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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：K9N7C7 New Search
12PDB entries
17Biological assembly
36chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4WUR The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin Deposited 2014-11-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1482–1801（320 aa） Fragment：UNP residues 1482-1801
Mutation：C111S IPA ISOPROPYL ALCOHOL × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.8；291 K；22% w/v PEG 4000, 15% v/v 2-propanol, 0.1M tri-sodium citrate pH 4.8 and 10% glycerol
Resolution 3.16 Å R-free 0.252
8PPL MERS-CoV Nsp1 bound to the human 43S pre-initiation complex Deposited 2023-07-07 Assembly 1 Protein–RNA Heteromer；Protein × 50 PDB declaration: 52-meric（52） Consistent with all polymers
Chain Aj 2–193（192 aa）
Not recorded ZN ZINC ION × 4 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 116 MET METHIONINE × 1 UNX UNKNOWN LIGAND × 129 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 2.65 Å
9INM Crystal structure of MERS main protease in complex with Bofutrelvir Deposited 2024-07-08 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3248–3548（301 aa）
Chain D 3248–3548（301 aa）
Not recorded FHR ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.2M Sodium formate, 0.1M BICINE pH8.5 20% PEG5000
Resolution 2.34 Å R-free 0.275
9INM Crystal structure of MERS main protease in complex with Bofutrelvir Deposited 2024-07-08 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 3248–3548（301 aa）
Chain C 3248–3548（301 aa）
Not recorded FHR ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.2M Sodium formate, 0.1M BICINE pH8.5 20% PEG5000
Resolution 2.34 Å R-free 0.275
9PAC Crystal structure of MERS-CoV 3CLpro with ALG-097608 (Inhibitor 1) Deposited 2025-06-25 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 3248–3553（306 aa）
Chain D 3248–3553（306 aa）
Not recorded A1CHF (1R,2R,3S,6S,7S)-4-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-10,10-difluoro-N-{(1E,2R)-1-imino-3-[(3R)-2-oxo-3,4-dihydro-2H-pyrrol-3-yl]propan-2-yl}-4-azatricyclo[5.2.1.0~2,6~]decane-3-carboxamide (non-preferred name) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2M NaCl, Sodium/Potassium Phosphate 6.2, and 18% PEG1000
Resolution 2.28 Å R-free 0.269
9PAC Crystal structure of MERS-CoV 3CLpro with ALG-097608 (Inhibitor 1) Deposited 2025-06-25 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3248–3553（306 aa）
Chain B 3248–3553（306 aa）
Not recorded A1CHF (1R,2R,3S,6S,7S)-4-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-10,10-difluoro-N-{(1E,2R)-1-imino-3-[(3R)-2-oxo-3,4-dihydro-2H-pyrrol-3-yl]propan-2-yl}-4-azatricyclo[5.2.1.0~2,6~]decane-3-carboxamide (non-preferred name) × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2M NaCl, Sodium/Potassium Phosphate 6.2, and 18% PEG1000
Resolution 2.28 Å R-free 0.269
9PAK Crystal structure of MERS-CoV 3CLpro with ALG-097655 (Inhibitor 2) Deposited 2025-06-25 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3248–3553（306 aa）
Chain B 3248–3553（306 aa）
Not recorded A1CHJ (1R,2S,3S,6R,7S)-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-[(2S)-4,4,4-trifluoro-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-4-azatricyclo[5.2.1.0~2,6~]dec-8-ene-3-carboxamide (non-preferred name) × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2M NaCl, Sodium/Potassium Phosphate 6.2, and 18% PEG1000
Resolution 1.86 Å R-free 0.239
9PAK Crystal structure of MERS-CoV 3CLpro with ALG-097655 (Inhibitor 2) Deposited 2025-06-25 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 3248–3553（306 aa）
Chain D 3248–3553（306 aa）
Not recorded A1CHJ (1R,2S,3S,6R,7S)-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-[(2S)-4,4,4-trifluoro-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-4-azatricyclo[5.2.1.0~2,6~]dec-8-ene-3-carboxamide (non-preferred name) × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2M NaCl, Sodium/Potassium Phosphate 6.2, and 18% PEG1000
Resolution 1.86 Å R-free 0.239
9XG7 The crystal structure of MERS-CoV Main protease in complex with inhibitor FD2-21 Deposited 2025-10-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3248–3551（304 aa）
Chain B 3248–3551（304 aa）
Not recorded A1EZ7 7-(5-azanylpyridin-3-yl)-2-(2-chlorophenyl)-5,7-diazaspiro[3.4]octane-6,8-dione × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289.15 K；0.05 M Magnesium chloride hexahydrate, 0.1 M HEPES pH 7.5, 30% v/v Polyethylene glycol monomethyl ether 550
Resolution 2.53 Å R-free 0.298
9XG7 The crystal structure of MERS-CoV Main protease in complex with inhibitor FD2-21 Deposited 2025-10-29 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 3248–3551（304 aa）
Chain D 3248–3551（304 aa）
Not recorded A1EZ7 7-(5-azanylpyridin-3-yl)-2-(2-chlorophenyl)-5,7-diazaspiro[3.4]octane-6,8-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289.15 K；0.05 M Magnesium chloride hexahydrate, 0.1 M HEPES pH 7.5, 30% v/v Polyethylene glycol monomethyl ether 550
Resolution 2.53 Å R-free 0.298
9Y8W MERS Mpro with EGT710 Deposited 2025-09-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3248–3553（306 aa）
Chain C 3248–3553（306 aa）
Not recorded A1CBU (4S)-4-(iminomethyl)-3-(isoquinolin-4-yl)-1-[6-(trifluoromethyl)pyridin-3-yl]imidazolidin-2-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1M Hepes pH 7.5, 8% Ethylene Glycol, 10% Peg 8000
Resolution 3.04 Å R-free 0.278
9Y8W MERS Mpro with EGT710 Deposited 2025-09-11 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 3248–3553（306 aa）
Chain D 3248–3553（306 aa）
Not recorded A1CBU (4S)-4-(iminomethyl)-3-(isoquinolin-4-yl)-1-[6-(trifluoromethyl)pyridin-3-yl]imidazolidin-2-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.1M Hepes pH 7.5, 8% Ethylene Glycol, 10% Peg 8000
Resolution 3.04 Å R-free 0.278
9YCK Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P15 RNA, monomeric form Deposited 2025-09-19 Assembly 1 Protein–RNA Homooligomer；Protein × 2 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 4238–4377（140 aa）
Chain B 5909–6432（524 aa）
Mutation：E191A ZN ZINC ION × 5 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9YCL Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P15 RNA, dimeric form Deposited 2025-09-19 Assembly 1 Protein–RNA Homooligomer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers
Chain A 4238–4377（140 aa）
Chain B 5909–6432（524 aa）
Chain D 4238–4377（140 aa）
Chain E 5909–6432（524 aa）
Mutation：E191A Mutation：E191A ZN ZINC ION × 10 MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
9YCM Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P14-U RNA Deposited 2025-09-19 Assembly 1 Protein–RNA Homooligomer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers
Chain A 4238–4377（140 aa）
Chain B 5909–6432（524 aa）
Chain D 4238–4377（140 aa）
Chain E 5909–6432（524 aa）
Mutation：E191A Mutation：E191A ZN ZINC ION × 10 MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.94 Å
9YCN Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P14-A RNA Deposited 2025-09-19 Assembly 1 Protein–RNA Homooligomer；Protein × 2 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 4238–4377（140 aa）
Chain B 5909–6432（524 aa）
Not recorded ZN ZINC ION × 5 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
9YCO Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P14-G RNA Deposited 2025-09-19 Assembly 1 Protein–RNA Homooligomer；Protein × 2 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 4238–4377（140 aa）
Chain B 5909–6432（524 aa）
Not recorded ZN ZINC ION × 5 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.