Current Protein Identity：P09471
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 21AG LY334370-bound serotonin 1F (5-HT1F) receptor-miniGoA protein complex Deposited 2025-12-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain C
4–51（48 aa）
Chain C
182–354（173 aa）
|
Not recorded | A1E2G 4-fluoranyl-~{N}-[3-(1-methylpiperidin-4-yl)-1~{H}-indol-5-yl]benzamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.13 Å |
| 6FUF Crystal structure of the rhodopsin-mini-Go complex Deposited 2018-02-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
18–354（337 aa）
|
Not recorded | RET RETINAL × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；0.1 M MES pH 5.5
10-20% PEG4000
|
Resolution 3.12 Å R-free 0.280 |
| 6G79 Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor Deposited 2018-04-05 | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
4–57（54 aa）
|
Not recorded | EP5 2-[5-[2-[4-(4-cyanophenyl)piperazin-1-yl]-2-oxidanylidene-ethoxy]-1~{H}-indol-3-yl]ethylazanium × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.78 Å |
| 6K41 cryo-EM structure of alpha2BAR-GoA complex Deposited 2019-05-23 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | CZX 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 6OIK Muscarinic acetylcholine receptor 2-Go complex Deposited 2019-04-09 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Mutation：E9D, R10K, L13V, A18M | IXO 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium × 1 2CU 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 6WWZ Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein Deposited 2020-05-09 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.34 Å |
| 7EJ0 Structure of the alpha2A-adrenergic receptor GoA signaling complex Deposited 2021-04-01 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | E5E Noradrenaline × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 7EJ8 Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine Deposited 2021-04-01 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | J59 Brimonidine × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 7EJA Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine Deposited 2021-04-01 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | CZX 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 7EJK Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline Deposited 2021-04-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | J5C Oxymetazoline × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7QVM Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex Deposited 2022-01-21 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
242–353（112 aa）
|
Mutation：E9D,R10K,L13V,A18M,I344L,A345Q,N346L,G350E,C351Y,G352N,Y354V | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.25 Å |
| 7T8X Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state Deposited 2021-12-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | ACH ACETYLCHOLINE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.21 Å |
| 7T90 Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state Deposited 2021-12-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | ACH ACETYLCHOLINE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.32 Å |
| 7T94 Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM Deposited 2021-12-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | ACH ACETYLCHOLINE × 1 2CU 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 7T96 Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM Deposited 2021-12-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | ACH ACETYLCHOLINE × 1 2CU 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.22 Å |
| 7W2Z Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex Deposited 2021-11-24 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I | CLR CHOLESTEROL × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 7W6P Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist Deposited 2021-12-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | W96 N-pyridin-4-ylisoquinolin-4-amine × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.47 Å |
| 7W7E Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist Deposited 2021-12-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | W58 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7XJJ Cryo-EM structure of the galanin-bound GALR1-miniGo complex Deposited 2022-04-18 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
242–354（113 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 7Y24 Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex Deposited 2022-06-09 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
5–57（53 aa）
Fragment：UNP residues 5-57, UNP residues 182-231, UNP residues 242-354
Chain A
182–231（50 aa）
Fragment：UNP residues 5-57, UNP residues 182-231, UNP residues 242-354
Chain A
242–354（113 aa）
Fragment：UNP residues 5-57, UNP residues 182-231, UNP residues 242-354
|
Mutation：G42N,E43N,A227D,G230D,L250D,I332A,V335I Mutation：G42N,E43N,A227D,G230D,L250D,I332A,V335I Mutation：G42N,E43N,A227D,G230D,L250D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.25 Å |
| 8DZQ momSalB bound Kappa Opioid Receptor in complex with GoA Deposited 2022-08-08 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | U99 methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxododecahydro-2H-naphtho[2,1-c]pyran-7-carboxylate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 2.82 Å |
| 8E9X CryoEM structure of miniGo-coupled hM4Di in complex with DCZ Deposited 2022-08-27 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
242–354（113 aa）
|
Not recorded | WEC 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 2.70 Å |
| 8FN1 CryoEM structure of Go-coupled NTSR1 Deposited 2022-12-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
1–57（57 aa）
Chain B
182–354（173 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5；20mM Hepes, 0.1M NaCl, 0.00075% LMNG, 0.00075% GDN
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 2.88 Å |
| 8HPT Structure of C5a-pep bound mouse C5aR1 in complex with Go Deposited 2022-12-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
4–57（54 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.39 Å |
| 8HQC Structure of a GPCR-G protein in complex with a natural peptide agonist Deposited 2022-12-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
4–57（54 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.89 Å |
| 8I95 Structure of EP54-C3aR-Go complex Deposited 2023-02-06 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Fragment：UNP residues 4-57,UNP residues 182-354
Chain A
182–354（173 aa）
Fragment：UNP residues 4-57,UNP residues 182-354
|
Mutation：G42D,E43N,A227D,G230D,I332A,V35I Mutation：G42D,E43N,A227D,G230D,I332A,V35I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.88 Å |
| 8I97 Structure of Apo-C3aR-Go complex (Glacios) Deposited 2023-02-06 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
4–57（54 aa）
Fragment：UNP residues 4-57,UNP residues 182-354
Chain A
182–354（173 aa）
Fragment：UNP residues 4-57,UNP residues 182-354
|
Mutation：G42D,E43N,A227D,G230D,I332A,V35I Mutation：G42D,E43N,A227D,G230D,I332A,V35I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.19 Å |
| 8I9L Structure of C3a-C3aR-Go complex (Composite map) Deposited 2023-02-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Fragment：UNP residues 4-57,UNP residues 182-354
Chain A
182–354（173 aa）
Fragment：UNP residues 4-57,UNP residues 182-354
|
Mutation：G42D, E43N Mutation：G42D, E43N | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.18 Å |
| 8I9S Structure of Apo-C3aR-Go complex (Titan) Deposited 2023-02-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.26 Å |
| 8IA2 Structure of C5a bound human C5aR1 in complex with Go (Composite map) Deposited 2023-02-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
4–57（54 aa）
Fragment：UNP residues 4-57,UNP residues 182-354
Chain B
182–354（173 aa）
Fragment：UNP residues 4-57,UNP residues 182-354
|
Mutation：G42D,E43N,A227D,G230D,I332A,V35I Mutation：G42D,E43N,A227D,G230D,I332A,V35I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.21 Å |
| 8IEC Cryo-EM structure of miniGo-scFv16 of GPR156-miniGo-scFv16 complex (local refine) Deposited 2023-02-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain C
1–56（56 aa）
Chain C
182–354（173 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.18 Å |
| 8IED Cryo-EM structure of GPR156-miniGo-scFv16 complex Deposited 2023-02-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain C
182–354（173 aa）
|
Not recorded | A1LYA [(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxy-propyl] 2-(trimethylazaniumyl)ethyl phosphate × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.33 Å |
| 8IY9 Structure of Niacin-GPR109A-G protein complex Deposited 2023-04-04 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
6–55（50 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | NIO NICOTINIC ACID × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.37 Å |
| 8IYH Structure of MK6892-GPR109A-G-protein complex Deposited 2023-04-04 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
6–53（48 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | FI7 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8IYW Structure of GSK256073-GPR109A-G-protein complex Deposited 2023-04-06 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
6–53（48 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | OKL 8-chloranyl-3-pentyl-7H-purine-2,6-dione × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.45 Å |
| 8J6D Structure of EP141-C3aR-Go complex Deposited 2023-04-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V35I Mutation：G42D,E43N,A227D,G230D,I332A,V35I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 8JER Structure of Acipimox-GPR109A-G protein complex Deposited 2023-05-16 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
6–57（52 aa）
Chain A
183–354（172 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | OJX 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.45 Å |
| 8JHN Structure of MMF-GPR109A-G protein complex Deposited 2023-05-24 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
183–354（172 aa）
|
Mutation：G42D, E43N, A227D, G230D, I332A, V335I | UR9 Monomethyl fumarate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.75 Å |
| 8JZP Structure of mouse C5a-human C5aR1-Go complex Deposited 2023-07-06 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
4–57（54 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.45 Å |
| 8JZZ Structure of human C5a-desArg bound human C5aR1 in complex with Go Deposited 2023-07-06 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain C
4–57（54 aa）
Chain C
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.31 Å |
| 8TZQ CryoEM structure of D2 dopamine receptor in complex with GoA KE Mutant, scFv16, and dopamine Deposited 2023-08-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | LDP L-DOPAMINE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 3.20 Å |
| 8U02 CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine Deposited 2023-08-28 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | LDP L-DOPAMINE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 3.28 Å |
| 8XWV Structure of CXCR2 bound to CXCL1 (CXCR2-CXCL1-Go Full map) Deposited 2024-01-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain A
6–53（48 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.07 Å |
| 8XX3 Structure of CXCR2 bound to CXCL3 (CXCR2-CXCL3-Go Full map) Deposited 2024-01-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain A
6–57（52 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D, E43N, A227D, G230D, I332A, V335I Mutation：G42D, E43N, A227D, G230D, I332A, V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.38 Å |
| 8XX6 Structure of CXCR2 bound to CXCL8 (CXCR2-CXCL8-Go Full map) Deposited 2024-01-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.99 Å |
| 8XX7 Structure of CXCR2 bound to CXCL5 (CXCR2-CXCL5-Go Full map) Deposited 2024-01-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
Chain F
4–57（54 aa）
Chain F
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.32 Å |
| 8XXH Structure of CXCR2 bound to CXCL2 (CXCR2-CXCL2-Go Full map) Deposited 2024-01-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D, E43N, A227D, G230D, I332A, V335I Mutation：G42D, E43N, A227D, G230D, I332A, V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 8XXR Structure of CXCR2 bound to CXCL6 (CXCR2-CXCL6-Go Full map) Deposited 2024-01-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.17 Å |
| 8XXX Structure of CXCR2 bound to CXCL6 (Composite map) Deposited 2024-01-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.17 Å |
| 8XXZ Structure of CXCR3 in the apo-state (Full map) Deposited 2024-01-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8XYK Structure of CXCR3 in complex with VUF10661 and Go (Full map) Deposited 2024-01-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | A1LW1 (3~{S})-~{N}-[(2~{S})-6-azanyl-1-(2,2-diphenylethylamino)-1-oxidanylidene-hexan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1~{H}-isoquinoline-3-carboxamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.03 Å |
| 8Y0N Structure of CXCR3 in complex with VUF11418 and Go (Full map) Deposited 2024-01-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | A1LW2 [(1~{R},5~{S})-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl-[[4-(2-iodanylphenyl)phenyl]methyl]-dimethyl-azanium × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.07 Å |
| 8YN7 Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo Deposited 2024-03-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
182–354（173 aa）
|
Mutation：A227D,G230D,I332A,V335I | A1LY2 4-(1H-imidazol-4-ylmethyl)pyridine × 1 CLR CHOLESTEROL × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.77 Å |
| 8YN8 Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo Deposited 2024-03-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
182–354（173 aa）
|
Mutation：A227D,G230D,I332A,V335I | A1LY3 5-(3-phenylmethoxypropyl)-1H-imidazole × 1 CLR CHOLESTEROL × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.77 Å |
| 9BSB Global reconstruction of DRD2 bound to LSD in complex with a mini-GoA and scFv16 obtained by cryo-electron microscopy (cryoEM) Deposited 2024-05-13 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | 7LD (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 2.32 Å |
| 9DYD Asenapine-bound serotonin 1A (5-HT1A) receptor-Goa protein complex Deposited 2024-10-14 | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | A1BIR (3aS,12bR)-asenapine × 1 CLR CHOLESTEROL × 3 J40 [(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force 3 for 3-5 seconds was used and subsequent grids were screened for ice thickness prior to data collection.
|
Resolution 2.96 Å |
| 9DYE Buspirone-bound serotonin 1A (5-HT1A) receptor-Goa protein complex Deposited 2024-10-14 | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | YLX Buspirone × 1 CLR CHOLESTEROL × 2 J40 [(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force 3 for 3-5 seconds was used and subsequent grids were screened for ice thickness prior to data collection.
|
Resolution 2.90 Å |
| 9F33 Cryo-EM structure of Dopamine 3 Receptor:Go complex bound to bitopic FOB02-04A - Conformation A Deposited 2024-04-24 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Mutation：S47N, G204A, E246A, M249K,A326S | A1H9N N-[2-[(1R,2S)-2-[[(2S,5S)-2-(6-azanylpyridin-3-yl)-5-methyl-morpholin-4-yl]methyl]cyclopropyl]ethyl]-1H-indole-2-carboxamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.05 Å |
| 9F34 Cryo-EM structure of Dopamine 3 receptor:Go complex bound to bitopic FOB02-04A - Conformation B Deposited 2024-04-24 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–181（181 aa）
Chain A
182–354（173 aa）
|
Mutation：S47N,G204A,E246A,M249K,A326S Mutation：S47N,G204A,E246A,M249K,A326S | A1H9N N-[2-[(1R,2S)-2-[[(2S,5S)-2-(6-azanylpyridin-3-yl)-5-methyl-morpholin-4-yl]methyl]cyclopropyl]ethyl]-1H-indole-2-carboxamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.09 Å |
| 9K20 Cryo-EM structure of ATP-bound P2Y purinoceptor 2-miniGo-scFv16 complex Deposited 2024-10-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
4–57（54 aa）
Chain B
182–354（173 aa）
|
Not recorded | ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.65 Å |
| 9KUG Structure of EP67 bound to human C5aR1 in complex with Go Deposited 2024-12-03 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
4–57（54 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.07 Å |
| 9KUT Structure of JR14a bound to human C3aR in complex with Go Deposited 2024-12-04 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | A1D9A (2~{S})-5-[bis(azanyl)methylideneamino]-2-[[5-[bis(4-chlorophenyl)methyl]-3-methyl-thiophen-2-yl]carbonylamino]pentanoic acid × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.29 Å |
| 9KV6 Structure of mouse TLQP21 bound to mouse C3aR in complex with Go Deposited 2024-12-04 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.88 Å |
| 9KV8 Structure of human TLQP21 bound to mouse C3aR in complex with Go Deposited 2024-12-04 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.17 Å |
| 9KVP Structure of SB290157 bound to human C3aR in complex with Go (Full map) Deposited 2024-12-05 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | A1L6Y (2S)-5-[bis(azanyl)methylideneamino]-2-[2-(2,2-diphenylethoxy)ethanoylamino]pentanoic acid × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.79 Å |
| 9KWG Structure of mouse C5a bound mouse C5aR1 in complex with Go Deposited 2024-12-05 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
4–57（54 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.15 Å |
| 9KWX Structure of mouse C5a-desArg bound mouse C5aR1 in complex with Go Deposited 2024-12-06 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
6–53（48 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.13 Å |
| 9KX6 Structure of human C5a-desArg bound mouse C5aR1 in complex with Go Deposited 2024-12-06 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
6–53（48 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.11 Å |
| 9KXS Structure of EP67 bound mouse C5aR1 in complex with Go Deposited 2024-12-07 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
4–53（50 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.31 Å |
| 9KZ2 Structure of EP67 bound human C3aR in complex with Go Deposited 2024-12-09 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.43 Å |
| 9KZ8 Structure of EP67 bound mouse C3aR in complex with Go Deposited 2024-12-10 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9KZK Structure of mouse C3a bound mouse C3aR in complex with Go Deposited 2024-12-10 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.54 Å |
| 9L0H Structure of JR14a bound mouse C3aR in complex with Go Deposited 2024-12-12 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
4–57（54 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | A1D9A (2~{S})-5-[bis(azanyl)methylideneamino]-2-[[5-[bis(4-chlorophenyl)methyl]-3-methyl-thiophen-2-yl]carbonylamino]pentanoic acid × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.57 Å |
| 9PLO Structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905) Deposited 2025-07-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | A1CIU N-(5-methylnaphthalen-1-yl)pyridin-4-amine × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5；CHS was solubilized in LMNG and GDN prior to diluting into buffers.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.74 Å |
| 9UMJ Structure of EP54 bound mouse C3aR in complex with Go Deposited 2025-04-22 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
4–53（50 aa）
Chain A
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.38 Å |
| 9UMR Structure of C5a-pep bound human C5aR1 in complex with Go Deposited 2025-04-22 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
4–57（54 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.15 Å |
| 9UMX Structure of EP54 bound human C5aR1 in complex with Go Deposited 2025-04-23 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain B
4–57（54 aa）
Chain B
182–354（173 aa）
|
Mutation：G42D,E43N,A227D,G230D,I332A,V335I Mutation：G42D,E43N,A227D,G230D,I332A,V335I | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9VAT Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Go complex in nucleotide-free C state Deposited 2025-06-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY | mmCIF provides none of the parsed conditions | Resolution 3.37 Å |
| 9VAU Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Go complex in nucleotide-free NC state 1 Deposited 2025-06-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY | mmCIF provides none of the parsed conditions | Resolution 2.95 Å |
| 9VAV Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Go complex in nucleotide-free NC state 2 Deposited 2025-06-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
1–354（354 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY | mmCIF provides none of the parsed conditions | Resolution 2.99 Å |
| 9VJ5 Cryo-EM structure of 5-HT1AR-GoA in complex with gepirone Deposited 2025-06-19 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | A1ESA Gepirone × 1 CLR CHOLESTEROL × 2 T7M (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.69 Å |
| 9VJE Cryo-EM structure of 5-HT1AR-GoA in complex with buspirone Deposited 2025-06-19 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | YLX Buspirone × 1 CLR CHOLESTEROL × 2 T7M (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.47 Å |
| 9VMY Cryo-EM structure of 5-HT1AR-GoA in complex with TMU4142 Deposited 2025-06-29 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | A1ES2 8-[3-[[(2~{S})-3-(1~{H}-indol-4-yloxy)-2-oxidanyl-propyl]amino]propyl]-8-azaspiro[4.5]decane-7,9-dione × 1 CLR CHOLESTEROL × 2 T7M (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.86 Å |
| 9VNF Cryo-EM structure of 5-HT1AR-GoA in complex with (S)-pindolol Deposited 2025-06-30 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1–354（354 aa）
|
Not recorded | A1ES4 (2~{S})-1-(1~{H}-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol × 1 CLR CHOLESTEROL × 2 T7M (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.74 Å |