Current Protein Identity：P01225
New Search
Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1FL7 HUMAN FOLLICLE STIMULATING HORMONE Deposited 2000-08-11 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
19–129（111 aa）
|
Mutation：T26A | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；283 K；0.9 - 1.2 M ammonium sulfate, 0.1 M glycine, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 10K
|
Resolution 3.00 Å R-free 0.294 |
| 1FL7 HUMAN FOLLICLE STIMULATING HORMONE Deposited 2000-08-11 | Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
19–129（111 aa）
|
Mutation：T26A | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；283 K；0.9 - 1.2 M ammonium sulfate, 0.1 M glycine, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 10K
|
Resolution 3.00 Å R-free 0.294 |
| 1FL7 HUMAN FOLLICLE STIMULATING HORMONE Deposited 2000-08-11 | Assembly 3 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
19–129（111 aa）
Chain D
19–129（111 aa）
|
Mutation：T26A Mutation：T26A | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；283 K；0.9 - 1.2 M ammonium sulfate, 0.1 M glycine, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 10K
|
Resolution 3.00 Å R-free 0.294 |
| 1XWD Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor Deposited 2004-10-30 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
19–129（111 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.4；293 K；PEG 3350, lithium sulfate, pH 6.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.92 Å R-free 0.259 |
| 1XWD Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor Deposited 2004-10-30 | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain E
19–129（111 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.4；293 K；PEG 3350, lithium sulfate, pH 6.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.92 Å R-free 0.259 |
| 4AY9 Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor Deposited 2012-06-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain E
19–129（111 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；0.1M HEPES PH 7.5, 10% (V/V) ISOPROPANOL AND 20% (W/V) POLYETHYLENE GLYCOL 4000
|
Resolution 2.50 Å R-free 0.269 |
| 4AY9 Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor Deposited 2012-06-19 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain H
19–129（111 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；0.1M HEPES PH 7.5, 10% (V/V) ISOPROPANOL AND 20% (W/V) POLYETHYLENE GLYCOL 4000
|
Resolution 2.50 Å R-free 0.269 |
| 4AY9 Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor Deposited 2012-06-19 | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
19–129（111 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；0.1M HEPES PH 7.5, 10% (V/V) ISOPROPANOL AND 20% (W/V) POLYETHYLENE GLYCOL 4000
|
Resolution 2.50 Å R-free 0.269 |
| 4MQW Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31) Deposited 2013-09-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
19–129（111 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 EDO 1,2-ETHANEDIOL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；The FSH-FSHRED complex was concentrated by ultrafiltration to about 10 mg/ml in HBS. 0.1M imidazole and 20% Jeffamine M-600, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.237 |
| 4MQW Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31) Deposited 2013-09-16 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain E
19–129（111 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；The FSH-FSHRED complex was concentrated by ultrafiltration to about 10 mg/ml in HBS. 0.1M imidazole and 20% Jeffamine M-600, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.237 |
| 4MQW Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31) Deposited 2013-09-16 | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain H
19–129（111 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 JEF O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；The FSH-FSHRED complex was concentrated by ultrafiltration to about 10 mg/ml in HBS. 0.1M imidazole and 20% Jeffamine M-600, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.237 |
| 8I2G FSHR-Follicle stimulating hormone-compound 716340-Gs complex Deposited 2023-01-14 | Assembly 1 Insufficient information Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain Y
19–127（109 aa）
|
Not recorded | CLR CHOLESTEROL × 13 PLM PALMITIC ACID × 3 MYR MYRISTIC ACID × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 O6F N-tert-butyl-N-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 2.80 Å |
| 9YXD Crystal structure of recombinant human follicle stimulating hormone in complex with an anti-FSH alpha Fab Deposited 2025-10-27 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
19–129（111 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291 K；0.05 M Calcium acetate, 0.1 M Bis-Tris pH 7, 30% v/v PEG 550 MME
|
Resolution 2.29 Å R-free 0.235 |