Current Protein Identity：O75473
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 4BSR Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P22121 crystal form Deposited 2013-06-11 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
22–543（522 aa）
Fragment：EXTRACELLULAR LRR DOMAIN, RESIDUES 22-543
Chain B
22–543（522 aa）
Fragment：EXTRACELLULAR LRR DOMAIN, RESIDUES 22-543
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 3.20 Å R-free 0.258 |
| 4BSS Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P21 crystal form Deposited 2013-06-11 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
22–543（522 aa）
Fragment：EXTRACELLULAR LRR DOMAIN, RESIDUES 22-543
Chain B
22–543（522 aa）
Fragment：EXTRACELLULAR LRR DOMAIN, RESIDUES 22-543
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 3.20 Å R-free 0.290 |
| 4BSS Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P21 crystal form Deposited 2013-06-11 | Assembly 2 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain E
22–543（522 aa）
Fragment：EXTRACELLULAR LRR DOMAIN, RESIDUES 22-543
Chain F
22–543（522 aa）
Fragment：EXTRACELLULAR LRR DOMAIN, RESIDUES 22-543
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 3.20 Å R-free 0.290 |
| 4BST Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P6122 crystal form Deposited 2013-06-11 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
22–543（522 aa）
Fragment：EXTRACELLULAR LRR DOMAIN, RESIDUES 22-543
Chain B
22–543（522 aa）
Fragment：EXTRACELLULAR LRR DOMAIN, RESIDUES 22-543
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 4.30 Å R-free 0.268 |
| 4BSU Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in C2 crystal form Deposited 2013-06-11 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain E
22–543（522 aa）
Chain F
22–543（522 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 3.20 Å R-free 0.287 |
| 4BSU Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in C2 crystal form Deposited 2013-06-11 | Assembly 2 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
22–543（522 aa）
Chain B
22–543（522 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 3.20 Å R-free 0.287 |
| 4KNG Crystal structure of human LGR5-RSPO1-RNF43 Deposited 2013-05-09 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–557（526 aa）
Fragment：extracellular domain
Chain B
32–557（526 aa）
Fragment：extracellular domain
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NI NICKEL (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；10% PEG4000, 0.2M ammonium sulfate, 7% Sucrose and 0.1 M TRIS pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.50 Å R-free 0.276 |
| 4UFR Structure of the ectodomain of LGR5 in complex with R-spondin-2 (Fu1Fu2) Deposited 2015-03-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
32–487（456 aa）
Fragment：ECTODOMAIN, RESIDUES 32-487 AND RESIDUES 538-544
Chain A
538–544（7 aa）
Fragment：ECTODOMAIN, RESIDUES 32-487 AND RESIDUES 538-544
Chain C
32–487（456 aa）
Fragment：ECTODOMAIN, RESIDUES 32-487 AND RESIDUES 538-544
Chain C
538–544（7 aa）
Fragment：ECTODOMAIN, RESIDUES 32-487 AND RESIDUES 538-544
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.5；25 %W/V PEG3350, 0.200 M LITHIUM SULPHATE, 0.100 M BIS-TRIS PH 5.5
|
Resolution 2.20 Å R-free 0.262 |
| 4UFS Low resolution structure R-spondin-2 (Fu1Fu2) in complex with the ectodomains of LGR5 and ZNRF3 Deposited 2015-03-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
32–487（456 aa）
Fragment：ECTODOMAIN, RESIDUES 32-487 AND RESIDUES 538-544
Chain A
538–544（7 aa）
Fragment：ECTODOMAIN, RESIDUES 32-487 AND RESIDUES 538-544
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6；0.100 M AMMONIUM ACETATE, 0.600 M SODIUM CHLORIDE, 0.050 M MES PH 6.0, 0.005 M MAGNESIUM SULPHATE
|
Resolution 4.80 Å R-free 0.313 |