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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P07237 New Search
14PDB entries
18Biological assembly
19chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1BJX HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 24 STRUCTURES Deposited 1998-06-29 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 136–245（110 aa） Fragment：B DOMAIN
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；300 K
Resolution not provided
1MEK HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES Deposited 1996-04-16 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 18–137（120 aa） Fragment：PROLYL 4-HYDROXYLASE BETA SUBUNIT
Not recorded No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
1X5C The solution structure of the second thioredoxin-like domain of human Protein disulfide-isomerase Deposited 2005-05-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 368–475（108 aa） Fragment：Thioredoxin like domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；296 K；Ionic strength (raw mmCIF value) 120mM；Pressure ambient
NMR sample composition 1.2mM thioredoxin like domain U-15N,13C; 20mM d-Tris HCl; 100mM NaCl; 1mM d-DTT; 0.02% NaN3; 10% D2O | 90% H2O/10% D2O
Resolution not provided
2BJX PROTEIN DISULFIDE ISOMERASE Deposited 1999-01-30 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 136–245（110 aa） Fragment：B DOMAIN
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；300 K；Pressure 1
Resolution not provided
2K18 Solution structure of bb' domains of human protein disulfide isomerase Deposited 2008-02-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 135–357（223 aa） Fragment：residues 135-357
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；303 K；Ionic strength (raw mmCIF value) 0.1；Pressure 1
NMR sample composition 2 mM [U-99% 13C; U-99% 15N] hPDI-bb, 25 mM sodium phosphate, 70 mM sodium chloride, 0.5 mM EDTA, 5 mM DTT, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 2 mM hPDI-bb, 25 mM sodium phosphate, 70 mM sodium chloride, 0.5 mM EDTA, 5 mM DTT, 100% D2O | 100% D2O
NMR sample composition 0.5 mM [U-99% 15N] hPDI-bb, 25 mM sodium phosphate, 70 mM sodium chloride, 0.5 mM EDTA, 5 mM DTT, 12 mg/mL Pf1 phages, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
3BJ5 Alternative conformations of the x region of human protein disulphide-isomerase modulate exposure of the substrate binding b' domain Deposited 2007-12-03 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 230–368（139 aa） Fragment：;b'x domain, UNPR residues 230-368 ;
Mutation：I272A SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；295.15 K；2.95M Ammonium sulfate, 0.2M NaCl, 0.1M Tris-HCl pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 295.15K
Resolution 2.20 Å R-free 0.255
3UEM Crystal structure of human PDI bb'a' domains Deposited 2011-10-30 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 137–479（343 aa） Fragment：;bb'a' domains ;
Not recorded D1D (4S,5S)-1,2-DITHIANE-4,5-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；25%(w/v) PEG3350, 0.1M Tris-HCl, 0.2M ammonium acetate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 2.29 Å R-free 0.280
4EKZ Crystal structure of reduced hPDI (abb'xa') Deposited 2012-04-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 18–479（462 aa） Fragment：reduced full-length hPDI, UNP residues 18-479
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 9.8；294 K；25% PEG 3350, 0.1M Bis-Tris, 0.2M ammonium acetate, pH 9.8, EVAPORATION, temperature 294K
Resolution 2.51 Å R-free 0.250
4EL1 Crystal structure of oxidized hPDI (abb'xa') Deposited 2012-04-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 18–479（462 aa） Fragment：oxidized full-length hPDI, UNP residues 18-479
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 9.8；294 K；25% PEG 3350, 0.1M Bis-Tris, 0.2M ammonium acetate, pH 9.8, EVAPORATION, temperature 294K
Resolution 2.88 Å R-free 0.281
4EL1 Crystal structure of oxidized hPDI (abb'xa') Deposited 2012-04-10 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 18–479（462 aa） Fragment：oxidized full-length hPDI, UNP residues 18-479
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 9.8；294 K；25% PEG 3350, 0.1M Bis-Tris, 0.2M ammonium acetate, pH 9.8, EVAPORATION, temperature 294K
Resolution 2.88 Å R-free 0.281
4JU5 Crystal structure of the dimeric form of the bb' domains of human protein disulfide isomerase Deposited 2013-03-24 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 135–367（233 aa） Fragment：;bb' domain ;
Chain B 135–367（233 aa） Fragment：;bb' domain ;
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；25% (w/v) polyethylene glycol 1500, 25 mM sodium malonate, 37.5 mM imidazole, 37.5 mM boric acid, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.28 Å R-free 0.290
6I7S Microsomal triglyceride transfer protein Deposited 2018-11-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 18–508（491 aa）
Not recorded CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 11 PGE TRIETHYLENE GLYCOL × 1 SO4 SULFATE ION × 7 PEG DI(HYDROXYETHYL)ETHER × 2 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.1 M Tris pH 8.25, 0.2 M Li2SO4, 32% v/v PEG 400, 2% Polypropylene glycol P425
Resolution 2.50 Å R-free 0.257
6I7S Microsomal triglyceride transfer protein Deposited 2018-11-17 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 18–508（491 aa）
Not recorded CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 8 PGE TRIETHYLENE GLYCOL × 5 SO4 SULFATE ION × 4 PEG DI(HYDROXYETHYL)ETHER × 7 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 PE4 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.1 M Tris pH 8.25, 0.2 M Li2SO4, 32% v/v PEG 400, 2% Polypropylene glycol P425
Resolution 2.50 Å R-free 0.257
7ZSC Crystal structure of the heterodimeric human C-P4H-II with truncated alpha subunit (C-P4H-II delta281) Deposited 2022-05-06 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 18–508（491 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；278 K；20% (w/v) PEG4000, 0.2 M lithium sulfate, 0.1 M MES, 3% methanol
Resolution 3.85 Å R-free 0.278
7ZSC Crystal structure of the heterodimeric human C-P4H-II with truncated alpha subunit (C-P4H-II delta281) Deposited 2022-05-06 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 18–508（491 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；278 K；20% (w/v) PEG4000, 0.2 M lithium sulfate, 0.1 M MES, 3% methanol
Resolution 3.85 Å R-free 0.278
8EOJ Microsomal triglyceride transfer protein Deposited 2022-10-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–508（508 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.07 Å
8GDY Crystal structure of the human PDI first domain with 9 mutations Deposited 2023-03-06 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 18–137（120 aa）
Mutation：K31R, K42R, K57R, K65R, K69R, K71R, K114R, K130R, K131R SCN THIOCYANATE ION × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6；277 K；0.1 M potassium thiocyanate, 0.1 M MES, and 24% (w/v) PEG 20k
Resolution 2.05 Å R-free 0.239
8GDY Crystal structure of the human PDI first domain with 9 mutations Deposited 2023-03-06 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 18–137（120 aa）
Mutation：K31R, K42R, K57R, K65R, K69R, K71R, K114R, K130R, K131R SCN THIOCYANATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6；277 K；0.1 M potassium thiocyanate, 0.1 M MES, and 24% (w/v) PEG 20k
Resolution 2.05 Å R-free 0.239

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.