当前蛋白身份:P01225 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
1FL7 HUMAN FOLLICLE STIMULATING HORMONE 提交 2000-08-11 Assembly 1 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 19–129(111 aa)
突变:T26A SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;283 K;0.9 - 1.2 M ammonium sulfate, 0.1 M glycine, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 10K
分辨率 3.00 Å R-free 0.294
1FL7 HUMAN FOLLICLE STIMULATING HORMONE 提交 2000-08-11 Assembly 2 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 19–129(111 aa)
突变:T26A SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;283 K;0.9 - 1.2 M ammonium sulfate, 0.1 M glycine, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 10K
分辨率 3.00 Å R-free 0.294
1FL7 HUMAN FOLLICLE STIMULATING HORMONE 提交 2000-08-11 Assembly 3 其他组合 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 B 19–129(111 aa)
链 D 19–129(111 aa)
突变:T26A 突变:T26A SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;283 K;0.9 - 1.2 M ammonium sulfate, 0.1 M glycine, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 10K
分辨率 3.00 Å R-free 0.294
1XWD Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor 提交 2004-10-30 Assembly 1 其他组合 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 19–129(111 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.4;293 K;PEG 3350, lithium sulfate, pH 6.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.92 Å R-free 0.259
1XWD Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor 提交 2004-10-30 Assembly 2 其他组合 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 E 19–129(111 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.4;293 K;PEG 3350, lithium sulfate, pH 6.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.92 Å R-free 0.259
4AY9 Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor 提交 2012-06-19 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 E 19–129(111 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 X-RAY DIFFRACTION
X-ray结晶条件 pH 7.5;0.1M HEPES PH 7.5, 10% (V/V) ISOPROPANOL AND 20% (W/V) POLYETHYLENE GLYCOL 4000
分辨率 2.50 Å R-free 0.269
4AY9 Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor 提交 2012-06-19 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 H 19–129(111 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 X-RAY DIFFRACTION
X-ray结晶条件 pH 7.5;0.1M HEPES PH 7.5, 10% (V/V) ISOPROPANOL AND 20% (W/V) POLYETHYLENE GLYCOL 4000
分辨率 2.50 Å R-free 0.269
4AY9 Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor 提交 2012-06-19 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 19–129(111 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 X-RAY DIFFRACTION
X-ray结晶条件 pH 7.5;0.1M HEPES PH 7.5, 10% (V/V) ISOPROPANOL AND 20% (W/V) POLYETHYLENE GLYCOL 4000
分辨率 2.50 Å R-free 0.269
4MQW Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31) 提交 2013-09-16 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 19–129(111 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 EDO 1,2-ETHANEDIOL × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;293 K;The FSH-FSHRED complex was concentrated by ultrafiltration to about 10 mg/ml in HBS. 0.1M imidazole and 20% Jeffamine M-600, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.90 Å R-free 0.237
4MQW Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31) 提交 2013-09-16 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 E 19–129(111 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;293 K;The FSH-FSHRED complex was concentrated by ultrafiltration to about 10 mg/ml in HBS. 0.1M imidazole and 20% Jeffamine M-600, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.90 Å R-free 0.237
4MQW Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31) 提交 2013-09-16 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 H 19–129(111 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 JEF O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;293 K;The FSH-FSHRED complex was concentrated by ultrafiltration to about 10 mg/ml in HBS. 0.1M imidazole and 20% Jeffamine M-600, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.90 Å R-free 0.237
8I2G FSHR-Follicle stimulating hormone-compound 716340-Gs complex 提交 2023-01-14 Assembly 1 信息不足 异源复合物;蛋白 × 7 PDB 声明:heptameric(7) 与蛋白数一致
链 Y 19–127(109 aa)
未记录 CLR CHOLESTEROL × 13 PLM PALMITIC ACID × 3 MYR MYRISTIC ACID × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 O6F N-tert-butyl-N-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamide × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 2.80 Å
9YXD Crystal structure of recombinant human follicle stimulating hormone in complex with an anti-FSH alpha Fab 提交 2025-10-27 Assembly 1 其他组合 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 B 19–129(111 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;291 K;0.05 M Calcium acetate, 0.1 M Bis-Tris pH 7, 30% v/v PEG 550 MME
分辨率 2.29 Å R-free 0.235