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9ux2

Cryo-EM structure of the human P2X2/3 heteromer receptor - class 2 (2:1)

Method: ELECTRON MICROSCOPY D_max: 109.1 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9ux2
deposition_date	2025-05-13
title	Cryo-EM structure of the human P2X2/3 heteromer receptor - class 2 (2:1)
keywords	P2X ion channal, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	33.03 Å
rg_electron	32.91 Å
i0	181414000.00
molecular_weight	108700.0 kDa
excluded_volume	136580 Å³
envelope_volume	186720 Å³
shell_volume	47968 Å³
envelope_diameter	117.3 Å
shell_rg	39.08 Å
envelope_rg	33.15 Å
shape_rg	32.86 Å
total_rg	33.58 Å
total_atoms	7640
n_residues	953
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	109.1 Å
rg_real	33.05 Å
rg_real_error	0.66 Å
i0_real	1.8140e+08
i0_real_error	2.4770e+06
rg_reciprocal	33.04 Å
i0_reciprocal	181400000.0000
total_estimate	0.8645
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	38.6 Å
skewness	0.449
kurtosis	0.011
angular_range	— – 0.2400 Å⁻¹
current_alpha	0.0000
highest_alpha	26560000.0000
n_real_points	49
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.809; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.807

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	P2X purinoceptor 3
formula_weight	40900.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	7640

MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNET

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	P2X purinoceptor 2
formula_weight	51815.0 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	B,C

MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 non-polymer

description	2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	221.2 kDa
src_method	syn
entity_count	7

Entity 4 non-polymer

description	ADENOSINE-5'-TRIPHOSPHATE
formula_weight	507.2 kDa
src_method	syn
entity_count	3

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.73 Å
resolution_method	—
num_particles	119692

fit	/app/data/saxs_computation/ux/9ux2/9ux2.fit
pddf	/app/data/pr_computation/ux/9ux2/9ux2.pr.out
profile	/app/data/saxs_computation/ux/9ux2/9ux2.dat

Cryo-EM structure of the human P2X2/3 heteromer receptor - class 2 (2:1)

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (4)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 non-polymer

Entity 4 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)