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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：O75084 New Search
12PDB entries
18Biological assembly
26chain/assembly records
Main Difference Dimensions in This Set
Different construct Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5T44 Crystal structure of Frizzled 7 CRD Deposited 2016-08-29 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 31–168（138 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.9；277 K；0.1M MES at pH6.9, 12% 1-propanol, 10% PEG 500MME
Resolution 1.99 Å R-free 0.252
5T44 Crystal structure of Frizzled 7 CRD Deposited 2016-08-29 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 31–168（138 aa）
Chain B 31–168（138 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.9；277 K；0.1M MES at pH6.9, 12% 1-propanol, 10% PEG 500MME
Resolution 1.99 Å R-free 0.252
5T44 Crystal structure of Frizzled 7 CRD Deposited 2016-08-29 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 31–168（138 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.9；277 K；0.1M MES at pH6.9, 12% 1-propanol, 10% PEG 500MME
Resolution 1.99 Å R-free 0.252
5URV Crystal structure of Frizzled 7 CRD in complex with C24 fatty acid Deposited 2017-02-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 30–168（139 aa）
Chain B 30–168（139 aa）
Not recorded NER (15E)-TETRACOS-15-ENOIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SO4 SULFATE ION × 8 1PG 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；0.1M MES sodium salt pH 6.5, 2.0M Ammonium sulfate, 5%(w/v) PEG 400
Resolution 2.20 Å R-free 0.210
5WBS Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21 Deposited 2017-06-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 30–178（149 aa）
Chain B 30–178（149 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；1-propanol 14% (v/v; cat. no. 09158; Fluka), 9% PEG5000 MME (cat. no. HR-2-615; Hampton Research), and 0.1 M MES at pH 6.9 (cat. no. HR2-243; Hampton Research)
Resolution 2.88 Å R-free 0.244
5WBS Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21 Deposited 2017-06-29 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 30–178（149 aa）
Chain D 30–178（149 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；1-propanol 14% (v/v; cat. no. 09158; Fluka), 9% PEG5000 MME (cat. no. HR-2-615; Hampton Research), and 0.1 M MES at pH 6.9 (cat. no. HR2-243; Hampton Research)
Resolution 2.88 Å R-free 0.244
5WBS Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21 Deposited 2017-06-29 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 30–178（149 aa）
Chain F 30–178（149 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；1-propanol 14% (v/v; cat. no. 09158; Fluka), 9% PEG5000 MME (cat. no. HR-2-615; Hampton Research), and 0.1 M MES at pH 6.9 (cat. no. HR2-243; Hampton Research)
Resolution 2.88 Å R-free 0.244
5WBS Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21 Deposited 2017-06-29 Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 30–178（149 aa）
Chain H 30–178（149 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；1-propanol 14% (v/v; cat. no. 09158; Fluka), 9% PEG5000 MME (cat. no. HR-2-615; Hampton Research), and 0.1 M MES at pH 6.9 (cat. no. HR2-243; Hampton Research)
Resolution 2.88 Å R-free 0.244
6NE2 Designed repeat protein in complex with Fz7 Deposited 2018-12-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 46–163（118 aa）
Not recorded ACT ACETATE ION × 9 SO4 SULFATE ION × 10 EDO 1,2-ETHANEDIOL × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；0.1 M Sodium Acetate: HCl, pH 4.5, 2 M Ammonium Sulfate
Resolution 1.30 Å R-free 0.184
6NE4 Designed repeat protein specifically in complex with Fz7CRD Deposited 2018-12-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 46–163（118 aa）
Not recorded SO4 SULFATE ION × 14 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；0.2 M Na2HPO4, citric acid, pH 4.2 and 2M Ammonium sulfate
Resolution 1.65 Å R-free 0.186
6O3A Crystal structure of Frizzled 7 CRD in complex with F7.B Fab Deposited 2019-02-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 42–179（138 aa）
Not recorded CXS 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID × 1 EDO 1,2-ETHANEDIOL × 6 NA SODIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 10；293 K；0.1 M CAPS, pH 10.5, 20% (w/v) PEG 3350, 0.2 M NaCl
Resolution 2.10 Å R-free 0.242
6O3B Crystal structure of Frizzled 7 CRD in complex with F6 Fab Deposited 2019-02-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 42–179（138 aa）
Not recorded GOL GLYCEROL × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；293 K；0.2 M Na2HPO4, 20% (w/v) PEG 3350
Resolution 2.50 Å R-free 0.283
6O3B Crystal structure of Frizzled 7 CRD in complex with F6 Fab Deposited 2019-02-26 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain H 42–179（138 aa）
Not recorded GOL GLYCEROL × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；293 K；0.2 M Na2HPO4, 20% (w/v) PEG 3350
Resolution 2.50 Å R-free 0.283
8QEO cryo-EM structure complex of Frizzled-7 and Clostridioides difficile toxin B Deposited 2023-09-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 33–574（542 aa）
Not recorded ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；100 mM TRIS-HCl pH 7.5 200 mM NaCl 0.002% LMNG 0.0002% CHS 0.0002% GDN
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.26 Å
8YY8 Fzd7 -Gs complex Deposited 2024-04-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 38–574（537 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.22 Å
9EPO High resolution structure of FZD7 in inactive conformation Deposited 2024-03-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 33–574（542 aa）
Chain D 33–574（542 aa）
Not recorded Y01 CHOLESTEROL HEMISUCCINATE × 4 PLM PALMITIC ACID × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 1.90 Å
9EW2 High resolution structure of FZD7 in complex with miniGs protein Deposited 2024-04-03 Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 38–574（537 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9RHG FZD7 in complex with negative allosteric modulator C407 Deposited 2025-06-09 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 33–574（542 aa）
Chain B 33–574（542 aa）
Not recorded Y01 CHOLESTEROL HEMISUCCINATE × 4 A1JGQ ethyl 3-[2-[(2-fluorophenyl)amino]-2-oxidanylidene-ethyl]-5-methyl-4-oxidanylidene-thieno[2,3-d]pyrimidine-6-carboxylate × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.