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9uww

Cryo-EM structure of the human P2X2 receptor in the apo closed state

Method: ELECTRON MICROSCOPY D_max: 120.1 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9uww
deposition_date	2025-05-13
title	Cryo-EM structure of the human P2X2 receptor in the apo closed state
keywords	P2X ion channal, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	35.02 Å
rg_electron	35.04 Å
i0	184159000.00
molecular_weight	112540.0 kDa
excluded_volume	142370 Å³
envelope_volume	193920 Å³
shell_volume	47813 Å³
envelope_diameter	123.9 Å
shell_rg	39.82 Å
envelope_rg	35.64 Å
shape_rg	34.93 Å
total_rg	35.76 Å
total_atoms	7924
n_residues	987
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	120.1 Å
rg_real	35.18 Å
rg_real_error	1.28 Å
i0_real	1.8420e+08
i0_real_error	3.0370e+06
rg_reciprocal	35.08 Å
i0_reciprocal	184100000.0000
total_estimate	0.8451
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	40.0 Å
skewness	0.581
kurtosis	0.048
angular_range	— – 0.2250 Å⁻¹
current_alpha	0.0000
highest_alpha	27380000.0000
n_real_points	46
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.716; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 0.986; Smooth: 0.850

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	P2X purinoceptor 2
formula_weight	51815.0 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	A,B,C
atom_count	7924

MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 non-polymer

description	2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	221.2 kDa
src_method	syn
entity_count	6

Entity 3 non-polymer

description	1,2-DIOCTANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL)
formula_weight	497.5 kDa
src_method	syn
entity_count	3

Entity 4 non-polymer

description	SODIUM ION
formula_weight	23.0 kDa
src_method	syn
entity_count	1

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6. Citations (1)

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resolution	2.19 Å
resolution_method	—
num_particles	285888

fit	/app/data/saxs_computation/uw/9uww/9uww.fit
pddf	/app/data/pr_computation/uw/9uww/9uww.pr.out
profile	/app/data/saxs_computation/uw/9uww/9uww.dat