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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P03692 New Search
18PDB entries
21Biological assembly
82chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1CR0 CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE4 PROTEIN OF BACTERIOPHAGE T7 Deposited 1999-08-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 271–566（296 aa） Fragment：HELICASE DOMAIN
Not recorded SO4 SULFATE ION × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 9；298 K；AMMONIUM SULFATE, ACES, pH 9.00, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.30 Å R-free 0.298
1CR1 CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE 4 PROTEIN OF BACTERIOPHAGE T7: COMPLEX WITH DTTP Deposited 1999-08-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 271–566（296 aa） Fragment：HELICASE DOMAIN
Not recorded SO4 SULFATE ION × 12 TTP THYMIDINE-5'-TRIPHOSPHATE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 9；298 K；AMMONIUM SULFATE, ACES, pH 9, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.30 Å R-free 0.288
1CR2 CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE 4 PROTEIN OF BACTERIOPHAGE T7: COMPLEX WITH DATP Deposited 1999-08-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 271–566（296 aa） Fragment：HELICASE DOMAIN
Not recorded SO4 SULFATE ION × 12 DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 9；298 K；ammonium sulfate, ACES, pH 9.00, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.30 Å R-free 0.296
1CR4 CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE 4 PROTEIN OF BACTERIOPHAGE T7: COMPLEX WITH DTDP Deposited 1999-08-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 271–566（296 aa） Fragment：HELICASE DOMAIN
Not recorded SO4 SULFATE ION × 12 TYD THYMIDINE-5'-DIPHOSPHATE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 9；298 K；AMMONIUM SULFATE, ACES, pH 9.00, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.50 Å R-free 0.287
1E0J gp4d helicase from phage T7 ADPNP complex Deposited 2000-03-30 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 261–549（289 aa） Fragment：DOMAIN 4D
Chain B 261–549（289 aa） Fragment：DOMAIN 4D
Chain C 261–549（289 aa） Fragment：DOMAIN 4D
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 4 MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9.5；pH 9.50
Resolution 3.00 Å R-free 0.304
1E0J gp4d helicase from phage T7 ADPNP complex Deposited 2000-03-30 Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 261–549（289 aa） Fragment：DOMAIN 4D
Chain E 261–549（289 aa） Fragment：DOMAIN 4D
Chain F 261–549（289 aa） Fragment：DOMAIN 4D
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 4 MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9.5；pH 9.50
Resolution 3.00 Å R-free 0.304
1E0K gp4d helicase from phage T7 Deposited 2000-03-30 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 261–549（289 aa） Fragment：DOMAIN 4D
Chain B 261–549（289 aa） Fragment：DOMAIN 4D
Chain C 261–549（289 aa） Fragment：DOMAIN 4D
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9.5；pH 9.50
Resolution 3.30 Å R-free 0.308
1E0K gp4d helicase from phage T7 Deposited 2000-03-30 Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 261–549（289 aa） Fragment：DOMAIN 4D
Chain E 261–549（289 aa） Fragment：DOMAIN 4D
Chain F 261–549（289 aa） Fragment：DOMAIN 4D
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9.5；pH 9.50
Resolution 3.30 Å R-free 0.308
1NUI Crystal Structure of the primase fragment of Bacteriophage T7 primase-helicase protein Deposited 2003-01-31 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–255（255 aa） Fragment：residues 1-255
Mutation：M64G ZN ZINC ION × 1 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；Sodium Formate, MES, DTT, ATP, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.90 Å R-free 0.277
1NUI Crystal Structure of the primase fragment of Bacteriophage T7 primase-helicase protein Deposited 2003-01-31 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–255（255 aa） Fragment：residues 1-255
Mutation：M64G ZN ZINC ION × 1 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；295 K；Sodium Formate, MES, DTT, ATP, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.90 Å R-free 0.277
1Q57 The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7 Deposited 2003-08-06 Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain A 64–566（503 aa）
Chain B 64–566（503 aa）
Chain C 64–566（503 aa）
Chain D 64–566（503 aa）
Chain E 64–566（503 aa）
Chain F 64–566（503 aa）
Chain G 64–566（503 aa）
Mutation：G317V, K318M Mutation：G317V, K318M Mutation：G317V, K318M Mutation：G317V, K318M Mutation：G317V, K318M Mutation：G317V, K318M Mutation：G317V, K318M No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；MES, sodium citrate, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 3.45 Å R-free 0.326
5IKN Crystal Structure of the T7 Replisome in the Absence of DNA Deposited 2016-03-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric（13） Consistent with protein count
Chain D 64–549（486 aa）
Chain E 64–549（486 aa）
Chain F 64–549（486 aa）
Chain G 64–549（486 aa）
Chain H 64–549（486 aa）
Chain I 64–549（486 aa）
Chain J 64–549（486 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295.15 K；1.47-1.62M Sodium Formate 0.1M Tris pH 7.5
Resolution 4.80 Å R-free 0.318
6N7I Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (gp4(5)-DNA) Deposited 2018-11-27 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 1–566（566 aa）
Chain B 1–566（566 aa）
Chain C 1–566（566 aa）
Chain D 1–566（566 aa）
Chain E 1–566（566 aa）
Chain F 1–566（566 aa）
Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q TTP THYMIDINE-5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
6N7N Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form I) Deposited 2018-11-27 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 1–566（566 aa）
Chain B 1–566（566 aa）
Chain C 1–566（566 aa）
Chain D 1–566（566 aa）
Chain E 1–566（566 aa）
Chain F 1–566（566 aa）
Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q TTP THYMIDINE-5'-TRIPHOSPHATE × 5 MG MAGNESIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
6N7S Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form II) Deposited 2018-11-28 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 1–566（566 aa）
Chain B 1–566（566 aa）
Chain C 1–566（566 aa）
Chain D 1–566（566 aa）
Chain E 1–566（566 aa）
Chain F 1–566（566 aa）
Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q TTP THYMIDINE-5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
6N7T Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form III) Deposited 2018-11-28 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 1–566（566 aa）
Chain B 1–566（566 aa）
Chain C 1–566（566 aa）
Chain D 1–566（566 aa）
Chain E 1–566（566 aa）
Chain F 1–566（566 aa）
Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q TTP THYMIDINE-5'-TRIPHOSPHATE × 5 MG MAGNESIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
6N7V Structure of bacteriophage T7 gp4 (helicase-primase, E343Q mutant) in complex with ssDNA, dTTP, AC dinucleotide, and CTP (from multiple lead complexes) Deposited 2018-11-28 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 1–566（566 aa）
Chain B 1–566（566 aa）
Chain C 1–566（566 aa）
Chain D 1–566（566 aa）
Chain E 1–566（566 aa）
Chain F 1–566（566 aa）
Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q TTP THYMIDINE-5'-TRIPHOSPHATE × 5 MG MAGNESIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
6N9U Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) interacting with primase domains of two gp4 subunits bound to an RNA/DNA hybrid and dTTP (from LagS1) Deposited 2018-12-04 Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: pentameric（5） Consistent with all polymers
Chain E 1–566（566 aa）
Chain F 1–566（566 aa）
Mutation：E343Q Mutation：E343Q ZN ZINC ION × 1 TTP THYMIDINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
6N9V Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS1) Deposited 2018-12-04 Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: nonameric（9） Consistent with all polymers
Chain A 1–566（566 aa）
Chain B 1–566（566 aa）
Chain C 1–566（566 aa）
Chain D 1–566（566 aa）
Chain E 1–566（566 aa）
Chain F 1–566（566 aa）
Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q TTP THYMIDINE-5'-TRIPHOSPHATE × 6 MG MAGNESIUM ION × 7 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6N9W Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS2) Deposited 2018-12-04 Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: nonameric（9） Consistent with all polymers
Chain A 1–566（566 aa）
Chain B 1–566（566 aa）
Chain C 1–566（566 aa）
Chain D 1–566（566 aa）
Chain E 1–566（566 aa）
Chain F 1–566（566 aa）
Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q ZN ZINC ION × 1 TTP THYMIDINE-5'-TRIPHOSPHATE × 5 MG MAGNESIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6N9X Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS3) Deposited 2018-12-04 Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: nonameric（9） Consistent with all polymers
Chain A 1–566（566 aa）
Chain B 1–566（566 aa）
Chain C 1–566（566 aa）
Chain D 1–566（566 aa）
Chain E 1–566（566 aa）
Chain F 1–566（566 aa）
Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q Mutation：E343Q ZN ZINC ION × 1 TTP THYMIDINE-5'-TRIPHOSPHATE × 5 MG MAGNESIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.