Current Protein Identity：P01317
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1APH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | DCE 1,2-DICHLOROETHANE × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1APH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1APH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1BPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 1 DCE 1,2-DICHLOROETHANE × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1BPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 2 DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1BPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 2 DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1BPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 2 DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1CPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 1 DCE 1,2-DICHLOROETHANE × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1CPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 3 DCE 1,2-DICHLOROETHANE × 3 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1CPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 2 DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1CPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 2 DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1CPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 2 DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1DPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 1 DCE 1,2-DICHLOROETHANE × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1DPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 2 DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1DPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 2 DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1DPH CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Deposited 1992-10-30 | Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | NA SODIUM ION × 2 DCE 1,2-DICHLOROETHANE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1HO0 NEW B-CHAIN MUTANT OF BOVINE INSULIN Deposited 2000-12-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–54（30 aa）
Fragment：B-CHAIN
|
Mutation：C7S, C19S | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 3.6；293 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition
0.5 mM peptide concentration | 70 % H2O / 30 % deuterated TFE
|
Resolution not provided |
| 1PID BOVINE DESPENTAPEPTIDE INSULIN Deposited 1995-11-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–49（25 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.30 Å |
| 1PID BOVINE DESPENTAPEPTIDE INSULIN Deposited 1995-11-22 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Chain D
25–49（25 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.30 Å |
| 2A3G The structure of T6 bovine insulin Deposited 2005-06-24 | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：insulin A chain, residues 85-105
Chain B
25–54（30 aa）
Fragment：insulin B chain, residues 25-54
Chain C
85–105（21 aa）
Fragment：insulin A chain, residues 85-105
Chain D
25–54（30 aa）
Fragment：insulin B chain, residues 25-54
|
Not recorded | ZN ZINC ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；298 K；HCl, ZINC ACETATE, SODIUM CITRATE, ACETONE, pH 6.2, SLOW COOLING, temperature 298 K, pH 6.20
|
Resolution 2.25 Å R-free 0.219 |
| 2BN1 Insulin after a high dose x-ray burn Deposited 2005-03-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：INSULIN A CHAIN, RESIDUES 85-105
Chain B
25–54（30 aa）
Fragment：INSULIN B CHAIN, RESIDUES 25-54
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
.4 M NAPO4/NA2HPO4 PH10.4, 0.001M EDTA, 30% ETHYLENE GLYCOL
|
Resolution 1.40 Å R-free 0.165 |
| 2BN3 Insulin before a high dose x-ray burn Deposited 2005-03-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：INSULIN A CHAIN, RESIDUES 85-105
Chain B
25–54（30 aa）
Fragment：INSULIN B CHAIN, RESIDUES 25-54
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
0.4 M NAPO4/NA2HPO4 PH 10.4, 0.001 M EDTA,30%ETHYLENE GLYCOL
|
Resolution 1.40 Å R-free 0.161 |
| 2INS THE STRUCTURE OF DES-PHE B1 BOVINE INSULIN Deposited 1982-05-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
26–54（29 aa）
Chain C
85–105（21 aa）
Chain D
26–54（29 aa）
|
Not recorded | ZN ZINC ION × 6 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 2INS THE STRUCTURE OF DES-PHE B1 BOVINE INSULIN Deposited 1982-05-10 | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
26–54（29 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 2INS THE STRUCTURE OF DES-PHE B1 BOVINE INSULIN Deposited 1982-05-10 | Assembly 3 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain C
85–105（21 aa）
Chain D
26–54（29 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 2INS THE STRUCTURE OF DES-PHE B1 BOVINE INSULIN Deposited 1982-05-10 | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
26–54（29 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 2INS THE STRUCTURE OF DES-PHE B1 BOVINE INSULIN Deposited 1982-05-10 | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Chain D
26–54（29 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 2ZP6 Crystal structure of Bovine Insulin (Hexameric form) Deposited 2008-06-27 | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；15% acetone, 0.6M Ammonium formate (metal basis), 0.6M sodium citrate, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.56 Å R-free 0.220 |
| 2ZP6 Crystal structure of Bovine Insulin (Hexameric form) Deposited 2008-06-27 | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain C
85–105（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；15% acetone, 0.6M Ammonium formate (metal basis), 0.6M sodium citrate, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.56 Å R-free 0.220 |
| 2ZP6 Crystal structure of Bovine Insulin (Hexameric form) Deposited 2008-06-27 | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
Chain C
85–105（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；15% acetone, 0.6M Ammonium formate (metal basis), 0.6M sodium citrate, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.56 Å R-free 0.220 |
| 4BS3 Bovin insulin structure determined by in situ crystal analysis and sulfur-SAD phasing at room temperature Deposited 2013-06-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 10.2；293 K；INSULIN (30 MG/ML) WAS CRYSTALLIZED AT 293K BY VAPOR DIFFUSION (SITTING DROP) IN CRYSTALQUICK X MICROPLATE USING A RESERVOIR SOLUTION CONTAINING 0.275 M NAHPO4 / NA3PO4 PH 10.2, 0.01 M NA3EDTA.
|
Resolution 2.30 Å R-free 0.169 |
| 4E7T The structure of T6 bovine insulin Deposited 2012-03-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；298 K；0.05M sodium citrate, 0.5mM zinc acetate, 15% acetone, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.40 Å R-free 0.229 |
| 4E7T The structure of T6 bovine insulin Deposited 2012-03-19 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；298 K；0.05M sodium citrate, 0.5mM zinc acetate, 15% acetone, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.40 Å R-free 0.229 |
| 4E7U The structure of T3R3 bovine insulin Deposited 2012-03-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
BATCH METHOD；pH 6.4；298 K；6.5mg/ml bovine insulin, 7mM zinc acetate, 0.05M sodium citrate, 15% acetone, 0.2M KSCN, pH 6.4, BATCH METHOD, temperature 298K
|
Resolution 1.30 Å R-free 0.179 |
| 4E7U The structure of T3R3 bovine insulin Deposited 2012-03-19 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 SCN THIOCYANATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
BATCH METHOD；pH 6.4；298 K；6.5mg/ml bovine insulin, 7mM zinc acetate, 0.05M sodium citrate, 15% acetone, 0.2M KSCN, pH 6.4, BATCH METHOD, temperature 298K
|
Resolution 1.30 Å R-free 0.179 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain 1
85–105（21 aa）
Chain 2
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 10 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain O
85–105（21 aa）
Chain P
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 11 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain Q
85–105（21 aa）
Chain R
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 12 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain S
85–105（21 aa）
Chain T
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 13 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain U
85–105（21 aa）
Chain V
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 14 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain W
85–105（21 aa）
Chain X
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 15 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain 3
85–105（21 aa）
Chain 4
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 16 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain 5
85–105（21 aa）
Chain 6
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 17 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain 1
85–105（21 aa）
Chain 2
25–54（30 aa）
Chain Y
85–105（21 aa）
Chain Z
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 6 ZN ZINC ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 18 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain 3
85–105（21 aa）
Chain 4
25–54（30 aa）
Chain 5
85–105（21 aa）
Chain 6
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 6 ZN ZINC ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 19 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain M
85–105（21 aa）
Chain N
25–54（30 aa）
Chain O
85–105（21 aa）
Chain P
25–54（30 aa）
Chain Q
85–105（21 aa）
Chain R
25–54（30 aa）
Chain S
85–105（21 aa）
Chain T
25–54（30 aa）
Chain U
85–105（21 aa）
Chain V
25–54（30 aa）
Chain W
85–105（21 aa）
Chain X
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 6 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 20 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
Chain C
85–105（21 aa）
Chain D
25–54（30 aa）
Chain E
85–105（21 aa）
Chain F
25–54（30 aa）
Chain G
85–105（21 aa）
Chain H
25–54（30 aa）
Chain I
85–105（21 aa）
Chain J
25–54（30 aa）
Chain K
85–105（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 6 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
85–105（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain G
85–105（21 aa）
Chain H
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain I
85–105（21 aa）
Chain J
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 7 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain K
85–105（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 8 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain Y
85–105（21 aa）
Chain Z
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4E7V The structure of R6 bovine insulin Deposited 2012-03-19 | Assembly 9 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain M
85–105（21 aa）
Chain N
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；2 ul 5 mg/ml bovine insulin + 2 ul reservoir equilibrated against 1 ml reservoir of: 0.12 M sodium citrate, 17 mM zinc acetate, 22% acetone, 0.5% m-cresol, 1.67 M NaCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.272 |
| 4I5Y Insulin protein crystallization via langmuir-blodgett Deposited 2012-11-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：UNP residues 85-105
Chain B
25–54（30 aa）
Fragment：UNP residues 25-54
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.80 Å R-free 0.222 |
| 4I5Z Insulin protein crystallization via langmuir-blodgett Deposited 2012-11-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：UNP residues 85-105
Chain B
25–54（30 aa）
Fragment：UNP residues 25-54
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.80 Å R-free 0.218 |
| 4IDW Polycrystalline T6 Bovine Insulin: Anisotropic Lattice Evolution and Novel Structure Refinement Strategy Deposited 2012-12-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | POWDER DIFFRACTION |
X-ray crystallization conditions
Batch；pH 6；295 K；polycrystalline samples of T6 hexameric insulin (Zn2[(AB)2]3, the pH was adjusted by mixing different ratios of 0.2M solutions of sodium monobasic monohydrate phosphate and potassium phosphate., Batch, temperature 295K
|
Resolution 2.70 Å |
| 4IDW Polycrystalline T6 Bovine Insulin: Anisotropic Lattice Evolution and Novel Structure Refinement Strategy Deposited 2012-12-13 | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain C
85–105（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | POWDER DIFFRACTION |
X-ray crystallization conditions
Batch；pH 6；295 K；polycrystalline samples of T6 hexameric insulin (Zn2[(AB)2]3, the pH was adjusted by mixing different ratios of 0.2M solutions of sodium monobasic monohydrate phosphate and potassium phosphate., Batch, temperature 295K
|
Resolution 2.70 Å |
| 4IHN High Resolution Insulin by Langmuir-Blodgett Modified Hanging Drop Vapour Diffusion Deposited 2012-12-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.16 Å R-free 0.260 |
| 4M4F Radiation damage study of Cu T6-insulin - 0.01 MGy Deposited 2013-08-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：Insulin A chain (UNP residues 85-105)
Chain B
25–54（30 aa）
Fragment：Insulin B chain (UNP residues 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.235 |
| 4M4F Radiation damage study of Cu T6-insulin - 0.01 MGy Deposited 2013-08-07 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Fragment：Insulin A chain (UNP residues 85-105)
Chain D
25–54（30 aa）
Fragment：Insulin B chain (UNP residues 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.235 |
| 4M4H Radiation damage study of Cu T6-insulin - 0.06 MGy Deposited 2013-08-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain B
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.220 |
| 4M4H Radiation damage study of Cu T6-insulin - 0.06 MGy Deposited 2013-08-07 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain D
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.220 |
| 4M4I Radiation damage study of Cu T6-insulin - 0.12 MGy Deposited 2013-08-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain B
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.202 |
| 4M4I Radiation damage study of Cu T6-insulin - 0.12 MGy Deposited 2013-08-07 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain D
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.202 |
| 4M4J Radiation damage study of Cu T6-insulin - 0.30 MGy Deposited 2013-08-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain B
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.220 |
| 4M4J Radiation damage study of Cu T6-insulin - 0.30 MGy Deposited 2013-08-07 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain D
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.220 |
| 4M4L The structure of Cu T6 bovine insulin Deposited 2013-08-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain B
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.45 Å R-free 0.204 |
| 4M4L The structure of Cu T6 bovine insulin Deposited 2013-08-07 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain D
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | CU COPPER (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；298 K；0.05M sodium citrate, 15%(v/v) acetone, 7.5mM copper(II)acetate, pH 7.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.45 Å R-free 0.204 |
| 4M4M The structure of Ni T6 bovine insulin Deposited 2013-08-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain B
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | NI NICKEL (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；0.05M sodium citrate, 15%(v/v) acetone, 15mM nickel(II)acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.50 Å R-free 0.224 |
| 4M4M The structure of Ni T6 bovine insulin Deposited 2013-08-07 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
85–105（21 aa）
Fragment：INSULIN A CHAIN (UNP RESIDUES 85-105)
Chain D
25–54（30 aa）
Fragment：INSULIN B CHAIN (UNP RESIDUES 25-54)
|
Not recorded | NI NICKEL (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；0.05M sodium citrate, 15%(v/v) acetone, 15mM nickel(II)acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.50 Å R-free 0.224 |
| 5AZZ Crystal structure of seleno-insulin Deposited 2015-10-23 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Mutation：C7(SEC) Mutation：C7(SEC) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；293 K；Sodium chloride, ethylene imine polymer,
citrate
|
Resolution 1.45 Å R-free 0.192 |
| 5KQV Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE) Deposited 2016-07-06 | Assembly 1 Other combination Heteromer；Protein × 20 PDB declaration: eicosameric（20） Consistent with protein count |
Chain A
85–105（21 aa）
Fragment：UNP Residues 85-105
Chain B
25–54（30 aa）
Fragment：UNP Residues 25-54
Chain I
85–105（21 aa）
Fragment：UNP Residues 85-105
Chain J
25–54（30 aa）
Fragment：UNP Residues 25-54
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；9% POLYETHYLENE GLYCOL 3350, 200MM PROLINE, 100MM HEPES/NAOH, PH 7.5
|
Resolution 4.40 Å R-free 0.266 |
| 5MIZ MD ensemble of bovine insulin Deposited 2016-11-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 2.86；293 K；Ionic strength (raw mmCIF value) 1.4；Pressure 1
NMR measurement conditions
pH 2.86；308 K；Ionic strength (raw mmCIF value) 1.4；Pressure 1
NMR sample composition
1.1 mM Bovine insulin, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 6KH8 Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9) Deposited 2019-07-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 1.9；298 K；Ionic strength (raw mmCIF value) 20% ACETIC ACID；Pressure 1
NMR sample composition
350 uM Bovine insulin Chain A, 350 uM Bovine Insulin chain B, 20% acetic acid-D4 | 20% acetic acid-D4
|
Resolution not provided |
| 6KH9 Solution structure of bovine insulin amyloid intermediate-1 Deposited 2019-07-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 1.9；298 K；Ionic strength (raw mmCIF value) 20% Acetic acid-d4；Pressure ambient
NMR sample composition
350 uM Bovine insulin, 20% acetic acid-d4 | 20% acetic acid-d4
|
Resolution not provided |
| 6KHA Solution structure of bovine insulin amyloid intermediate-2 Deposited 2019-07-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 1.9；298 K；Ionic strength (raw mmCIF value) 20% Acetic acid-d4；Pressure AMBIENT
NMR sample composition
350 uM NONE BOVINE INSULIN, 20% ACETIC ACID D4 | 20% ACETIC ACID D4
|
Resolution not provided |
| 6OR0 Crystal structure of Insulin from Non-merohedrally twinned crystals Deposited 2019-04-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–53（29 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 10；293 K；0.2 M Na2HPO4/Na3PO4, pH 10.0 and 0.01 M Na EDTA
|
Resolution 1.55 Å R-free 0.215 |
| 6Q8Q Bovine Insulin under 2 kbar of argon Deposited 2018-12-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | AR ARGON × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；PROTEIN DROP: 10 MG/ML. RESERVOIR: 1.2 M TMAO + 0.1 M SODIUM MALATE, PH 5.5
|
Resolution 2.00 Å R-free 0.199 |
| 6QQ7 Bovine insulin at ambient pressure Deposited 2019-02-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 10；293 K；0.01 M Na2HPO4, 0.1 M Na2EDTA
|
Resolution 1.65 Å R-free 0.190 |
| 6QQG High pressure structure of bovine insulin (60 MPa) Deposited 2019-02-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 10；293 K；0.01 M Na3EDTA, 0.1 M Na2HPO4
|
Resolution 2.15 Å R-free 0.176 |
| 6QRH High pressure structure of bovine insulin (100 MPa) Deposited 2019-02-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 10；293 K；0.01 M Na3 EDTA, 0.1 M Na2HEDTA
|
Resolution 2.15 Å R-free 0.232 |
| 6QRK High pressure structure of bovine insulin (200 MPa) Deposited 2019-02-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 10；293 K；0.01 Na3EDTA, 0.1 MNa2HEDTA
|
Resolution 2.10 Å R-free 0.248 |
| 6ZHB 3D electron diffraction structure of bovine insulin Deposited 2020-06-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
Chain C
85–105（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | ELECTRON CRYSTALLOGRAPHY |
cryo-EM buffer
pH 6.5；MES buffer, 50 mM
cryo-EM vitrification conditions
Cryogen ETHANE；Manual plunger
|
Resolution 3.25 Å R-free 0.319 |
| 6ZI8 X-ray diffraction structure of bovine insulin at 2.3 A resolution Deposited 2020-06-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain A
1–105（105 aa）
Chain B
1–105（105 aa）
Chain C
1–105（105 aa）
Chain D
1–105（105 aa）
|
Not recorded | ZN ZINC ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
BATCH MODE；pH 6.5；293 K；50mM MES pH 6.5, 10mM ZnCl2, 10mM NaCl in double-distilled water
|
Resolution 2.30 Å R-free 0.238 |
| 7ELJ Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping Deposited 2021-04-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
85–105（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 2.6；298 K；Ionic strength (raw mmCIF value) 1；Pressure 1
NMR sample composition
1 mM Proton Bovine Insulin, 1 mM Proton-15N, 13C Peptide, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |