Current Protein Identity：P07357
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2QOS Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8 Deposited 2007-07-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
188–198（11 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；26-28% PEG6K, 0.1M Tris pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.81 Å R-free 0.244 |
| 2QQH Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense Deposited 2007-07-26 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
133–366（234 aa）
Chain A
410–492（83 aa）
|
Mutation：C164S Mutation：C164S | SO4 SULFATE ION × 3 NI NICKEL (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；303 K；1M LiSO4, 5mM NiCl2, 100mM Tris, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 303K
|
Resolution 2.50 Å R-free 0.287 |
| 2RD7 Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins Deposited 2007-09-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
133–492（360 aa）
|
Not recorded | CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；289 K；6% PEG 20,000, 0.1 M citric acid, 0.025 M Mg(NO3)2, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.15 Å R-free 0.261 |
| 3OJY Crystal Structure of Human Complement Component C8 Deposited 2010-08-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
31–584（554 aa）
Fragment：unp residues 31-584
|
Not recorded | CA CALCIUM ION × 2 BMA beta-D-mannopyranose × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；281 K；14-16% PEG 4K, 100mM TAPS pH 9.0, 400mM NaCl, 10mM SrCl2, VAPOR DIFFUSION, HANGING DROP, temperature 281K
|
Resolution 2.51 Å R-free 0.337 |
| 6H03 OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX Deposited 2018-07-06 | Assembly 1 Other combination Heteromer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count |
Chain F
31–584（554 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 37 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.60 Å |
| 6H04 Closed conformation of the Membrane Attack Complex Deposited 2018-07-06 | Assembly 1 Other combination Heteromer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count |
Chain F
31–584（554 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 38 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.60 Å |
| 7NYC cryoEM structure of 3C9-sMAC Deposited 2021-03-22 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain E
31–584（554 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 7 CA CALCIUM ION × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FUC alpha-L-fucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.54 Å |
| 7NYD cryoEM structure of 2C9-sMAC Deposited 2021-03-22 | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain E
31–584（554 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 6 CA CALCIUM ION × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 FUC alpha-L-fucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.27 Å |
| 8B0F CryoEM structure of C5b8-CD59 Deposited 2022-09-07 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain E
1–584（584 aa）
|
Not recorded | CA CALCIUM ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 8B0G 2C9, C5b9-CD59 structure Deposited 2022-09-07 | Assembly 1 Other combination Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count |
Chain E
1–584（584 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；20 mM HEPES pH 7.4, 120 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8B0H 2C9, C5b9-CD59 cryoEM structure Deposited 2022-09-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain E
1–584（584 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；20 mM HEPES pH 7.4, 120 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |