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2nll

RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTEIN (RETINOIC ACID RECEPTOR)

Homo sapiens

UniProt P19793

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 2 DNA 2 ;DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3') ; × 1 PROTEIN (THYROID HORMONE RECEPTOR) × 1 （P10828） ZINC ION × 4 water × 4 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1rxr

1 assemblies

Homodimer
1fby 5tbp 5tbp 6hn6

4 assemblies

Homotetramer
1g1u 1g5y 4n5g 4n8r 5tbp 5zqu 6jno 7cfo

8 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1by4 1by4 1dsz 1fm6 1fm6 1fm9 1k74 1mv9 1mvc 1mzn 1mzn 1r0n

126 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RXRA_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 1–66； UniProt 135–200

PROTEIN (THYROID HORMONE RECEPTOR)

Homo sapiens

UniProt P10828

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 2 DNA 2 ;DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3') ; × 1 PROTEIN (RETINOIC ACID RECEPTOR) × 1 （P19793） ZINC ION × 4 water × 4 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1nax 1nq0 1nq1 1nq2 1nuo 1q4x 1r6g 1xzx 1y0x 2j4a 3gws 3imy

14 assemblies; showing the first 12

Homodimer
1n46 1nax 1nq0 1nq1 1nq2 1xzx 1y0x 2pin 3d57 3imy

10 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1bsx 1bsx 2nll 4zo1 6kkb 6kke 6knu 6knv 6knw 7wlx 7wmg 7wmh

19 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name THB1_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain B； PDBConstruct 1–103； UniProt 104–206

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2nll
Deposition date deposition_date1996-11-20
Structure title titleRETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
Keywords keywords;COMPLEX (TRANSCRIPTION REGULATION-DNA), DNA-BINDING, NUCLEAR PROTEIN, ZINC- FINGER, MULTIGENE FAMILY, ALTERNATIVE SPLICING, RECEPTOR, TRANSCRIPTION-DNA COMPLEX ;; TRANSCRIPTION/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2nll__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2nll__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2nll__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）21.56 Å
Rg (electron density)21.32 Å
Total Rg21.93 Å
Atom count2115
Residues204
Excluded volume35233 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2nll__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd2nlla_
Class classg — Small proteins
Fold Fold foldg.39 — Glucocorticoid receptor-like (DNA-binding domain)
Superfamily Superfamily superfamilyg.39.1 — Glucocorticoid receptor-like (DNA-binding domain)
Family Family familyg.39.1.2 — Nuclear receptor
Domain ID domain_idd2nllb_
Class classg — Small proteins
Fold Fold foldg.39 — Glucocorticoid receptor-like (DNA-binding domain)
Superfamily Superfamily superfamilyg.39.1 — Glucocorticoid receptor-like (DNA-binding domain)
Family Family familyg.39.1.2 — Nuclear receptor

CATH v4.4 (2 domains)

Domain ID domain_id2nllA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology50 — Erythroid Transcription Factor GATA-1; Chain A
Homologous superfamily homologous superfamily10 — Erythroid Transcription Factor GATA-1, subunit A
Domain ID domain_id2nllB00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology50 — Erythroid Transcription Factor GATA-1; Chain A
Homologous superfamily homologous superfamily10 — Erythroid Transcription Factor GATA-1, subunit A
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7. Citations (1)