Structure of human URAT1 bound with sulfinpyrazone

Method: ELECTRON MICROSCOPY D_max: 82.4 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9us8
deposition_date	2025-05-01
title	Structure of human URAT1 bound with sulfinpyrazone
keywords	SLC22, urate, gout, sulfinpyrazone, TRANSPORT PROTEIN; TRANSPORT PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	23.39 Å
rg_electron	22.80 Å
i0	59764700.00
molecular_weight	41682.0 kDa
excluded_volume	41003 Å³
envelope_volume	67173 Å³
shell_volume	25000 Å³
envelope_diameter	83.9 Å
shell_rg	29.55 Å
envelope_rg	23.41 Å
shape_rg	22.82 Å
total_rg	23.38 Å
total_atoms	3161
n_residues	414
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	82.4 Å
rg_real	23.47 Å
rg_real_error	0.66 Å
i0_real	5.9760e+07
i0_real_error	8.6730e+05
rg_reciprocal	23.45 Å
i0_reciprocal	59760000.0000
total_estimate	0.8472
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	26.6 Å
skewness	0.519
kurtosis	-0.037
angular_range	— – 0.3400 Å⁻¹
current_alpha	0.0000
highest_alpha	8503000.0000
n_real_points	66
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.702; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.926; Smooth: 0.976

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.32 Å
resolution_method	—
num_particles	196309

description	Solute carrier family 22 member 12
formula_weight	59546.6 kDa
src_method	man
entity_count	1

type	polypeptide(L)
strand_id	A
atom_count	3161

Structure of human URAT1 bound with sulfinpyrazone

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Source

Entity 2 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

description	Sulfinpyrazone
formula_weight	404.5 kDa
src_method	syn
entity_count	1

fit	/app/data/saxs_computation/us/9us8/9us8.fit
pddf	/app/data/pr_computation/us/9us8/9us8.pr.out
profile	/app/data/saxs_computation/us/9us8/9us8.dat