← Back to search

9z2h

Crystal structure of A10 Fab in complex with the EGFR peptide

Method: X-RAY DIFFRACTION D_max: 92.8 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

▼

1. Structure Basics

entry_id	9z2h
deposition_date	2025-11-05
last_revision	2026-04-08
title	Crystal structure of A10 Fab in complex with the EGFR peptide
keywords	EGFRvIII, epidermal growth factor receptor variant III, IMMUNE SYSTEM; IMMUNE SYSTEM
method	X-RAY DIFFRACTION

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	30.85 Å
rg_electron	29.70 Å
i0	152648000.00
molecular_weight	96872.0 kDa
excluded_volume	120980 Å³
envelope_volume	156430 Å³
shell_volume	43095 Å³
envelope_diameter	96.3 Å
shell_rg	37.80 Å
envelope_rg	29.19 Å
shape_rg	29.68 Å
total_rg	30.55 Å
total_atoms	13499
n_residues	900
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	92.8 Å
rg_real	30.62 Å
rg_real_error	0.60 Å
i0_real	1.5260e+08
i0_real_error	2.3470e+06
rg_reciprocal	30.72 Å
i0_reciprocal	152700000.0000
total_estimate	0.9056
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	1
r_peak_primary	41.9 Å
skewness	0.043
kurtosis	-0.538
angular_range	— – 0.2550 Å⁻¹
current_alpha	0.0000
highest_alpha	18340000.0000
n_real_points	52
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.942; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.983; Smooth: 0.959

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (5)

Entity 1 polymer

description	Epidermal growth factor receptor
formula_weight	2823.1 kDa
ec_number	2.7.10.1
src_method	syn
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,E
atom_count	13673

ACGADSYEMEEDGVRKCKHHHHHH

Entity 2 polymer

description	Fab heavy chain of the A10 antibody
formula_weight	26156.9 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	H,HH

QVTLKESGPVLVKPTETLTLTCTVSGFSLTNYGIHWLRQPPGKALEWLGMMWRGGGTDYNAAFISRLTITKDTSKSQVVFTMTNMDPVDTATYYCARKGVGMGLGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Mus musculus

Entity 3 polymer

description	Fab light chain of the A10 antibody
formula_weight	23264.8 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	L,LL

DIQMTQSPSSVSASVGDRVTITCLASQTIGTWVAWYQQKPGKSPQLLIYGATNLADGVPSRFSGSGSGTKFTLTISSLQPEDFATYYCQQLYSNPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Mus musculus

Entity 4 non-polymer

description	ACETATE ION
formula_weight	59.0 kDa
src_method	syn
entity_count	5

Entity 5 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	174

▶

6. Citations (1)

▶

length_a	129.617 Å
length_b	129.617 Å
length_c	144.898 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	120.00 °
z_pdb	12

space_group	P 32 2 1
int_tables_number	154
crystal_system	trigonal

resolution	2.450 Å
resolution_low	33.250 Å
r_factor	0.1920
r_work	0.1904
r_free	0.2227

fit	/app/data/saxs_computation/z2/9z2h/9z2h.fit
pddf	/app/data/pr_computation/z2/9z2h/9z2h.pr.out
profile	/app/data/saxs_computation/z2/9z2h/9z2h.dat

Crystal structure of A10 Fab in complex with the EGFR peptide

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (5)

Entity 1 polymer

Polymer

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 non-polymer

Entity 5 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)