8b0h

2C9, C5b9-CD59 cryoEM structure

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

CD59 glycoprotein

Homo sapiens

UniProt P13987

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 Complement component C8 beta chain × 1 (P07358) Complement component C8 gamma chain × 1 (P07360) Complement component C8 alpha chain × 1 (P07357) Complement C5 × 1 (P01031) Complement component C7 × 1 (P10643) Complement component C6 × 1 (P13671) Complement component C9 × 2 (P02748) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CD59_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain G; PDBConstruct 1–128; UniProt 1–128

Complement component C8 beta chain

OrganismNot specified

UniProt P07358

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 CD59 glycoprotein × 1 (P13987) Complement component C8 gamma chain × 1 (P07360) Complement component C8 alpha chain × 1 (P07357) Complement C5 × 1 (P01031) Complement component C7 × 1 (P10643) Complement component C6 × 1 (P13671) Complement component C9 × 2 (P02748) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CO8B_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain D; PDBConstruct 1–591; UniProt 1–591

Complement component C8 gamma chain

OrganismNot specified

UniProt P07360

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 CD59 glycoprotein × 1 (P13987) Complement component C8 beta chain × 1 (P07358) Complement component C8 alpha chain × 1 (P07357) Complement C5 × 1 (P01031) Complement component C7 × 1 (P10643) Complement component C6 × 1 (P13671) Complement component C9 × 2 (P02748) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CO8G_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain F; PDBConstruct 1–202; UniProt 1–202

Complement component C8 alpha chain

OrganismNot specified

UniProt P07357

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 CD59 glycoprotein × 1 (P13987) Complement component C8 beta chain × 1 (P07358) Complement component C8 gamma chain × 1 (P07360) Complement C5 × 1 (P01031) Complement component C7 × 1 (P10643) Complement component C6 × 1 (P13671) Complement component C9 × 2 (P02748) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CO8A_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain E; PDBConstruct 1–584; UniProt 1–584

Complement C5

OrganismNot specified

UniProt P01031

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 CD59 glycoprotein × 1 (P13987) Complement component C8 beta chain × 1 (P07358) Complement component C8 gamma chain × 1 (P07360) Complement component C8 alpha chain × 1 (P07357) Complement component C7 × 1 (P10643) Complement component C6 × 1 (P13671) Complement component C9 × 2 (P02748) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CO5_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain A; PDBConstruct 1–1676; UniProt 1–1676

Complement component C7

OrganismNot specified

UniProt P10643

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 CD59 glycoprotein × 1 (P13987) Complement component C8 beta chain × 1 (P07358) Complement component C8 gamma chain × 1 (P07360) Complement component C8 alpha chain × 1 (P07357) Complement C5 × 1 (P01031) Complement component C6 × 1 (P13671) Complement component C9 × 2 (P02748) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CO7_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain C; PDBConstruct 1–843; UniProt 1–843

Complement component C6

OrganismNot specified

UniProt P13671

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 CD59 glycoprotein × 1 (P13987) Complement component C8 beta chain × 1 (P07358) Complement component C8 gamma chain × 1 (P07360) Complement component C8 alpha chain × 1 (P07357) Complement C5 × 1 (P01031) Complement component C7 × 1 (P10643) Complement component C9 × 2 (P02748) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CO6_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain B; PDBConstruct 1–934; UniProt 1–934

Complement component C9

OrganismNot specified

UniProt P02748

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 CD59 glycoprotein × 1 (P13987) Complement component C8 beta chain × 1 (P07358) Complement component C8 gamma chain × 1 (P07360) Complement component C8 alpha chain × 1 (P07357) Complement C5 × 1 (P01031) Complement component C7 × 1 (P10643) Complement component C6 × 1 (P13671) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CO9_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain H; PDBConstruct 1–559; UniProt 1–559 Author chain I; PDBConstruct 1–559; UniProt 1–559

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8b0h
Deposition date deposition_date2022-09-07
Structure title title2C9, C5b9-CD59 cryoEM structure
Keywords keywordsComplement, CD59, MAC, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8b0h__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8b0h__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8b0h__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)67.36 Å
Rg (electron density)67.99 Å
Total Rg68.06 Å
Atom count72850
Residues4703
Excluded volume655010 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8b0h__assembly_1__model_1 nonameric (9) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (8)

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7. Citations (1)