Current Protein Identity：P14867
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 6CDU Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone Deposited 2018-02-09 | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
249–340（92 aa）
Chain A
415–444（30 aa）
Chain B
249–340（92 aa）
Chain B
415–444（30 aa）
Chain C
249–340（92 aa）
Chain C
415–444（30 aa）
Chain D
249–340（92 aa）
Chain D
415–444（30 aa）
Chain E
249–340（92 aa）
Chain E
415–444（30 aa）
|
Not recorded | EY4 (3a,5a)-3-Hydroxypregnane-11,20-dione × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.1；277 K；PEG400, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, NaSCN
|
Resolution 3.45 Å R-free 0.286 |
| 6CDU Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone Deposited 2018-02-09 | Assembly 2 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain F
249–340（92 aa）
Chain F
415–444（30 aa）
Chain G
249–340（92 aa）
Chain G
415–444（30 aa）
Chain H
249–340（92 aa）
Chain H
415–444（30 aa）
Chain I
249–340（92 aa）
Chain I
415–444（30 aa）
Chain J
249–340（92 aa）
Chain J
415–444（30 aa）
|
Not recorded | EY4 (3a,5a)-3-Hydroxypregnane-11,20-dione × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.1；277 K；PEG400, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, NaSCN
|
Resolution 3.45 Å R-free 0.286 |
| 6D1S Crystal structure of an apo chimeric human alpha1GABAA receptor Deposited 2018-04-12 | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
249–340（92 aa）
Chain A
415–444（30 aa）
Chain B
249–340（92 aa）
Chain B
415–444（30 aa）
Chain C
249–340（92 aa）
Chain C
415–444（30 aa）
Chain D
249–340（92 aa）
Chain D
415–444（30 aa）
Chain E
249–340（92 aa）
Chain E
415–444（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.1；277.1 K；100 mM 2-(N-morpholino)ethanesulfonic acid, 400mM NaSCN, 21% PEG400
|
Resolution 3.20 Å R-free 0.269 |
| 6D1S Crystal structure of an apo chimeric human alpha1GABAA receptor Deposited 2018-04-12 | Assembly 2 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain F
249–340（92 aa）
Chain F
415–444（30 aa）
Chain G
249–340（92 aa）
Chain G
415–444（30 aa）
Chain H
249–340（92 aa）
Chain H
415–444（30 aa）
Chain I
249–340（92 aa）
Chain I
415–444（30 aa）
Chain J
249–340（92 aa）
Chain J
415–444（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.1；277.1 K；100 mM 2-(N-morpholino)ethanesulfonic acid, 400mM NaSCN, 21% PEG400
|
Resolution 3.20 Å R-free 0.269 |
| 6D6T Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B Deposited 2018-04-22 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ABU GAMMA-AMINO-BUTANOIC ACID × 2 Y01 CHOLESTEROL HEMISUCCINATE × 12 FYP ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3 seconds blot time
|
Resolution 3.86 Å |
| 6D6U Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A Deposited 2018-04-22 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 Y01 CHOLESTEROL HEMISUCCINATE × 12 FYP ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3 seconds blot time
|
Resolution 3.92 Å |
| 6HUJ CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38. Deposited 2018-10-08 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 RI5 (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione × 1 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.04 Å |
| 6HUK CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38. Deposited 2018-10-08 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | H0Z bicuculline methochloride × 2 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.69 Å |
| 6HUO CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38. Deposited 2018-10-09 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 08H 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.26 Å |
| 6HUP CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38. Deposited 2018-10-09 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 DZP 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.58 Å |
| 6I53 Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc Deposited 2018-11-12 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
1–456（456 aa）
Chain D
1–456（456 aa）
|
Not recorded | POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 3 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 6X3S Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide Deposited 2020-05-21 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 J94 (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium × 2 MAN alpha-D-mannopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 3.12 Å |
| 6X3T Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol Deposited 2020-05-21 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 2.55 Å |
| 6X3U Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil Deposited 2020-05-21 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ABU GAMMA-AMINO-BUTANOIC ACID × 2 FYP ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 3.50 Å |
| 6X3V Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate Deposited 2020-05-21 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 V8D Etomidate × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 3.50 Å |
| 6X3W Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital Deposited 2020-05-21 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ABU GAMMA-AMINO-BUTANOIC ACID × 2 UQA 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 3.30 Å |
| 6X3X Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam Deposited 2020-05-21 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 DZP 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE × 4 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 2.92 Å |
| 6X3Z Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA Deposited 2020-05-21 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 3.23 Å |
| 6X40 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin Deposited 2020-05-21 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 RI5 (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 2.86 Å |
| 7PBD a1b3 GABA-A receptor + GABA Deposited 2021-08-02 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 HSM HISTAMINE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.04 Å |
| 7PBZ a1b3 GABA-A receptor + GABA + Zn2+ Deposited 2021-08-03 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 UND UNDECANE × 2 OCT N-OCTANE × 2 HEX HEXANE × 4 ABU GAMMA-AMINO-BUTANOIC ACID × 2 ZN ZINC ION × 1 HSM HISTAMINE × 1 D10 DECANE × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.79 Å |
| 7PC0 GABA-A receptor bound by a-Cobratoxin Deposited 2021-08-03 | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 HSM HISTAMINE × 1 ZN ZINC ION × 1 HEX HEXANE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 7T0W Complex of GABA-A synaptic receptor with autoimmune antibody Fab115 Deposited 2021-11-30 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–445（28 aa）
Chain D
28–339（312 aa）
Chain D
418–445（28 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 7T0Z Complex of GABA-A synaptic receptor with autoimmune antibody Fab175 Deposited 2021-11-30 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–445（28 aa）
Chain D
28–339（312 aa）
Chain D
418–445（28 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 MAN alpha-D-mannopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 8DD2 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem Deposited 2022-06-17 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain D
28–339（312 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 R5R Zolpidem × 3 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 2.90 Å |
| 8DD3 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM Deposited 2022-06-17 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain D
28–339（312 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 R63 methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 second blot
|
Resolution 2.90 Å |
| 8PET Cryo-EM structure of the full-length human alpha1beta3 GABA(A) receptor (babba arrangement) in complex with nanobody Nb25, expressed with a 5-fold excess of beta3 over alpha1 Deposited 2023-06-14 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
37–456（420 aa）
Chain C
37–456（420 aa）
|
Not recorded | R16 HEXADECANE × 2 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 D10 DECANE × 12 ZN ZINC ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.60 Å |
| 8SGO Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate Deposited 2023-04-12 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 PTY PHOSPHATIDYLETHANOLAMINE × 6 Q3G O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine × 1 A8W Pregnenolone sulfate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.65 Å |
| 8SI9 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone Deposited 2023-04-14 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 Y4B allopregnanolone × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.98 Å |
| 8SID Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus dehydroepiandrosterone sulfate Deposited 2023-04-14 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 ZWY 17-oxoandrost-5-en-3beta-yl hydrogen sulfate × 1 PTY PHOSPHATIDYLETHANOLAMINE × 6 Q3G O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine × 1 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.71 Å |
| 8VQY Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone Deposited 2024-01-19 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain D
28–339（312 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 A1ADG 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one × 3 PTY PHOSPHATIDYLETHANOLAMINE × 4 Q3G O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.82 Å |
| 8VRN Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus PPTQ Deposited 2024-01-22 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain D
28–339（312 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 A1ADN 3-(4-methylphenyl)-2-phenylquinazolin-4(3H)-one × 2 PTY PHOSPHATIDYLETHANOLAMINE × 5 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 Q3G O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.57 Å |
| 9CRS Native human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 assembly Deposited 2024-07-22 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5s blot
|
Resolution 2.90 Å |
| 9CRV Native human GABAA receptor of beta2-alpha1-gamma2-beta2-alpha2 assembly Deposited 2024-07-22 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5s blot
|
Resolution 3.18 Å |
| 9CSB Native human GABAA receptor of beta3-alpha1-beta2-alpha2-gamma2 assembly Deposited 2024-07-23 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 3.34 Å |
| 9CT0 Native human GABAA receptor of beta2-alpha1-beta2-alpha2-gamma2 assembly Deposited 2024-07-24 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 3.19 Å |
| 9CTJ Native human GABAA receptor of beta2-alpha1-beta3-alpha2-gamma2 assembly Deposited 2024-07-25 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 3.74 Å |
| 9CTP Native human GABAA receptor of beta2-alpha1-beta2-alpha3-gamma2 assembly Deposited 2024-07-25 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 3.62 Å |
| 9CTV Native human GABAA receptor of beta2-alpha1-gamma2-beta1-alpha2 assembly Deposited 2024-07-25 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 3.36 Å |
| 9CX7 Native human GABAA receptor of beta3-alpha1-gamma2-beta3-alpha2 assembly Deposited 2024-07-30 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 3.30 Å |
| 9CXA Native human GABAA receptor of beta2-alpha1-beta3-alpha1-gamma2 assembly Deposited 2024-07-31 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
1–456（456 aa）
Chain D
1–456（456 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.04 Å |
| 9CXB Native human GABAA receptor of beta2-alpha1-beta1-alpha2-gamma2 assembly Deposited 2024-07-31 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 3.33 Å |
| 9CXC Native human GABAA receptor of beta3-alpha1-gamma2-beta2-alpha2 assembly Deposited 2024-07-31 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 3.30 Å |
| 9CXD Native human GABAA receptor of beta2-alpha1-beta1-beta1-gamma2 assembly Deposited 2024-07-31 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain B
28–456（429 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 1 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 3.36 Å |
| 9DRX Human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 subtype in complex with GABA plus Lamotrigine Deposited 2024-09-26 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
28–339（312 aa）
Chain B
418–456（39 aa）
Chain D
28–339（312 aa）
Chain D
418–456（39 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 IYJ (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3.5 s Blot.
|
Resolution 2.95 Å |
| 9EQG CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin Deposited 2024-03-21 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PGW (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate × 2 D10 DECANE × 11 HEX HEXANE × 10 PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 2 R16 HEXADECANE × 5 PLM PALMITIC ACID × 3 CL CHLORIDE ION × 3 ABU GAMMA-AMINO-BUTANOIC ACID × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 A1H6W Puerarin × 1 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；15 mM Hepes pH 7.4, 100 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.40 Å |
| 9FAJ CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38, in a desensitised state (StateD1) Deposited 2024-05-10 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain A
37–449（413 aa）
Chain D
37–449（413 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 PGW (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate × 5 D10 DECANE × 12 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 5 ABU GAMMA-AMINO-BUTANOIC ACID × 2 CL CHLORIDE ION × 4 R16 HEXADECANE × 4 HEX HEXANE × 7 PLM PALMITIC ACID × 5 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 1 CLR CHOLESTEROL × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；15 mM Hepes pH 7.4, 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.60 Å |
| 9FAK CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38 in a desensitised state (StateD2) Deposited 2024-05-10 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain A
37–449（413 aa）
Chain D
37–449（413 aa）
|
Not recorded | HEX HEXANE × 6 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 PGW (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate × 5 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 5 D10 DECANE × 7 PLM PALMITIC ACID × 8 CL CHLORIDE ION × 4 ABU GAMMA-AMINO-BUTANOIC ACID × 2 R16 HEXADECANE × 3 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 1 CLR CHOLESTEROL × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；15 mM Hepes pH 7.4, 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.60 Å |
| 9FAM CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38 in a desensitised state (StateD3) Deposited 2024-05-10 | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
37–449（413 aa）
Chain D
37–449（413 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 CL CHLORIDE ION × 3 HEX HEXANE × 7 D10 DECANE × 1 PLM PALMITIC ACID × 1 CLR CHOLESTEROL × 1 PGW (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；15 mM Hepes pH 7.4, 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 9FAP CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC1) Deposited 2024-05-10 | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
39–443（405 aa）
Chain D
39–443（405 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 PGW (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate × 5 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 2 PLM PALMITIC ACID × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CLR CHOLESTEROL × 1 D10 DECANE × 1 HEX HEXANE × 2 CL CHLORIDE ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；15 mM Hepes pH 7.4, 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9FAQ CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC2) Deposited 2024-05-10 | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
39–443（405 aa）
Chain D
39–443（405 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 PGW (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate × 5 D10 DECANE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PLM PALMITIC ACID × 5 CLR CHOLESTEROL × 1 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 1 HEX HEXANE × 2 CL CHLORIDE ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；15 mM Hepes pH 7.4, 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 9FAS CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with pregnenolone sulfate Deposited 2024-05-10 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
37–445（409 aa）
Chain D
37–445（409 aa）
|
Not recorded | HEX HEXANE × 8 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 PGW (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate × 3 D10 DECANE × 17 PLM PALMITIC ACID × 3 CL CHLORIDE ION × 3 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 1 R16 HEXADECANE × 5 A8W Pregnenolone sulfate × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；15 mM Hepes pH 7.4, 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 9FAT CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, Megabody38 and pregnenolone sulfate Deposited 2024-05-10 | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
37–449（413 aa）
Chain D
37–449（413 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 PGW (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate × 3 D10 DECANE × 3 CL CHLORIDE ION × 2 R16 HEXADECANE × 1 HEX HEXANE × 3 PLM PALMITIC ACID × 1 CLR CHOLESTEROL × 1 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 1 A8W Pregnenolone sulfate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；15 mM Hepes pH 7.4, 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 9FFL Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived symmetric bound-closed state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | D10 DECANE × 6 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 2 CL CHLORIDE ION × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 R16 HEXADECANE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9FFM Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with Mb25 in the resting state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | D10 DECANE × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 9FFN Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric bound-closed 1 state of branch 1 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | D10 DECANE × 3 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 2 CL CHLORIDE ION × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9FFO Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric bound-closed 2 state of branch 1 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 ABU GAMMA-AMINO-BUTANOIC ACID × 2 D10 DECANE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9FFP Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric open state of branch 1 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 9FFQ Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric desensitised state of branch 1 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | CL CHLORIDE ION × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9FFR Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric bound-closed state of branch 2 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | CLR CHOLESTEROL × 1 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9FFS Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric open state of branch 2 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9FFT Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric desensitised state of branch 2 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9FFU Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the long-lived symmetric desensitised state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | D10 DECANE × 6 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 2 CL CHLORIDE ION × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 R16 HEXADECANE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 9FFV Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with Nb38 in the long-lived symmetric resting state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | D10 DECANE × 5 CL CHLORIDE ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9FFW Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived symmetric bound-closed state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 D10 DECANE × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9FFX Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric bound-closed state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 9FFY Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric open1 state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | D3D (19S,22R,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9E)-octadec-9-enoate × 1 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9FFZ Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric desensitised 1 state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 D3D (19S,22R,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9E)-octadec-9-enoate × 1 CLR CHOLESTEROL × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9FG0 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric open 2 state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
37–339（303 aa）
Chain A
418–445（28 aa）
Chain D
37–339（303 aa）
Chain D
418–445（28 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 9FG1 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric desensitised 2 state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | ABU GAMMA-AMINO-BUTANOIC ACID × 2 D3D (19S,22R,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9E)-octadec-9-enoate × 2 D10 DECANE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9FG2 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the long-lived symmetric desensitised state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | D3D (19S,22R,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9E)-octadec-9-enoate × 2 CL CHLORIDE ION × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 D10 DECANE × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 9FG3 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 bound twice in the long-lived symmetric desensitised state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain A
32–339（308 aa）
Chain A
418–456（39 aa）
Chain D
32–339（308 aa）
Chain D
418–456（39 aa）
|
Not recorded | D10 DECANE × 5 D3D (19S,22R,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9E)-octadec-9-enoate × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9FG4 Cryo-EM structure of the full-length alpha1beta3 GABA(A) receptor in the long-lived symmetric resting state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9FG5 Cryo-EM structure of the full-length alpha1beta3 GABA(A) receptor in complex with GABA in the short-lived symmetric bound-closed state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9FG6 Cryo-EM structure of the full-length alpha1beta3 GABA(A) receptor in complex with GABA and HSM in the long-lived symmetric desensitised state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 HSM HISTAMINE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9FG7 Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in complex with GABA in the short-lived symmetric bound-closed state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 D10 DECANE × 3 CL CHLORIDE ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 9FG8 Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in complex with GABA in the long-lived symmetric desensitised state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | CL CHLORIDE ION × 1 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 D10 DECANE × 5 ABU GAMMA-AMINO-BUTANOIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 9FG9 Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Etomidate in the long-lived symmetric desensitised state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | CL CHLORIDE ION × 3 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 D10 DECANE × 5 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 2 R16 HEXADECANE × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 V8D Etomidate × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 9FGA Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in SMALPs bound to two PIP2 molecules and in complex with Mb38 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 D10 DECANE × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9FGB Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in SMALPs bound to one PIP2 molecule at chain alpha1-A and in complex with Mb38 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.80 Å |
| 9FGC Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in SMALPs bound to one PIP2 molecule at chain alpha1-D and in complex with Mb38 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | D10 DECANE × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9FGD Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in SMALPs without PIP2 and in complex with Mb38 Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 D10 DECANE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9FGF Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in Saposin A nanodisc in the long-lived symmetric resting state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | CL CHLORIDE ION × 3 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 R16 HEXADECANE × 2 D10 DECANE × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 9FGG Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in Saposin A nanodisc bound to GABA and Etomidate in the long-lived symmetric desensitised state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 D10 DECANE × 5 CL CHLORIDE ION × 3 ABU GAMMA-AMINO-BUTANOIC ACID × 2 V8D Etomidate × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 R16 HEXADECANE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.60 Å |
| 9FGH Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in large MSP2N2 nanodisc in complex with GABA in the long-lived symmetric desensitised state Deposited 2024-05-23 | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
28–456（429 aa）
Chain D
28–456（429 aa）
|
Not recorded | PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 2 CL CHLORIDE ION × 3 ABU GAMMA-AMINO-BUTANOIC ACID × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 9H9E Cryo-EM structure of the human GABAA receptor alpha1 subunit in complex with the assembly factor NACHO/TMEM35A Deposited 2024-10-30 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
37–456（420 aa）
Chain D
37–456（420 aa）
|
Not recorded | PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 PC7 (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE × 2 PGT (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE × 2 CLR CHOLESTEROL × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |