Current Protein Identity：P10828
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1BSX STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS Deposited 1998-08-31 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：LIGAND BINDING DOMAIN
|
Not recorded | T3 3,5,3'TRIIODOTHYRONINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 4.9；pH 4.9
|
Resolution 3.70 Å R-free 0.299 |
| 1BSX STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS Deposited 1998-08-31 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
202–461（260 aa）
Fragment：LIGAND BINDING DOMAIN
|
Not recorded | T3 3,5,3'TRIIODOTHYRONINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 4.9；pH 4.9
|
Resolution 3.70 Å R-free 0.299 |
| 1N46 CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC Deposited 2002-10-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
204–461（258 aa）
Chain B
204–461（258 aa）
|
Not recorded | PFA [4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-3,5-DIMETHYL-PHENYL]-6-AZAURACIL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6；pH 6.0, temperature 100K
|
Resolution 2.20 Å R-free 0.256 |
| 1NAX Thyroid receptor beta1 in complex with a beta-selective ligand Deposited 2002-11-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
209–460（252 aa）
Fragment：Ligand binding domain (residues 209-460)
|
Not recorded | IH5 {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；ammonium sulphate, TRIS, NDSB-201, pH 8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.70 Å R-free 0.237 |
| 1NAX Thyroid receptor beta1 in complex with a beta-selective ligand Deposited 2002-11-29 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
209–460（252 aa）
Fragment：Ligand binding domain (residues 209-460)
|
Not recorded | IH5 {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；ammonium sulphate, TRIS, NDSB-201, pH 8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.70 Å R-free 0.237 |
| 1NQ0 TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD Deposited 2003-01-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：LIGAND BINDING DOMAIN
|
Mutation：A234T | 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 1 ARS ARSENIC × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；277 K；700 mM sodium acetate, 100mM Sodium Cacodylate, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å R-free 0.258 |
| 1NQ0 TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD Deposited 2003-01-20 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：LIGAND BINDING DOMAIN
|
Mutation：A234T | 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 2 ARS ARSENIC × 12 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；277 K；700 mM sodium acetate, 100mM Sodium Cacodylate, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å R-free 0.258 |
| 1NQ1 TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD Deposited 2003-01-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：LIGAND BINDING DOMAIN
|
Mutation：R243Q | 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 1 ARS ARSENIC × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；277 K；700 mM sodium acetate, 100mM Sodium Cacodylate, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å R-free 0.287 |
| 1NQ1 TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD Deposited 2003-01-20 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：LIGAND BINDING DOMAIN
|
Mutation：R243Q | 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 2 ARS ARSENIC × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；277 K；700 mM sodium acetate, 100mM Sodium Cacodylate, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å R-free 0.287 |
| 1NQ2 Two RTH Mutants with Impaired Hormone Binding Deposited 2003-01-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：LIGAND BINDING DOMAIN
|
Not recorded | NA SODIUM ION × 1 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 1 ARS ARSENIC × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；277 K；700 mM sodium acetate, 200mM sodium succinate 100mM sodium cacodylate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å R-free 0.264 |
| 1NQ2 Two RTH Mutants with Impaired Hormone Binding Deposited 2003-01-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：LIGAND BINDING DOMAIN
|
Not recorded | NA SODIUM ION × 2 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 2 ARS ARSENIC × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；277 K；700 mM sodium acetate, 200mM sodium succinate 100mM sodium cacodylate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å R-free 0.264 |
| 1NUO Two RTH Mutants with Impaired Hormone Binding Deposited 2003-01-31 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
201–461（261 aa）
Fragment：LIGAND BINDING DOMAIN
|
Not recorded | 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；277 K；800 mM sodium acetate, 100mM Sodium Cacodylate, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.10 Å R-free 0.302 |
| 1Q4X Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24 Deposited 2003-08-04 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
209–461（253 aa）
Fragment：Ligand Binding Domain
|
Not recorded | G24 [4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.9；291 K；PEG 3350, sodium acetate, glucose, cymal-2, pH 4.9, VAPOR DIFFUSION, SITTING DROP, temperature 291.0K
|
Resolution 2.80 Å R-free 0.264 |
| 1R6G Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound Deposited 2003-10-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
203–461（259 aa）
Fragment：ligand binding domain
|
Not recorded | 442 2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；Sodium acetate, sodium cacodylate , pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.00 Å R-free 0.347 |
| 1XZX Thyroxine-Thyroid Hormone Receptor Interactions Deposited 2004-11-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain X
202–461（260 aa）
Fragment：ligand binding domain (residues 202-461)
|
Not recorded | CAC CACODYLATE ION × 6 T3 3,5,3'TRIIODOTHYRONINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；279 K；sodium acetate, cacodylate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.50 Å R-free 0.244 |
| 1XZX Thyroxine-Thyroid Hormone Receptor Interactions Deposited 2004-11-12 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain X
202–461（260 aa）
Fragment：ligand binding domain (residues 202-461)
|
Not recorded | CAC CACODYLATE ION × 12 T3 3,5,3'TRIIODOTHYRONINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；279 K；sodium acetate, cacodylate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.50 Å R-free 0.244 |
| 1Y0X Thyroxine-Thyroid Hormone Receptor Interactions Deposited 2004-11-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain X
202–461（260 aa）
Fragment：ligand binding domain (residues 202-461)
|
Not recorded | CAC CACODYLATE ION × 6 T44 3,5,3',5'-TETRAIODO-L-THYRONINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；279 K；sodium acetate, cacodylate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 3.10 Å R-free 0.266 |
| 1Y0X Thyroxine-Thyroid Hormone Receptor Interactions Deposited 2004-11-16 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain X
202–461（260 aa）
Fragment：ligand binding domain (residues 202-461)
|
Not recorded | CAC CACODYLATE ION × 12 T44 3,5,3',5'-TETRAIODO-L-THYRONINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；279 K；sodium acetate, cacodylate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 3.10 Å R-free 0.266 |
| 2J4A Human Thyroid hormone receptor beta ligand binding domain in complex with KB131084 Deposited 2006-08-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
209–461（253 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 209-461
|
Mutation：YES | OEF 3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
0.45 M AMMONIUMSULFATE, 100 MMTRIS PH8.0, 100MM NDSB
|
Resolution 2.20 Å R-free 0.273 |
| 2NLL RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA Deposited 1996-11-20 | Assembly 1 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain B
104–206（103 aa）
|
Not recorded | ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7；CRYSTALLIZED FROM 40% PEG 3350 25 MM IMADAZOLE BUFFER, PH 7.0, 400 MM NH4CL, 10 MM DTT, AND 5 MM MGCL2
|
Resolution 1.90 Å R-free 0.269 |
| 2PIN Thyroid receptor beta in complex with inhibitor Deposited 2007-04-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
209–461（253 aa）
Fragment：Ligand-binding domain (residues 209-461)
Chain B
209–461（253 aa）
Fragment：Ligand-binding domain (residues 209-461)
|
Mutation：D355R Mutation：D355R | 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 2 LEG 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.256 |
| 3D57 TR Variant D355R Deposited 2008-05-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
209–460（252 aa）
Fragment：C-terminal domain
Chain B
209–460（252 aa）
Fragment：C-terminal domain
|
Mutation：D355R Mutation：D355R | 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；25% ethylene glycol, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.240 |
| 3GWS Crystal Structure of T3-Bound Thyroid Hormone Receptor Deposited 2009-04-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain X
202–460（259 aa）
Fragment：Ligand Binding Domain (UNP residues 202 to 460)
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | T3 3,5,3'TRIIODOTHYRONINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；298 K；100MM SODIUM CACODYLATE, 1.4M SODIUM ACETATE, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.233 |
| 3IMY Structure of TR-beta bound to selective thyromimetic GC-1 Deposited 2009-08-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：UNP residues 202-461
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | B72 {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.5；291 K；100mM NaCac, 1.2M NaAc, 200mM Na succinate, pH 7.5, VAPOR DIFFUSION, temperature 291K
|
Resolution 2.55 Å R-free 0.271 |
| 3IMY Structure of TR-beta bound to selective thyromimetic GC-1 Deposited 2009-08-11 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：UNP residues 202-461
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | B72 {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.5；291 K；100mM NaCac, 1.2M NaAc, 200mM Na succinate, pH 7.5, VAPOR DIFFUSION, temperature 291K
|
Resolution 2.55 Å R-free 0.271 |
| 3JZC Crystal Structure of TR-beta bound to the selective thyromimetic TRIAC Deposited 2009-09-23 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
202–461（260 aa）
Fragment：UNP residues 202-461, Ligand Binding Domain
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | 4HY [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.8；291 K；100mM Sodium Cacodylate, 1.4M sodium acetate, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.50 Å R-free 0.246 |
| 4ZO1 Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha Deposited 2015-05-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain X
210–461（252 aa）
Fragment：ligand binding domain unp residues 210-461
|
Not recorded | T3 3,5,3'TRIIODOTHYRONINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；294 K；20% PEG 3350, 100 mM Tris pH 8.0, 0.1 M ammonium acetate, and 1 mM Methoprene acid
|
Resolution 3.22 Å R-free 0.281 |
| 6KKB A novel agonist of THRb Deposited 2019-07-24 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain X
211–460（250 aa）
|
Not recorded | 8HO 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2M Sodium citrate tribasic dihydrate, 20%(w/v) Polyethylene glycol 3,350
|
Resolution 1.70 Å R-free 0.197 |
| 6KKE THRb mutation with a novel agonist Deposited 2019-07-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
211–459（249 aa）
|
Mutation：H435L | 8HO 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.2 M Ammonium citrate tribasic pH 7.0, 20% w/v Polyethylene glycol 3,350
|
Resolution 2.58 Å R-free 0.217 |
| 6KNU THRb mutation with a novel agonist Deposited 2019-08-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
211–460（250 aa）
|
Mutation：V264D | 8HO 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1M Sodium acetate trihydrate pH 4.6, 2.0M Sodium formate
|
Resolution 2.70 Å R-free 0.231 |
| 6KNV THRb mutation with a novel agonist Deposited 2019-08-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
211–460（250 aa）
|
Mutation：R438W | 8HO 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2% v/v Tacsimate pH 5.0, 0.1 M Sodium citrate tribasic dihydrate pH 5.6, 16% w/v Polyethylene glycol 3,350
|
Resolution 2.80 Å R-free 0.265 |
| 6KNW THRb mutation with a novel agonist Deposited 2019-08-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
211–460（250 aa）
|
Mutation：R438H | 8HO 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100mM Nacl 20% PEG 4000
|
Resolution 2.67 Å R-free 0.244 |
| 7WLX A novel chemical derivative(53) of THRB agonist Deposited 2022-01-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–476（260 aa）
|
Not recorded | 9GC 2-[[1-methoxy-4-oxidanyl-7-[4-(phenylmethyl)phenoxy]isoquinolin-3-yl]carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2% v/v tacsimate pH 5.0, 0.1 M sodium citrate tribasic dihydrate pH 5.6 and 16% w/v polyethylene glycol 3,350.
|
Resolution 2.39 Å R-free 0.270 |
| 7WMG A novel chemical derivative(52) of THRB agonist Deposited 2022-01-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–476（260 aa）
|
Not recorded | 9IF 2-[[1-methoxy-4-oxidanyl-7-(4-phenoxyphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium formate pH 7.0 and 20% w/v polyethylene glycol 3,350.
|
Resolution 2.93 Å R-free 0.298 |
| 7WMH A novel chemical derivative(56) of THRB agonist Deposited 2022-01-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–476（260 aa）
|
Not recorded | 9II 2-[[1-methoxy-4-oxidanyl-7-(4-phenylphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M MgSO4 and 5% PEG 8000
|
Resolution 1.97 Å R-free 0.253 |
| 7WMJ A novel chemical derivative(71) of THRB agonist Deposited 2022-01-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–476（260 aa）
|
Not recorded | 9IL 2-[[7-[2,6-dimethyl-4-(phenylcarbonyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；25% v/v ethylene glycol.
|
Resolution 2.81 Å R-free 0.274 |
| 7WML A novel chemical derivative(85) of THRB agonist Deposited 2022-01-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–476（260 aa）
|
Not recorded | 9IQ 2-[[7-[4-(3,5-dimethylphenyl)carbonyl-2,6-dimethyl-phenoxy]-1-ethoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M MgSO4 and 12% PEG 6000.
|
Resolution 2.67 Å R-free 0.245 |
| 7WMN A novel chemical derivative(89) of THRB agonist Deposited 2022-01-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–476（260 aa）
|
Not recorded | 9IT 2-[[7-[2,6-dimethyl-4-(3-methylphenyl)carbonyl-phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M MgSO4 and 12% PEG 6000.
|
Resolution 2.57 Å R-free 0.261 |
| 7WMO A novel chemical derivative(92) of THRB agonist Deposited 2022-01-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–476（260 aa）
|
Not recorded | 9IW 2-[[1-ethoxy-7-[4-(3-fluoranyl-5-methoxy-phenyl)carbonyl-2,6-dimethyl-phenoxy]-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium malonate pH 6.0 and 20% w/v Polyethylene glycol 3,350
|
Resolution 2.56 Å R-free 0.241 |
| 8RQN Human thyroid hormone receptor beta ligand binding domain in complex with beta-selective agonist ALG-055009 Deposited 2024-01-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
202–461（260 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | A1H2J 6-azanyl-2-[3,5-bis(chloranyl)-4-[(6-oxidanylidene-5-propan-2-yl-1~{H}-pyridazin-3-yl)oxy]phenyl]-1,2,4-triazine-3,5-dione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.40 M NaAcetate, 0.10 M NaCacodylate pH 7.0
|
Resolution 2.88 Å R-free 0.262 |
| 9IX5 An agonist(compound 15n) of Thyroid Hormone Receptor B Deposited 2024-07-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
203–461（259 aa）
|
Not recorded | A1EAC 2-[(1-methoxy-7-naphthalen-2-yloxy-4-oxidanyl-isoquinolin-3-yl)carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.35 M Sodium citrate tribasic dihydrate, 22%(w/v) Polyethylene glycol 3,350
|
Resolution 2.65 Å R-free 0.277 |
| 9J0K An agonist(compound 14e)of Thyroid Hormone Receptor B Deposited 2024-08-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
202–461（260 aa）
|
Not recorded | A1EAE 2-[[7-[3-(aminomethyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.3 M ammonium sulfate, 0.1 M MES monohydrate pH 6.7 and 13% v/v 1,4-Dioxane
|
Resolution 2.70 Å R-free 0.275 |
| 9J0K An agonist(compound 14e)of Thyroid Hormone Receptor B Deposited 2024-08-02 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
202–461（260 aa）
|
Not recorded | A1EAE 2-[[7-[3-(aminomethyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.3 M ammonium sulfate, 0.1 M MES monohydrate pH 6.7 and 13% v/v 1,4-Dioxane
|
Resolution 2.70 Å R-free 0.275 |