Current Protein Identity：P15379
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2JCP The hyaluronan binding domain of murine CD44 Deposited 2007-01-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–174（152 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-174
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；DROPLETS COMPRISING 200NL CD4425-174 (AT A CONCENTRATION OF 0.5MM) MIXED WITH 200NL WELL SOLUTION WERE DISPENSED AS SITTING DROPS AND UNDERWENT VAPOR DIFFUSION WITH A WELL SOLUTION OF 30% PEG MONOMETHYLETHER 5000, AND 200 MM (NH4)2SO4 IN 100 MM MES BUFFER PH 6.5
|
Resolution 1.30 Å R-free 0.191 |
| 2JCQ The hyaluronan binding domain of murine CD44 in a Type A complex with an HA 8-mer Deposited 2007-01-03 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–174（152 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-174
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7；CO-CRYSTALS OF THE CD44/HA8 COMPLEX WERE PREPARED AFTER ADDITION OF HA8 (2MM FINAL CONCENTRATION) TO THE 0.5MM PROTEIN SOLUTION FOLLOWED BY MIXING 1:1 WITH WELL SOLUTIONS CONTAINING 25% (W/V) PEG 3350 AND 100MM NACL IN 100MM HEPES BUFFERED AT EITHER PH 7.0 OR PH 8.0
|
Resolution 1.25 Å R-free 0.156 |
| 2JCR The hyaluronan binding domain of murine CD44 in a Type B complex with an HA 8-mer Deposited 2007-01-03 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–174（152 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-174
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 8；CO-CRYSTALS OF THE CD44/HA8 COMPLEX WERE PREPARED AFTER ADDITION OF HA8 (2MM FINAL CONCENTRATION) TO THE 0.5 MM PROTEIN SOLUTION FOLLOWED BY MIXING 1:1 WITH WELL SOLUTIONS CONTAINING 25% (W/V) PEG 3350 AND 100MM NACL IN 100MM HEPES BUFFERED AT PH 8.0
|
Resolution 2.00 Å R-free 0.254 |
| 2ZPY Crystal structure of the mouse radxin FERM domain complexed with the mouse CD44 cytoplasmic peptide Deposited 2008-07-31 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
708–727（20 aa）
Fragment：residues 293-312
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.6；277 K；0.1M Tris, 0.2M Potassium thiocyanate, 15% PEG 3350 , pH 8.6, VAPOR DIFFUSION, temperature 277K
|
Resolution 2.10 Å R-free 0.256 |
| 4MRD Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2013-09-17 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–171（149 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-171
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% PEG MME 5000, 100 mM MES, 200mM (NH4)2SO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.55 Å R-free 0.245 |
| 4MRE Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule Deposited 2013-09-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–171（149 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-171
|
Not recorded | DMS DIMETHYL SULFOXIDE × 1 2C9 3-methylbenzene-1,2-diamine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% PEG MME 5000, 100 mM MES, 200 mM (NH4)2SO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.58 Å R-free 0.223 |
| 4MRF Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2013-09-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–171（149 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-171
|
Not recorded | DMS DIMETHYL SULFOXIDE × 1 GOL GLYCEROL × 1 2CK 1,2,3,4-tetrahydroisoquinoline × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% PEG MME 5000, 100 mM MES, 200 mM (NH4)2SO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.55 Å R-free 0.215 |
| 4MRG Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2013-09-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–171（149 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-174
|
Mutation：H23M, Q24N | 24W 1,2,3,4-tetrahydroisoquinolin-5-amine × 1 DMS DIMETHYL SULFOXIDE × 1 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% PEG MME 5000, 100 mM MES, 200 mM (NH4)2SO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.69 Å R-free 0.206 |
| 4MRH Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule Deposited 2013-09-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–171（149 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-171
|
Not recorded | 2CQ 4-chloro-5-methylbenzene-1,2-diamine × 1 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% PEG MME 5000, 100 mM MES, 200 mM (NH4)2SO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.12 Å R-free 0.184 |
| 4NP2 Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule Deposited 2013-11-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–171（149 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-171
|
Not recorded | 2L1 2-[(4-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroisoquinoline × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 2 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.75 Å R-free 0.217 |
| 4NP3 Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2013-11-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–171（149 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-174
|
Not recorded | 2L2 2-[(4-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroisoquinolin-8-amine × 1 DMS DIMETHYL SULFOXIDE × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.61 Å R-free 0.225 |
| 5BZC Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
22–171（150 aa）
Fragment：HYALURONAN BINDING DOMAIN, unp RESIDUES 21-171
|
Not recorded | 4WT 4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline × 1 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.95 Å R-free 0.232 |
| 5BZE Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–171（149 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 21-171
|
Mutation：H23M; Q24N | DMS DIMETHYL SULFOXIDE × 1 SO4 SULFATE ION × 1 68N [(1S)-1,2,3,4-tetrahydroisoquinolin-1-yl]methanol × 1 6BT [(1R)-1,2,3,4-tetrahydroisoquinolin-1-yl]methanol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.31 Å R-free 0.195 |
| 5BZF Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, UNP RESIDUES 21-171
|
Mutation：H23M; Q24N | 4X3 2-ethyl-1,2,3,4-tetrahydroisoquinolin-5-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 2.77 Å R-free 0.293 |
| 5BZG Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, UNP RESIDUES 21-171
|
Mutation：H23M; Q24N | DMS DIMETHYL SULFOXIDE × 1 4X6 2-methyl-1,2,3,4-tetrahydroisoquinolin-5-amine × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 2.19 Å R-free 0.242 |
| 5BZH Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
|
Mutation：H23M, Q24N | DMS DIMETHYL SULFOXIDE × 1 4X1 3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-1-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% PEG MME 5000, 100 mM MES, 200 mM (NH4)2SO4
|
Resolution 1.95 Å R-free 0.227 |
| 5BZI Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 21-171
|
Mutation：H23M; Q24N | 4WU 1,2,3,4-tetrahydroisoquinolin-8-amine × 1 DMS DIMETHYL SULFOXIDE × 1 GOL GLYCEROL × 3 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.32 Å R-free 0.202 |
| 5BZJ Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, unp residues 21-171
|
Mutation：H23M; Q24N | DMS DIMETHYL SULFOXIDE × 1 SO4 SULFATE ION × 2 4WN 2-[2-(1-methyl-1H-imidazol-2-yl)ethyl]-1,2,3,4-tetrahydroisoquinolin-8-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.40 Å R-free 0.209 |
| 5BZK Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
|
Not recorded | DMS DIMETHYL SULFOXIDE × 1 4WP methyl 3-(3,4-dihydroisoquinolin-2(1H)-yl)propanoate × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；EG MME 5000, MES, (NH4)2SO4
|
Resolution 1.40 Å R-free 0.209 |
| 5BZL Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 21-171
|
Mutation：H23M; Q24N | DMS DIMETHYL SULFOXIDE × 1 SO4 SULFATE ION × 1 4WO methyl 3-(8-amino-3,4-dihydroisoquinolin-2(1H)-yl)propanoate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.23 Å R-free 0.188 |
| 5BZM Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 21-171
|
Mutation：H23M; Q24N | 4X8 2-[(4-amino-3-methylpyridin-2-yl)methyl]-1,2,3,4-tetrahydroisoquinolin-8-amine × 1 DMS DIMETHYL SULFOXIDE × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.25 Å R-free 0.222 |
| 5BZN Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 21-171
|
Mutation：H23M; Q24N | DMS DIMETHYL SULFOXIDE × 1 4XD 2-(2-methoxyethyl)-1,2,3,4-tetrahydroisoquinolin-8-amine × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.23 Å R-free 0.196 |
| 5BZO Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 21-171
|
Mutation：H23M; Q24N | 4XC 3-(8-amino-3,4-dihydroisoquinolin-2(1H)-yl)-N-methylpropanamide × 1 DMS DIMETHYL SULFOXIDE × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.22 Å R-free 0.182 |
| 5BZP Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 23-174
|
Mutation：H23M; Q24N | 4XG 2-[3-(dimethylamino)propyl]-1,2,3,4-tetrahydroisoquinolin-8-amine × 1 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.23 Å R-free 0.206 |
| 5BZQ Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, UNP RESIDUES 21-171
|
Mutation：H23M; Q24N | 4XL 2-[3-(morpholin-4-yl)propyl]-1,2,3,4-tetrahydroisoquinolin-8-amine × 1 DMS DIMETHYL SULFOXIDE × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.20 Å R-free 0.181 |
| 5BZR Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 21-171
|
Mutation：H23M; Q24N | DMS DIMETHYL SULFOXIDE × 1 4XM 2-[3-(tetrahydro-2H-pyran-4-yloxy)propyl]-1,2,3,4-tetrahydroisoquinolin-8-amine × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.15 Å R-free 0.188 |
| 5BZS Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 21-171
|
Mutation：H23M; Q24N | 4XK 2-[3-(tetrahydro-2H-pyran-4-yloxy)propyl]-1,2,3,4-tetrahydroisoquinolin-5-amine × 1 DMS DIMETHYL SULFOXIDE × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.50 Å R-free 0.242 |
| 5BZT Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Deposited 2015-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–171（151 aa）
Fragment：HYALURONAN BINDING DOMAIN, RESIDUES 21-171
|
Mutation：H23M; Q24N | DMS DIMETHYL SULFOXIDE × 1 SO4 SULFATE ION × 1 4XJ 2-(1,3-dimethoxypropan-2-yl)-1,2,3,4-tetrahydroisoquinolin-8-amine × 2 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG MME 5000, MES, (NH4)2SO4
|
Resolution 1.25 Å R-free 0.192 |
| 5SBK CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z1258992717 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 89W N-[(3R)-piperidin-3-yl]benzamide × 1 DMS DIMETHYL SULFOXIDE × 2 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.23 Å R-free 0.226 |
| 5SBL CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z126932614 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | T6J 2-[(methylsulfonyl)methyl]-1H-benzimidazole × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.20 Å R-free 0.195 |
| 5SBM CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z1267885772 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | DMS DIMETHYL SULFOXIDE × 4 EDO 1,2-ETHANEDIOL × 2 8AB (3S)-3-methyl-1-(6-methylpyridin-2-yl)piperazine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.14 Å R-free 0.188 |
| 5SBN CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z57040482 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 9KS N-(2-hydroxyphenyl)acetamide × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.18 Å R-free 0.195 |
| 5SBO CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z2856434878 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8A5 4-[(3,4-dimethoxyphenyl)methyl]morpholine × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.27 Å R-free 0.234 |
| 5SBP CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z1229798311 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8BC 2-acetamido-6-fluorobenzoic acid × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.27 Å R-free 0.204 |
| 5SBQ CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z44592329 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | K0G N-phenyl-N'-pyridin-3-ylurea × 1 PGE TRIETHYLENE GLYCOL × 1 DMS DIMETHYL SULFOXIDE × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 0.99 Å R-free 0.171 |
| 5SBR CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z1259341012 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8B2 (1R)-1-[4-(morpholin-4-yl)phenyl]ethan-1-amine × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.29 Å R-free 0.207 |
| 5SBS CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z340495298 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8AK N-cyclopropyl-5-methyl-N-(propan-2-yl)-1,2-oxazole-3-carboxamide × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.02 Å R-free 0.194 |
| 5SBT CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z445856640 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | VZP N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]-N-methyl-N'-propan-2-ylurea × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.16 Å R-free 0.192 |
| 5SBU CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z839988838 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8C2 N-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]cyclohexanamine × 1 PGE TRIETHYLENE GLYCOL × 1 DMS DIMETHYL SULFOXIDE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.04 Å R-free 0.179 |
| 5SBV CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z31721798 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | NW4 3-cyclohexyl-1-(morpholin-4-yl)propan-1-one × 1 DMS DIMETHYL SULFOXIDE × 2 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.11 Å R-free 0.209 |
| 5SBW CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z2856434874 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | O0M 1-{[4-(propan-2-yl)phenyl]methyl}piperidin-4-ol × 1 DMS DIMETHYL SULFOXIDE × 4 EDO 1,2-ETHANEDIOL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.15 Å R-free 0.190 |
| 5SBX CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z53825479 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8BT N-cyclopentylmethanesulfonamide × 1 PEG DI(HYDROXYETHYL)ETHER × 1 DMS DIMETHYL SULFOXIDE × 2 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.05 Å R-free 0.149 |
| 5SBY CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z1878656559 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8BI (1R,2R)-2,4,4-trimethyl-N-[(1H-pyrazol-3-yl)methyl]cyclopentan-1-amine × 1 PEG DI(HYDROXYETHYL)ETHER × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.22 Å R-free 0.200 |
| 5SBZ CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z768399682 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | K0D [(2R,5S)-2,5-dimethylmorpholin-4-yl](1,2,5-thiadiazol-3-yl)methanone × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.17 Å R-free 0.166 |
| 5SC0 CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z2856434899 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | T0Y 1-[(thiophen-3-yl)methyl]piperidin-4-ol × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.19 Å R-free 0.169 |
| 5SC1 CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z431807512 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8DH N-methyl-3-oxo-N-(propan-2-yl)piperazine-1-sulfonamide × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.17 Å R-free 0.174 |
| 5SC2 CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z190780124 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8D8 (3S)-N-[(1R)-1-cyclopropylethyl]-2-oxo-2,3-dihydropyridine-3-carboxamide × 2 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.21 Å R-free 0.185 |
| 5SC3 CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z422471910 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8CZ N-[(1S)-1-cyclopropylethyl]-N,4-dimethyl-1,3-thiazole-5-carboxamide × 1 DMS DIMETHYL SULFOXIDE × 2 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.24 Å R-free 0.172 |
| 5SC4 CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z927412236 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8CN (2R)-2-amino-1-[(2S)-2-methylpiperidin-1-yl]propan-1-one × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.17 Å R-free 0.155 |
| 5SC5 CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z56827661 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | VZY N-(3-methylbenzene-1-carbonyl)glycine × 1 DMS DIMETHYL SULFOXIDE × 2 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.17 Å R-free 0.191 |
| 5SC6 CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with POB0019 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | 8CH methyl (2S,3R)-1-(methanesulfonyl)-3-methylpiperidine-2-carboxylate × 1 DMS DIMETHYL SULFOXIDE × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.33 Å R-free 0.238 |
| 5SC7 CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with POB0120 Deposited 2021-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–172（150 aa）
|
Not recorded | W2M (2R)-1',4'-dihydro-2'H-spiro[pyrrolidine-2,3'-quinolin]-2'-one × 1 DMS DIMETHYL SULFOXIDE × 5 EDO 1,2-ETHANEDIOL × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；200mM ammonium sulphate, 100mM MES, 24% PEG 5,000 MME
|
Resolution 1.20 Å R-free 0.182 |
| 9EJW MCMV immunoevasin m11 binding murine CD44 Deposited 2024-11-29 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
23–174（152 aa）
Fragment：UNP residues 23-174
|
Not recorded | SO4 SULFATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CYS CYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；30% w/v PEG3000, 0.2 M lithium sulfate, 0.1 M Tris-HCl, pH 8.5
|
Resolution 1.40 Å R-free 0.202 |