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9uwi

Cryo-EM structure of human V1aR bound with atosiban at a resolution of 2.8 angstrom

Method: ELECTRON MICROSCOPY D_max: 86.9 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9uwi
deposition_date	2025-05-12
title	Cryo-EM structure of human V1aR bound with atosiban at a resolution of 2.8 angstrom
keywords	GPCR, small molecule, antagonist, nanobody, SIGNALING PROTEIN; SIGNALING PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	28.39 Å
rg_electron	27.41 Å
i0	56491800.00
molecular_weight	65175.0 kDa
excluded_volume	84213 Å³
envelope_volume	98394 Å³
shell_volume	29396 Å³
envelope_diameter	90.2 Å
shell_rg	34.87 Å
envelope_rg	27.81 Å
shape_rg	27.40 Å
total_rg	28.26 Å
total_atoms	9282
n_residues	550
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	86.9 Å
rg_real	28.33 Å
rg_real_error	0.54 Å
i0_real	5.6490e+07
i0_real_error	8.6410e+05
rg_reciprocal	28.35 Å
i0_reciprocal	56490000.0000
total_estimate	0.9074
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	3
r_peak_primary	40.4 Å
skewness	0.170
kurtosis	-0.659
angular_range	— – 0.2800 Å⁻¹
current_alpha	0.0000
highest_alpha	14110000.0000
n_real_points	57
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.966; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.987; Smooth: 0.908

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Vasopressin V1a receptor
formula_weight	43695.1 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	9282

EALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNCCCKPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	Atosiban
formula_weight	995.2 kDa
src_method	syn
entity_count	2

Polymer

type	polypeptide(L)
strand_id	C,D

XXITNCPAGX

Entity 3 non-polymer

description	CHOLESTEROL
formula_weight	386.7 kDa
src_method	syn
entity_count	4

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.800 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	2.80 Å
resolution_method	—
num_particles	340153

fit	/app/data/saxs_computation/uw/9uwi/9uwi.fit
pddf	/app/data/pr_computation/uw/9uwi/9uwi.pr.out
profile	/app/data/saxs_computation/uw/9uwi/9uwi.dat

Cryo-EM structure of human V1aR bound with atosiban at a resolution of 2.8 angstrom

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Entity 3 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)