D_max: 72.5 Å Quality: REASONABLE

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9tu0
deposition_date	2026-01-08
last_revision	2026-02-25
title	Crystal structure of human ERK1 in complex with the KIM1 motif of the T. gondii protein GRA24
keywords	phosphoryl transfer, kinase, MAPK, GRA24, toxoplasma, TRANSFERASE; TRANSFERASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	22.67 Å
rg_electron	21.43 Å
i0	26886300.00
molecular_weight	40212.0 kDa
excluded_volume	50632 Å³
envelope_volume	60870 Å³
shell_volume	23681 Å³
envelope_diameter	74.6 Å
shell_rg	28.28 Å
envelope_rg	21.57 Å
shape_rg	21.40 Å
total_rg	22.42 Å
total_atoms	2824
n_residues	342
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	72.5 Å
rg_real	22.59 Å
rg_real_error	0.40 Å
i0_real	2.6890e+07
i0_real_error	3.2380e+05
rg_reciprocal	22.61 Å
i0_reciprocal	26890000.0000
total_estimate	0.7257
solution_quality	REASONABLE a REASONABLE solution
n_peaks	2
r_peak_primary	26.4 Å
skewness	0.238
kurtosis	-0.406
angular_range	— – 0.3500 Å⁻¹
current_alpha	0.0000
highest_alpha	5698000.0000
n_real_points	67
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.904; Stabil: 1.000; Sysdev: 0.242; Positv: 1.000; Valcen: 0.998; Smooth: 0.991

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Mitogen-activated protein kinase 3
formula_weight	43270.5 kDa
ec_number	2.7.11.24
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	2894

MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	;Escherichia coli 'BL21-Gold(DE3)pLysS AG' ;

Entity 2 polymer

description	Putative transmembrane protein
formula_weight	57402.1 kDa
src_method	syn
entity_count	1

Polymer

type	polypeptide(L)
strand_id	D

MLQMARYTANICAVSICSLVLVVALSVGILPTPDWKDRVKMGGTESGPFVLQVCASDPLLHDPKERESGSDSTRGYHGGSSSGGSSSRQGTTVRSDAGLSSQSSQSSASTSAKTSENHRQGPAFLTSVFRKGETPALDWVPYGTLEGAKWHPGQQKSKRRSSATTSRRQGASHSGNPGQLPAPRGGLQPTTTLSGTGGQPRTDSTDEGAAATSVIPNRSGYPQPVPYLIHPVGFLSGDYRSLGMLGLVPSVYTATSVQHMVGQPGTIIPLVLLPGKQEPEGLVSTGTLSDSLVYEPLGVVNLGTEMPNQGSTSQSGAVASRKRPAGGANGPDKRRRVEPAGLTESRLRPEPSLSSLTEKGSTAFSTRPPSSRSALEGLTQETVEMLLDTPSYPISSVVSSPPPARKSSTSSSQHLEARLSQSRGPPRTRPPFNPWSTKTGLLERRGVSELPPLYIPRPLASGYRNPADSRKHSTVTPQTTPPARKSSTSSSQHLEARLSQSRGPPRTRPPFNPWSTKTGLLERRGVSELPPLRIVKPPTKGN

Entity 3 non-polymer

description	SULFATE ION
formula_weight	96.1 kDa
src_method	syn
entity_count	3

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	70

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6. Citations (1)

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length_a	59.817 Å
length_b	59.817 Å
length_c	388.698 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	120.00 °
z_pdb	12

space_group	P 65 2 2
int_tables_number	179
crystal_system	hexagonal

resolution	2.170 Å
resolution_low	19.930 Å
r_factor	0.2399
r_work	0.2370
r_free	0.2920

fit	/app/data/saxs_computation/tu/9tu0/9tu0.fit
pddf	/app/data/pr_computation/tu/9tu0/9tu0.pr.out
profile	/app/data/saxs_computation/tu/9tu0/9tu0.dat

Crystal structure of human ERK1 in complex with the KIM1 motif of the T. gondii protein GRA24

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (4)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Entity 3 non-polymer

Entity 4 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)