Structural insights into IL-31 signaling inhibition by a neutralization antibody

entry_id	9vp0
deposition_date	2025-07-02
title	Structural insights into IL-31 signaling inhibition by a neutralization antibody
keywords	cytokine; signaling pathway; interleukin, CYTOKINE/IMMUNE SYSTEM, CYTOKINE-IMMUNE SYSTEM complex; CYTOKINE/IMMUNE SYSTEM
method	X-RAY DIFFRACTION

rg_guinier	29.78 Å
rg_electron	29.69 Å
i0	55302300.00
molecular_weight	59276.0 kDa
excluded_volume	74483 ų
envelope_volume	95284 ų
shell_volume	28814 ų
envelope_diameter	110.8 Å
shell_rg	34.54 Å
envelope_rg	29.74 Å
shape_rg	29.66 Å
total_rg	30.23 Å
total_atoms	4174
n_residues	537
n_harmonics	20
q_range	— – 0.5000 Å−1
n_points	101
shell_type	directional
solvent_density	0.3340 e/ų
contrast_shell	0.0300 e/ų
crysol_version	4.1.3

dmax	105.8 Å
rg_real	30.05 Å
rg_real_error	1.30 Å
i0_real	5.5300e+07
i0_real_error	1.0370e+06
rg_reciprocal	29.93 Å
i0_reciprocal	55300000.0000
total_estimate	0.8370
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	29.9 Å
skewness	0.588
kurtosis	-0.081
angular_range	— – 0.2650 Å−1
current_alpha	0.0000
highest_alpha	9996000.0000
n_real_points	54
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.720; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 0.759; Smooth: 0.962

Unit Cell

length_a	42.190 Å
length_b	100.814 Å
length_c	128.639 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	4

Symmetry

space_group	P 21 21 21
int_tables_number	19
crystal_system	orthorhombic

Refinement

resolution	2.100 Å
resolution_low	39.460 Å
r_factor	0.1929
r_work	0.1908
r_free	0.2335

Diffraction

temperature

100.0 K

Files (7)

• pr_distribution /app/data/pr_computation/vp/9vp0/pr_distribution.json
• pr_output /app/data/pr_computation/vp/9vp0/9vp0.pr.out
• pr_plot /app/data/visualization/pr_computation/vp/9vp0/9vp0_pr_distribution.png
• saxs_curve_dat /app/data/saxs_computation/vp/9vp0/9vp0.dat
• saxs_fit /app/data/saxs_computation/vp/9vp0/9vp0.fit
• saxs_log /app/data/saxs_computation/vp/9vp0/9vp0.log
• saxs_plot /app/data/visualization/saxs_computation/vp/9vp0/9vp0_saxs_profile.png

Curves (3)

fit	/app/data/saxs_computation/vp/9vp0/9vp0.fit
pddf	/app/data/pr_computation/vp/9vp0/9vp0.pr.out
profile	/app/data/saxs_computation/vp/9vp0/9vp0.dat