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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P00451 New Search
26PDB entries
30Biological assembly
46chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
12JP Structural determination of lipid-bound Factor VIII Deposited 2026-04-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 20–2351（2332 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.46 Å
12JV Structural determination of lipid-bound Factor VIII Deposited 2026-04-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 20–2351（2332 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.56 Å
1CFG MEMBRANE-BINDING PEPTIDE FROM THE C2 DOMAIN OF FACTOR VIII FORMS AN AMPHIPATHIC STRUCTURE AS DETERMINED BY NMR SPECTROSCOPY Deposited 1994-11-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2322–2343（22 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
1D7P Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A Deposited 1999-10-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain M 2190–2348（159 aa） Fragment：C2-DOMAIN
Mutation：S2296C SO4 SULFATE ION × 2 CYS CYSTEINE × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；AMMONIUM SULFATE, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 298.0K
Resolution 1.50 Å R-free 0.215
1FAC COAGULATION FACTOR VIII, NMR, 1 STRUCTURE Deposited 1996-06-30 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2322–2342（21 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 4；308.3 K
Resolution not provided
1IQD Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab. Deposited 2001-07-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 2193–2348（156 aa） Fragment：C-TERMINAL DOMAIN
Mutation：S2296C No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；PEG8000, sodium chloride, HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.00 Å R-free 0.253
2R7E Crystal Structure Analysis of Coagulation Factor VIII Deposited 2007-09-07 Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 19–760（742 aa） Fragment：residues 19-760
Chain B 1582–2351（770 aa） Fragment：residues 1582-2351
Mutation：F1838S CA CALCIUM ION × 3 CU COPPER (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；8-10% PEG 8000, 0.1M Imidazole, 100-300 mM NaCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 3.70 Å R-free 0.347
3CDZ Crystal structure of human factor VIII Deposited 2008-02-27 Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 20–759（740 aa） Fragment：B-domain deleted (UNP residues 20-764)
Chain B 1668–2351（684 aa） Fragment：B-domain deleted (UNP residues 1668-2351)
Not recorded CU COPPER (II) ION × 2 CA CALCIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；100 mM Tris-HCl, 10% EtOH, 7% PEG 3350, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 3.98 Å R-free 0.327
3HNB Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Deposited 2009-05-31 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain M 2189–2347（159 aa） Fragment：C2 domain of Factor VIIIa light chain, UNP residues 2189-2347
Not recorded 768 (2R)-1-(2,4-dichlorophenoxy)-3-[(2E)-2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；2.8M sodium chloride, 0.1M Tris-HCl, 3% glycol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.15 Å R-free 0.220
3HNY Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Deposited 2009-06-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain M 2189–2347（159 aa） Fragment：factor VIII c2 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；2.8M sodium chloride, 0.1M Tris-HCl, 3% glycol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.07 Å R-free 0.201
3HOB Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Deposited 2009-06-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain M 2189–2347（159 aa） Fragment：factor VIII c2 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；30.0% PEG 2000, MME 0.15M KBr, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.07 Å R-free 0.263
3HOB Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Deposited 2009-06-01 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2189–2347（159 aa） Fragment：factor VIII c2 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；30.0% PEG 2000, MME 0.15M KBr, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.07 Å R-free 0.263
3J2Q Model of membrane-bound factor VIII organized in 2D crystals Deposited 2012-12-11 Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 20–764（745 aa） Fragment：UNP residues 20-764
Chain B 1668–2351（684 aa） Fragment：UNP residues 1668-2351
Not recorded CU COPPER (II) ION × 2 CA CALCIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON CRYSTALLOGRAPHY mmCIF provides none of the parsed conditions Resolution 15.00 Å
3J2S Membrane-bound factor VIII light chain Deposited 2012-12-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1710–2351（642 aa） Fragment：UNP residues 1710-2356
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20 mM Tris-HCl, 150 mM NaCl, 5mM CaCl2；pH 7.4；20 mM Tris-HCl, 150 mM NaCl, 5mM CaCl2
cryo-EM vitrification conditions Blot for 3.5 seconds before plunging；95 K；Cryogen ETHANE；Blot for 3.5 seconds before plunging into liquid ethane (Vitrobot Mark III)
Resolution 15.00 Å
4BDV CRYSTAL STRUCTURE OF A TRUNCATED B-DOMAIN HUMAN FACTOR VIII Deposited 2012-10-08 Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 20–769（750 aa） Fragment：COAGULATION FACTOR VIII, RESIDUES 20-769,1657-1666
Chain A 1657–1666（10 aa） Fragment：COAGULATION FACTOR VIII, RESIDUES 20-769,1657-1666
Chain B 1667–2351（685 aa） Fragment：RESIDUES 1667-2351
Not recorded ZN ZINC ION × 1 CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 2 CU1 COPPER (I) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；3% PEG550, 0.100 M NACL, 0.100 M TRIS-HCL PH 7.5, 10% ETHANOL
Resolution 3.98 Å R-free 0.246
4KI5 Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99 Deposited 2013-05-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain M 2190–2351（162 aa） Fragment：C2 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；28% PEG-1000, 0.15 M sodium acetate, 0.025 M Tris-HCl, 0.05 M NaCl, 0.15 M ammonium nitrate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.47 Å R-free 0.238
4PT6 The discobody: an engineered discoidin domain from factor VIII that binds v 3 integrin with antibody-like affinities Deposited 2014-03-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2190–2351（162 aa） Fragment：unp residues 2190-2351
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.252
4PT6 The discobody: an engineered discoidin domain from factor VIII that binds v 3 integrin with antibody-like affinities Deposited 2014-03-10 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 2190–2351（162 aa） Fragment：unp residues 2190-2351
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.252
4XZU Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody Deposited 2015-02-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain M 2193–2346（154 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；12-18% PEG 8000, MES, 0-200 mM magnesium chloride
Resolution 2.61 Å R-free 0.267
4XZU Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody Deposited 2015-02-05 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain G 2193–2346（154 aa）
Not recorded MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；12-18% PEG 8000, MES, 0-200 mM magnesium chloride
Resolution 2.61 Å R-free 0.267
5K8D Crystal structure of rFVIIIFc Deposited 2016-05-29 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 20–759（740 aa）
Chain B 1713–2350（638 aa）
Not recorded CA CALCIUM ION × 3 CU COPPER (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.3；297 K；5% Ethanol, 100mM TRIS pH 7.3
Resolution 4.19 Å R-free 0.362
6MF0 Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII Deposited 2018-09-07 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: monomeric（1） Review required
Chain A 387–761（375 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain A 2039–2351（313 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain B 387–761（375 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain B 2039–2351（313 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Not recorded CA CALCIUM ION × 2 ZN ZINC ION × 2 CU1 COPPER (I) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；16% PEG3350, 0.025 M magnesium chloride, 0.025 M HEPES
Resolution 3.20 Å R-free 0.287
6MF0 Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII Deposited 2018-09-07 Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 387–761（375 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain A 2039–2351（313 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Not recorded CA CALCIUM ION × 1 ZN ZINC ION × 1 CU1 COPPER (I) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；16% PEG3350, 0.025 M magnesium chloride, 0.025 M HEPES
Resolution 3.20 Å R-free 0.287
6MF2 Improved Model of Human Coagulation Factor VIII Deposited 2018-09-08 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 19–760（742 aa） Fragment：UNP residues 19-760,1582-2351
Chain A 1582–2351（770 aa） Fragment：UNP residues 19-760,1582-2351
Not recorded CA CALCIUM ION × 1 ZN ZINC ION × 1 CU1 COPPER (I) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；8-10% PEG8000, 0.1 M imidazole, 100-300 mM sodium chloride
Resolution 3.61 Å R-free 0.284
7K66 Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor Deposited 2020-09-18 Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 406–761（356 aa）
Chain A 2039–2351（313 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CU COPPER (II) ION × 1 CA CALCIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.7；293 K；17.5 %(w/v) PEG 1500, 50 mM HEPES (pH 7.7)
Resolution 3.92 Å R-free 0.322
7KBT Factor VIII in complex with the anti-C2 domain antibody, G99 Deposited 2020-10-02 Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 387–761（375 aa）
Chain A 2039–2351（313 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CU COPPER (II) ION × 1 ZN ZINC ION × 1 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；8 - 18% PEG 1500, PEG 6K, or PEG 10K and 50mM malic acid, pH 7.
Resolution 4.15 Å R-free 0.338
8G6I Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor Deposited 2023-02-15 Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 406–761（356 aa）
Chain A 2039–2351（313 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；150 mM NaCl, 20 mM HEPES pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.23 Å
8TY1 Cryo-EM structure of coagulation factor VIII bound to NB2E9 Deposited 2023-08-24 Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 392–771（380 aa）
Chain A 2039–2351（313 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM HEPES (pH 7.4) and 150 mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.46 Å
9D5D Crystal Structure of Blood Coagulation Factor VIII C2 Domain Mutant L2251A/L2252A Deposited 2024-08-13 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain M 2191–2351（161 aa） Fragment：C2 domain (UNP residues 2191-2351)
Mutation：L2251A,L2252A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；4 M potassium formate, 0.1 M Bis-Tris propane, pH 9, 2% w/v PEG2000 MME
Resolution 1.83 Å R-free 0.223
9JBV Structure of Engineered Coagulation Factor VIII with Enhanced Secretion and Coagulation Potential Deposited 2024-08-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–764（764 aa）
Chain A 1659–2351（693 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.3
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.17 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.