Current Protein Identity：P05107
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1L3Y INTEGRIN EGF-LIKE MODULE 3 FROM THE BETA-2 SUBUNIT Deposited 2002-03-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
535–574（40 aa）
Fragment：RESIDUES 535-574
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.2；298 K；Ionic strength (raw mmCIF value) 5mM NaPO4；Pressure ambient
NMR sample composition
1 mM I-EGF3 U-15N, 5 mM NaPO4 | 90% H2O/10% D2O
NMR sample composition
1 mM I-EGF3, 5 mM NaPO4 | 100% D2O
|
Resolution not provided |
| 1YUK The crystal structure of the PSI/Hybrid domain/ I-EGF1 segment from the human integrin beta2 at 1.8 resolution Deposited 2005-02-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
23–125（103 aa）
Fragment：PSI domain
Chain B
365–482（118 aa）
Fragment：I-EGF domain
|
Not recorded | NDG 2-acetamido-2-deoxy-alpha-D-glucopyranose × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；18% PEG 8000, 0.2M calcium acetate, 0.1M Sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.80 Å R-free 0.253 |
| 2JF1 CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA2 CYTOPLASMIC TAIL PEPTIDE Deposited 2007-01-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain T
735–769（35 aa）
Fragment：RESIDUES 735-769
|
Not recorded | GOL GLYCEROL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 4.6；1.6-1.58 M AMMONIUM SULPHATE, 0.1 M NA-ACETATE PH 4.6
|
Resolution 2.20 Å R-free 0.278 |
| 2P26 Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit Deposited 2007-03-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–122（100 aa）
Fragment：PHE2 and PHE3
Chain A
362–535（174 aa）
Fragment：PHE2 and PHE3
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；0.2M Magnesium acetate, 0.1M sodium acetate, pH4.6, 18% PEG3350, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.75 Å R-free 0.253 |
| 2P28 Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit Deposited 2007-03-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
23–122（100 aa）
Fragment：PHE2 fragment
Chain B
362–574（213 aa）
Fragment：PHE3 fragment
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2M ammonium sulphate, 15% PEG4000, 5% isopropanol, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.20 Å R-free 0.308 |
| 3K6S Structure of integrin alphaXbeta2 ectodomain Deposited 2009-10-09 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | MAN alpha-D-mannopyranose × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 4 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6.5；277 K；0.55M tri-sodium citrate,
0.1M imidazole, pH 6.5, EVAPORATION, temperature 277K
|
Resolution 3.50 Å R-free 0.335 |
| 3K6S Structure of integrin alphaXbeta2 ectodomain Deposited 2009-10-09 | Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6.5；277 K；0.55M tri-sodium citrate,
0.1M imidazole, pH 6.5, EVAPORATION, temperature 277K
|
Resolution 3.50 Å R-free 0.335 |
| 3K6S Structure of integrin alphaXbeta2 ectodomain Deposited 2009-10-09 | Assembly 3 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6.5；277 K；0.55M tri-sodium citrate,
0.1M imidazole, pH 6.5, EVAPORATION, temperature 277K
|
Resolution 3.50 Å R-free 0.335 |
| 3K6S Structure of integrin alphaXbeta2 ectodomain Deposited 2009-10-09 | Assembly 4 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain H
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6.5；277 K；0.55M tri-sodium citrate,
0.1M imidazole, pH 6.5, EVAPORATION, temperature 277K
|
Resolution 3.50 Å R-free 0.335 |
| 3K6S Structure of integrin alphaXbeta2 ectodomain Deposited 2009-10-09 | Assembly 5 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain B
23–700（678 aa）
Fragment：residues 23-700
Chain D
23–700（678 aa）
Fragment：residues 23-700
Chain F
23–700（678 aa）
Fragment：residues 23-700
Chain H
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | MAN alpha-D-mannopyranose × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 CA CALCIUM ION × 16 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6.5；277 K；0.55M tri-sodium citrate,
0.1M imidazole, pH 6.5, EVAPORATION, temperature 277K
|
Resolution 3.50 Å R-free 0.335 |
| 3K71 Structure of integrin alphaX beta2 ectodomain Deposited 2009-10-11 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.55M tri-sodium citrate,
0.05M MgCl2, 0.1M imidazole, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.95 Å R-free 0.373 |
| 3K71 Structure of integrin alphaX beta2 ectodomain Deposited 2009-10-11 | Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.55M tri-sodium citrate,
0.05M MgCl2, 0.1M imidazole, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.95 Å R-free 0.373 |
| 3K71 Structure of integrin alphaX beta2 ectodomain Deposited 2009-10-11 | Assembly 3 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.55M tri-sodium citrate,
0.05M MgCl2, 0.1M imidazole, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.95 Å R-free 0.373 |
| 3K71 Structure of integrin alphaX beta2 ectodomain Deposited 2009-10-11 | Assembly 4 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain H
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 4 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.55M tri-sodium citrate,
0.05M MgCl2, 0.1M imidazole, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.95 Å R-free 0.373 |
| 3K71 Structure of integrin alphaX beta2 ectodomain Deposited 2009-10-11 | Assembly 5 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain B
23–700（678 aa）
Fragment：residues 23-700
Chain D
23–700（678 aa）
Fragment：residues 23-700
Chain F
23–700（678 aa）
Fragment：residues 23-700
Chain H
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 CA CALCIUM ION × 16 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.55M tri-sodium citrate,
0.05M MgCl2, 0.1M imidazole, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.95 Å R-free 0.373 |
| 3K72 Structure of integrin alphaX beta2 Deposited 2009-10-11 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；277 K；0.915M sodium/potassium phosphate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.70 Å R-free 0.335 |
| 3K72 Structure of integrin alphaX beta2 Deposited 2009-10-11 | Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 4 MAN alpha-D-mannopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；277 K；0.915M sodium/potassium phosphate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.70 Å R-free 0.335 |
| 3K72 Structure of integrin alphaX beta2 Deposited 2009-10-11 | Assembly 3 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain B
23–700（678 aa）
Fragment：residues 23-700
Chain D
23–700（678 aa）
Fragment：residues 23-700
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 14 CA CALCIUM ION × 16 MAN alpha-D-mannopyranose × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；277 K；0.915M sodium/potassium phosphate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.70 Å R-free 0.335 |
| 4NEH An internal ligand-bound, metastable state of a leukocyte integrin, aXb2 Deposited 2013-10-29 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–696（674 aa）
Fragment：CD18
|
Mutation：N190D, N232K, V674C | CA CALCIUM ION × 5 MG MAGNESIUM ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CL CHLORIDE ION × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；297 K；6% PEG 8000, 0.2 M Mg acetate, 0.1 M Na cacodylate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.75 Å R-free 0.225 |
| 4NEN An internal ligand-bound, metastable state of a leukocyte integrin, aXb2 Deposited 2013-10-29 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–696（674 aa）
Fragment：CD18
|
Mutation：N190D, N232K and V696C | CA CALCIUM ION × 5 MG MAGNESIUM ION × 2 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；297 K；6% PEG 8000, 0.2 M Mg acetate, 0.1 M Na cacodylate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.90 Å R-free 0.264 |
| 5E6R Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand Deposited 2015-10-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–482（460 aa）
Fragment：UNP residues 23-482
|
Mutation：N232R | MG MAGNESIUM ION × 1 CA CALCIUM ION × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 6.5, 15% PEG 3350
|
Resolution 2.90 Å R-free 0.229 |
| 5E6S Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand Deposited 2015-10-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–482（460 aa）
Fragment：UNP residues 23-482
|
Not recorded | MG MAGNESIUM ION × 1 CA CALCIUM ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；0.1 M Tris, pH 8, 0.1 M NaCl, and 8% polyethylene glycol (PEG) 20,000
|
Resolution 2.15 Å R-free 0.234 |
| 5E6S Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand Deposited 2015-10-10 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
23–482（460 aa）
Fragment：UNP residues 23-482
|
Not recorded | MG MAGNESIUM ION × 1 CA CALCIUM ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；0.1 M Tris, pH 8, 0.1 M NaCl, and 8% polyethylene glycol (PEG) 20,000
|
Resolution 2.15 Å R-free 0.234 |
| 5E6S Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand Deposited 2015-10-10 | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
23–482（460 aa）
Fragment：UNP residues 23-482
|
Not recorded | MG MAGNESIUM ION × 1 CA CALCIUM ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；0.1 M Tris, pH 8, 0.1 M NaCl, and 8% polyethylene glycol (PEG) 20,000
|
Resolution 2.15 Å R-free 0.234 |
| 5E6S Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand Deposited 2015-10-10 | Assembly 4 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
23–482（460 aa）
Fragment：UNP residues 23-482
Chain D
23–482（460 aa）
Fragment：UNP residues 23-482
Chain F
23–482（460 aa）
Fragment：UNP residues 23-482
|
Not recorded | MG MAGNESIUM ION × 3 CA CALCIUM ION × 15 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；0.1 M Tris, pH 8, 0.1 M NaCl, and 8% polyethylene glycol (PEG) 20,000
|
Resolution 2.15 Å R-free 0.234 |
| 5E6U Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand Deposited 2015-10-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–482（460 aa）
Fragment：UNP residues 23-482
|
Not recorded | MG MAGNESIUM ION × 2 CA CALCIUM ION × 4 CL CHLORIDE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M Mg-formate dehydrate and 15% PEG 3350
|
Resolution 2.50 Å R-free 0.226 |
| 5E6V Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit Deposited 2015-10-10 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–125（103 aa）
Fragment：UNP residues 23-125, 365-482
Chain A
365–482（118 aa）
Fragment：UNP residues 23-125, 365-482
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.80 Å R-free 0.229 |
| 5E6W Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit Deposited 2015-10-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–122（100 aa）
Fragment：UNP residues 23-122, 362-574
Chain A
362–574（213 aa）
Fragment：UNP residues 23-122, 362-574
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.20 Å R-free 0.270 |
| 5E6X Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit Deposited 2015-10-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–122（100 aa）
Fragment：UNP residues 23-122 and 362 535
Chain A
362–535（174 aa）
Fragment：UNP residues 23-122 and 362 535
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.75 Å R-free 0.245 |
| 5ES4 RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION Deposited 2015-11-16 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–696（674 aa）
Fragment：UNP residues 23-696
|
Not recorded | CA CALCIUM ION × 4 MG MAGNESIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.55M TRI-SODIUM CITRATE, 0.1M
IMIDAZOLE, PH 6.5, EVAPORATION, TEMPERATURE 277K
|
Resolution 3.30 Å R-free 0.307 |
| 5ES4 RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION Deposited 2015-11-16 | Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
23–696（674 aa）
Fragment：UNP residues 23-696
|
Not recorded | CA CALCIUM ION × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.55M TRI-SODIUM CITRATE, 0.1M
IMIDAZOLE, PH 6.5, EVAPORATION, TEMPERATURE 277K
|
Resolution 3.30 Å R-free 0.307 |
| 5ES4 RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION Deposited 2015-11-16 | Assembly 3 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
23–696（674 aa）
Fragment：UNP residues 23-696
|
Not recorded | CA CALCIUM ION × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.55M TRI-SODIUM CITRATE, 0.1M
IMIDAZOLE, PH 6.5, EVAPORATION, TEMPERATURE 277K
|
Resolution 3.30 Å R-free 0.307 |
| 5ES4 RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION Deposited 2015-11-16 | Assembly 4 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain H
23–696（674 aa）
Fragment：UNP residues 23-696
|
Not recorded | CA CALCIUM ION × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.55M TRI-SODIUM CITRATE, 0.1M
IMIDAZOLE, PH 6.5, EVAPORATION, TEMPERATURE 277K
|
Resolution 3.30 Å R-free 0.307 |
| 5XR1 Structure of FLN IG21 domain in complex with C-terminal peptide of beta-2 Deposited 2017-06-07 | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
752–763（12 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.2；298 K；Ionic strength (raw mmCIF value) 150；Pressure 1
NMR sample composition
300 uM [U-13C; U-15N] FLN IG21 domain, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 5ZAZ Solution structure of integrin b2 monomer tranmembrane domain in bicelle Deposited 2018-02-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
689–739（51 aa）
|
Mutation：C695S | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.7；303 K；Ionic strength (raw mmCIF value) 20；Pressure 1
NMR sample composition
0.6 mM [U-13C; U-15N] integrin b2, 20 mM Bis-Tris, 240 mM DHPC, 48 mM POPC, 24 mM POPG, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 9ECL Structure of the human integrin beta2 transmembrane domain Deposited 2024-11-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
696–735（40 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 7.4；313.2 K；Ionic strength (raw mmCIF value) 0.025；Pressure 1
NMR sample composition
1.2 mM [U-100% 13C; U-100% 15N; U-80% 2H] alphaX peptide, 350 mM 1,2-dihexanoyl-sn-glycero-3-phosphoholine, 105 mM 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 25 mM HEPES, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 9RM9 Cryo-EM structure of alphaM/beta2 headpiece complex without alphaM I-domain - the consensus map from alphaM/beta2:C3d-anti-CR3-Nb headpiece complex Deposited 2025-06-18 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–482（460 aa）
|
Not recorded | CA CALCIUM ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 MN MANGANESE (II) ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；0.02 % w/v CHAPS added to sample just before vitrification
|
Resolution 2.60 Å |
| 9T3Y Cryo-EM structure of alphaM/beta2:C3d-anti-CR3-Nb headpiece complex (HPO2 3D class reconstruction) Deposited 2025-10-30 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
23–482（460 aa）
|
Not recorded | CA CALCIUM ION × 5 MN MANGANESE (II) ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；0.02 % w/v CHAPS added to sample just before vitrification
|
Resolution 3.44 Å |
| 9T5V Cryo-EM structure of alphaM/beta2:C3d-anti-CR3-Nb headpiece complex (HPO1 3D class reconstruction) Deposited 2025-11-06 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
23–485（463 aa）
|
Not recorded | CA CALCIUM ION × 5 MN MANGANESE (II) ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；0.02 % w/v CHAPS added to sample just before vitrification
|
Resolution 3.06 Å |
| 9T5W Cryo-EM structure of mutant R61H alphaM/beta2 headpiece complex Deposited 2025-11-06 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
23–482（460 aa）
|
Not recorded | CA CALCIUM ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 MN MANGANESE (II) ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；0.02 % w/v CHAPS added to sample just before vitrification
|
Resolution 2.74 Å |
| 9T5Z Cryo-EM structure of alphaM/beta2:MEM148-Fab headpiece complex (without alphaM I-domain) Deposited 2025-11-06 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
23–485（463 aa）
|
Not recorded | CA CALCIUM ION × 5 MN MANGANESE (II) ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |