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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P16234 New Search
14PDB entries
14Biological assembly
25chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5GRN Crystal structure of PDGFRA in Complex with WQ-C-159 Deposited 2016-08-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa） Fragment：UNP residues 550-696 and 769-973
Chain A 769–973（205 aa） Fragment：UNP residues 550-696 and 769-973
Not recorded 748 N-[2-(dimethylamino)ethyl]-N-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide × 1 CL CHLORIDE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2M KCl, 20% PEG 3350, pH 7.0
Resolution 1.77 Å R-free 0.179
5K5X Crystal structure of human PDGFRA Deposited 2016-05-24 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa） Fragment：UNP residues 550-696,769-973
Chain A 769–973（205 aa） Fragment：UNP residues 550-696,769-973
Not recorded SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1M HEPES pH7.5, 1.6M (NH4)2SO4, 0.1M NaCl
Resolution 2.17 Å R-free 0.224
6A32 Crystal structure of PDGFRA kinase domain mutant T674I Deposited 2018-06-14 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa）
Chain A 769–973（205 aa）
Mutation：T674I Mutation：T674I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris pH 5.5, 27% PEG 3350
Resolution 1.87 Å R-free 0.240
6JOI Crystal structure of PDGFRA T674I in complex with crenolanib by co-crystallization Deposited 2019-03-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa）
Chain A 769–973（205 aa）
Mutation：T674I Mutation：T674I 6T2 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1M NaCl, 0.1M Tris pH 8.0, 15% PEG 4000
Resolution 3.10 Å R-free 0.244
6JOJ Crystal structure of PDGFRA T674I in complex with crenolanib by soaking Deposited 2019-03-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa）
Chain A 769–973（205 aa）
Not recorded 6T2 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine × 1 SO4 SULFATE ION × 2 CL CHLORIDE ION × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1M HEPES pH6.9, 1.6M (NH4)2SO4, 0.1M NaCl
Resolution 2.60 Å R-free 0.233
6JOK Crystal structure of PDGFRA in complex with sunitinib by soaking Deposited 2019-03-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa）
Chain A 769–973（205 aa）
Not recorded B49 N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide × 1 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1M HEPES pH6.9, 1.6M (NH4)2SO4, 0.1M NaCl
Resolution 3.80 Å R-free 0.282
6JOL Crystal structure of PDGFRA in complex with imatinib by co-crystallization Deposited 2019-03-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa）
Chain A 769–973（205 aa）
Not recorded STI 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1M Sodium citrate pH4.5, 20% PEG 4000
Resolution 1.90 Å R-free 0.236
7LBF CryoEM structure of the HCMV Trimer gHgLgO in complex with human Platelet-derived growth factor receptor alpha and neutralizing fabs 13H11 and MSL-109 Deposited 2021-01-07 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain D 1–524（524 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；The sample was gently cross-linked with 0.025% (v/v) EM-grade glutaraldehyde for 10 min at RT and quenched with 9 mM Tris pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 2.5 seconds before plunging
Resolution 2.80 Å
7RAM Cryo-EM Structure of the HCMV gHgLgO Trimer Derived from AD169 and TR strains in complex with PDGFRalpha Deposited 2021-07-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain D 1–524（524 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；300mM NaCl and 20mM HEPES7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.43 Å
8PQH PDGFRA T674I mutant kinase domain in complex with avapritinib Deposited 2023-07-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa）
Chain A 769–973（205 aa）
Mutation：T674I Mutation：T674I 9JI Avapritinib × 1 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；10 mg/mL, 13% PEG3350, 200 mM KCl
Resolution 2.50 Å R-free 0.249
8PQI PDGFRA T674I mutant kinase domain in complex with avapritinib derivative 9 Deposited 2023-07-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa）
Chain A 769–973（205 aa）
Mutation：T674I Mutation：T674I 9OO (1~{S})-~{N}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine × 1 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；5 mg/mL, 5% PEG3350, 200 mM KCl
Resolution 2.60 Å R-free 0.254
8PQJ PDGFRA wild-type kinase domain Deposited 2023-07-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa）
Chain A 769–973（205 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；285.15 K；10 mg/mL, 15% PEG3350, 100 mM Bis-Tris-Propane, pH 7.5
Resolution 1.82 Å R-free 0.215
8PQK APO crystal structure of PDGFRA-T674I kinase domain Deposited 2023-07-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–696（147 aa）
Chain A 769–973（205 aa）
Mutation：T674I Mutation：T674I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；10 mg/mL, 22% PEG3350, 100 mM Bis-Tris-Propane, pH 7.5
Resolution 2.00 Å R-free 0.222
9GZH PDGFRA-T674I in complex with covalent ponatinib derivative 19 Deposited 2024-10-04 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–973（424 aa）
Mutation：T674I A1IRC 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-~{N}-[4-(propanoylamino)-3-(trifluoromethyl)phenyl]benzamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；5 mg/mL, 18% PEG3350, 100 mM KCl
Resolution 2.20 Å R-free 0.215

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.