Current Protein Identity：P01275
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1BH0 STRUCTURE OF A GLUCAGON ANALOG Deposited 1998-06-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
53–81（29 aa）
|
Mutation：R17K, R18K, D21E | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
slow cooling of saturated soln；SLOW COOLING OF HEATED SUPERSATURATED SOLUTION, slow cooling of saturated soln
|
Resolution 3.00 Å |
| 1D0R SOLUTION STRUCTURE OF GLUCAGON-LIKE PEPTIDE-1-(7-36)-AMIDE IN TRIFLUOROETHANOL/WATER Deposited 1999-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
98–127（30 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 2.5；300 K；Pressure AMBIENT
NMR sample composition
1.4MM GLUCAGON-LIKE PEPTIDE 1-(7-36)-AMIDE
NMR sample composition
1.4MM GLUCAGON-LIKE PEPTIDE 1-(7-36)-AMIDE
|
Resolution not provided |
| 1NAU NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles Deposited 2002-11-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–81（29 aa）
|
Mutation：DEL(H53), DEL(F58), D7E Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6；310 K；Ionic strength (raw mmCIF value) 50 mM sodium phosphate; 1mM sodium azide；Pressure ambient
NMR sample composition
7mM [desHis1, desPhe6, Glu9]Glucagon Amide; 50 mM sodium phosphate buffer; 283 mM dodecylphosphocholine-d38 micelles; 1 mM sodium azide; 90% H2O, 10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2L63 NMR solution structure of GLP-2 in 2,2,2 trifluroethanol Deposited 2010-11-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
146–178（33 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 3.9；310 K；Pressure ambient
NMR sample composition
33 % TFE-1, trifluoroethanol/water | trifluoroethanol/water
|
Resolution not provided |
| 2L64 NMR Solution structure of GLP-2 in DHPC micelles Deposited 2010-11-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
146–178（33 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 3.9；310 K；Pressure ambient
NMR sample composition
350 mM DHPC-1, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2M5P Solution structure of lipidated glucagon analog in water Deposited 2013-03-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain X
53–81（29 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GGL GAMMA-L-GLUTAMIC ACID × 2 PLM PALMITIC ACID × 1 | SOLUTION NMR |
NMR measurement conditions
pH 4.7；298 K；Ionic strength (raw mmCIF value) 0.02；Pressure ambient
NMR sample composition
0.7 mM peptide, 20 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2M5Q Solution structure of lipidated glucagon analog in d-TFE Deposited 2013-03-04 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain X
53–81（29 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GGL GAMMA-L-GLUTAMIC ACID × 2 PLM PALMITIC ACID × 1 | SOLUTION NMR |
NMR measurement conditions
pH 5；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition
0.7 mM protein, 95% [U-100% 2H] TFE/5% H2O | 95% [U-100% 2H] TFE/5% H2O
|
Resolution not provided |
| 3IOL Crystal structure of Glucagon-Like Peptide-1 in complex with the extracellular domain of the Glucagon-Like Peptide-1 Receptor Deposited 2009-08-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
98–128（31 aa）
Fragment：UNP residues 98-128
|
Not recorded | 10M decyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.9；291 K；0.1M N-(2-Acetamido) Iminodiacetic Acid (ADA), pH 6.9, 14 vol-% (+/-)-2-Methyl-2,4-pentanediol (MPD), 9mM n-decyl-beta-D-thiomaltoside, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.10 Å R-free 0.226 |
| 4APD Liraglutide Deposited 2012-04-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
98–128（31 aa）
|
Not recorded | D6M N-hexadecanoyl-L-glutamic acid × 1 | SOLUTION NMR |
NMR measurement conditions
pH 7.9；300 K；Pressure 1.0
NMR sample composition
10% D2O / 90% H2O
|
Resolution not provided |
| 5OTU Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Hcs Deposited 2017-08-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
98–128（31 aa）
|
Mutation：A8HCS, T11HCS Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Morpheus from Molecular Dimensions, solution G1: 0.1 M Carboxylic acids, 0.1 Buffer system 1 pH 6.5, 20% (v/v) PEG500mme, 10% (w/v) PEG20000
|
Resolution 1.80 Å R-free 0.211 |
| 5OTU Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Hcs Deposited 2017-08-22 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
98–128（31 aa）
|
Mutation：A8HCS, T11HCS Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Morpheus from Molecular Dimensions, solution G1: 0.1 M Carboxylic acids, 0.1 Buffer system 1 pH 6.5, 20% (v/v) PEG500mme, 10% (w/v) PEG20000
|
Resolution 1.80 Å R-free 0.211 |
| 5OTV Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cyc/Thr11Hcs Deposited 2017-08-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
98–128（31 aa）
|
Mutation：A8C, T11HCS Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Morpheus from Molecular Dimensions, solution E5: 0.12 M Ethylene Glycols, 0.1 M Buffer System 2 pH 7.5, 205 (v/v) PEg500mme, 10% (w/v) PEG20000
|
Resolution 2.00 Å R-free 0.246 |
| 5OTV Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cyc/Thr11Hcs Deposited 2017-08-22 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
98–128（31 aa）
|
Mutation：A8C, T11HCS Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Morpheus from Molecular Dimensions, solution E5: 0.12 M Ethylene Glycols, 0.1 M Buffer System 2 pH 7.5, 205 (v/v) PEg500mme, 10% (w/v) PEG20000
|
Resolution 2.00 Å R-free 0.246 |
| 5OTW Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Cys Deposited 2017-08-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
98–128（31 aa）
|
Mutation：A8HCS, T11C Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Morpheus from Molecular Dimensions, solution E12: 0.12 M ethylene Glycols, 0.1 M Buffer system 3 pH 8.5, 12.5% (v/v) MPD, 12.5% (w/v) PEG1000, 12.5% (w/v) PEG3350
|
Resolution 2.10 Å R-free 0.239 |
| 5OTW Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Cys Deposited 2017-08-22 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
98–128（31 aa）
|
Mutation：A8HCS, T11C Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Morpheus from Molecular Dimensions, solution E12: 0.12 M ethylene Glycols, 0.1 M Buffer system 3 pH 8.5, 12.5% (v/v) MPD, 12.5% (w/v) PEG1000, 12.5% (w/v) PEG3350
|
Resolution 2.10 Å R-free 0.239 |
| 5OTX Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cys/Thr11Cys Deposited 2017-08-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
98–128（31 aa）
|
Mutation：A8C, T11C | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Morpheus from Molecular Dimensions solution F2:
0.12 M Monosaccharides, 0.1 M Buffer system 1 pH 6.5, 20% (v/v) Ethylene Glycol, 10% (w/v) PEG8000
|
Resolution 2.00 Å R-free 0.240 |
| 5OTX Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cys/Thr11Cys Deposited 2017-08-22 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
98–128（31 aa）
|
Mutation：A8C, T11C | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Morpheus from Molecular Dimensions solution F2:
0.12 M Monosaccharides, 0.1 M Buffer system 1 pH 6.5, 20% (v/v) Ethylene Glycol, 10% (w/v) PEG8000
|
Resolution 2.00 Å R-free 0.240 |
| 5VAI Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein Deposited 2017-03-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain P
98–128（31 aa）
Fragment：UNP residues 98-128
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.10 Å |
| 6EDS Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Glucagon and Substrate-selective Macrocyclic Inhibitor 63 Deposited 2018-08-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
53–81（29 aa）
|
Not recorded | J22 {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 PEG DI(HYDROXYETHYL)ETHER × 1 DIO 1,4-DIETHYLENE DIOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；0.1M HEPES pH 7.0, 12% Tacsimate pH 7.0, 13% PEGMME, 10% Dioxane
|
Resolution 3.18 Å R-free 0.222 |
| 6EDS Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Glucagon and Substrate-selective Macrocyclic Inhibitor 63 Deposited 2018-08-10 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
53–81（29 aa）
|
Not recorded | J22 {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 PEG DI(HYDROXYETHYL)ETHER × 1 DIO 1,4-DIETHYLENE DIOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；0.1M HEPES pH 7.0, 12% Tacsimate pH 7.0, 13% PEGMME, 10% Dioxane
|
Resolution 3.18 Å R-free 0.222 |
| 6LMK Cryo-EM structure of the human glucagon receptor in complex with Gs Deposited 2019-12-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain E
53–81（29 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 6LML Cryo-EM structure of the human glucagon receptor in complex with Gi1 Deposited 2019-12-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain E
53–81（29 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.90 Å |
| 6NZN Dimer-of-dimer amyloid fibril structure of glucagon Deposited 2019-02-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 16 PDB declaration: hexadecameric（16） Consistent with protein count |
Chain A
53–81（29 aa）
Chain B
53–81（29 aa）
Chain C
53–81（29 aa）
Chain D
53–81（29 aa）
Chain E
53–81（29 aa）
Chain F
53–81（29 aa）
Chain G
53–81（29 aa）
Chain H
53–81（29 aa）
Chain I
53–81（29 aa）
Chain J
53–81（29 aa）
Chain K
53–81（29 aa）
Chain L
53–81（29 aa）
Chain M
53–81（29 aa）
Chain N
53–81（29 aa）
Chain O
53–81（29 aa）
Chain P
53–81（29 aa）
|
Not recorded | No recorded non-water small molecule | SOLID-STATE NMR |
NMR measurement conditions
pH 2；293 K；Ionic strength (raw mmCIF value) 0.01；Pressure 1
NMR sample composition
0.1 mg/uL {U-13C; U-15N]-G4,S8,L14,A19,V23 Glucagon, water | water
NMR sample composition
0.1 mg/uL {U-13C; U-15N]-S2,Q3,G4,T5,Q24,W25,L26,M27,N28 Glucagon, water | water
NMR sample composition
0.1 mg/uL {U-13C; U-15N]-T5,F6,T7,S8,D9,Y10,S11,A19,Q20,D21,F22,V23,Q24 Glucagon, water | water
NMR sample composition
0.1 mg/uL {U-13C; U-15N]-S11,K12,Y13,L14,D15,S16,R17,R18,A19 Glucagon, water | water
|
Resolution not provided |
| 6PHI Crystal structure of native glucagon in space group I41 at 1.1 A resolution Deposited 2019-06-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–81（29 aa）
Fragment：UNP residues 53-81
|
Not recorded | CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；2.5 M sodium chloride, 0.1 M imidazole, pH 8
|
Resolution 1.10 Å R-free 0.139 |
| 6PHJ Crystal structure of native glucagon in space group P213 at 1.99 A resolution Deposited 2019-06-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–81（29 aa）
Fragment：UNP residues 53-81
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；1 M sodium/potassium tartrate, 0.2 M lithium sulfate, 0.1 M Tris, pH 7
|
Resolution 1.99 Å R-free 0.307 |
| 6PHK Crystal structure of glucagon analog with mono-stereoinversion at position 21 (D-Asp21) in space group I41 at 1.18 A resolution Deposited 2019-06-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–81（29 aa）
Fragment：UNP residues 53-81
|
Mutation：D21D-Asp Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.2 M lithium sulfate, 20% butanediol, 0.1 M MES, pH 6
|
Resolution 1.18 Å R-free 0.162 |
| 6PHL Crystal structure of glucagon analog with mono-stereoinversion at position 23 (D-Val23) in space group I41 at 1.44 A resolution Deposited 2019-06-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–81（29 aa）
Fragment：UNP residues 53-81
|
Mutation：V23D-Val Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；tri-sodium citrate, pH 5.5, 20% PEG3000
|
Resolution 1.44 Å R-free 0.169 |
| 6PHO Crystal structure of glucagon analog with selenomethionine substitutions at position 1 and 27 in space group I41 at 1.42 A resolution Deposited 2019-06-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–81（29 aa）
Fragment：UNP residues 53-81
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M tri-potassium citrate, 20% PEG3350
|
Resolution 1.42 Å R-free 0.189 |
| 6PHP Crystal structure of glucagon analog with 4-bromo-phenylalanine substitutions at position 6 and 22 in space group I41 at 1.65 A resolution Deposited 2019-06-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–81（29 aa）
Fragment：UNP residues 53-81
|
Mutation：F6BrF, F22BrF Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；Tacsimate, pH 4, 16% PEG3350, 0.1 M sodium acetate, pH 4.6
|
Resolution 1.65 Å R-free 0.246 |
| 6VCB Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator Deposited 2019-12-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain P
98–128（31 aa）
|
Not recorded | QW7 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 6X18 GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor Deposited 2020-05-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain P
98–127（30 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.10 Å |
| 7D68 Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex Deposited 2020-09-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain P
146–178（33 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 7DUQ Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex Deposited 2021-01-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain P
98–127（30 aa）
|
Not recorded | HNO N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine × 1 CLR CHOLESTEROL × 7 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 7XM8 Glucagon amyloid fibril Deposited 2022-04-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 22 PDB declaration: 22-meric（22） Consistent with protein count |
Chain A
53–81（29 aa）
Chain B
53–81（29 aa）
Chain C
53–81（29 aa）
Chain D
53–81（29 aa）
Chain E
53–81（29 aa）
Chain F
53–81（29 aa）
Chain G
53–81（29 aa）
Chain H
53–81（29 aa）
Chain I
53–81（29 aa）
Chain J
53–81（29 aa）
Chain K
53–81（29 aa）
Chain L
53–81（29 aa）
Chain M
53–81（29 aa）
Chain N
53–81（29 aa）
Chain O
53–81（29 aa）
Chain P
53–81（29 aa）
Chain Q
53–81（29 aa）
Chain R
53–81（29 aa）
Chain S
53–81（29 aa）
Chain T
53–81（29 aa）
Chain U
53–81（29 aa）
Chain V
53–81（29 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 2.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.90 Å |
| 8JRV Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1 Deposited 2023-06-17 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain G
53–81（29 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9E2A Glucagon Like Peptide Receptor-1 (GLP1R) A316T mutant with GLP-1 peptide. Dominant negative Gs complex. Deposited 2024-10-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain P
98–127（30 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9N0E Cryo-EM structure of GCGR-Gs complex with oxyntomodulin Deposited 2025-01-24 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain P
53–89（37 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.30 Å |
| 9X20 Cryo-EM structure of the GLP-1-bound human GLP-1R-Gi complex Deposited 2025-10-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain P
98–127（30 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.18 Å |
| 9X22 Cryo-EM structure of the GLP-1-bound human GLP-1R-Gq complex Deposited 2025-10-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain P
98–127（30 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.92 Å |